Infotropism as the underlying principle of perceptual organization

Whether perceptual organization favors the simplest or most likely interpretation of a distal stimulus has long been debated. An unbridgeable gulf has seemed to separate these, the Gestalt and Helmholtzian viewpoints. But in recent decades, the proposal that likelihood and simplicity are two sides of the same coin has been gaining ground, to the extent that their equivalence is now widely assumed. What then arises is a desire to know whether the two principles can be reduced to one. Applying Occam's Razor in this way is particularly desirable given that, as things stand, an account referencing one principle alone cannot be completely satisfactory. The present paper argues that unification of the two principles is possible, and that it can be achieved in terms of an incremental notion of `information seeking' (infotropism). Perceptual processing that is infotropic can be shown to target both simplicity and likelihood. The ability to see perceptual organization as governed by either objective can then be explained in terms of it being an infotropic process. Infotropism can be identified as the principle which underlies, and thus generalizes the principles of likelihood and simplicity

Soluble tumor necrosis factor receptor 1 and 2 predict outcomes in advanced chronic kidney disease : a prospective cohort study

Background : Soluble tumor necrosis factor receptors 1 (sTNFR1) and 2 (sTNFR2) have been associated to progression of renal failure, end stage renal disease and mortality in early stages of chronic kidney disease (CKD), mostly in the context of diabetic nephropathy. The predictive value of these markers in advanced stages of CKD irrespective of the specific causes of kidney disease has not yet been defined. In this study, the relationship between sTNFR1 and sTNFR2 and the risk for adverse cardiovascular events (CVE) and all-cause mortality was investigated in a population with CKD stage 4-5, not yet on dialysis, to minimize the confounding by renal function. Patients and methods : In 131 patients, CKD stage 4-5, sTNFR1, sTNFR2 were analysed for their association to a composite endpoint of all-cause mortality or first non-fatal CVE by univariate and multivariate Cox proportional hazards models. In the multivariate models, age, gender, CRP, eGFR and significant comorbidities were included as covariates. Results : During a median follow-up of 33 months, 40 events (30.5%) occurred of which 29 deaths (22.1%) and 11 (8.4%) first non-fatal CVE. In univariate analysis, the hazard ratios (HR) of sTNFR1 and sTNFR2 for negative outcome were 1.49 (95% confidence interval (CI): 1.28-1.75) and 1.13 (95% CI: 1.06-1.20) respectively. After adjustment for clinical covariables (age, CRP, diabetes and a history of cardiovascular disease) both sTNFRs remained independently associated to outcomes (HR: sTNFR1: 1.51, 95% CI: 1.30-1.77; sTNFR2: 1.13, 95% CI: 1.06-1.20). A subanalysis of the non-diabetic patients in the study population confirmed these findings, especially for sTNFR1. Conclusion : sTNFR1 and sTNFR2 are independently associated to all-cause mortality or an increased risk for cardiovascular events in advanced CKD irrespective of the cause of kidney disease

Invariant template matching in systems with spatiotemporal coding: a vote for instability

We consider the design of a pattern recognition that matches templates to images, both of which are spatially sampled and encoded as temporal sequences. The image is subject to a combination of various perturbations. These include ones that can be modeled as parameterized uncertainties such as image blur, luminance, translation, and rotation as well as unmodeled ones. Biological and neural systems require that these perturbations be processed through a minimal number of channels by simple adaptation mechanisms. We found that the most suitable mathematical framework to meet this requirement is that of weakly attracting sets. This framework provides us with a normative and unifying solution to the pattern recognition problem. We analyze the consequences of its explicit implementation in neural systems. Several properties inherent to the systems designed in accordance with our normative mathematical argument coincide with known empirical facts. This is illustrated in mental rotation, visual search and blur/intensity adaptation. We demonstrate how our results can be applied to a range of practical problems in template matching and pattern recognition.Comment: 52 pages, 12 figure

Temporal Information Extraction by Predicting Relative Time-lines

The current leading paradigm for temporal information extraction from text consists of three phases: (1) recognition of events and temporal expressions, (2) recognition of temporal relations among them, and (3) time-line construction from the temporal relations. In contrast to the first two phases, the last phase, time-line construction, received little attention and is the focus of this work. In this paper, we propose a new method to construct a linear time-line from a set of (extracted) temporal relations. But more importantly, we propose a novel paradigm in which we directly predict start and end-points for events from the text, constituting a time-line without going through the intermediate step of prediction of temporal relations as in earlier work. Within this paradigm, we propose two models that predict in linear complexity, and a new training loss using TimeML-style annotations, yielding promising results.Comment: Accepted at the Conference on Empirical Methods in Natural Language Processing (EMNLP 2018

Modification of Sand Fly Biting Behavior by \u3ci\u3eLeishmania\u3c/i\u3e Leads to Increased Parasite Transmission

To attempt rodent-sand fly-rodent transmission of Leishmania major, laboratory-reared Phlebotomus doboscqi were fed on L. major-infected mice and then refed on uninfected mice 21 days later. Flies which refed either probed 1–2 times and took a full blood meal in less than 10 minutes or probed 3 or more times and took little or no blood during a period of 15 minutes or more. When dissected, 7 of 8 flies which experienced difficulty in obtaining a blood meal had flagellates in their cibaria, an observation supporting the hypothesis that parasites in this part of the alimentary canal modify normal blood feeding behavior. None of the infected females which probed 1–2 times had similar anterior station infections. Infected sand flies transmitted L. major to uninfected mice and a single fly, transferred from 1 mouse to the next while repeatedly attempting to take blood, infected 5 mice. During a year-long survey in Baringo District, Kenya, we collected 9,182 female sand flies. Only 2 of the 278 P. duboscqi captured during this collection were infected with L. major; however, 18 of the 789 small rodents from this area were infected with L. major. Parasite interference with normal blood feeding may explain how a relatively small population of P. duboscqi, only a few of which are infected with L. major, can amplify parasite transmission thereby maintaining a disproportionately large reservoir in local rodents