Generalised simulation environment for software testing

International audienceThe cost of the verification process is certainly one of the major engineering issue in the domain of embedded safety-sensitive systems such as avionis. Test environments, made up of dedicated software and hardware means, are among the most significantly contributing factors. This paper reports about an alternative approach where test environments are totally simulated for all test phases. Simulation is not per se a new approach, the expected positive gap is expected from its generalisation. test phases coverage. Our works on this generalised simulation approach are part the ongoing RNTL/ATLAS research project

How to measure the relevance of a retargeting approach?

International audienceMost cell phones today can receive and display video content. Nonetheless, we are still significantly behind the point where premium made for mobile content is mainstream, largely available, and affordable. Significant issues must be overcome. The small screen size is one of them. Indeed, the direct transfer of conventional contents (not specifically shot for mobile devices) will provide a video in which the main characters or objects of interest may become indistinguishable from the rest of the scene. Therefore, it is required to retarget the content. Different solutions exist, either based on distortion of the image, on removal of redundant areas, or cropping. The most efficient ones are based on dynamic adaptation of the cropping window. They significantly improve the viewing experience by zooming in the regions of interest. Currently, there is no common agreement on how to compare different solutions. A retargeting metric is proposed in order to gauge its quality. Eye-tracking experiments, zooming effect through coverage ratio and temporal consistency are introduced and discussed

Sociologie, histoire, anthropologie des dynamiques culturelles

Jean-Pierre Chauveau, directeur de recherche à l’IRDJean-Philippe Colin, IRDPierre-Yves Le Meur, GRET Ethnographie des institutions et des droits fonciers Le séminaire examine, sous l’angle de l’anthropologie, de la géographie et de l’économie, les rapports que les hommes entretiennent à propos de l’accès à la terre et à ses ressources dans le contexte contemporain des sociétés africaines et du monde en développement. La présentation des approches et méthodes d’ethnographie des droits, des in..

Sociologie, histoire, anthropologie des dynamiques culturelles

Jean-Pierre Chauveau, directeur de recherche à l’IRDJean-Philippe Colin, IRDPierre-Yves Le Meur, GRET Ethnographie des institutions et des droits fonciers Le séminaire examine, sous l’angle de l’anthropologie, de la géographie et de l’économie, les rapports que les hommes entretiennent à propos de l’accès à la terre et à ses ressources dans le contexte contemporain des sociétés africaines et du monde en développement. La présentation des approches et méthodes d’ethnographie des droits, des in..

A strategy for monitoring systemic vulnerability to marine erosion and flooding

Littoralisation, or the concentration of people and activities in coastal areas, associated with the intrinsic mobility of coasts and with the context of climate change, tends to increase the vulnerability of coastal areas. This article presents a new interdisciplinary approach towards the concept of vulnerability that makes it possible to move beyond the nature/society dichotomy, and an inter-sectorial researcher-manager method for the development of a series of monitoring indicators for the four components of systemic vulnerability: hazards, stakes, management and representations. These indicators are precursors of an integrated observatory that will act as a source of data for research and inform public policy for coastal areas.Le phénomène de littoralisation du peuplement et des activités, associé à la mobilité intrinsèque des côtes et au contexte de changement climatique, tend à accroître la vulnérabilité des territoires côtiers. Cet article propose, d’une part, une approche interdisciplinaire renouvelée du concept de vulnérabilité permettant de dépasser la dichotomie nature/société. D’autre part, il présente une méthode intersectorielle chercheurs-gestionnaires de construction d’une série d’indicateurs de suivi des quatre composantes de la vulnérabilité systémique (aléa, enjeux, gestion et représentations). Ces indicateurs préfigurent un observatoire intégré, à la fois source de données pour la recherche, et au service des politiques publiques pour les territoires côtiers

ADHERE: randomized controlled trial comparing renal function in de novo kidney transplant recipients receiving prolonged-release tacrolimus plus mycophenolate mofetil or sirolimus

ADHERE was a randomized, open-label, Phase IV study comparing renal function at Week 52 postkidney transplant, in patients who received prolongedrelease tacrolimus-based immunosuppressive regimens. On Days 0?27, patients received prolonged-release tacrolimus (initially 0.2 mg/kg/day), corticosteroids, and mycophenolate mofetil (MMF). Patients were randomized on Day 28 to receive either prolonged-release tacrolimus plus MMF (Arm 1) or prolongedrelease tacrolimus (?25% dose reduction on Day 42) plus sirolimus (Arm 2). The primary endpoint was glomerular filtration rate by iohexol clearance (mGFR) at Week 52. Secondary endpoints included eGFR, creatinine clearance (CrCl), efficacy failure (patient withdrawal or graft loss), and patient/graft survival. Tolerability was analyzed. The full-analysis set comprised 569 patients (Arm 1: 287; Arm 2: 282). Week 52 mean mGFR was similar in Arm 1 versus Arm 2 (40.73 vs. 41.75 ml/min/1.73 m2; P = 0.405), as were the secondary endpoints, except composite efficacy failure, which was higher in Arm 2 versus 1 (18.2% vs. 11.5%; P = 0.002) owing to a higher postrandomization withdrawal rate due to adverse events (AEs) (14.4% vs. 5.2%). Results from this study show comparable renal function between arms at Week 52, with fewer AEs leading to study discontinuation with prolonged-release tacrolimus plus MMF (Arm 1) versus lower dose prolonged-release tacrolimus plus sirolimus (Arm 2)

Immune Response and Mitochondrial Metabolism Are Commonly Deregulated in DMD and Aging Skeletal Muscle

Duchenne Muscular Dystrophy (DMD) is a complex process involving multiple pathways downstream of the primary genetic insult leading to fatal muscle degeneration. Aging muscle is a multifactorial neuromuscular process characterized by impaired muscle regeneration leading to progressive atrophy. We hypothesized that these chronic atrophying situations may share specific myogenic adaptative responses at transcriptional level according to tissue remodeling. Muscle biopsies from four young DMD and four AGED subjects were referred to a group of seven muscle biopsies from young subjects without any neuromuscular disorder and explored through a dedicated expression microarray. We identified 528 differentially expressed genes (out of 2,745 analyzed), of which 328 could be validated by an exhaustive meta-analysis of public microarray datasets referring to DMD and Aging in skeletal muscle. Among the 328 validated co-expressed genes, 50% had the same expression profile in both groups and corresponded to immune/fibrosis responses and mitochondrial metabolism. Generalizing these observed meta-signatures with large compendia of public datasets reinforced our results as they could be also identified in other pathological processes and in diverse physiological conditions. Focusing on the common gene signatures in these two atrophying conditions, we observed enrichment in motifs for candidate transcription factors that may coordinate either the immune/fibrosis responses (ETS1, IRF1, NF1) or the mitochondrial metabolism (ESRRA). Deregulation in their expression could be responsible, at least in part, for the same transcriptome changes initiating the chronic muscle atrophy. This study suggests that distinct pathophysiological processes may share common gene responses and pathways related to specific transcription factors

De novo TBR1 variants cause a neurocognitive phenotype with ID and autistic traits:report of 25 new individuals and review of the literature

TBR1, a T-box transcription factor expressed in the cerebral cortex, regulates the expression of several candidate genes for autism spectrum disorders (ASD). Although TBR1 has been reported as a high-confidence risk gene for ASD and intellectual disability (ID) in functional and clinical reports since 2011, TBR1 has only recently been recorded as a human disease gene in the OMIM database. Currently, the neurodevelopmental disorders and structural brain anomalies associated with TBR1 variants are not well characterized. Through international data sharing, we collected data from 25 unreported individuals and compared them with data from the literature. We evaluated structural brain anomalies in seven individuals by analysis of MRI images, and compared these with anomalies observed in TBR1 mutant mice. The phenotype included ID in all individuals, associated to autistic traits in 76% of them. No recognizable facial phenotype could be identified. MRI analysis revealed a reduction of the anterior commissure and suggested new features including dysplastic hippocampus and subtle neocortical dysgenesis. This report supports the role of TBR1 in ID associated with autistic traits and suggests new structural brain malformations in humans. We hope this work will help geneticists to interpret TBR1 variants and diagnose ASD probands