Determination of Instantaneous Powers from a Novel Time-Domain Parameter Identification Method of Non-Linear Single-Phase Circuits

This paper proposes a systematic method for the identification of the load circuit parameters (say the R, L, and C elements) based only on the information of the instantaneous volt- age and current measured at the point of common coupling (pcc). Geometric Algebra (GA) and concepts of differential geometry are used to produce a rigorous mathematical framework. The identification is formulated as a multidimensional geometrical problem that is solved conveniently by means of GA. Once the passive elements of the load have been identified, the active and reactive powers can be computed from first electromagnetic principles (Maxwell Equations). The theory is general and is verified with linear and nonlinear circuits. The paper shows single-phase circuits but the theory can be extended to three- phase circuits. The method is easy to program and has shown to be very robust for all tested cases. Because of its generality, the method presented will find applications beyond electric circuit

Arquitectura de validación de diseños didácticos para la formación de profesores de matemáticas

Este artículo presenta los resultados del proyecto “Desarrollo didáctico y tecnológico en escenarios didácticos para la formación de profesores que acogen la diversidad”. La investigación incorpora una perspectiva teórica del diseño universal y una posición ético-política de una educación matemática con todos. Se entrega como resultado de investigación una arquitectura para validar las hipótesis didácticas que fundamentan el diseño de un ambiente y tres objetos virtuales de aprendizaje. Los diseños didácticos son validados en un curso para formación de profesores de matemáticas de la educación básica, con diseño instruccional para la interacción cara a cara y en línea (virtual). La arquitectura como estructura de validación articula las metodologías provenientes de experimento de enseñanza, investigación en diseño y comunidades de práctica. Los resultados se centran en la validación de hipótesis sobre formación de profesores de matemáticas para acoger la diversidad de poblaciones, diseños didácticos accesibles y metodologías para la validación didáctica en comunidades de práctica

Multiple Sclerosis and Its Relationship with Oxidative Stress, Glutathione Redox System, ATPase System, and Membrane Fluidity

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) with a focus on inflammation, demyelination, and damage to axons leading to neurological deficits. MS pathology is associated with excessive reactive oxygen species (ROS) and generation of reactive nitrogen species (RNS), causing oxidative/nitrosative stress. Deregulation of glutathione homeostasis and alterations in glutathione‐dependent enzymes are implicated in MS. Reactive oxygen species enhance both monocyte adhesion and migration across brain endothelial cells. In addition, ROS can activate the expression of the nuclear transcription factor‐kappa, which upregulates the expression of many genes involved in MS, such as tumor necrosis factor‐α and nitric oxide synthase, among others, leading to mitochondrial dysfunction and energy deficits that result in mitochondrial and cellular calcium overload. Loss of mitochondrial membrane potential can increase the release of cytochrome c, one pathway that leads to neuronal apoptosis. Clinical studies suggest that omega‐3 long‐chain polyunsaturated fatty acids (PUFAs) including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have anti‐inflammatory, antioxidant, and neuroprotective effects in MS and animal models of MS. Here, we review the relationship of oxidative stress, the glutathione redox system, the ATPase system, and membrane fluidity with the development of MS. In addition, we describe the main findings of a clinical trial conducted with relapsing‐remitting MS patients who received a diet supplemented with 4 g/day of fish oil or olive oil. The effects of PUFAs supplementation on the parameters indicated above are analyzed in this work

Arquitetura de validação de projetos didáticos para a formação de professores de matemáticas

This article presents the results of the project “Didactic and technological development in didactic scenarios for the training of teachers who embrace diversity”. From a theoretical perspective of the universal design and from a political-ethical position of a mathematical education with everyone, the research provides an architecture as a research result to validate the didactic hypotheses that serve as the basis for the design of an environment and three virtual objects of learning. The didactic designs are validated in a training course for elementary school mathematics teachers, with instructional design for both face-to-face and online interactions. Architecture as a validation structure articulates the methodologies resulting from teaching experiments, design research, and communities of practice. The results focus on the validation of hypotheses about training of pre-service math teachers to accommodate the diversity of populations, accessible didactic designs, and methodologies for didactic validation in communities of practiceEste artículo presenta los resultados del proyecto “Desarrollo didáctico y tecnológico en escenarios didácticos para la formación de profesores que acogen la diversidad”. La investigación incorpora una perspectiva teórica del diseño universal y una posición ético-política de una educación matemática con todos. Se entrega como resultado de investigación una arquitectura para validar las hipótesis didácticas que fundamentan el diseño de un ambiente y tres objetos virtuales de aprendizaje. Los diseños didácticos son validados en un curso para formación de profesores de matemáticas de la educación básica, con diseño instruccional para la interacción cara a cara y en línea (virtual). La arquitectura como estructura de validación articula las metodologías provenientes de experimento de enseñanza, investigación en diseño y comunidades de práctica. Los resultados se centran en la validación de hipótesis sobre formación de profesores de matemáticas para acoger la diversidad de poblaciones, diseños didácticos accesibles y metodologías para la validación didáctica en comunidades de práctica.Este artigo apresenta os resultados do projeto “Desenvolvimento didático e tecnológico em cenários didáticos para a formação de professores que adotam a diversidade”. A pesquisa incorpora uma perspectiva teórica do design universal e uma posição ético-política de uma educação matemática com todos. Como resultado de investigação, é apresentada uma arquitetura para validar as hipóteses didáticas que fundamentam o desenho de um ambiente e três objetivos virtuais de aprendizagem. Os projetos didáticos são validados em uma aula para formação de professores de matemáticas de educação básica, com design instrucional para a interação face a face e online. A arquitetura como estrutura de validação articula as metodologias provenientes de experimento de ensino, pesquisa em projeto e comunidades de prática. Os resultados centram-se na validação de hipóteses sobre formação de professores de matemáticas para adotar a diversidade de populações, projetos didáticos acessíveis e metodologias para a validação didática em comunidades de prática

Manejo multidisciplinario de la Neutropenia Febril: Consenso Institucional. Lima, Perú.

Background: To provide recommendations based on the best available scientific evidence for the multidisciplinary management of febrile neutropenia. The development included the stages: approval of the creation of the Working Group (WG); CPG search; analysis and synthesis of the evidence that led to establishing the recommendation of the selected CPGs, design of the consensus document, internal review. All phases were carried out through panel meetings using virtual platforms during 03 months. The “GRADE” system was used to establish the strength and direction of the recommendations. The recommendations cover the prevention, diagnosis and treatment of febrile neutropenia in oncohematological patients. Twenty-eight recommendations were developed. The topics approached were: correct evaluation; timely diagnosis, adequate antibiotic treatment, vaccination against influenza and pneumococcus, administration of colony-stimulating factor and special management of pediatric patients for diagnosis, treatment.Introducción: Brindar recomendaciones basadas en la mejor evidencia científica disponible para el manejo multidisciplinario de la neutropenia febril. El desarrollo abarco las etapas: aprobación de la conformación del Grupo Elaborador (GE); búsqueda de GPC; análisis y síntesis de la evidencia que llevó al establecimiento de la recomendación de las GPC seleccionadas, diseño del documento consenso, revisión interna. Todas las fases fueron llevadas a cabo mediante reuniones de panel a través del uso de plataformas virtuales durante 03 meses. Se utilizó el sistema “GRADE” para establecer la fuerza y dirección de las recomendaciones. Las recomendaciones abarcan la prevención, el diagnóstico y tratamiento de la neutropenia febril en pacientes oncohematológicos. Se formularon 28 recomendaciones. Los temas abordados han sido relacionados a: correcta evaluación; diagnóstico oportuno, tratamiento antibiótico adecuado, vacunación contra influenza y neumococo, administración de factor estimulante de colonias y manejo especial en pacientes pediátricos para diagnóstico, tratamiento

Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe

Combined searches for the production of supersymmetric top quark partners in proton-proton collisions at root s=13 TeV

A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb(-1) collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on themodel, the combined result excludes a top squarkmass up to 1325 GeV for amassless neutralino, and a neutralinomass up to 700 GeV for a top squarkmass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV

Probing effective field theory operators in the associated production of top quarks with a Z boson in multilepton final states at root s=13 TeV

Peer reviewe

MUSiC : a model-unspecific search for new physics in proton-proton collisions at root s=13TeV

Results of the Model Unspecific Search in CMS (MUSiC), using proton-proton collision data recorded at the LHC at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1), are presented. The MUSiC analysis searches for anomalies that could be signatures of physics beyond the standard model. The analysis is based on the comparison of observed data with the standard model prediction, as determined from simulation, in several hundred final states and multiple kinematic distributions. Events containing at least one electron or muon are classified based on their final state topology, and an automated search algorithm surveys the observed data for deviations from the prediction. The sensitivity of the search is validated using multiple methods. No significant deviations from the predictions have been observed. For a wide range of final state topologies, agreement is found between the data and the standard model simulation. This analysis complements dedicated search analyses by significantly expanding the range of final states covered using a model independent approach with the largest data set to date to probe phase space regions beyond the reach of previous general searches.Peer reviewe