Práticas feministas em torno do direito ao aborto na Argentina: : aproximações às ações coletivas das Socorristas en Red

In Argentina abortion is not punishable only if the pregnancy is the result a rape or if it endangers the life of the pregnant woman. In any other case than those aforementioned it is considered a crime against life  according  to  the Penal Code. However if a woman gets pregnant without wanting it, she will look for different ways to terminate her pregnancy. Since 1980 the feminist and women’s movement organizes groups and alliances in order to reclaim the legalization of abortion. In this article, I will go into some experiences that have pushed  forward  the  National Campaign for the Legalization  of Safe Abortion for Free (Campaña Nacional por el Derecho al Aborto Legal, Seguro y Gratuito).  Finally, I will focus on new and original collective actions on abortion and the setting of the organization “Socorristas en Red (Feministas que abortamos)”.O aborto na Argentina é uma prática tipificada pelo código penal como crime contra a vida, ainda que existam duas exceções não puníveis: quando a gravidez é resultado de um estupro ou quando pressupõe um risco para a saúde da mulher e não pode ser evitado por outros meios. Apesar disso, quando uma mulher engravida e não deseja a gestação recorre à diferentes mecanismos para interromper o processo gestacional. Assim, desde a década de 1980, na Argentina, o movimento feminista e de mulheres têm se organizado de diferentes formas e formado grupos e coalizões diversas para reivindicar o aborto legal. Neste artigo proponho traçar um caminho sobre algumas dessas experiências de articulação que nutrem a existência da Campanha Nacional pelo Direito ao Aborto Legal, Seguro e Gratuito. Finalmente, me interessa particularizar, uma forma inovadora de organização de ações coletivas em relação ao aborto, o surgimento das Socorristas em Rede (Feministas que abortamos)

Existence and Stability of Kayaking Orbits for Nematic Liquid Crystals in Simple Shear Flow

We use geometric methods of equivariant dynamical systems to address a long-standing open problem in the theory of nematic liquid crystals, namely a proof of the existence and asymptotic stability of kayaking periodic orbits in response to steady shear flow. These are orbits for which the principal axis of orientation of the molecular field (the director) rotates out of the plane of shear and around the vorticity axis. With a small parameter attached to the symmetric part of the velocity gradient, the problem can be viewed as a symmetry-breaking bifurcation from an orbit of the rotation group SO(3) that contains both logrolling (equilibrium) and tumbling (periodic rotation of the director within the plane of shear) regimes as well as a continuum of neutrally stable kayaking orbits. The results turn out to require expansion to second order in the perturbation parameter

Influence of nano-aluminum filler on the microstructure of SiOC ceramics

Ceramic SiC–mullite–Al2O3 based nanocomposites were successfully obtained at temperatures below 1500 °C after pyrolysis and annealing of green compacts prepared by cross-linking and shaping in a warm press step of commercial poly(methylsilsesquioxane) MK polymer mechanically mixed with aluminum filler having nanoparticle size. The heat treatment takes place under the exclusion of oxygen (inert argon atmosphere) and temperatures as low as 800 °C initiate the crystallization of a silicon carbide phase. The influence of the nano-aluminum filler and of the pyrolysis temperature on the crystallization behavior of the materials has been investigated. It was confirmed that an appropriate amount of nano-aluminum filler leads to a cristobalite free bulk SiOC ceramic. In consequence, the received ceramic samples have to be considered as a nano/micro-ceramic composite consisting of crystals of mullite (average dimension in the range of 200 nm), silicon carbide (20 nm) and α-alumina (50 nm)

One-pot synthesis of a C/SiFeN(O)-based ceramic paper with in-situ generated hierarchical micro/nano-morphology

In the present study, a C/SiFeN(O)-based ceramic paper with in situ generated hierarchical micro/nano-morphology was prepared upon thermal treatment of a cellulose-base paper surface-modified with a polymeric single-source precursor prepared from perhydropolysilazane (PHPS) and iron(II) acetylacetonate (Fe(acac)2). The ammonolysis at 1000 °C of the paper/precursor hybrid materials leads to a C/SiFeN(O)-based ceramic paper which exhibits the same morphology as that of the cellulose paper. Subsequent annealing of the ceramic paper in nitrogen atmosphere at temperatures from 1200 to 1400 °C results in the in-situ generation of ultra-long silicon nitride nanowires with aspect ratios in the range of 103 on the surface and in the macropores of the ceramic paper. The nanowires exhibit round Fe3Si tips at the end, indicating that the growth occurred via iron-catalyzed VLS (vapor-liquid-solid) mechanism. The combination of single-source precursor, porous template and in situ VLS growth of 1D nanostructures provides a convenient one-pot synthesis approach to produce ceramic nanocomposites with hierarchical morphologies

Localization of the Priming Factors CAPS1 and CAPS2 in Mouse Sensory Neurons Is Determined by Their N-Termini

Both paralogs of the calcium-dependent activator protein for secretion (CAPS) are required for exocytosis of synaptic vesicles (SVs) and large dense core vesicles (LDCVs). Despite approximately 80% sequence identity, CAPS1 and CAPS2 have distinct functions in promoting exocytosis of SVs and LDCVs in dorsal root ganglion (DRG) neurons. However, the molecular mechanisms underlying these differences remain enigmatic. In this study, we applied high- and super-resolution imaging techniques to systematically assess the subcellular localization of CAPS paralogs in DRG neurons deficient in both CAPS1 and CAPS2. CAPS1 was found to be more enriched at the synapses. Using – in-depth sequence analysis, we identified a unique CAPS1 N-terminal sequence, which we introduced into CAPS2. This CAPS1/2 chimera reproduced the pre-synaptic localization of CAPS1 and partially rescued synaptic transmission in neurons devoid of CAPS1 and CAPS2. Using immunoprecipitation combined with mass spectrometry, we identified CAPS1-specific interaction partners that could be responsible for its pre-synaptic enrichment. Taken together, these data suggest an important role of the CAPS1-N terminus in the localization of the protein at pre-synapses

Gewalt gegen Maedchen und Frauen im Sport Pilotstudie im Auftrag des Ministeriums fuer Frauen, Jugend, Familie und Gesundheit des Landes Nordrhein-Westfalen

Die Verfasser praesentieren eine systematisierende Aufarbeitung der zum Thema 'Gewalt gegen Maedchen im Sport' vorliegenden Stellungnahmen und Veroeffentlichungen. Ergaenzend wurden 35 Experteninterviews mit Personen aus verschiedenen Bereichen des Sports durchgefuehrt. Die Ergebnisse werden differenziert nach den Bereichen Schulsport, Leistungssport,Sportschulen, Sportvereine und spezielle Problemfelder (Sportstudium, Behindertensport) vorgelegt. Die Untersuchung macht ein breites Gewaltspektrum von verbaler bis zu massiver sexueller Gewalt deutlich. Abschliessend werden weitere Forschungsperspektiven skizziert und gewaltpraeventive Massnahmen vorgeschlagen. (ICE)SIGLEAvailable from UuStB Koeln(38)-20000106532 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Tumor Cell-Surface Binding of Immune Stimulating Polymeric Glyco-Adjuvant via Cysteine-Reactive Pyridyl Disulfide Promotes Antitumor Immunity

Immune stimulating agents like Toll-like receptor 7 (TLR7) agonists induce potent antitumor immunity but are limited in their therapeutic window due to off-target immune activation. Here, we developed a polymeric delivery platform that binds excess unpaired cysteines on tumor cell surfaces and debris to adjuvant tumor neoantigens as an in situ vaccine. The metabolic and enzymatic dysregulation in the tumor microenvironment produces these exofacial free thiols, which can undergo efficient disulfide exchange with thiol-reactive pyridyl disulfide moieties upon intratumoral injection. These functional monomers are incorporated into a copolymer with pendant mannose groups and TLR7 agonists to target both antigen and adjuvant to antigen presenting cells. When tethered in the tumor, the polymeric glyco-adjuvant induces a robust antitumor response and prolongs survival of tumor-bearing mice, including in checkpoint-resistant B16F10 melanoma. The construct additionally reduces systemic toxicity associated with clinically relevant small molecule TLR7 agonists

Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC.

Polyinosinic:polycytidylic acid (poly IC), a double-stranded RNA, is an effective adjuvant in vivo. IFN-λs (also termed IL-28/29) are potent immunomodulatory and antiviral cytokines. We demonstrate that poly IC injection in vivo induces large amounts of IFN-λ, which depended on hematopoietic cells and the presence of TLR3 (Toll-like receptor 3), IRF3 (IFN regulatory factor 3), IRF7, IFN-I receptor, Fms-related tyrosine kinase 3 ligand (FL), and IRF8 but not on MyD88 (myeloid differentiation factor 88), Rig-like helicases, or lymphocytes. Upon poly IC injection in vivo, the IFN-λ production by splenocytes segregated with cells phenotypically resembling CD8α(+) conventional dendritic cells (DCs [cDCs]). In vitro experiments revealed that CD8α(+) cDCs were the major producers of IFN-λ in response to poly IC, whereas both CD8α(+) cDCs and plasmacytoid DCs produced large amounts of IFN-λ in response to HSV-1 or parapoxvirus. The nature of the stimulus and the cytokine milieu determined whether CD8α(+) cDCs produced IFN-λ or IL-12p70. Human DCs expressing BDCA3 (CD141), which is considered to be the human counterpart of murine CD8α(+) DCs, also produced large amounts of IFN-λ upon poly IC stimulation. Thus, IFN-λ production in response to poly IC is a novel function of mouse CD8α(+) cDCs and their human equivalents