La estructura de la pasarela de acceso al Centro Especial de Empleo Aspanias. Polígono G3 de Burgos, 1994.

The paper describes the wooden structure of a pedestrian bridge of a mixed use building with (residential and working) for disabled people.It has been analyzed from the process of design to the structure itself and questions about materials and treatmentsThe building was built 13 years ago, when the wooden construction was really reduced in Spain; something to keep in mind in the analysis of this work.El artículo describe la estructura de una pasarela de madera de acceso a un edificio de uso mixto residencial y laboral para discapacitados.Se recorren los aspectos de proyecto, del diseño de la estructura y otros más técnicos relativos al tipo de materiales y tratamientos.La obra se construyó hace unos 13 años, momento en el que en España la construcción con madera era mínima; algo que sin duda no puede perderse de vista al analizar esta obra

La estructura de la cubierta de la pieza de recepción del Centro Especial de Empleo Aspanias. Morales del Vino, Zamora, 1993

The paper describes the wooden structure of a pedestrian bridge of a mixed use building with (residential and working) for disabled people. It has been analyzed from the process of design to the structure itself and questions about materials and treatments. The building was built 13 years ago, when the wooden construction was really reduced in Spain; something to keep in mind in the analysis of this work.El artículo describe el proyecto y la construcción de una estructura de cubierta madera de la pieza de acceso a un edificio de uso mixto residencial y laboral para discapacitados. Se describen algunos aspectos de proyecto, del diseño de la estructura y otros más técnicos relativos al tipo de materiales y tratamientos. La obra se construyó hace unos 13 años, momento en el que en España la construcción con madera era mínima; algo que sin duda no puede perderse de vista al analizar esta obra

Design Space Exploration of Accelerators and End-to-End DNN Evaluation with TFLITE-SOC

Recently there has been a rapidly growing demand for faster machine learning (ML) processing in data centers and migration of ML inference applications to edge devices. These developments have prompted both industry and academia to explore custom accelerators to optimize ML executions for performance and power. However, identifying which accelerator is best equipped for performing a particular ML task is challenging, especially given the growing range of ML tasks, the number of target environments, and the limited number of integrated modeling tools. To tackle this issue, it is of paramount importance to provide the computer architecture research community with a common framework capable of performing a comprehensive, uniform, and fair comparison across different accelerator designs targeting a particular ML task. To this aim, we propose a new framework named TFLITESOC (System On Chip) that integrates a lightweight system modeling library (SystemC) for fast design space exploration of custom ML accelerators into the build/execution environment of Tensorflow Lite (TFLite), a highly popular ML framework for ML inference. Using this approach, we are able to model and evaluate new accelerators developed in SystemC by leveraging the language’s hierarchical design capabilities, resulting in faster design prototyping. Furthermore, any accelerator designed using TFLITE-SOC can be benchmarked for inference with any DNN model compatible with TFLite, which enables end-to-end DNN processing and detailed (i.e., per DNN layer) performance analysis. In addition to providing rapid prototyping, integrated benchmarking, and a range of platform configurations, TFLITESOC offers comprehensive performance analysis of accelerator occupancy and execution time breakdown as well as a rich set of modules that can be used by new accelerators to implement scaling up studies and optimized memory transfer protocols. We present our framework and demonstrate its utility by considering the design space of a TPU-like systolic array and describing possible directions for optimization. Using a compression technique, we implement an optimization targeting reducing the memory traffic between DRAM and on-device buffers. Compared to the baseline accelerator, our optimized design shows up to 1.26x speedup on accelerated operations and up to 1.19x speedup on end-to-end DNN execution

Influence of the addition of LPG-reformate and H2 on an engine dually fuelled with LPG–diesel, –RME and –GTL Fuels

AbstractDual fuel compression ignition engine has been proposed as one approach to reduce diesel engine regulated emissions (NOX and Soot) and to also allow the utilisation of other non-traditional fuels in transportation, in order to improve fuel security and CO2 emissions. In an attempt to improve the combustion characteristics of the LPG–diesel dual fuelled engine the influence of the (a) hydrogen and reformate (H2 and CO) additions and (b) properties of the in-cylinder injected diesel fuel, in this case diesel, biodiesel and synthetic diesel fuel were investigated.Improvements on engine thermal efficiency and HC (including particular HC species) emissions with the reformate and further improvements on CO, soot and particulate matter with hydrogen with respect to LPG–diesel dual fuel combustion were obtained. However, an increase in NOX was obtained due to the high in-cylinder temperature as a result of the shorter advanced premixed combustion. Moreover, the RME’s oxygen content, different injection (i.e. different high bulk modulus) and combustion characteristics as a result of its properties modified the combustion process and hence produced even lower HC, CO, soot and PM emissions. On the other hand, the lower density of GTL has changed the diesel fuel injection and combustion characteristics in dual fuelling mode which resulted in the increased regulated (HC and CO) and unregulated emissions. However, LPG–GTL dual fuelling with reformate and H2 addition showed better smoke-NOX trade-off compared to that of ULSD and RME

Telotristat ethyl in carcinoid syndrome: safety and efficacy in the TELECAST phase 3 trial

Telotristat ethyl, a tryptophan hydroxylase inhibitor, was efficacious and well tolerated in the phase 3 TELESTAR study in patients with carcinoid syndrome (CS) experiencing ≥4 bowel movements per day (BMs/day) while on somatostatin analogs (SSAs). TELECAST, a phase 3 companion study, assessed the safety and efficacy of telotristat ethyl in patients with CS (diarrhea, flushing, abdominal pain, nausea or elevated urinary 5-hydroxyindoleacetic acid (u5-HIAA)) with <4 BMs/day on SSAs (or ≥1 symptom or ≥4 BMs/day if not on SSAs) during a 12-week double-blind treatment period followed by a 36-week open-label extension (OLE). The primary safety and efficacy endpoints were incidence of treatment-emergent adverse events (TEAEs) and percent change from baseline in 24-h u5-HIAA at week 12. Patients (N = 76) were randomly assigned (1:1:1) to receive placebo or telotristat ethyl 250 mg or 500 mg 3 times per day (tid); 67 continued receiving telotristat ethyl 500 mg tid during the OLE. Through week 12, TEAEs were generally mild to moderate in severity; 5 (placebo), 1 (telotristat ethyl 250 mg) and 3 (telotristat ethyl 500 mg) patients experienced serious events, and the rate of TEAEs in the OLE was comparable. At week 12, significant reductions in u5-HIAA from baseline were observed, with Hodges–Lehmann estimators of median treatment differences from placebo of −54.0% (95% confidence limits, −85.0%, −25.1%, P < 0.001) and −89.7% (95% confidence limits, −113.1%, −63.9%, P < 0.001) for telotristat ethyl 250 mg and 500 mg. These results support the safety and efficacy of telotristat ethyl when added to SSAs in patients with CS diarrhea (ClinicalTrials.gov identifier: Nbib2063659)

Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure

Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of hospitalization for heart failure or death from cardiovascular causes among patients with stable heart failure. However, the safety and efficacy of SGLT2 inhibitors when initiated soon after an episode of decompensated heart failure are unknown

Experimental and thermodynamic analysis of a bottoming Organic Rankine Cycle (ORC) of gasoline engine using swash-plate expander

This paper deals with the experimental testing of an Organic Rankine Cycle (ORC) integrate in a 2 liter turbocharged gasoline engine using ethanol as working fluid. The main components of the cycle are a boiler, a condenser, a pump and a swash-plate expander. Five engine operating points have been tested, they correspond to a nominal heat input into the boiler of 5, 12, 20, 25 and 30 kW. With the available bill of material based on prototypes, power balances and cycles efficiencies were estimated, obtaining a maximum improvement in the ICE mechanical power and an expander shaft power of 3.7% and 1.83 kW respectively. A total of 28 steady-state operating points were measured to evaluate performance of the swash-plate expander prototype. Operating parameters of the expander, such as expander speed and expansion ratio, were shifted. The objective of the tests is to master the system and understand physical parameters influence. The importance of each parameter was analyzed by fixing all the parameters, changing each time one specific value. In these sensitivity studies, maximum ideal and real Rankine efficiency value of 19% and 6% were obtained respectively.This work is part of a research project called "Evaluation of bottoming cycles in IC engines to recover waste heat energies" funded by a National Project of the Spanish Government with reference TRA2013-46408-R.Galindo, J.; Ruiz Rosales, S.; Dolz Ruiz, V.; Royo Pascual, L.; Haller, R.; Nicolas, B.; Glavatskaya, Y. (2015). Experimental and thermodynamic analysis of a bottoming Organic Rankine Cycle (ORC) of gasoline engine using swash-plate expander. Energy Conversion and Management. 103:519-532. https://doi.org/10.1016/j.enconman.2015.06.085S51953210

Instability of the steady states of some Ginzburg–Landau-like equations with real coefficients

The instability of the steady states with nonconstant amplitude is analysed for a nonlocal Ginzburg–Landau equation with real coefficients and quasiperiodic boundary conditions. The results are obtained in terms of easily recognized, qualitative properties of the steady states. Some of the results are new, even for the standard (local) Ginzburg–Landau equation with real coefficients. A related Ginzburg–Landau equation coupled to a mean field is also considered that appears in the analyses of counter-propagating waves in extended systems, nonoscillatory instabilities with a conservation law, and viscous Faraday waves in large aspect ratio containers