Engineering students\u27 preferred roles: Are they stable, are there gender differences?

Being able to situate oneself in an engineering role is a developmental process. Students may initially have idealized perceptions of a professional role and over time, they make this role more congruent with their own values and goals [1]. In light of this, Higher Education Institutions are being challenged to offer learning experiences and career exploration activities to enable students to clarify their interests, values and competencies in relation to a professional role [2]. This study compared the professional role preferences of more than 700 engineering students at TU Dublin (Ireland) and KU Leuven (Belgium). Professional role preference was measured with PREFER Explore, a personal preference test for engineers. The test aligns students to three professional roles for early career engineers: Product leadership (focus on radical innovation), Operational excellence (focus on process optimization) and Customer intimacy (focus on tailored solutions and customer satisfaction). A comparison was drawn between the role preference of first year students at TU Dublin and KU Leuven to establish if there were significant differences in preference across both universities. The results suggest that the role preference of engineering students does not shift from first to third year. There is also evidence that the PREFER Explore is sensitive to gender differences, with female students showing a greater preference for customer intimacy than males and males showing a greater preference for operational excellence than females at TU Dublin. The data have a number of implications for the labor market in Ireland and Belgium

Surface Magnetization of Aperiodic Ising Quantum Chains

We study the surface magnetization of aperiodic Ising quantum chains. Using fermion techniques, exact results are obtained in the critical region for quasiperiodic sequences generated through an irrational number as well as for the automatic binary Thue-Morse sequence and its generalizations modulo p. The surface magnetization exponent keeps its Ising value, beta_s=1/2, for all the sequences studied. The critical amplitude of the surface magnetization depends on the strength of the modulation and also on the starting point of the chain along the aperiodic sequence.Comment: 11 pages, 6 eps-figures, Plain TeX, eps

Local critical behaviour at aperiodic surface extended perturbation in the Ising quantum chain

The surface critical behaviour of the semi--infinite one--dimensional quantum Ising model in a transverse field is studied in the presence of an aperiodic surface extended modulation. The perturbed couplings are distributed according to a generalized Fredholm sequence, leading to a marginal perturbation and varying surface exponents. The surface magnetic exponents are calculated exactly whereas the expression of the surface energy density exponent is conjectured from a finite--size scaling study. The system displays surface order at the bulk critical point, above a critical value of the modulation amplitude. It may be considered as a discrete realization of the Hilhorst--van Leeuwen model.Comment: 13 pages, TeX file + 6 figures, epsf neede

Surface Magnetization of Aperiodic Ising Systems: a Comparative Study of the Bond and Site Problems

We investigate the influence of aperiodic perturbations on the critical behaviour at a second order phase transition. The bond and site problems are compared for layered systems and aperiodic sequences generated through substitution. In the bond problem, the interactions between the layers are distributed according to an aperiodic sequence whereas in the site problem, the layers themselves follow the sequence. A relevance-irrelevance criterion introduced by Luck for the bond problem is extended to discuss the site problem. It involves a wandering exponent for pairs, which can be larger than the one considered before in the bond problem. The surface magnetization of the layered two-dimensional Ising model is obtained, in the extreme anisotropic limit, for the period-doubling and Thue-Morse sequences.Comment: 19 pages, Plain TeX, IOP macros + epsf, 6 postscript figures, minor correction

Anomalous Diffusion in Aperiodic Environments

We study the Brownian motion of a classical particle in one-dimensional inhomogeneous environments where the transition probabilities follow quasiperiodic or aperiodic distributions. Exploiting an exact correspondence with the transverse-field Ising model with inhomogeneous couplings we obtain many new analytical results for the random walk problem. In the absence of global bias the qualitative behavior of the diffusive motion of the particle and the corresponding persistence probability strongly depend on the fluctuation properties of the environment. In environments with bounded fluctuations the particle shows normal diffusive motion and the diffusion constant is simply related to the persistence probability. On the other hand in a medium with unbounded fluctuations the diffusion is ultra-slow, the displacement of the particle grows on logarithmic time scales. For the borderline situation with marginal fluctuations both the diffusion exponent and the persistence exponent are continuously varying functions of the aperiodicity. Extensions of the results to disordered media and to higher dimensions are also discussed.Comment: 11 pages, RevTe

Surface Magnetization and Critical Behavior of Aperiodic Ising Quantum Chains

We consider semi-infinite two-dimensional layered Ising models in the extreme anisotropic limit with an aperiodic modulation of the couplings. Using substitution rules to generate the aperiodic sequences, we derive functional equations for the surface magnetization. These equations are solved by iteration and the surface magnetic exponent can be determined exactly. The method is applied to three specific aperiodic sequences, which represent different types of perturbation, according to a relevance-irrelevance criterion. On the Thue-Morse lattice, for which the modulation is an irrelevant perturbation, the surface magnetization vanishes with a square root singularity, like in the homogeneous lattice. For the period-doubling sequence, the perturbation is marginal and the surface magnetic exponent varies continuously with the modulation amplitude. Finally, the Rudin-Shapiro sequence, which corresponds to the relevant case, displays an anomalous surface critical behavior which is analyzed via scaling considerations: Depending on the value of the modulation, the surface magnetization either vanishes with an essential singularity or remains finite at the bulk critical point, i.e., the surface phase transition is of first order.Comment: 8 pages, 7 eps-figures, uses RevTex and epsf, minor correction

The Ageing Brain: Effects on DNA Repair and DNA Methylation in Mice

The Centre for Ageing & Vitality is funded by the MRC and BBSRC (Grant Reference MR/L016354/1). This work was further supported by the Centre for Integrated Systems Biology of Ageing and Nutrition funded by the BBSRC and EPSRC (G0700718). Part of the work was supported by BBSRC Grant BB/K010867/1

An ECVAG† trial on assessment of oxidative damage to DNA measured by the comet assay

The increasing use of single cell gel electrophoresis (the comet assay) highlights its popularity as a method for detecting DNA damage, including the use of enzymes for assessment of oxidatively damaged DNA. However, comparison of DNA damage levels between laboratories can be difficult due to differences in assay protocols (e.g. lysis conditions, enzyme treatment, the duration of the alkaline treatment and electrophoresis) and in the end points used for reporting results (e.g. %DNA in tail, arbitrary units, tail moment and tail length). One way to facilitate comparisons is to convert primary comet assay end points to number of lesions/106 bp by calibration with ionizing radiation. The aim of this study was to investigate the inter-laboratory variation in assessment of oxidatively damaged DNA by the comet assay in terms of oxidized purines converted to strand breaks with formamidopyrimidine DNA glycosylase (FPG). Coded samples with DNA oxidation damage induced by treatment with different concentrations of photosensitizer (Ro 19-8022) plus light and calibration samples irradiated with ionizing radiation were distributed to the 10 participating laboratories to measure DNA damage using their own comet assay protocols. Nine of 10 laboratories reported the same ranking of the level of damage in the coded samples. The variation in assessment of oxidatively damaged DNA was largely due to differences in protocols. After conversion of the data to lesions/106 bp using laboratory-specific calibration curves, the variation between the laboratories was reduced. The contribution of the concentration of photosensitizer to the variation in net FPG-sensitive sites increased from 49 to 73%, whereas the inter-laboratory variation decreased. The participating laboratories were successful in finding a dose–response of oxidatively damaged DNA in coded samples, but there remains a need to standardize the protocols to enable direct comparisons between laboratories

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.

Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety 'Mode of Action' framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology