Vremenska i prostorna obilježja ubojstava u obitelji u RH

Unatoč zakonodavnoj zaštiti života i obitelji postoje različite, najčešće konfliktne situacije unutar obitelji, koje prethode ubojstvu u obitelji, a koje prema svojim obilježjima ne ulaze u domenu kažnjivih radnji ili, pak, predstavljaju dio tamne brojke. Stoga je iznimno važna prevencija kojom bi se spriječio nastanak, ako ne svih, onda onih najtežih posljedica odnosno smrti nekog člana obitelji. Stoga vremenska i prostorna obilježja mogu predstavljati važan indikator za usmjeravanje preventivnih mjera i radnji kada su posrijedi kaznena djela ubojstava unutar obitelji. Detekcija prostorne i vremenske povezanosti omogućuje intenzivniji preventivni pristup na određenom području i u određenom vremenskom periodu. Za uzorak istraživanja korišteni su sekundarni izvori podataka odnosno prikupljeni policijski spisi ubojstava i teških ubojstava u obitelji počinjenih na području Republike Hrvatske u razdoblju od 1. siječnja 2005. godine do 31. prosinca 2010. godine. Tijekom istraživanja ukupno je analizirano 113 policijskih spisa ubojstava i teških ubojstava u obitelji, a uzorak je obuhvaćao 113 počinitelja i 128 žrtava, obzirom da je određeni broj počinitelja počinio kazneno djelo na štetu više žrtava. Cilj provedenog istraživanja je stjecanje uvida u vremenska i prostorna obilježja obiteljskih ubojstava dok je specifični cilj istraživanja utvrđivanje postojanja razlika u vremenskim i prostornim obilježjima ubojstava u obitelji obzirom na srodstvo žrtve i počinitelja te spol počinitelja. S praktičnog aspekta rad bi svim stručnjacima koji se bave različitim aspektima vezanim uz obitelj i njihove odnose, a primarno policijskim službenicima trebao pružiti informaciju o postojanju pojedinih vremenskih i prostornih specifičnosti obiteljskih ubojstava te specifičnosti u odnosu na srodstvo žrtve i počinitelja te spol počinitelja s ciljem usmjeravanja preventivnih mjera i radnji

Die Pflicht, up-to-date zu sein: Adressierungen (werdender) Eltern durch Schwangerschafts- und Erziehungsapps

Software-Apps sind inzwischen zentraler Bestandteil des alltäglichen Lebens. Vor dem Hintergrund dieser umfassenden Digitalisierung des Sozialen fragt der Beitrag danach, welche Selbstverhältnisse und generationalen Beziehungen durch Erziehungs- und Schwangerschaftsapps konstruiert und adressiert werden, welche normierenden Effekte diese Apps haben und welche Themen ausgeklammert werden. Der Beitrag beruht auf einer qualitativen Analyse von 55 Inhaltsbeschreibungen von Schwangerschafts- und Erziehungsapps aus App-Stores. Wir zeigen, dass neben hetero- und geschlechternormativen Adressierungen Schwangere und Eltern als vorausschauende Subjekte adressiert werden, die im Sinne einer antizipatorischen Risikologik insbesondere mit einem Regime des Upto-Date- bzw. Alert-sein-Müssens und einer 'Pflicht zum Wissen' konfrontiert sind. Der Handlungsdruck, der auf diese Weise erzeugt wird, geht zugleich mit dem Versprechen einher, diese Aufgaben an die App abgeben zu können.Software apps have become a central part of everyday life. Against the backdrop of the digital transformation of the social, this article asks which self-relations and generational relations are constructed and addressed through parenting and pregnancy apps, what normative effects these apps have and what topics they disregard. The article is based on a qualitative analysis of 55 content descriptions in app stores. We show that, in addition to heteronormative and gender-normative interpellations, pregnant women and parents are addressed both in a heteronormative and gender-normative way and as forward-looking subjects who, in terms of an anticipatory risk logic, are in particular confronted with a regime that requires them to be up to date and alert and imposes on them a "duty to know". The pressure to act that is generated in this way is simultaneously intertwined with the promise that these tasks can be ceded to the app

What Do We Want From Explainable Artificial Intelligence (XAI)? -- A Stakeholder Perspective on XAI and a Conceptual Model Guiding Interdisciplinary XAI Research

Previous research in Explainable Artificial Intelligence (XAI) suggests that a main aim of explainability approaches is to satisfy specific interests, goals, expectations, needs, and demands regarding artificial systems (we call these stakeholders' desiderata) in a variety of contexts. However, the literature on XAI is vast, spreads out across multiple largely disconnected disciplines, and it often remains unclear how explainability approaches are supposed to achieve the goal of satisfying stakeholders' desiderata. This paper discusses the main classes of stakeholders calling for explainability of artificial systems and reviews their desiderata. We provide a model that explicitly spells out the main concepts and relations necessary to consider and investigate when evaluating, adjusting, choosing, and developing explainability approaches that aim to satisfy stakeholders' desiderata. This model can serve researchers from the variety of different disciplines involved in XAI as a common ground. It emphasizes where there is interdisciplinary potential in the evaluation and the development of explainability approaches.Comment: 57 pages, 2 figures, 1 table, to be published in Artificial Intelligence, Markus Langer, Daniel Oster and Timo Speith share first-authorship of this pape

Permafrost Thaw and Liberation of Inorganic Nitrogen in Eastern Siberia

The currently observed climate warming will lead to widespread degradation of near-surface permafrost, which may release substantial amounts of inorganic nitrogen (N) into arctic ecosystems. We studied 11 soil profiles at three different sites in arctic eastern Siberia to assess the amount of inorganic N stored in arctic permafrost soils. We modelled the potential thickening of the active layer for these sites using the CryoGrid2 permafrost model and representative concentration pathways (RCPs) 4.5 (a stabilisation scenario) and 8.5 (a business as usual emission scenario, with increasing carbon emissions). The modelled increases in active-layer thickness (ALT) were used to estimate potential annual liberation of inorganic N from permafrost soils during the course of climate change. We observed significant stores of inorganic ammonium in permafrost, up to 40-fold higher than in the active layer. The modelled increase in ALT under the RCP8.5 scenario can result in substantial liberation of N, reaching values up to the order of magnitude of annual fixation of atmospheric N in arctic soils. However, the thaw-induced liberation of N represents only a small flux in comparison with the overall ecosystem N cycling

Intravenous versus oral etoposide : efficacy and correlation to clinical outcome in patients with high-grade metastatic gastroenteropancreatic neuroendocrine neoplasms (WHO G3)

High-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs, G3) are aggressive cancers of the digestive system with poor prognosis and survival. Platinum-based chemotherapy (cisplatin/carboplatin + etoposide) is considered the first-line palliative treatment. Etoposide is frequently administered intravenously; however, oral etoposide may be used as an alternative. Concerns for oral etoposide include decreased bioavailability, inter-and intra-patient variability and patient compliance. We aimed to evaluate possible differences in progression-free survival (PFS) and overall survival (OS) in patients treated with oral etoposide compared to etoposide given as infusion. Patients (n = 236) from the Nordic NEC study were divided into three groups receiving etoposide as a long infusion (24 h, n = 170), short infusion (= 5 h, n = 33) or oral etoposide (n = 33) according to hospital tradition. PFS and OS were analyzed with Kaplan-Meier (log-rank), cox proportional hazard ratios and confidence intervals. No statistical differences were observed in PFS or OS when comparing patients receiving long infusion (median PFS 3.8 months, median OS 14.5 months), short infusion (PFS 5.6 months, OS 11.0 months) or oral etoposide (PFS 5.4 months, OS 11.3 months). We observed equal efficacy for the three administration routes suggesting oral etoposide may be safe and efficient in treating high-grade GEP-NEN, G3 patients scheduled for cisplatin/carboplatin + etoposide therapy.Peer reviewe

Eliminating Preventable HIV-Related Maternal Mortality in Sub-Saharan Africa: What Do We Need to Know?

Introduction: HIV makes a significant contribution to maternal mortality, and women living in sub-Saharan Africa are most affected. International commitments to eliminate preventable maternal mortality and reduce HIV-related deaths among pregnant and postpartum women by 50% will not be achieved without a better understanding of the links between HIV and poor maternal health outcomes and improved health services for the care of women living with HIV (WLWH) during pregnancy, childbirth, and postpartum. Methods: This article summarizes priorities for research and evaluation identified through consultation with 30 international researchers and policymakers with experience in maternal health and HIV in sub-Saharan Africa and a review of the published literature. Results: Priorities for improving the evidence about effective interventions to reduce maternal mortality and improve maternal health among WLWH include better quality data about causes of maternal death among WLWH, enhanced and harmonized program monitoring, and research and evaluation that contributes to improving: (1) clinical management of pregnant and postpartum WLWH, including assessment of the impact of expanded antiretroviral therapy on maternal mortality and morbidity, (2) integrated service delivery models, and (3) interventions to create an enabling social environment for women to begin and remain in care. Conclusions: As the global community evaluates progress and prepares for new maternal mortality and HIV targets, addressing the needs of WLWH must be a priority now and after 2015. Research and evaluation on maternal health and HIV can increase collaboration on these 2 global priorities, strengthen political constituencies and communities of practice, and accelerate progress toward achievement of goals in both areas

Observations of chemical differentiation in clumpy molecular clouds

We have extensively mapped a sample of dense molecular clouds (L1512, TMC-1C, L1262, Per 7, L1389, L1251E) in lines of HC3N, CH3OH, SO and C^{18}O. We demonstrate that a high degree of chemical differentiation is present in all of the observed clouds. We analyse the molecular maps for each cloud, demonstrating a systematic chemical differentiation across the sample, which we relate to the evolutionary state of the cloud. We relate our observations to the cloud physical, kinematical and evolutionary properties, and also compare them to the predictions of simple chemical models. The implications of this work for understanding the origin of the clumpy structures and chemical differentiation observed in dense clouds are discussed.Comment: 20 pages, 7 figures. Higher quality figures appear in the published journal articl

Expression of p53 protein in high-grade gastroenteropancreatic neuroendocrine carcinoma

Background Gastroenteropancreatic neuroendocrine carcinomas (GEP-NECs) are aggressive, rapidly proliferating tumors. Therapeutic response to current chemotherapy regimens is usually short lasting. The aim of this study was to examine the expression and potential clinical importance of immunoreactive p53 protein in GEP-NEC. Materials and methods Tumor tissues from 124 GEP-NEC patients with locally advanced or metastatic disease treated with platinum-based chemotherapy were collected from Nordic centers and clinical data were obtained from the Nordic NEC register. Tumor proliferation rate and differentiation were re-evaluated. All specimens were immunostained for p53 protein using a commercially available monoclonal antibody. Kaplan-Meier curves and cox regression analyses were used to assess progression-free survival (PFS) and overall survival (OS). Results All tumor tissues were immunoreactive for either one or both neuroendocrine biomarkers (chromogranin A and synaptophysin) and Ki67 index was >20% in all cases. p53 immunoreactivity was only shown in 39% of the cases and was not found to be a prognostic marker for the whole cohort. However, p53 immunoreactivity was correlated with shorter PFS in patients with colorectal tumors (HR = 2.1, p = 0.03) in a univariate analysis as well as to poorer PFS (HR = 2.6, p = 0.03) and OS (HR = 3.4, p = 0.02) in patients with colorectal tumors with distant metastases, a correlation which remained significant in the multivariate analyses. Conclusion In this cohort of GEP-NEC patients, p53 expression could not be correlated with clinical outcome. However, in patients with colorectal NECs, p53 expression was correlated with shorter PFS and OS. Further studies are needed to establish the role of immunoreactive p53 as a prognostic marker for GEP-NEC patients.Peer reviewe

Permafrost thaw and release of inorganic nitrogen from polygonal tundra soils in eastern Siberia

The currently observed climate warming will lead to substantial permafrost degradation and mobilization of formerly freeze-locked matter. Based on recent findings, we assume that there are substantial stocks of inorganic nitrogen (N) within the perennially frozen ground of arctic ecosystems. We studied eleven soil profiles down to one meter depth below surface at three different sites in arctic eastern Siberia, covering polygonal tundra and river floodplains, to assess the amount of inorganic N stores in arctic permafrost-affected soils. Furthermore, we modeled the potential thickening of the seasonally unfrozen uppermost soil (active) layer for these sites, using the CryoGrid2 permafrost model and representation concentration pathway (RCP) 4.5 and 8.5 scenarios. The first scenario, RCP4.5, is a stabilization pathway that reaches plateau atmospheric carbon concentrations early in the 21st century; the second, RCP8.5, is a business as usual emission scenario with increasing carbon emissions. The modeled increases in active layer thickness (ALT) were used to estimate potential annual N mobilization from permafrost-affected soils in the course of climate-induced active-layer deepening. We observed significant stores of inorganic ammonium in the perennially frozen ground of all investigated soils, up to 40-fold higher than in the active layer. The modeled ALT increase until 2100 under the RCP8.5 scenario was between 19 ± 3 cm and 35 ± 6 cm, depending on the location. Under the RCP4.5 scenario, the ALT remained stable in all investigated soils. Our estimated mean annual N release under the RCP8.5 scenario is between 8 ± 3 mg m−2 and 81 ± 14 mg m−2 for the different locations, which reaches values up to the order of magnitude of annual fixation of atmospheric N in arctic soils. However, the thawing induced release of N represents only a small flux in comparison with the overall ecosystem N cycling