2,124 research outputs found
Tachyon kinks on non BPS D-branes
We consider solitonic solutions of the DBI tachyon effective action for a
non-BPS brane. When wrapped on a circle, these solutions are regular and have a
finite energy. We show that in the decompactified limit, these solitons give
Sen's infinitely thin finite energy kink -- interpreted as a BPS brane --
provided that some conditions on the potential hold. In particular, if for
large the potential is exponential, , then Sen's solution is
only found for . For power-law potentials , one must have
. If these conditions are not satisfied, we show that the lowest energy
configuration is the unstable tachyon vacuum with no kinks. We examine the
stability of the solitons and the spectrum of small perturbations.Comment: 16 pages, 2 figure
Novel ETHE1 mutation in a carrier couple having prior offspring affected with ethylmalonic encephalopathy: Genetic analysis, clinical management and reproductive outcome.
Ethylmalonic encephalopathy (EE) is an autosomally recessive inherited disorder with a relentlessly progressive decline in neurological function, usually fatal by the age of ten. It is characterised by generalised hypotonia, psychomotor regression, spastic tetraparesis, dystonia, seizures and, eventually, global neurological failure. Approximately 50 reports have been published worldwide describing this devastating disease, most involving patients of Mediterranean or Arab origin. The fundamental defect in EE likely involves the impairment of a mitochondrial sulphur dioxygenase coded by the ETHE1 gene responsible for the catabolism of sulphide, which subsequently accumulates to toxic levels. A diagnosis of EE should initiate careful genetic evaluation and counselling, particularly if the parents intend to have additional offspring. The present report describes the diagnosis of EE in a reproductive endocrinology context, where both members of a non-consanguineous couple were confirmed to be carriers of an identical A↷G mutation. This previously unknown mutation at nucleotide position c.494 resulted in an amino acid substitution, p.Asp165Gly. Although consideration was given to in vitro fertilisation, embryo biopsy and single gene pre-implantation genetic diagnosis, the couple decided to first utilise a less aggressive therapeutic approach with donor sperm insemination. Pregnancy with a low risk of EE was indeed achieved; however, the infant was affected with a different anomaly (hypoplastic left heart). As this case demonstrates, prior to the initiation of fertility therapy, genetic analysis may be used to provide a confirmatory diagnosis when EE is suspected
Revisiting soliton contributions to perturbative amplitudes
Open Access funded by SCOAP3. CP is
a Royal Society Research Fellow and partly supported by the U.S. Department of Energy
under grants DOE-SC0010008, DOE-ARRA-SC0003883 and DOE-DE-SC0007897. ABR
is supported by the Mitchell Family Foundation. We would like to thank the Mitchell
Institute at Texas A&M and the NHETC at Rutgers University respectively for hospitality
during the course of this work. We would also like to acknowledge the Aspen Center for
Physics and NSF grant 1066293 for a stimulating research environment
Toxic metal enrichment and boating intensity: sediment records of antifoulant copper in shallow lakes of eastern England
Tributyltin (TBT), an aqueous biocide derived from antifouling paint pollution, is known to have impacted coastal marine ecosystems, and has been reported in the sediment of the Norfolk and Suffolk Broads, a network of rivers and shallow lakes in eastern England. In the marine environment, the 1987 TBT ban has resulted in expanded use of alternative biocides, raising the question of whether these products too have impacted the Broads ecosystem and freshwaters in general. Here we examine the lake sediment record in the Norfolk and Suffolk Broads for contamination by copper (Cu) (as an active biocide agent) and zinc (Zn) (as a component of booster biocides), to assess their occurrence and potential for causing environmental harm in freshwater ecosystems. We find that, after the introduction of leisure boating, there is a statistically significant difference in Cu enrichment between heavily and lightly boated sites, while no such difference exists prior to this time. At the heavily boated sites the onset of Cu enrichment coincides with a period of rapid increase in leisure boating. Such enrichment is maintained to the present day, with some evidence of continued increase. We conclude that Cu-based antifouling has measurably contaminated lakes exposed to boating, at concentrations high enough to cause ecological harm. Similar findings can be expected at other boated freshwater ecosystems elsewhere in the world
Re-entrance of the metallic conductance in a mesoscopic proximity superconductor
We present an experimental study of the diffusive transport in a normal metal
near a superconducting interface, showing the re-entrance of the metallic
conductance at very low temperature. This new mesoscopic regime comes in when
the thermal coherence length of the electron pairs exceeds the sample size.
This re-entrance is suppressed by a bias voltage given by the Thouless energy
and can be strongly enhanced by an Aharonov Bohm flux. Experimental results are
well described by the linearized quasiclassical theory.Comment: improved version submitted to Phys. Rev. lett., 4 pages, 5 included
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Resolving the dusty circumstellar environment of the A[e] supergiant HD 62623 with the VLTI/MIDI
B[e] stars are hot stars surrounded by circumstellar gas and dust responsible
for the presence of emission lines and IR-excess in their spectra. How dust can
be formed in this highly illuminated and diluted environment remains an open
issue. HD 62623 is one of the very few A-type supergiants showing the B[e]
phenomenon. We obtained nine calibrated visibility measurements using the
VLTI/MIDI instrument in SCI-PHOT mode and PRISM spectral dispersion mode with
projected baselines ranging from 13 to 71 m and with various position angles.
We used geometrical models and physical modeling with a radiative transfer code
to analyze these data. The dusty circumstellar environment of HD 62623 is
partially resolved by the VLTI/MIDI even with the shortest baselines. The
environment is flattened and can be separated into two components: a compact
one whose extension grows from 17 mas at 8 microns to 30 mas at 9.6 microns and
stays almost constant up to 13 microns, and a more extended one that is
over-resolved even with the shortest baselines. Using the radiative transfer
code MC3D, we managed to model HD 62623's circumstellar environment as a dusty
disk with an inner radius of 3.85+-0.6 AU, an inclination angle of 60+-10 deg,
and a mass of 2x10^-7Mo. It is the first time that the dusty disk inner rim of
a supergiant star exhibiting the B[e] phenomenon is significantly constrained.
The inner gaseous envelope likely contributes up to 20% to the total N band
flux and acts like a reprocessing disk. Finally, the hypothesis of a stellar
wind deceleration by the companion's gravitational effects remains the most
probable case since the bi-stability mechanism does not seem to be efficient
for this star.Comment: 13 pages, 11 figures. A&A accepted pape
Two dimensional smoothing via an optimised Whittaker smoother
Background In many applications where moderate to large datasets are used, plotting relationships between pairs of variables can be problematic. A large number of observations will produce a scatter-plot which is difficult to investigate due to a high concentration of points on a simple graph. In this article we review the Whittaker smoother for enhancing scatter-plots and smoothing data in two dimensions. To optimise the behaviour of the smoother an algorithm is introduced, which is easy to programme and computationally efficient. Results The methods are illustrated using a simple dataset and simulations in two dimensions. Additionally, a noisy mammography is analysed. When smoothing scatterplots the Whittaker smoother is a valuable tool that produces enhanced images that are not distorted by the large number of points. The methods is also useful for sharpening patterns or removing noise in distorted images. Conclusion The Whittaker smoother can be a valuable tool in producing better visualisations of big data or filter distorted images. The suggested optimisation method is easy to programme and can be applied with low computational cost
Vaccine-associated enhanced disease : case definition and guidelines for data collection, analysis, and presentation of immunization safety data
This is a Brighton Collaboration Case Definition of the term & ldquo;Vaccine Associated Enhanced Disease & rdquo; to be utilized in the evaluation of adverse events following immunization. The Case Definition was developed by a group of experts convened by the Coalition for Epidemic Preparedness Innovations (CEPI) in the context of active development of vaccines for SARS-CoV-2 vaccines and other emerging pathogens. The case definition format of the Brighton Collaboration was followed to develop a consensus definition and defined levels of certainty, after an exhaustive review of the literature and expert consultation. The document underwent peer review by the Brighton Collaboration Network and by selected Expert Reviewers prior to submission.
(c) 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Generic Mechanism of Emergence of Amyloid Protofilaments from Disordered Oligomeric aggregates
The presence of oligomeric aggregates, which is often observed during the
process of amyloid formation, has recently attracted much attention since it
has been associated with neurodegenerative conditions such as Alzheimer's and
Parkinson's diseases. We provide a description of a sequence-indepedent
mechanism by which polypeptide chains aggregate by forming metastable
oligomeric intermediate states prior to converting into fibrillar structures.
Our results illustrate how the formation of ordered arrays of hydrogen bonds
drives the formation of beta-sheets within the disordered oligomeric aggregates
that form early under the effect of hydrophobic forces. Initially individual
beta-sheets form with random orientations, which subsequently tend to align
into protofilaments as their lengths increases. Our results suggest that
amyloid aggregation represents an example of the Ostwald step rule of first
order phase transitions by showing that ordered cross-beta structures emerge
preferentially from disordered compact dynamical intermediate assemblies.Comment: 14 pages, 4 figure
Incidence, Risk Factors, and Impact of Severe Neutropenia After Hyperthermic Intraperitoneal Mitomycin C
Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are considered the standard of care for patients with peritoneal dissemination of appendiceal cancer and are increasingly being evaluated for use in patients with carcinomatosis from colon cancer. Mitomycin C (MMC) is one of the most frequently used HIPEC agents in the management of peritoneal-based gastrointestinal malignancies. This study analyzes the incidence and risk factors for developing neutropenia following MMC-HIPEC combined with CRS.
All patients undergoing CRS and MMC-HIPEC for appendiceal cancer between January 1993 and October 2006 were retrospectively reviewed. Logistic regression was used to identify risk factors for the development of neutropenia, defined as an absolute neutrophil count (ANC) <1,000/mm3.
One hundred and twenty MMC-HIPEC were performed in 117 patients with appendiceal cancer. The incidence of neutropenia was 39%. Neutropenia occurred in 57.6% of female and 21.3% of male patients (p < 0.0001). Female gender and MMC dose per body surface area (BSA) were independent risk factors for neutropenia on multivariable logistic regression [odds ratio (OR) of neutropenia in females = 3.58 (95% confidence interval, CI: 1.52, 8.43); OR for 5 unit (mg/m2) increase in MMC dose per BSA = 3.37 (95% CI: 1.72, 6.63)]. Neutropenia did not increase the risk of mortality, postoperative infection or length of hospital stay.
Neutropenia is a frequent complication associated with MMC-HIPEC. Female sex and MMC dose per BSA are independent risk factors for neutropenia. These differences must be considered in the management of patients undergoing MMC-HIPEC to minimize the toxicity of the procedure
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