Virial masses of late-type galaxies from the SDSS DR16

Motivated by the challenges of calculating the dynamical masses of late-type galaxies (LTGs) and the enormous amount of data from the Sloan Digital Sky Survey (SDSS), we calculate virial masses of a sample of approximately 126 000 LTGs from the sixteenth data release of the SDSS. The virial mass estimations were made considering Newtonian mechanics, virial equilibrium and velocity dispersion from stars and gas. The procedure gave as a result seven mass estimations for each galaxy. The calculated masses were calibrated using a sample of spiral galaxies with velocity rotation curves. Considering the results from the calibration, we find that the correlation between virial and dynamical (rotation curve) masses is stronger for high inclination values. Therefore, the calibration relies more on the available data for higher inclination angle galaxies. We also show that if we have a heterogeneous sample of galaxies one must take into consideration the size and colour of these galaxies by using the following variables: Sersic index n, concentration index, and colour of the stars. For relatively smaller and bluer LTGs, the gas velocity dispersion provides a more consistent mass calculation, while for LTGs that are relatively larger and redder the stellar velocity dispersion provides a better correlated mass calculation.Fil: Nigoche Netro, A.. Universidad de Guadalajara; México. Instituto de Astronomía y Meteorologia de la Universidad de Guadalajara; MéxicoFil: De La Fuente, E.. Universidad de Guadalajara; México. University of Tokyo; JapónFil: Diaz, Ruben Joaquin. United States Gemini Office; Estados Unidos. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba; ArgentinaFil: Agüero, Maria Paz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba; ArgentinaFil: Kemp, S. N.. Instituto de Astronomía y Meteorologia de la Universidad de Guadalajara; MéxicoFil: Marquez Lugo, R. A.. Instituto de Astronomía y Meteorologia de la Universidad de Guadalajara; MéxicoFil: Lagos, P.. Centro de Astrofísica Da Universidade Do Porto; PortugalFil: Ruelas Mayorga, A.. Universidad Nacional Autónoma de México; MéxicoFil: López Contreras, N. L.. Instituto de Astronomía y Meteorologia de la Universidad de Guadalajara; Méxic

Systematic Evaluation of Serotypes Causing Invasive Pneumococcal Disease among Children Under Five: The Pneumococcal Global Serotype Project

Hope Johnson and colleagues calculate the global and regional burden of serotype-specific pneumococcal disease in children under the age of five

Un examen actualizado de la percepción de las barreras para la implementación de la farmacogenómica y la utilidad de los pares fármaco/gen en América Latina y el Caribe

La farmacogenómica (PGx) se considera un campo emergente en los países en desarrollo. La investigación sobre PGx en la región de América Latina y el Caribe (ALC) sigue siendo escasa, con información limitada en algunas poblaciones. Por lo tanto, las extrapolaciones son complicadas, especialmente en poblaciones mixtas. En este trabajo, revisamos y analizamos el conocimiento farmacogenómico entre la comunidad científica y clínica de ALC y examinamos las barreras para la aplicación clínica. Realizamos una búsqueda de publicaciones y ensayos clínicos en este campo en todo el mundo y evaluamos la contribución de ALC. A continuación, realizamos una encuesta regional estructurada que evaluó una lista de 14 barreras potenciales para la aplicación clínica de biomarcadores en función de su importancia. Además, se analizó una lista emparejada de 54 genes/fármacos para determinar una asociación entre los biomarcadores y la respuesta a la medicina genómica. Esta encuesta se comparó con una encuesta anterior realizada en 2014 para evaluar el progreso en la región. Los resultados de la búsqueda indicaron que los países de América Latina y el Caribe han contribuido con el 3,44% del total de publicaciones y el 2,45% de los ensayos clínicos relacionados con PGx en todo el mundo hasta el momento. Un total de 106 profesionales de 17 países respondieron a la encuesta. Se identificaron seis grandes grupos de obstáculos. A pesar de los continuos esfuerzos de la región en la última década, la principal barrera para la implementación de PGx en ALC sigue siendo la misma, la "necesidad de directrices, procesos y protocolos para la aplicación clínica de la farmacogenética/farmacogenómica". Las cuestiones de coste-eficacia se consideran factores críticos en la región. Los puntos relacionados con la reticencia de los clínicos son actualmente menos relevantes. Según los resultados de la encuesta, los pares gen/fármaco mejor clasificados (96%-99%) y percibidos como importantes fueron CYP2D6/tamoxifeno, CYP3A5/tacrolimus, CYP2D6/opioides, DPYD/fluoropirimidinas, TMPT/tiopurinas, CYP2D6/antidepresivos tricíclicos, CYP2C19/antidepresivos tricíclicos, NUDT15/tiopurinas, CYP2B6/efavirenz y CYP2C19/clopidogrel. En conclusión, aunque la contribución global de los países de ALC sigue siendo baja en el campo del PGx, se ha observado una mejora relevante en la región. La percepción de la utilidad de las pruebas PGx en la comunidad biomédica ha cambiado drásticamente, aumentando la concienciación entre los médicos, lo que sugiere un futuro prometedor en las aplicaciones clínicas de PGx en ALC.Pharmacogenomics (PGx) is considered an emergent field in developing countries. Research on PGx in the Latin American and the Caribbean (LAC) region remains scarce, with limited information in some populations. Thus, extrapolations are complicated, especially in mixed populations. In this paper, we reviewed and analyzed pharmacogenomic knowledge among the LAC scientific and clinical community and examined barriers to clinical application. We performed a search for publications and clinical trials in the field worldwide and evaluated the contribution of LAC. Next, we conducted a regional structured survey that evaluated a list of 14 potential barriers to the clinical implementation of biomarkers based on their importance. In addition, a paired list of 54 genes/drugs was analyzed to determine an association between biomarkers and response to genomic medicine. This survey was compared to a previous survey performed in 2014 to assess progress in the region. The search results indicated that Latin American and Caribbean countries have contributed 3.44% of the total publications and 2.45% of the PGx-related clinical trials worldwide thus far. A total of 106 professionals from 17 countries answered the survey. Six major groups of barriers were identified. Despite the region’s continuous efforts in the last decade, the primary barrier to PGx implementation in LAC remains the same, the “need for guidelines, processes, and protocols for the clinical application of pharmacogenetics/pharmacogenomics”. Cost-effectiveness issues are considered critical factors in the region. Items related to the reluctance of clinicians are currently less relevant. Based on the survey results, the highest ranked (96%–99%) gene/drug pairs perceived as important were CYP2D6/tamoxifen, CYP3A5/tacrolimus, CYP2D6/opioids, DPYD/fluoropyrimidines, TMPT/thiopurines, CYP2D6/tricyclic antidepressants, CYP2C19/tricyclic antidepressants, NUDT15/thiopurines, CYP2B6/efavirenz, and CYP2C19/clopidogrel. In conclusion, although the global contribution of LAC countries remains low in the PGx field, a relevant improvement has been observed in the region. The perception of the usefulness of PGx tests in biomedical community has drastically changed, raising awareness among physicians, which suggests a promising future in the clinical applications of PGx in LAC

May Measurement Month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension

Aims Raised blood pressure (BP) is the biggest contributor to mortality and disease burden worldwide and fewer than half of those with hypertension are aware of it. May Measurement Month (MMM) is a global campaign set up in 2017, to raise awareness of high BP and as a pragmatic solution to a lack of formal screening worldwide. The 2018 campaign was expanded, aiming to include more participants and countries. Methods and results Eighty-nine countries participated in MMM 2018. Volunteers (≥18 years) were recruited through opportunistic sampling at a variety of screening sites. Each participant had three BP measurements and completed a questionnaire on demographic, lifestyle, and environmental factors. Hypertension was defined as a systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg, or taking antihypertensive medication. In total, 74.9% of screenees provided three BP readings. Multiple imputation using chained equations was used to impute missing readings. 1 504 963 individuals (mean age 45.3 years; 52.4% female) were screened. After multiple imputation, 502 079 (33.4%) individuals had hypertension, of whom 59.5% were aware of their diagnosis and 55.3% were taking antihypertensive medication. Of those on medication, 60.0% were controlled and of all hypertensives, 33.2% were controlled. We detected 224 285 individuals with untreated hypertension and 111 214 individuals with inadequately treated (systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg) hypertension. Conclusion May Measurement Month expanded significantly compared with 2017, including more participants in more countries. The campaign identified over 335 000 adults with untreated or inadequately treated hypertension. In the absence of systematic screening programmes, MMM was effective at raising awareness at least among these individuals at risk

Global urban environmental change drives adaptation in white clover

Urbanization transforms environments in ways that alter biological evolution. We examined whether urban environmental change drives parallel evolution by sampling 110,019 white clover plants from 6169 populations in 160 cities globally. Plants were assayed for a Mendelian antiherbivore defense that also affects tolerance to abiotic stressors. Urban-rural gradients were associated with the evolution of clines in defense in 47% of cities throughout the world. Variation in the strength of clines was explained by environmental changes in drought stress and vegetation cover that varied among cities. Sequencing 2074 genomes from 26 cities revealed that the evolution of urban-rural clines was best explained by adaptive evolution, but the degree of parallel adaptation varied among cities. Our results demonstrate that urbanization leads to adaptation at a global scale

Uso de tarjeta universitaria y tecnología móvil para el control de acceso a instalaciones universitarias y su posterior análisis en términos de rendimiento académicos y control de asistencia en clase = Use of university card and mobile technology to study and improve academic performance and class attendance control

Hoy en día es habitual que las universidades ofrezcan a sus alumnos carnés que los identifican con el fin de poder hacer uso de las instalaciones universitarias, así como de identificarse como estudiantes fuera del ámbito universitario. De igual modo, es cada vez más frecuente que dichos carnés incorporen las últimas tecn ologías, como las contactless NFC o RFID para hacer un uso más dinámico del carné. El presente artículo explora el desarrollo de un nuevo servicio a implantar en las universidades mediante el uso del carné con tecnología contactless y, dispositivos móviles . Concretamente los objetivos del servicio son, por una parte, permitir el control de acceso de los usuarios potenciales de las bibliotecas, y por otra parte, su aplicación en las aulas de clases como medio de control de asistencia para sustituir a los pro cedimientos basados en firmas. Finalmente, el proyecto presenta múltiples posibles explotaciones y casos de uso adicionales que pueden ser aplicados en base a la explotación de los datos recogidos y que permitirán analizar y fomentar un mejor rendimiento a cadémico, por parte de los estudiantes, así como una mejor gestión de las instalaciones universitarias. El caso de estudio de aplicación del proyecto descrito en el presente artículo es la Universidad Politécnica de Madrid (UPM). ---ABSTRACT--- hat those cards incorporate the last technologies such as NFC or RFID (contactless technologies) to allow a more dynamic use of the card. This paper explores the development a new service to be implemented in the univer sities by means of using identity cards with contactless technologies and mobile devices. The goal of the service is twofold: on one hand it aims to control the access of the users to the university libraries; on the other hand it aims to be used in the classroom to control the attendance. Finally, the project has several other exploitations and additional use cases focused on analysing and encouraging the academic performance. The project is under implementation in Universidad Politécnica de Madrid (UPM)