10 research outputs found
Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial
- Author
- Abbas J
- Abbate A
- Abdullakutty J
- Abhyanakar AD
- Aboyans V
- Abrantes JAM
- Abu-Fadel M
- Acevedo M
- Adamkova V
- Adhyapak S
- Agarwal H
- Aggarwal R
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- Aguirre A
- Ahmed H
- Ahremark U
- Ahuad Guerrero RA
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- Airaksinen JK
- Aitken D
- Akatova E
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- Ako J
- Akright L
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- Al Joundi T
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- Alcocer Gamba MA
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- Tomala T
- Tonnessen G
- Torstensson I
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- Trevelyan J
- Triana MAU
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- Tse H-F
- Tseluyko V
- Tumbev HS
- Tunon Fernandez J
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- Tyrenko VV
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- Ueng K-C
- Ungi I
- Ural E
- Ushakov O
- Utsu N
- Vahula V
- Vakaluyk I
- Valgimigli M
- Vallejo GS
- Vallejos JA
- Van Der Wal RMA
- Van Der Zwaan CC
- van Diepen SFP
- Van Huysduynen-Monraats PSH
- Van Zyl LJ
- Vardi G
- Varleta P
- Vatutin M
- Vedere A
- Vejar M
- Velasquez JRD
- Velcheva ES
- Verdel GJE
- Vered Z
- Vervoort G
- Vico ML
- Vida M
- Videbaek L
- Vidotti MH
- Vidovich M
- Viergever EP
- Viigimaa M
- Vijay N
- Vijayaraghavan R
- Vikman S
- Viktorova I
- Violini R
- Vishnevsky AY
- Vizel S
- Vo A
- Voeller H
- Voevoda MI
- Vogel R
- Vohra R
- Vora K
- Voyce S
- Vrolix MCM
- Vulic D
- Vuurmans T
- Wada A
- Waider W
- Waisman GD
- Waites JH
- Wali A
- Walichiewicz PM
- Waltenberger J
- Waltman J
- Wang J
- Wang J
- Wang J
- Wattanakit K
- Wei M
- Weidinger F
- Weil J
- Weintraub H
- Weissbrodt M
- Welka S
- Welker J
- Wells T
- Werner N
- Whitaker J
- White HD
- White L
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- Wiersma JJ
- Wilkins G
- Wilkinson P
- Willems FF
- Wilson MD
- Winkelmann B
- Wiseman A
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- Wojewoda P
- Wollaert B
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- Xu D
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- Yagensky A
- Yakushin S
- Yan AT-K
- Yan BPY
- Yanez M
- Yang E
- Yang X
- Yang X
- Yao Z
- Yazdani S
- Yerra SK
- Yin W-H
- Yong H
- Yoon JH
- Younis L
- Yu Y
- Yuan Z
- Yusoff K
- Zahger D
- Zaidman CJ
- Zainea M
- Zaman A
- Zeiher AM
- Zhang W
- Zhang X
- Zhang Z
- Zhao X
- Zheng Y
- Zheng Z
- Zhou Y
- Zhu H
- Zirlik A
- Zizka J
- Zong W
- Zrazhevsky K
- Zuniga JDH
- Zurakowski A
- Zuran I
- Zweiker R
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2019
- Field of study
Aims The third Universal Definition of Myocardial Infarction (MI) Task Force classified MIs into five types: Type 1, spontaneous; Type 2, related to oxygen supply/demand imbalance; Type 3, fatal without ascertainment of cardiac biomarkers; Type 4, related to percutaneous coronary intervention; and Type 5, related to coronary artery bypass surgery. Low-density lipoprotein cholesterol (LDL-C) reduction with statins and proprotein convertase subtilisin–kexin Type 9 (PCSK9) inhibitors reduces risk of MI, but less is known about effects on types of MI. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome (ACS) and elevated LDL-C (≥1.8 mmol/L) despite intensive statin therapy. In a pre-specified analysis, we assessed the effects of alirocumab on types of MI. Methods and results Median follow-up was 2.8 years. Myocardial infarction types were prospectively adjudicated and classified. Of 1860 total MIs, 1223 (65.8%) were adjudicated as Type 1, 386 (20.8%) as Type 2, and 244 (13.1%) as Type 4. Few events were Type 3 (n = 2) or Type 5 (n = 5). Alirocumab reduced first MIs [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77–0.95; P = 0.003], with reductions in both Type 1 (HR 0.87, 95% CI 0.77–0.99; P = 0.032) and Type 2 (0.77, 0.61–0.97; P = 0.025), but not Type 4 MI. Conclusion After ACS, alirocumab added to intensive statin therapy favourably impacted on Type 1 and 2 MIs. The data indicate for the first time that a lipid-lowering therapy can attenuate the risk of Type 2 MI. Low-density lipoprotein cholesterol reduction below levels achievable with statins is an effective preventive strategy for both MI types.For complete list of authors see http://dx.doi.org/10.1093/eurheartj/ehz299</p
Numerical methods for the design and description of in vitro expansion processes of human mesenchymal stem cells
- Author
- A Bailón-Plaza
- A Delafosse
- A Delafosse
- A Reichardt
- A Schellenberg
- AB Yeatts
- AB Yeatts
- AJ Steward
- AK-L Chen
- AL vn Wezel
- AS Simaria
- AW Nienow
- AW Nienow
- B Weyand
- B Weyand
- B Weyand
- C Capelli
- C Ferrari
- C García-Fernández
- C Ikebe
- C Lange
- C Schirmaier
- CJ Hewitt
- CM Stoots
- D Cholewa
- DE Discher
- E Bartolini
- E Scibona
- E Shearier
- EK Yim
- F dos Santos
- G Higuera
- G Ren
- G Yourek
- G Yourek
- H Abdelrazik
- H Page
- H Zhang
- J Leber
- J Lo Surdo
- J Wu
- JA Zimmermann
- JD Berry
- JD Michaels
- JE Frith
- JG Carmelo
- JH Ferziger
- JH YlÖstalo
- K Cierpka
- KM Panchalingam
- KT Kunas
- L Mancuso
- L-G Zhao
- LG Villa-Diaz
- LM Allen
- M Dominici
- M Hoffmann
- M Szczypka
- M-L Collignon
- M-Z Ismadi
- MMJ Caron
- MS Croughan
- N-C Cheng
- P Bourin
- P Godara
- P Horn
- P Sucosky
- PG Layer
- PR Baraniak
- QA Rafiq
- QA Rafiq
- QA Rafiq
- QA Rafiq
- R Das
- R Edmondson
- R Gruber
- RV Venkat
- S Alimperti
- S Frauenschuh
- S Gottipamula
- S Hassan
- S Ibrahim
- S Kaiser
- S Rodriguez
- S Sart
- S Sharma
- SC Kaiser
- SH Bhang
- SM Badenes
- SM Carter
- T Lawson
- T-M Achilli
- TJ Bartosh
- TRJ Heathman
- TRJ Heathman
- TRJ Heathman
- TRJ Heathman
- TRJJ Heathman
- V Dufey
- V Jossen
- V Jossen
- V Jossen
- V Jossen
- V Jossen
- W Wagner
- Y Chisti
- Y Lei
- YY Lipsitz
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 23/10/2020
- Field of study
Human mesenchymal stem cells (hMSCs) are a valuable source of cells for clinical applications (e.g., treatment of acute myocardial infarction or inflammatory diseases), especially in the field of regenerative medicine. However, for autologous (patient-specific) and allogeneic (off-the-shelf) hMSC-based therapies, in vitro expansion is necessary prior to the clinical application in order to achieve the required cell numbers. Safe, reproducible, and economic in vitro expansion of hMSCs for autologous and allogeneic therapies can be problematic because the cell material is restricted and the cells are sensitive to environmental changes. It is beneficial to collect detailed information on the hydrodynamic conditions and cell growth behavior in a bioreactor system, in order to develop a so called “Digital Twin” of the cultivation system and expansion process. Numerical methods, such as Computational Fluid Dynamics (CFD) which has become widely used in the biotech industry for studying local characteristics within bioreactors or kinetic growth modelling, provide possible solutions for such tasks.
In this review, we will present the current state-of-the-art for the in vitro expansion of hMSCs. Different numerical tools, including numerical fluid flow simulations and cell growth modelling approaches for hMSCs, will be presented. In addition, a case study demonstrating the applicability of CFD and kinetic growth modelling for the development of an microcarrier-based hMSC process will be shown
Effect of alirocumab on mortality after acute coronary syndromes. An analysis of the ODYSSEY OUTCOMES randomized clinical trial
- Author
- Abbas J
- Abbate A
- Abdullakutty J
- Abdullkutty J
- Abhyanakar AD
- Aboyans V
- Abrantes JAM
- Abu-Fadel M
- Acevedo M
- Adamkova V
- Adamo A
- Adhyapak S
- Agarwal H
- Aggarwal R
- Aggarwal RK
- Agnetti V
- Aguirre A
- Ahmed H
- Ahremark U
- Ahuad Guerrero RA
- Aidar Ayoub JC
- Airaksinen JK
- Aitken D
- Akatova E
- Akhter F
- Ako J
- Akright L
- Akyea-Djamson A
- Al Joundi T
- Al-Windy NYY
- Alan D
- Alcocer Gamba MA
- Alexander JH
- Alexander K
- Alexandru TM
- Alexopoulos D
- Alings M
- Alonso Martin JJ
- Alonso Orcajo N
- Alsweiler C
- Alvarisqueta AF
- Alves De Lima AE
- Amarasekera S
- Amarasena N
- Amir O
- Amlani M
- Amosova E
- Amuchastegui M
- Anchante Hernandez HA
- Andersen D
- Andersen K
- Andersen R
- Anderson J
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- Angel Hominal M
- Annam S
- Anscombe R
- Apostolovic SR
- Appel K-F
- Arandjelovic A
- Araneda G
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- Arstall MA
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- Athyros V
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- Berli MA
- Berlowitz M
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- Bernan A
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- Bittner VA
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- Breedveld RW
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- Brocklehurst M
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- Terzic I
- Tesloianu DN
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- Triana MAU
- Tricoci P
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- Tse H-F
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- Vahula V
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- Valdivielso P
- Valdovinos PCM
- Valdovinos PCM
- Valgimigli M
- Valiris J
- Vallejo GS
- Vallejos JA
- Van Der Wal RMA
- Van Der Zwaan CC
- Van Diepen SFP
- Van Huysduynen-Monraats PSH
- Van Zyl LJ
- Vardas P
- Vardi G
- Vargas Gonzales RJ
- Varleta P
- Vatutin M
- Vedere A
- Vejar M
- Velcheva ES
- Verdel GJE
- Vered Z
- Verrier M
- Vervoort G
- Vico ML
- Vida M
- Videbaek L
- Vidotti MH
- Vidovich M
- Viergever EP
- Viigimaa M
- Vijay N
- Vijayaraghavan R
- Vikman S
- Viktorova I
- Vincendet M
- Violini R
- Vishnevsky AY
- Vizel S
- Vo A
- Voeller H
- Voevoda MI
- Vogel R
- Vohra R
- Vora K
- Voyce S
- Vrolix MCM
- Vulic D
- Vuurmans T
- Wada A
- Waider W
- Waisman GD
- Waites JH
- Wali A
- Walichiewicz PM
- Waltenberger J
- Waltman J
- Wang J
- Wang J
- Wang J
- Wattanakit K
- Wei M
- Weidinger F
- Weil J
- Weintraub H
- Weissbrodt M
- Welka S
- Welker J
- Wells T
- Werner N
- Westbrook M
- Westerhausen D
- Whitaker J
- White HD
- White L
- White M
- Wiersma JJ
- Wilkins G
- Wilkinson P
- Willems FF
- Wilson MD
- Winkelmann B
- Wiseman A
- Witt N
- Wlodarczak A
- Wojewod P
- Wollaert B
- Wong Y-K
- Wongpraparut N
- Wozniak J
- Wright S
- Wu C
- Xavier D
- Xenakis M
- Xu B
- Xu D
- Xu X
- Xu Y
- Yagensky A
- Yakushin S
- Yan AT-K
- Yan BPY
- Yanez M
- Yang E
- Yang X
- Yang X
- Yao Z
- Yazdani S
- Yerra SK
- Yin W-H
- Yong H
- Yoon JH
- Younis L
- Yu Y
- Yuan Z
- Yusoff K
- Yusoff K
- Zahger D
- Zaidman CJ
- Zainea M
- Zaman A
- Zapata G
- Zdravko B
- Zea Nunez CA
- Zeiher AM
- Zeiher AM
- Zhang R
- Zhang W
- Zhang X
- Zhang Z
- Zhao X
- Zheleznyy V
- Zheng Y
- Zheng Z
- Zhou Y
- Zhu C
- Zhu H
- Zhu J
- Zirlik A
- Zizka J
- Zobouyan I
- Zong W
- Zrazhevsky K
- Zurakowski A
- Zuran I
- Zweiker R
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 04/01/2019
- Field of study
Background: Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. Methods: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) was a double-blind, randomized comparison of alirocumab or placebo in 18 924 patients who had an ACS 1 to 12 months previously and elevated atherogenic lipoproteins despite intensive statin therapy. Alirocumab dose was blindly titrated to target achieved low-density lipoprotein cholesterol (LDL-C) between 25 and 50 mg/dL. We examined the effects of treatment on all-cause death and its components, cardiovascular and noncardiovascular death, with log-rank testing. Joint semiparametric models tested associations between nonfatal cardiovascular events and cardiovascular or noncardiovascular death. Results: Median follow-up was 2.8 years. Death occurred in 334 (3.5%) and 392 (4.1%) patients, respectively, in the alirocumab and placebo groups (hazard ratio [HR], 0.85; 95% CI, 0.73 to 0.98; P=0.03, nominal P value). This resulted from nonsignificantly fewer cardiovascular (240 [2.5%] vs 271 [2.9%]; HR, 0.88; 95% CI, 0.74 to 1.05; P=0.15) and noncardiovascular (94 [1.0%] vs 121 [1.3%]; HR, 0.77; 95% CI, 0.59 to 1.01; P=0.06) deaths with alirocumab. In a prespecified analysis of 8242 patients eligible for ≥3 years follow-up, alirocumab reduced death (HR, 0.78; 95% CI, 0.65 to 0.94; P=0.01). Patients with nonfatal cardiovascular events were at increased risk for cardiovascular and noncardiovascular deaths (P<0.0001 for the associations). Alirocumab reduced total nonfatal cardiovascular events (P<0.001) and thereby may have attenuated the number of cardiovascular and noncardiovascular deaths. A post hoc analysis found that, compared to patients with lower LDL-C, patients with baseline LDL-C ≥100 mg/dL (2.59 mmol/L) had a greater absolute risk of death and a larger mortality benefit from alirocumab (HR, 0.71; 95% CI, 0.56 to 0.90; Pinteraction=0.007). In the alirocumab group, all-cause death declined wit h achieved LDL-C at 4 months of treatment, to a level of approximately 30 mg/dL (adjusted P=0.017 for linear trend). Conclusions: Alirocumab added to intensive statin therapy has the potential to reduce death after acute coronary syndrome, particularly if treatment is maintained for ≥3 years, if baseline LDL-C is ≥100 mg/dL, or if achieved LDL-C is low. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01663402
Effects of Mountain Ultra-Marathon Running on ROS Production and Oxidative Damage by Micro-Invasive Analytic Techniques
- Author
- A Dejam
- A Steensberg
- AE Holley
- Alessandra Vezzoli
- Alessandro Tonacci
- Andrea Borghini
- B Kłapcińska
- B Scotney
- B. Halliwell
- BK Pedersen
- C Huber
- C Keller
- C Murr
- C Vassalle
- Cinzia Dellanoce
- D Tsikas
- D Tsikas
- DC Nieman
- DM Bailey
- EC Gomes
- F Degache
- FJ Larsen
- Francesca Mastorci
- G Lippi
- Guido Giardini
- J Finaud
- J Liu
- J Liu
- JE Turner
- JE Turner
- JF Brun
- JR Poortmans
- K Ostrowski
- K Sugama
- K Sugama
- LG Rodriguez-Plaza
- LG Rodriguez-Plaza
- Lorenza Pratali
- M Comassi
- M Fernström
- M Totzeck
- M Valko
- MA Febbraio
- Maristella Gussoni
- MG Nikolaidis
- MG Nikolaidis
- Michela Montorsi
- ML Liu
- MM Kanter
- P Robach
- P Steinbacher
- P Tacchini
- Pedro Tauler
- Philippe Tacchini
- R Kohen
- RG Sajfutdinov
- RI Reid
- S Basu
- S Mrakic-Sposta
- S Mrakic-Sposta
- S Mrakic-Sposta
- S Reichhold
- Sarah Moretti
- SI Dikalov
- Simona Mrakic-Sposta
- SK Powers
- Y Collins
- Y Michailidis
- Z Radák
- Z Shao
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Supramolecular associates of double-decker lanthanide phthalocyanines with macromolecular structures and nanoparticles as the basis of biosensor devices
- Author
- AG Martynov
- AG Martynov
- AYu Tsivadze
- C Medina-Plaza
- D Patra
- DKP Ng
- E Giuliani
- I Yahia
- J Jiang
- JS Lindsey
- JT Lu
- LG Tomilova
- M Rodriguez-Méndez
- MG Vivas
- ML Rodriquez-Méndez
- N Ishikawa
- N Kiliné
- NF Goldshleger
- NF Gol’dshleger
- OD Hendrickson
- P Ma
- P Zhu
- R Bai
- R Slota
- RD Shannon
- SL Selector
- SL Selektor
- SR Chatterjee
- SS Smola
- T Basova
- VE Baulin
- VE Pushkarev
- Y Gorbunova
- Y Gorbunova
- Y Inaki
- YG Gorbunova
- YuG Gorbunova
- YuG Gorbunova
- Publication venue
- 'Pleiades Publishing Ltd'
- Publication date
- Field of study
Salivary Glands, Head and Neck
- Author
- A Alvi
- A Anand
- A Benhammou
- A Carbone
- A Franzen
- A Kawahara
- A Monabati
- A Rapkiewicz
- A Seichter
- A Shahin
- AA Connolly
- AC Lin
- AH Deshpande
- AL Namiq
- AM Jamal
- AP Aggarwal
- AT Savera
- AV Jones
- AV Parwani
- B Maes
- B Maly
- B Siewert
- BA Jereczek-Fossa
- BM Al-Khafaji
- C Chai
- C Furuse
- C Zhang
- CC Chuang
- CC Lin
- CE Schmalbach
- CG Gourin
- CJ Stewart
- CM Bacon
- CM Croitoru
- CM Dobson
- CM Eneroth
- CM Eneroth
- CM Eneroth
- CM Eneroth
- CM Milroy
- CM Milroy
- CS Kong
- CS Lim
- D Baschinsky
- D Dayan
- D Gibbons
- D Hayashi
- D Saggese
- D Tamiolakis
- D Wang
- DB Cleveland
- DC Chhieng
- DC Chhieng
- DC Chhieng
- DC Chhieng
- DC Howlett
- DE Cruz Perez Da
- DE Tunkel
- DK Das
- DK Das
- DK Das Cervicofacial Actinomycosis
- DN Nassour
- DR Gnepp
- DS Foley
- DT Oliveira
- DW Bahler
- E Maiorano
- EE Mooney
- EG Cohen
- EG Cristallini
- F Brand de
- F Darvishian
- F Elmasalme
- F Erdogan
- F Fulciniti
- F Lopez-Rios
- FB Johnson
- FS Daoud
- G Cai
- G Cerulli
- G Favia
- G Jayaram
- G Kocjan
- G Pettinato
- G Seifert
- G Singh
- GC Yang
- GL Ellis
- H Arabi
- H Deere
- H Hara
- H Hara
- H Maier
- HA Saleh
- HF Frierson Jr
- HG Hass
- HJ Carson
- I Dahl
- I Dardick
- I Ramzy
- IA Hag El
- IA Hag el
- IS Jan
- J Akhter
- J Banich
- J Boutonnat
- J Caubet Biayna
- J Cinberg
- J Gonzales
- J Klijanienko
- J Klijanienko
- J Klijanienko
- J Klijanienko
- J Rodriguez-Fernandez
- J Saenz-Santamaria
- J Saenz-Santamaria
- J Zajicek
- J Zajicek
- JA DiGuiseppe
- JA Plaza
- JB Taxy
- JC Jacobs
- JC Jacobs
- JF Nasuti
- JF Nasuti
- JF Nasuti
- JH Park
- JI Lopez
- JL Boyle
- JL Roh
- JM Viguer
- JN Elliott
- JR Miliauskas
- JR Parfitt
- JS Mueller
- JW Eveson
- JY Ro
- K Marsot-Dupuch
- K Sugihara
- K Thomas
- K Verma
- K Verma
- KA Newkirk
- KD Horn
- KJ Cho
- KK Koeller
- KL Burgess
- KN Chahine
- KT Jäkel
- KT Robbins
- KT Wong
- L Alos
- L Gallego
- L Mandel
- L Walaas
- LA Granville
- LC Tao
- LG Dodd
- LJ Layfield
- LJ Layfield
- LJ Layfield
- LR Pisharodi
- M Bhanote
- M Bianco
- M Gross
- M Hasiotou
- M Kobayashi
- M Kraft
- M Martinez del Pero
- M Prieto-Rodriguez
- M Schneider
- M Supriya
- M Tiemann
- M Ustün
- M Voulgarelis
- MA Vengrove
- MB Cohen
- MB Mosunjac
- ME O’Donnell
- MJ Ashraf
- MJ Babb
- ML Cohn
- MM Hayes
- MM Shaffer
- MS Ballo
- MS Ballo
- MS Oyafuso
- MS Pogodzinski
- MW Brekel van den
- MW Stanley
- MW Stanley
- MW Stanley
- N Azarpira
- N Kanjanavirojkul
- N Kumar
- N Netto Jde
- N Siddaraju
- NE Langlois
- NH Siddiqui
- NL Harris
- NL Wong
- NP McIvor
- O David
- O Driemel
- O Günhan
- O Pons Vicente
- P Boccato
- P Gete Garcia
- P Gonzalez-Peramato
- P Malhotra
- P Milde
- P Sheahan
- P Zbären
- PA Kay
- PA Vargas
- PA Vuuren Van
- PC Edwards
- PL McCallum
- PV Kumar
- R Gonzalez-Garcia
- R Goyal
- RA Otto
- RB Ramdall
- RH Hruban
- RJ Beatenburg de Jong
- RL Peel
- RR Seethala
- RS Saad
- S Anne
- S Carino
- S Elagoz
- S Kaba
- S Li
- S Negahban
- S Nigam
- S Nordemar
- S Pereira
- S Rottey
- S Sharma
- S Torabinezad
- SA Goonewardene
- SB Kapadia
- SE Kountakis
- SP Dave
- SR Flint
- SR Granter
- SS Raab
- SS Raab
- T Brent Ponder
- T Farrell
- T Hansen
- T Hatada
- T Kim
- T Kimura
- T Löwhagen
- T Moriki
- T Nagao
- T Sauer
- T Shet
- TH Al-Khateeb
- TL Chow
- TM Elsheikh
- TP Witcher
- U Bockmühl
- U Engzell
- U Engzell
- U Schmid
- V Paleri
- VC Araujo
- VK Gidvani
- VS Nijhawan
- W Cheuk
- W Höbling
- W O’Mara
- WK Ng
- WS Chong
- WY Yih
- Y Daneshbod
- YH Kim
- YY Lee
- Z Turkyilmaz
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
Tumours of the Neuroendocrine System and the Peripheral Nervous System
- Author
- A Adamiak
- A Ariza
- A Beiras
- A Beiras
- A Cremonini
- A Franchi
- A Henmi
- A Lesourd
- A Llombart-Bosch
- A Ooi
- A Ooi
- A Ooi
- A Ooi
- A Perry
- A Pierre-Kahn
- A Saad
- A Simsir
- A Srivastava
- A Takeuchi
- A Talerman
- A Talerman
- A Tanimura
- A Tsubura
- A Urabe
- A Van Nguyen
- A Wee
- A Zavala-Pompa
- AA McNab
- AD Glick
- AK Uri
- AK Uri
- AL Folpe
- AM Landolt
- AP Chaudhry
- AP Dhillon
- AR Chitale
- AR Chitale
- AR Graham
- AS Patchefsky
- ASY Leong
- AT Mesquita
- B Christen
- B Eyden
- B Eyden
- B Eyden
- B Eyden
- B Eyden
- B Eyden
- B Frigerio
- B Lach
- B Mackay
- B Monroe
- B Perez-Ordonez
- B Rekhi
- B Smith
- BF Walker
- BG Zelger
- BI Tranmer
- BL Bender
- BS Bhagavan
- BT Collins
- BW Scheithauer
- C Bordi
- C Capella
- C Di Bella
- C Fisher
- C Giannini
- C Hsueh
- C Matthias
- C Otal-Salaverri
- C Sanguinetti
- C Turc-Carel
- C Vital
- C Zuber
- CE Anderson
- CEM Blomjous
- CH Chien
- CH Jokinen
- CH Suh
- CK Tang
- CM Payne
- CM Payne
- CN Sun
- CW Sexton
- D Bani
- D Hirano
- D Knöbber
- D Rampisela
- DA Charney
- DJ Grignon
- DJ McComb
- DK White
- DL Koppersmith
- DM Alessi
- DM Parham
- DR Ryder
- DS Horoupian
- DT Moran
- DW Henderson
- DY Rhee
- E Alvarez-Fernandez
- E Babin
- E Haneke
- E Hess
- E Horvath
- E Horvath
- E Horvath
- E Horvath
- E Kaiserling
- E Kaiserling
- E Kawahara
- E Pannese
- E Perentes
- E Sereti
- E Seretis
- E Solcia
- EA Turbat-Herrera
- EE Lack
- EF DiCarlo
- EG Silva
- EJ Livnat
- EJ Wills
- EJ Yunis
- EW Bingham
- F Gonzalez-Crussi
- F Le Marc’hadour
- F Le Marc’hadour
- F Plenat
- FG Zak
- FJ Rodriguez
- FN Ghadially
- FN Ghadially
- FN Ghadially
- FP Selvaggi
- G Berger
- G Berger
- G Berger
- G Bussolati
- G Bussolati
- G Cenacchi
- G Chejfec
- G Mendelsohn
- G Perrin
- G Spalke
- G Tozbikian
- G Ueda
- G Vassallo
- G Woodruff
- GA Herrera
- GC Stone
- GH Rühl
- GJ Snipes
- GL Taccagni
- GR Dickersin
- GS Pearl
- GS Sidhu
- GS Sidhu
- GW Mierau
- H Battifora
- H Cohen
- H Dominguez-Malagon
- H Feiner
- H Inaba
- H Kitamura
- H Matsushita
- H Murayama
- H Ohtsuki
- H Rask-Andersen
- H Rubin
- H Sonobe
- H Takahashi
- H Watanabe
- HD Chung
- HF Frierson Jr
- HJ Sobel
- HJ Sobel
- HJ Sobel
- HL Waldum
- HSH Choi
- HY Huang
- I Battacharyya
- I Dardick
- I Uzoaru
- I Vajtai
- I Zbieranowski
- IA Eltoum
- ID Buley
- Illyés Gy
- IM Ambros
- IM Fawcett
- IS Seo
- J Crosbie
- J Ferreiro
- J Hannah
- J Hassoun
- J Larriva-Sahd
- J Lee
- J Lehmann
- J Lloreta
- J Rinaggio
- J Thiele
- JA Bombi
- JA Carney
- JA Ferry
- JA Kaye
- JA Plaza
- JA Ramsay
- JA Tucker
- JB Taxy
- JB Taxy
- JC Fanburg-Smith
- JC Nesbitt
- JC Papadimitriou
- JD Elema
- JD Elema
- JE Griego
- JE Salter Jr
- JF Geddes
- JG Azzopardi
- JJ Navas-Palacios
- JJ Ríos-Martín
- JL Hornick
- JL Hornick
- JM Nesland
- JM Orenstein
- JM Pearson
- JM Rohrbach
- JM Sweet
- JM Theaker
- JM Woodruff
- JM Woodruff
- JMB Bloodworth Jr
- JN Webb
- JP Mahoney
- JR Goldblum
- JR Goodlad
- JR Miliauskas
- JV Johannessen
- JV Johannessen
- JW Bolen
- JW Ironside
- JY Ro
- K Aoki
- K Chorneyko
- K Chowdhury
- K Dellagi
- K Hewan-Lowe
- K Honma
- K Kakudo
- K Kamijo
- K Kovacs
- K Kovacs
- K Kovacs
- K Kovacs
- K Kusama
- K Miura
- KE Kliewer
- KE Schoedel
- KG Morgan
- KG Morgan
- KH Allison
- KH Marquart
- KK Berg
- KM Weidenheim
- KP Dingemans
- KR Mittal
- KW Min
- KW Min
- L Díaz-Flores
- LA Langford
- LG Kindblom
- LJ Copeland
- LJ McWilliam
- LJ Medeiros
- LP Dehner
- LS Cutler
- M Akhtar
- M Akhtar
- M Barbareschi
- M Drlicek
- M Fukushima
- M Guarino
- M Honda
- M Huntrakoon
- M Iwafuchi
- M Katayama
- M Küchle
- M Lacroix-Triki
- M Lurie
- M Melissari
- M Miettinen
- M Miettinen
- M Mukai
- M Nagoshi
- M Shintaku
- M Sobrinho-Simoes
- M Sparagana
- M Takahashi
- M Tanabe
- M Thewes
- M Tsokos
- M Tsuneyoshi
- M Åkerman
- MA Houreih
- MA Houreih
- MA Martorell
- MB Stokes
- MD Garcia Prats
- MD Johnson
- MH Gray
- MH Neal
- MJ Hicks
- ML Carlson
- ML Christ
- MM Silver
- MN Murphy
- MR Wick
- MR Wick
- MT Mazur
- MVE Gallivan
- MW Lee
- N Dourov
- N Kato
- N Monma
- N Nakashima
- N Weidner
- N Yagihashi
- N Yamashita
- NA Wright
- NG Ordóñez
- NG Ordóñez
- NG Ordóñez
- NG Ordóñez
- NG Ordóñez
- NG Ordóñez
- NS Penneys
- NV Adsay
- O Nilsson
- O Scheck
- P Abenoza
- P Argani
- P Dhimes
- P Emmanuel
- P Lodding
- P Lodding
- P Meister
- P Pagesy
- P Park
- P Park
- P Park
- P Robbins
- P Schenk
- P Troncoso
- PA Abrahamsson
- PA di Sant’Agnese
- PA di Sant’Agnese
- PA Stagno
- PB Marcus
- PC Huettner
- PCM De Wilde
- PD Unger
- PE LeBoit
- PE Swanson
- PH Cooper
- PHB Carstens
- PHB Carstens
- PJ Heenan
- PJ Kurtin
- PL Fernandez
- PM Carpenter
- PN Brawn
- PP Parayno
- PRL Sonneland
- PT Osborne
- R Caltabiano
- R Chetty
- R Jaffe
- R Lagacé
- R Moll
- R Singh
- R Stuart-Harris
- R Vang
- RA Erlandson
- RA Erlandson
- RA Erlandson
- RA Erlandson
- RA Erlandson
- RE Mrak
- RE Stahl
- RH Rhodes
- RHM King
- RJ Zarbo
- RK Sibley
- RK Sibley
- RM Williams
- RT Vollmer
- RW Stirling
- RY Osamura
- S Abe
- S Battersby
- S Cinti
- S Hammar
- S Holck
- S Matsumoto
- S Mount
- S Mount
- S Pilotti
- S Suster
- S Tamai
- S Tylstedt
- S Vidal
- S Vidal
- S Yagihashi
- S Young
- SA Vinores
- SD Gurley
- SG Romansky
- SH Barsky
- SM Bator
- SM Sood
- SN Huang
- SR Longway
- SR Saba
- SS Banerjee
- SS Lazarus
- ST Chuang
- ST Gokaslan
- SY Chen
- SY Wong
- T Arai
- T Ehara
- T Hirose
- T Hirose
- T Hirose
- T Hirose
- T Hirose
- T Hirose
- T Hirose
- T Hirose
- T Kameya
- T Khansur
- T Kuwahara
- T Masuda
- T Mentzel
- T Motoyama
- T Nakamura
- T Nishioka
- T Ohno
- T Ohta
- T Shimokama
- T Tachibana
- T Wierzba-Bobrowicz
- TFCS Warner
- TFCS Warner
- TFCS Warner
- TH Liu
- TJ Triche
- TL Johnson
- U Yamaguchi
- UB Kottler
- VA Memoli
- VE Gould
- VE Gould
- VE Gould
- VE Gould
- VJ Ojeda
- VJ Ojeda
- VL Castañeda
- W Creutzfeldt
- W Jurecka
- W Paulus
- WB Laskin
- WH Warren
- WJ Mooi
- WN Christensen
- WR Hart
- Y Abe
- Y Asada
- Y Dayal
- Y Dayal
- Y Dobashi
- Y Hachitanda
- Y Horie
- Y Kuwashima
- Y Oda
- Y Oda
- Y Sadahira
- Y Shi
- Y Takeda
- Y Takei
- Y Takeshima
- Y Yoshida
- YP Xi
- ZL Nelson
- ZR Cohen
- Ö Kurtkaya-Yapicier
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study
Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients
- Author
- A A
- Abbott Jd
- Abdullah S
- Abib E Jr
- Ables Lr
- Abrantes Ja
- Acosta R
- Adams A
- Adams F
- Adroer Martori R
- Agafina As
- Agaiby Jm
- Aggarwala G
- Agraou B
- Aguilarsalinas Ca
- Ahmad A
- Ajala B
- Akdeniz B
- Akhtar N
- Akright L
- Aksentiev S
- Al-Zoebi A
- Alappat P
- Albert M
- Alfieri Ad
- Alhakim M
- Allaw Ma
- Alpizar-Salazar M
- Altafullah Im
- Alvarado Op
- Alvarez Ca
- Alvarez Jg
- Alvarez Ms
- Alvarez-Sala Walther La
- Alves AR Jr
- Alwine Lk
- Alzand B
- Amarenco P.
- Ambrovicova V
- Amerena J
- Andersen Jl
- Andersen Lt
- Anderson P
- Anderson Tj
- Andrassy P
- Andrei Ld
- Andreka P
- Angoulvant D
- Angun M
- Annamalai N
- Ansari Sh
- Anselmi M
- Antonicelli R
- Appel Kf
- Aracil Villar J
- Arain S
- Arambula Rm
- Araz M
- Arca M
- Arcanese Ml
- Arden C
- Areas Ca
- Ari H
- Ariani Mk
- Arif I
- Aroney C
- Aronson R
- Arstall M
- Arstila L
- Arya Kw
- Asamoah-Owusu N
- Askonen K
- Aslam Aa
- Assadourian A
- Assef V
- Atar S
- Auriel E
- Avaca H
- Averna M
- Avornyo Aa
- Avram Ri
- Axthelm C
- Ayesu K
- Aylward Pe
- Ayoub Jc
- Baar M
- Babapulle M
- Badat Ae
- Bailey Sr
- Bajaj H
- Bajcsi D
- Baker J
- Bakhai A
- Baldari D
- Ball Em
- Ballantyne Cm
- Ballyuzek M
- Balo T
- Banaszkiewicz K
- Bandeira e Farias FA
- Banerjee M
- Banik M
- Banyai M
- Baranova E
- Barbarash Ol
- Barbieri Ds
- Barettella Mb
- Barker Ba
- Barnum O
- Barreda Gonzalez Mj
- Barrera Cm
- Barrington P
- Baultrukonis D
- Bax Wa
- Bayat J
- Bayron Cj
- Bays He
- Beaudry P
- Beckett Pl
- Begg A
- Behmanesh B
- Behnke T
- Belenkiy Di
- Belicova M
- Bellido Guerrero D
- Bellingar B
- Beltran Lg
- Benacka J
- Benatar Jr
- Benczur B
- Benitez O
- Benjamin Sa
- Berenguer Ra
- Bergeron J
- Bergerot C
- Berk Mr
- Berli M
- Berlingieri Jc
- Bernard Jv
- Berrouschot J
- Bertolet Bd
- Bhindi R
- Bianco Ht
- Bijata-Bronisz R
- Bilz S
- Bittar Gd
- Bitzur R
- Bjasker Kr
- Blach E
- Black H
- Blagden Md
- Blaha V
- Blake G
- Blanco Coronado Jl
- Blaze K
- Blignault Sc
- Blokhin A
- Bloom Sa
- Bocek P
- Bod E
- Bogaard K
- Bogdanov E
- Bokern Mj
- Boman K
- Bonansea Tc
- Bonfanti Ja
- Bonner Jh
- Bonora E
- Boonyavarakul A
- Borer Js
- Botas Rodrigues J
- Botelho Rv
- Botella Serrano M
- Botero-Lopez R
- Botta Ce
- Bourgeois R
- Bourhaial H
- Boye A
- Boyett Be
- Brandon Dm
- Brar Hs
- Brauer C
- Bravo P
- Bredlau Ce
- Breedveld Rw
- Brenner H
- Breton Cf
- Bretton Em
- Brito Sanfiel Ma
- Broncel M
- Bronnum Schou J
- Brotons Cuixart C
- Broughton R
- Bruguera Cortada J
- Brunell R.
- Bruno Rl
- Budassi N
- Budoff Mj
- Bueno Diez M
- Bufka V
- Buganova I
- Bulanova N
- Buonanno M
- Burgess Lj
- Burnier M
- Burova N
- Busch Rs
- Busegeanu M
- Butuk Dj
- Buynak Rj
- Buysschaert I
- Bybee Ka
- Cabella Pr
- Cabezas Mc
- Caccavo A
- Calin A
- Calvo Gomez C
- Camp Ad
- Capiau L
- Caputo Rp
- Caramori Pr
- Carlier M
- Carlier Sg
- Carmena R
- Carnero Gs
- Carroll Pa
- Casabella Te
- Casaubon L
- Castro Montes Be
- Castro Ma
- Castro Nm
- Catano Js
- Caudmont S
- Cayla G
- Cech V
- Cecil Jt
- Cequier Fillat Ar
- Cerci R
- Ceska R
- Ceyhan C
- Cha Jy
- Chahin M
- Chakrabarti A
- Chambers Jd
- Chandna H
- Chang Ar
- Chang Kc
- Changlani M
- Chati Z
- Chaudhuri S
- Cheek Hb
- Chen J
- Chen Jc
- Cherlin Rs
- Chernyatina Ma
- Cheung Ss
- Chiang Ce
- Chilka S
- Chiong R
- Cho Br
- Cho Ys
- Chochinov Rh
- Chorin E
- Chouinard G
- Chueca Fernandez Je
- Chun H
- Cifkova R
- Ciomag Rm
- Civeira Murillo F
- Civeira F.
- Clark Gb
- Clark R
- Claudio J
- Clemens Pc
- Codutti Or
- Coetzer Tf
- Cohen Aj
- Cohen Ss
- Coisne D
- Collier Dj
- Colombo Hr
- Colquhoun D
- Colquhoun D
- Comlekci A
- Conde Dg
- Cone Cl
- Connelly T
- Connery L
- Contzen C
- Conway Jr
- Cools F
- Copaci I
- Corder Cn
- Corin A
- Cornett Gm
- Cortada Jb
- Couffinhal T
- Cramer E
- Crater Ta
- Crean P
- Crimmins Ds
- Crisby M
- Cropp A
- Cruz Fernandez Jm
- Csanadi Ma
- Cuadrado Ja
- Cucher Fh
- Cui G
- Curiac D
- Curto M
- Cusimano S
- Czarnecka D
- D'Emden M
- da Costa Fa
- Da Stephan U
- Dada Fa
- Dahl Cf
- Dan Ga
- Dan Ga
- Dart Am
- Dave Kn
- Davidovits Z
- Davidsen F
- Davidson E
- Davis Sm
- Davis T
- de Barros e Silva PG
- De Belder M
- De Bruyne L
- De Castro R
- De Dios Garcia Diaz J
- De La Cuesta Mayor C
- De La Fuente Ra
- de Lima e Silva FA
- De Looze F
- De los Rios Ibarra Mo
- de Mora Martin M
- de Moraes Junior Jb
- De Nooijer C
- de Oliveira Paiva Ms
- de Santos Mo
- de Souza Wk
- De Sutter J
- De Wolf L
- Deak L
- Dearborn-Tomazos J
- Debroye C
- Decaigney Sc
- Deck K
- Decoulx E
- Degertekin M
- Dela Llana A
- Delarche N
- Delforge Md
- Delgado Jp
- Delgado Mi
- Demin A
- Demirci D
- den Hartog Fr
- Denker Ps
- Derwahl Km
- Desai V
- Descamps Os
- Desfontaines P
- Desrosiers D
- Destefano P
- Detweiler Ro
- Di Gennaro Jp
- Diaz Jl
- Digiovanna Mj
- Diller Pm
- Dimas Al
- Dion D
- Distiller La
- Dixon L
- Dominguez Escribano Jr
- Dominguez Lopez M
- Donders Sh
- Dor I
- Dorsel T
- dos Santos Fr
- Doshi A
- Douglas F
- Dracoulakis Md
- Drapkina Om
- Drozdz J
- Du Y
- Dubrava J
- Dufreny A
- Dulkova K
- Duplyakov D
- Duprez D
- Durakoglugil E
- Duran Garcia S
- Duris T
- Dutra Op
- Dy J
- Dyke Ck
- Dzupina A
- Eaves Wb
- Ebrahim Io
- Edes I
- Edes I
- Edris Ma
- Egstrup K
- Eitan A
- El Hafi Se
- El Shahawy M
- El-Shahawy M
- Elbaz M
- Elbl L
- Elegeert I
- Eliaschewitz Fg
- Elis A
- Elizondo Moreno Er
- Ellison Hs
- Elosegui Am
- Emanuel S
- Engelbrecht Iv
- Engelbrecht Jm
- Epsley C
- Eraso Am
- Erkan Af
- Eryshev S
- Escudier Villa Jm
- Esperon Ga
- Essandoh Lk
- Estevez R
- Estol Cc
- Evans B
- Fabryova L
- Faes D
- Fagan Tc
- Faghih M
- Fahdi Ie
- Farago K
- Farhat Nz
- Farias Ef
- Farris Nr
- Farsad R
- Fazekas F
- Fedacko J
- Fedele Francesco
- Feldman J
- Felicio Js
- Felix S
- Felten Wr
- Ferkl R
- Fernandez Aa
- Ferrari E
- Fialkow Ja
- Field A
- Field Jc
- Figueiredo El
- Figueras Camos R
- Figueroa-Cruz Wl
- Filardi Pp
- Filippov A
- Fiore G
- First Bp
- Fiserova N
- Fishbein Gj
- fitz-Patrick D
- Flather M.
- Flores E
- Fonseca Fa
- Foody J
- Fordan S
- Forgosh Lb
- Fortes Ja
- Fouche L
- Fox Ke
- Fragoso Vg
- Franceschini E
- Francyk Dm
- Franczek S
- Fraser Nj
- Frederich R
- French Wj
- Frias Jj
- Frisoli A
- Frolova M
- Frost L
- Fruntelata Ag
- Fuchs S
- Fujita K
- Fulmer Jj
- Funk Gs
- Furie Kl
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- Galatius S
- Gallo Hj
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- Ganesh S
- Gao R
- Garcia Castillo A
- Garcia Hernandez Pa
- Garcia Puig J
- Garcia B
- Garcia Dk
- Garcia Hl
- Garcia-Moll Marimon X
- Garden Pi
- Garzone P
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- Gaudet D
- Gavish D
- Gaztambide Saenz Ms
- Gelersztein E
- Gelfand E
- Gelormini J
- Geohas Jg
- George Ar
- Gerke S
- Geskin G
- Gibson Jm
- Gilbert Jm
- Gilfillan Cp
- Gilford T
- Gillespie E
- Gilmore Rm
- Gimness Mp
- Ginzburg M
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- Gleason Gp
- Glenny Ja
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- Gogia Hs
- Goisse M
- Goktekin O
- Goldenberg Rm
- Goldhaber A
- Goloshchekin Bm
- Gomez Je
- Gomez Ni
- Gonzalbez Morgaez Jd
- Gonzalez Juanatey C
- Gonzalez Juanatey Jr
- Gonzalez Ej
- Gonzalez-Gonzalez Jg
- Gonzalez-Ortiz M
- Gordeev Ig
- Gordon Mb
- Gorman Ta
- Gorog Da
- Gorosito Vm
- Gosselink Ma
- Gottlieb Dw
- Gottsater A
- Goube P
- Goyes Ar
- Graff A
- Grant Dc
- Green Cb
- Gregoire J.
- Gregóire Jc
- Greiff J
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- Grobbee D
- Grodman R
- Groenemeijer Be
- Grosman I
- Groutars Rg
- Grégoire J
- Guarnieri Tt
- Guenzel A
- Guerrero Ra
- Guice Mj
- Guimarães Filho Fv
- Gullu H
- Gumbiner B
- Gunstone Ae
- Gupta Ak
- Gupta Dk
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- Gutmann Je
- Haddad Tm
- Hagemann D
- Hagstrom E
- Hajdu C
- Hala T
- Halcox J
- Halperin Fa
- Hamilton Me
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- Wronska D
- Wuerzner G
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- Zemour G
- Zeng X
- Zeno Ml
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- Zhang X
- Zhang Y
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- Zidkova E
- Zieba B
- Zilahi Z
- Zoet-Nugteren Sk
- Zrazhevskiy K
- Zubek V
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Bococizumab is a humanized monoclonal antibody that inhibits proprotein convertase subtilisin- kexin type 9 (PCSK9) and reduces levels of low-density lipoprotein (LDL) cholesterol. We sought to evaluate the efficacy of bococizumab in patients at high cardiovascular risk. METHODS In two parallel, multinational trials with different entry criteria for LDL cholesterol levels, we randomly assigned the 27,438 patients in the combined trials to receive bococizumab (at a dose of 150 mg) subcutaneously every 2 weeks or placebo. The primary end point was nonfatal myocardial infarction, nonfatal stroke, hospitalization for unstable angina requiring urgent revascularization, or cardiovascular death; 93% of the patients were receiving statin therapy at baseline. The trials were stopped early after the sponsor elected to discontinue the development of bococizumab owing in part to the development of high rates of antidrug antibodies, as seen in data from other studies in the program. The median follow-up was 10 months. RESULTS At 14 weeks, patients in the combined trials had a mean change from baseline in LDL cholesterol levels of -56.0% in the bococizumab group and +2.9% in the placebo group, for a between-group difference of -59.0 percentage points (P<0.001) and a median reduction from baseline of 64.2% (P<0.001). In the lower-risk, shorter-duration trial (in which the patients had a baseline LDL cholesterol level of ≥70 mg per deciliter [1.8 mmol per liter] and the median follow-up was 7 months), major cardiovascular events occurred in 173 patients each in the bococizumab group and the placebo group (hazard ratio, 0.99; 95% confidence interval [CI], 0.80 to 1.22; P = 0.94). In the higher-risk, longer-duration trial (in which the patients had a baseline LDL cholesterol level of ≥100 mg per deciliter [2.6 mmol per liter] and the median follow-up was 12 months), major cardiovascular events occurred in 179 and 224 patients, respectively (hazard ratio, 0.79; 95% CI, 0.65 to 0.97; P = 0.02). The hazard ratio for the primary end point in the combined trials was 0.88 (95% CI, 0.76 to 1.02; P = 0.08). Injection-site reactions were more common in the bococizumab group than in the placebo group (10.4% vs. 1.3%, P<0.001). CONCLUSIONS In two randomized trials comparing the PCSK9 inhibitor bococizumab with placebo, bococizumab had no benefit with respect to major adverse cardiovascular events in the trial involving lower-risk patients but did have a significant benefit in the trial involving higher-risk patients
Risk categorization using New American College of Cardiology/American Heart Association guidelines for cholesterol management and its relation to alirocumab treatment following acute coronary syndromes
- Author
- Abbas J
- Abbate A
- Abdullakutty J
- Abdullkutty J
- Abhyanakar AD
- Aboyans V
- Abrantes JAM
- Abu-Fadel M
- Acevedo M
- Adamkova V
- Adamo A
- Adhyapak S
- Agarwal H
- Aggarwal R
- Aggarwal RK
- Agnetti V
- Aguirre A
- Ahmed H
- Ahremark U
- Ahuad Guerrero RA
- Aidar Ayoub JC
- Airaksinen JK
- Aitken D
- Akatova E
- Akhter F
- Ako J
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- Zeiher AM
- Zeiher AM
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- Zurakowski A
- Zuran I
- Zweiker R
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/08/2019
- Field of study
Background: The 2018 US cholesterol management guidelines recommend additional lipid-lowering therapies for secondary prevention in patients with low-density lipoprotein cholesterol ≥70 mg/dL or non−high-density lipoprotein cholesterol ≥100 mg/dL despite maximum tolerated statin therapy. Such patients are considered at very high risk (VHR) based on a history of >1 major atherosclerotic cardiovascular disease (ASCVD) event or a single ASCVD event and multiple high-risk conditions. We investigated the association of US guideline-defined risk categories with the occurrence of ischemic events after acute coronary syndrome and reduction of those events by alirocumab, a PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor. Methods: In the ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab), patients with recent acute coronary syndrome and residual dyslipidemia despite optimal statin therapy were randomly assigned to alirocumab or placebo. The primary trial outcome (major adverse cardiovascular events, ie, coronary heart disease death, nonfatal myocardial infarction, ischemic stroke, or hospitalization for unstable angina) was examined according to American College of Cardiology/American Heart Association risk category. Results: Of 18 924 participants followed for a median of 2.8 years, 11 935 (63.1%) were classified as VHR: 4450 (37.3%) had multiple prior ASCVD events and 7485 (62.7%) had 1 major ASCVD event and multiple high-risk conditions. Major adverse cardiovascular events occurred in 14.4% of placebo-treated patients at VHR versus 5.6% of those not at VHR. In the VHR category, major adverse cardiovascular events occurred in 20.4% with multiple prior ASCVD events versus 10.7% with 1 ASCVD event and multiple high-risk conditions. Alirocumab was associated with consistent relative risk reductions in both risk categories (hazard ratio=0.84 for VHR; hazard ratio=0.86 for not VHR; Pinteraction=0.820) and by stratification within the VHR group (hazard ratio=0.86 for multiple prior ASCVD events; hazard ratio=0.82 for 1 major ASCVD event and multiple high-risk conditions; Pinteraction=0.672). The absolute risk reduction for major adverse cardiovascular events with alirocumab was numerically greater (but not statistically different) in the VHR group versus those not at VHR (2.1% versus 0.8%; Pinteraction=0.095) and among patients at VHR with multiple prior ASCVD events versus a single prior ASCVD event (2.4% versus 1.8%; Pinteraction=0.661). Conclusions: The US guideline criteria identify patients with recent acute coronary syndrome and dyslipidemia who are at VHR for recurrent ischemic events and who may derive a larger absolute benefit from treatment with alirocumab. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01663402
Notes for genera – Ascomycota
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- WJ Li
- WJ Li
- WL Bruckart
- WM Jaklitsch
- WM Jaklitsch
- WM Jaklitsch
- WM Jaklitsch
- WM Jaklitsch
- WM Jaklitsch
- WM Jaklitsch
- WM Jaklitsch
- WM Jaklitsch
- WM Jaklitsch
- WM Jaklitsch
- WM Jaklitsch
- WM Pitt
- WP Pfliegler
- WP Pfliegler
- WT Beaulieu
- WV Brackel
- WV Brackel
- WV Brackel
- WV Brackel
- WV Brackel
- WV Brackel
- WV Brackel
- WV Brackel
- WV Brackel
- WY Zhuang
- WY Zhuang
- WY Zhuang
- WY Zhuang
- WY Zhuang
- X Guang-yu
- X Sun
- X Vazquéz-Campos
- X Wang
- X Wang
- X Xu
- X Zhang
- X Zhao
- X Zhao
- XD Zhou
- XF Li
- XF Zhu
- XH Wang
- Xiang-Yu Zeng
- Xiaoya Ma
- XL Cheng
- XL Cheng
- XL Fan
- XL Fan
- XL Fan
- XL Fan
- XL Fan
- XM Hou
- XM Niu
- XQ Zhu
- XW Wang
- XX Liu
- XY Wang
- XY Wang
- XY Wang
- XY Wang
- XY Zeng
- Y Ando
- Y Chen
- Y Cho
- Y Cho
- Y Chu
- Y Cui
- Y Hanying
- Y Harimoto
- Y Hirooka
- Y Hirooka
- Y Hirooka
- Y Hirooka
- Y Hirooka
- Y Huang
- Y Joshi
- Y Joshi
- Y Joshi
- Y Joshi
- Y Joshi
- Y Kajitani
- Y Kambar
- Y Karagöz
- Y Li
- Y Marin-Felix
- Y Marin-Felix
- Y Marin–Felix
- Y Matsuda
- Y Matsuwaki
- Y Miyamoto
- Y Miyamoto
- Y Nagano
- Y Ohmura
- Y Ohmura
- Y Suto
- Y Suzuki
- Y Takashima
- Y Wang
- Y Wang
- Y Wang
- Y Wang
- Y Wang
- Y Wu
- Y Yang
- Y Yavuz
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhou
- Yamini Agrawal
- YB Lee
- YB Lee
- YC Chang
- YD Zhang
- YD Zhang
- YD Zhang
- YD Zhang
- YD Zhang
- YD Zhang
- YD Zhang
- YD Zhang
- YD Zhang
- YF Han
- YH Geng
- YJ Choi
- YJ Zhao
- YL Chen
- YL Jiang
- YL Jiang
- YL Jiang
- YL Wang
- YL Zhang
- YM Li
- YM Shabana
- YM Wu
- YM Wu
- YM Wu
- YM Wu
- YM Wu
- YM Wu
- YM Wu
- YM Zhang
- YM Zhang
- Yong-Zhong Lu
- YP Ge
- YP Tan
- YQ Du
- YR Ma
- YR Ma
- YR Ma
- YT Huang
- YW Lim
- YX Liu
- YY Chen
- YY Su
- YZ Lu
- YZ Lu
- YZ Lu
- YZ Wang
- YZ Wang
- Z Du
- Z Fangyan
- Z Ferencova
- Z Jurjevic
- Z Jurjevic
- Z Zakeri
- Z Zhang
- ZA Dyer
- ZA Randriamanantany
- ZF Yu
- ZJ Li
- ZL Luo
- ZL Luo
- ZL Luo
- ZL Luo
- ZL Luo
- ZL Yuan
- Zong-Long Luo
- ZQ Liang
- ZQ Zeng
- ZQ Zeng
- ZW Beer de
- ZW Beer de
- ZW Beer de
- ZW Ge
- Å Kruys
- Å Kruys
- Å Kruys
- Ö Tufan-Çetin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Knowledge of the relationships and thus the classification of fungi, has developed rapidly with increasingly widespread use of molecular techniques, over the past 10--15 years, and continues to accelerate. Several genera have been found to be polyphyletic, and their generic concepts have subsequently been emended. New names have thus been introduced for species which are phylogenetically distinct from the type species of particular genera. The ending of the separate naming of morphs of the same species in 2011, has also caused changes in fungal generic names. In order to facilitate access to all important changes, it was desirable to compile these in a single document. The present article provides a list of generic names of Ascomycota (approximately 6500 accepted names published to the end of 2016), including those which are lichen-forming. Notes and summaries of the changes since the last edition of `Ainsworth Bisby's Dictionary of the Fungi' in 2008 are provided. The notes include the number of accepted species, classification, type species (with location of the type material), culture availability, life-styles, distribution, and selected publications that have appeared since 2008. This work is intended to provide the foundation for updating the ascomycete component of the ``Without prejudice list of generic names of Fungi'' published in 2013, which will be developed into a list of protected generic names. This will be subjected to the XIXth International Botanical Congress in Shenzhen in July 2017 agreeing to a modification in the rules relating to protected lists, and scrutiny by procedures determined by the Nomenclature Committee for Fungi (NCF). The previously invalidly published generic names Barriopsis, Collophora (as Collophorina), Cryomyces, Dematiopleospora, Heterospora (as Heterosporicola), Lithophila, Palmomyces (as Palmaria) and Saxomyces are validated, as are two previously invalid family names, Bartaliniaceae and Wiesneriomycetaceae. Four species of Lalaria, which were invalidly published are transferred to Taphrina and validated as new combinations. Catenomycopsis Tibell Constant. is reduced under Chaenothecopsis Vain., while Dichomera Cooke is reduced under Botryosphaeria Ces. De Not. (Art. 59)