Effect of Vascepa (icosapent ethyl) on progression of coronary atherosclerosis in patients with elevated triglycerides (200-499 mg/dL) on statin therapy: Rationale and design of the EVAPORATE study.

Despite reducing progression and promoting regression of coronary atherosclerosis, statin therapy does not fully address residual cardiovascular (CV) risk. High-purity eicosapentaenoic acid (EPA) added to a statin has been shown to reduce CV events and induce regression of coronary atherosclerosis in imaging studies; however, data are from Japanese populations without high triglyceride (TG) levels and baseline EPA serum levels greater than those in North American populations. Icosapent ethyl is a high-purity prescription EPA ethyl ester approved at 4 g/d as an adjunct to diet to reduce TG levels in adults with TG levels >499 mg/dL. The objective of the randomized, double-blind, placebo-controlled EVAPORATE study is to evaluate the effects of icosapent ethyl 4 g/d on atherosclerotic plaque in a North American population of statin-treated patients with coronary atherosclerosis, TG levels of 200 to 499 mg/dL, and low-density lipoprotein cholesterol levels of 40 to 115 mg/dL. The primary endpoint is change in low-attenuation plaque volume measured by multidetector computed tomography angiography. Secondary endpoints include incident plaque rates; quantitative changes in different plaque types and morphology; changes in markers of inflammation, lipids, and lipoproteins; and the relationship between these changes and plaque burden and/or plaque vulnerability. Approximately 80 patients will be followed for 9 to 18 months. The clinical implications of icosapent ethyl 4 g/d treatment added to statin therapy on CV endpoints are being evaluated in the large CV outcomes study REDUCE-IT. EVAPORATE will provide important imaging-derived data that may add relevance to the clinically derived outcomes from REDUCE-IT

Superfluid Bosons and Flux Liquids: Disorder, Thermal Fluctuations, and Finite-Size Effects

The influence of different types of disorder (both uncorrelated and correlated) on the superfluid properties of a weakly interacting or dilute Bose gas, as well as on the corresponding quantities for flux line liquids in high-temperature superconductors at low magnetic fields are reviewed, investigated and compared. We exploit the formal analogy between superfluid bosons and the statistical mechanics of directed lines, and explore the influence of the different "imaginary time" boundary conditions appropriate for a flux line liquid. For superfluids, we discuss the density and momentum correlations, the condensate fraction, and the normal-fluid density as function of temperature for two- and three-dimensional systems subject to a space- and time-dependent random potential as well as conventional point-, line-, and plane-like defects. In the case of vortex liquids subject to point disorder, twin boundaries, screw dislocations, and various configurations of columnar damage tracks, we calculate the corresponding quantities, namely density and tilt correlations, the ``boson'' order parameter, and the tilt modulus. The finite-size corrections due to periodic vs. open "imaginary time" boundary conditions differ in interesting and important ways. Experimental implications for vortex lines are described briefly.Comment: 78 pages, RevTex, 4 figures included (sorry, there are no ps-files for the remaining 2 figures; if needed, please send mail to [email protected]); brief erratum appended (2 pages

B(H) Constitutive Relations Near H_c1 in Disordered Superconductors

We provide a self-contained account of the B vs. H constitutive relation near H_c1 in Type II superconductors with various types of quenched random disorder. The traditional Abrikosov result B ~ [ln (H - H_c1)]^{-2}, valid in the absence of disorder and thermal fluctuations, changes significantly in the presence of disorder. Moreover, the constitutive relations will depend strongly on the type of disorder. In the presence of point disorder, B ~ (H - H_c1)^{3/2} in three-dimensional (thick) superconductors, as shown by Nattermann and Lipowsky. In two-dimensional (thin film) superconductors with point disorder, B ~ (H - H_c1). In the presence of parallel columnar disorder, we find that B ~ exp[-C / (H - H_c1)] in three dimensions, while B ~ exp[-K / (H - H_c1)^{1/2}] in two dimensions. In the presence of nearly isotropically splayed disorder, we find that B ~ (H - H_c1)^{3/2} in both two and three dimensions.Comment: 37 pages, 12 figures included in text; submitted to Physica

Electromagnetic Coulomb Gas with Vector Charges and "Elastic'' Potentials : Renormalization Group Equations

We present a detailed derivation of the renormalization group equations for two dimensional electromagnetic Coulomb gases whose charges lie on a triangular lattice (magnetic charges) and its dual (electric charges). The interactions between the charges involve both angular couplings and a new electromagnetic potential. This motivates the denomination of ``elastic'' Coulomb gas. Such elastic Coulomb gases arise naturally in the study of the continuous melting transition of two dimensional solids coupled to a substrate, either commensurate or with quenched disorder

The formation of silver /I/ chloride by the action of silver /I/ ion on carbon tetrachloride in 2-butanol and methanol

Formation of silver chloride by action of silver ion on carbon tetrachloride in 2-butanol and methano

Topological transitions and freezing in XY models and Coulomb gases with quenched disorder: renormalization via traveling waves

We study the two dimensional XY model with quenched random phases and its Coulomb gas formulation. A novel renormalization group (RG) method is developed which allows to study perturbatively the glassy low temperature XY phase and the transition at which frozen topological defects (vortices) proliferate. This RG approach is constructed both from the replicated Coulomb gas and, equivalently without the use of replicas, using the probability distribution of the local disorder (random defect core energy). By taking into account the fusion of environments (i.e charge fusion in the replicated Coulomb gas) this distribution is shown to obey a Kolmogorov's type (KPP) non linear RG equation which admits travelling wave solutions and exhibits a freezing phenomenon analogous to glassy freezing in Derrida's random energy models. The resulting physical picture is that the distribution of local disorder becomes broad below a freezing temperature and that the transition is controlled by rare favorable regions for the defects, the density of which can be used as the new perturbative parameter. The determination of marginal directions at the disorder induced transition is shown to be related to the well studied front velocity selection problem in the KPP equation and the universality of the novel critical behaviour obtained here to the known universality of the corrections to the front velocity. Applications to other two dimensional problems are mentionned at the end.Comment: 86 pages, 15 eps files include

A New Phase of Tethered Membranes: Tubules

We show that fluctuating tethered membranes with {\it any} intrinsic anisotropy unavoidably exhibit a new phase between the previously predicted ``flat'' and ``crumpled'' phases, in high spatial dimensions $d$ where the crumpled phase exists. In this new "tubule" phase, the membrane is crumpled in one direction but extended nearly straight in the other. Its average thickness is $R_G\sim L^{\nu_t}$ with $L$ the intrinsic size of the membrane. This phase is more likely to persist down to $d=3$ than the crumpled phase. In Flory theory, the universal exponent $\nu_t=3/4$, which we conjecture is an exact result. We study the elasticity and fluctuations of the tubule state, and the transitions into it.Comment: 4 pages, self-unpacking uuencoded compressed postscript file with figures already inside text; unpacking instructions are at the top of file. To appear in Phys. Rev. Lett. November (1995

Sinai model in presence of dilute absorbers

We study the Sinai model for the diffusion of a particle in a one dimension random potential in presence of a small concentration $\rho$ of perfect absorbers using the asymptotically exact real space renormalization method. We compute the survival probability, the averaged diffusion front and return probability, the two particle meeting probability, the distribution of total distance traveled before absorption and the averaged Green's function of the associated Schrodinger operator. Our work confirms some recent results of Texier and Hagendorf obtained by Dyson-Schmidt methods, and extends them to other observables and in presence of a drift. In particular the power law density of states is found to hold in all cases. Irrespective of the drift, the asymptotic rescaled diffusion front of surviving particles is found to be a symmetric step distribution, uniform for $|x| < {1/2} \xi(t)$, where $\xi(t)$ is a new, survival length scale ($\xi(t)=T \ln t/\sqrt{\rho}$ in the absence of drift). Survival outside this sharp region is found to decay with a larger exponent, continuously varying with the rescaled distance $x/\xi(t)$. A simple physical picture based on a saddle point is given, and universality is discussed.Comment: 21 pages, 2 figure

The flat phase of fixed-connectivity membranes

The statistical mechanics of flexible two-dimensional surfaces (membranes) appears in a wide variety of physical settings. In this talk we discuss the simplest case of fixed-connectivity surfaces. We first review the current theoretical understanding of the remarkable flat phase of such membranes. We then summarize the results of a recent large scale Monte Carlo simulation of the simplest conceivable discrete realization of this system \cite{BCFTA}. We verify the existence of long-range order, determine the associated critical exponents of the flat phase and compare the results to the predictions of various theoretical models.Comment: 7 pages, 5 figures, 3 tables. LaTeX w/epscrc2.sty, combined contribution of M. Falcioni and M. Bowick to LATTICE96(gravity), to appear in Nucl. Phys. B (proc. suppl.