Force–velocity profiles in CrossFit athletes: A cross-sectional study considering sex, age, and training frequency

Introduction: The force–velocity profile has been analysed previously in different sports modalities; nevertheless, it has not been analysed in CrossFit. Objective: The aim of this study was to report neuromuscular characteristics of CrossFit athletes using their individual force-velocity profile, investigating differences according to sex, age, and training frequency. Materials and Meth-ods: 72 males (33.17 ± 6.86 years; BMI: 25.93 ± 3.64 kg/m2) and 18 females (30.11 ± 6.92 years; BMI: 23.53 ± 3.98 kg/m2) participated in this study. The force-velocity profile was calculated using Samo-zino’s method. Furthermore, neuromuscular characterization was completed with a squat jump and three drop jumps (20, 30, and 40 cm). Results: Regarding sex, significant differences in all analysed mechanical variables (p < 0.001) were found except for the theoretical maximal force (p = 0.944). No significant differences were found between age groups. Considering training frequency, athletes who train more than 5 days per week showed higher performance in all analysed mechanical variables (p < 0.05). Conclusion: CrossFit athletes have a force-velocity profile more oriented towards velocity than force. Males and females have different neuromuscular characteristics, also neuromus-cular improvements can be achieved at any age. Moreover, higher neuromuscular performance is developed with a training frequency of 5 days or more per week

The variability of strength production capacities during a judo contest

Background. The muscular response of athletes in a judo contest is one of the most important aspect to measure with precision. Objective. Our purpose was to obtain and analyse the variability of strength associated to muscular performance parameters during a judo contest. Methods. Thirty-five men performed five 5-minute bouts with 15 minutes of passive rest. Immediately after each bout, muscular performance parameters were tested: countermovement jump (CMJ), maximal dynamic strength capacities (mean power velocity (MPV), mean strength (MS), maximum strength (MXS), mean power (MP) and maximum power (MXP)) in upper body, dominant (DHS) and non-dominant handgrip isometric strength (NDHS). ANOVA to compare baseline test data and successive bouts was used. Results. ANOVA revealed significant differences in NDHS (p<0.001), DHS (p<0.001), CMJ (p<0.001), MPV (p<0.001), MXS (p<0.001), MP (p<0.001) and MXP (p<0.001). No significant differences in MS (p = 0.008) were found. Some significant correlations between NDHS and ΔPMX (r=0.368, p=0.050), MPV and ΔMXS (r=0.528, p=0.001) and ΔMXP (r=0.683, p<0.001), MPX and ΔMXS (r=0.528, p=0.001) and ΔMP (r=0.877, p<0.001) were found. Conclusion. Due to judo contest can be considered a high intensity exercise, it produces an amount of muscular fatigue and therefore significant loss strength that it cannot be recovery during rest-times between successive bouts. For this reason, it was a high variability in strength production capacities, which are modified during a judo contest

Assessment of the influence of direct tobacco smoke on infection and active TB management

Smoking is a risk factor for tuberculosis (TB) infection and disease progression. Tobacco smoking increases susceptibility to TB in a variety of ways, one of which is due to a reduction of the IFN-γ response. Consequently, an impaired immune response could affect performance of IFN-γ Release Assays (IGRAs).Miguel Servet program of the Instituto de Salud Carlos III (Spain). ML was supported by a joint ERS/SEPAR fellowship (LTRF 2015). The research was partially supported by a grant from the Instituto de Salud Carlos III (PI 13/01546 and PI 16/01912), integrated in the Plan Nacional de I+D+I and cofunded by the ISCIII Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER); and a grant from the Sociedad Española de Neumología y Cirugía Torácica (SEPAR; Barcelona, Spain) (Smoking Integrated Research Programme Call) to NA

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Pasados y presente. Estudios para el profesor Ricardo García Cárcel

Ricardo García Cárcel (Requena, 1948) estudió Historia en Valencia bajo el magisterio de Joan Reglà, con quien formó parte del primer profesorado de historia moderna en la Universidad Autónoma de Barcelona. En esta universidad, desde hace prácticamente cincuenta años, ha desarrollado una extraordinaria labor docente y de investigación marcada por un sagaz instinto histórico, que le ha convertido en pionero de casi todo lo que ha estudiado: las Germanías, la historia de la Cataluña moderna, la Inquisición, las culturas del Siglo de Oro, la Leyenda Negra, Felipe II, Felipe V, Austrias y Borbones, la guerra de la Independencia, la historia cultural, los mitos de la historia de España... Muy pocos tienen su capacidad para reflexionar, ordenar, analizar, conceptualizar y proponer una visión amplia y llena de matices sobre el pasado y las interpretaciones historiográficas. A su laboriosidad inimitable se añade una dedicación sin límites en el asesoramiento de alumnos e investigadores e impulsando revistas, dosieres, seminarios o publicaciones colectivas. Una mínima correspondencia a su generosidad lo constituye este volumen a manera de ineludible agradecimiento

Influence of the β parameter of the Haverkamp model on the transient soil water infiltration curve

28 Pags.- 5 Figs.- 3 Tabls. The definitive version is available at: https://www.sciencedirect.com/science/journal/00221694Soil water infiltration can be described with the quasi-analytical Haverkamp et al. (1994) equation, defined by the hydraulic conductivity (Ks), sorptivity (S) and the β parameter. Ks and S are commonly estimated from the transient cumulative infiltration curve, using a constant β value. The objective of this work was to study the influence of β on the estimation of Ks and S. The study was first performed on synthetic 1-D infiltration curves generated at different infiltration times for loam sandy, loamy and silty soils, and next extrapolated to a 3-D loam synthetic soil and on 10 infiltrations curves measured on the field with a disc infiltrometer on different types of soils. The infiltration measurements lasted between 600 and 900 s. The results showed that, while early infiltration times (i.e. 100 s) promoted good estimations for S, longer infiltrations (i.e. 1.000 s) were required to estimate accurately Ks. Only very long infiltration (i.e. 10.000 s) allowed defining the actual β value. A similar behaviour was observed for the 3-D infiltration measurements. Except for β, significant relationships (R2 = 0.99) were obtained between the Ks and S of the three theoretical soils and the corresponding values calculated by optimizing the three hydraulic parameters on 2.000 s 1-D infiltration curves. The large confidence interval observed in β (between 0.3 and 2.0) resulted from the fact that β had a small effect on the infiltration curve. A significant relationship (R2 = 0.99) was also obtained between the Ks and S optimized from the experimental curves using a β = 1.1 and the corresponding values obtained by simultaneous optimization of the three hydraulic parameters. These results demonstrated that S and Ks can be accurately estimated using a constant β and that downward infiltration is not an appropriate procedure to estimate β.This research was supported by Ministry of Economy, Industry and Innovation (CGL2014-53017-C2-1-R and CGL2016-80783-R).Peer reviewe

Study of CD27 and CCR4 markers on specific CD4+ T-cells as immune tools for active and latent tuberculosis management

This research was supported by: (i) a grant from the Instituto de Salud Carlos III (PI 13/01546, PI16/01912, and PI18/00411), integrated in the Plan Nacional de I+D+I and cofunded by the ISCIII Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER); and (ii) a grant from the Sociedad Española de Neumología y Cirugía Torácica (project 25/2016; SEPAR; Barcelona, Spain). JD is a researcher from the Miguel Servet programme.The immunological characterization of different cell markers has opened the possibility of considering them as immune tools for tuberculosis (TB) management, as they could correlate with TB latency/disease status and outcome. CD4+ T-cells producing IFN-γ+ with a low expression of CD27 have been described as an active TB marker. In addition, there are unknown homing receptors related to TB, such as CCR4, which might be useful for understanding TB pathogenesis. The aim of our study is focused on the assessment of several T-cell subsets to understand immune-mechanisms in TB. This phenotypic immune characterization is based on the study of the specific immune responses of T-cells expressing CD27 and/or CCR4 homing markers. Subjects enrolled in the study were: (i) 22 adult patients with active TB, and (ii) 26 individuals with latent TB infection (LTBI). Blood samples were drawn from each patient. The expression of CD27 and/or CCR4 markers were analyzed within CD4+ T-cells producing: (i) IFN-γ+, (ii) TNF-α+, (iii) TNF-α+IFN-γ+, and (iv) IFN-γ+ and/or TNF-α+. The percentage of CD27. within all CD4+ T-cell populations analyzed was significantly higher on active TB compared to LTBI after PPD or ESAT-6/CFP-10 stimulation. As previously reported, a ratio based on the CD27 median fluorescence intensity (MFI) was also explored (MFI of CD27 in CD4+ T-cells over MFI of CD27 in IFN-γ+CD4+ T-cells), being significantly increased during disease (p < 0.0001 after PPD or ESAT-6/CFP-10 stimulation). This ratio was also assessed on the other CD4+ T-cells functional profiles after specific stimulation, being significantly associated with active TB. Highest diagnostic accuracies for active TB (AUC ≥ 0.91) were achieved for: (i) CD27 within IFN-γ+TNF-α+CD4+ T-cells in response to ESAT-6/CFP-10, (ii) CD27 and CCR4 markers together within IFN-γ+CD4+ T-cells in response to PPD, and (iii) CD27 MFI ratio performed on IFN-γ+TNF-α+CD4+ T-cells after ESAT-6/CFP-10 stimulation. The lowest diagnostic accuracy was observed when CCR4 marker was evaluated alone (AUC ≤ 0.77). CD27 and CCR4 expression detection could serve as a good method for immunodiagnosis. Moreover, the immunological characterization of markers/subset populations could be a promising tool for understanding the biological basis of the disease