263 research outputs found
A 2-set-up Routley-Meyer Semantics for the 4-valued Relevant Logic E4
The logic BN4 can be considered as the 4-valued logic of the relevant conditional and the logic E4, as the 4-valued logic of (relevant) entailment. The aim of this paper is to endow E4 with a 2-set-up Routley-Meyer semantics. It is proved that E4 is strongly sound and complete w.r.t. this semantics
Informe sobre la Primera Reunión de Campo del Grupo de Cuaternario Madrileño GQM -AEQUA Madrid, febrero 2007
Relational semantics for the 4-valued relevant logics BN4 and E4
The logic BN4 was defined by R.T. Brady in 1982. It can be considered as the 4-valued logic of the relevant conditional. E4 is a variant of BN4 that can be considered as the 4-valued logic of (relevant) entailment. The aim of this paper is to define reduced general Routley-Meyer semantics for BN4 and E4. It is proved that BN4 and E4 are strongly sound and complete w.r.t. their respective semantics
Geomorphological setting and main technological features of new Middle and Upper Pleistocene sites in the Lower Manzanares River Valley (Madrid, Spain)
Las intervenciones arqueológicas llevadas a cabo durante los años 1996 en Tafesa, 2005 en el yacimiento
Hospital 12 de Octubre y 2006 en la desembocadura del arroyo Butarque (Villaverde-Barrio de
Butarque) situados al sur de la ciudad de Madrid (España), han aportado nuevos conjuntos líticos contextualizados
estratigráficamente en los depósitos fluviales pleistocenos correspondientes al tramo inferior
del valle del río Manzanares. Los yacimientos arqueológicos analizados se sitúan geomorfológicamente
en la denominada “Terraza Compleja del Manzanares” (TCMZ), la cual constituye un nivel fluvial
engrosado (20-15 m de potencia) situado entre +22-16 m sobre el cauce actual del río, a lo largo de su
margen derecha. Este nivel fluvial ha sido tradicionalmente considerado de edad Pleistoceno medio en
base a la industria achelense y complejos faunísticos encontrados en sus niveles inferiores. Ciertamente,
Tafesa es un yacimiento situado en la parte inferior-media de la terraza de +22 m con industria achelense
y fauna de Pleistoceno medio. Por el contrario, los niveles superiores de esta misma terraza en
los sectores del 12 de Octubre y Villaverde-Butarque se encuentran asociados a industrias del Paleolítico
inferior y medio ya pertenecientes al Pleistoceno superior, como sugieren el conjunto de dataciones
OSL y TL existentes para la zona. Los datos analizados en este trabajo indican que el desarrollo de
este nivel de terraza engrosado comienza durante la parte final de Pleistoceno medio y abarca todo el
Estadio Isotópico OIS 5, ya dentro del Pleistoceno superiorThe archaeological works developed during the years 1996 in the site of Tafesa, 2005 in the 12 de
Octubre Metro Station site and 2006 in the confluence of the Butarque Stream (Villaverde-Barrio de
Butarque site) located south of the Madrid City (Spain), have provided new lithic assemblages. These
assemblages have been stratigraphically contextualized in the Pleistocene deposits of the Lower Manzanares
river valley within the so-called “Manzanares Complex Terrace” (TCMZ). This fluvial terrace
constitutes an anomalous thickened (20-15m) deposit at +22-16m above the present river thalweg mainly developed along the right (southern) valley margin. This fluvial level has been traditionally considered
of middle Pleistocene age on the basis of the acheulian lithics and faunal assemblages typically located
within its lower stratigraphic layers. Certainly, the Tafesa is a fluvial terrace site at +22 m with acheulian
industry and middle Pleistocene faunal remains at its lower sedimentary sequence. However, the upper
sedimentary levels of this same terrace in the 12 de Octubre y Villaverde-Butarque sites throw lithic
assemblages of the lower and upper Paleolithic belonging to upper Pleistocene, as suggested by the
available set of TL and OSL dates for the zone. The analyses developed in this study indicate that the
development of this thickened fluvial terrace started during the end of the middle Pleistocene, but also
comprise the whole Oxygen Isotopic Stage OIS 5 during the upper Pleistocene
Real-time detection of riboflavin production by Lactobacillus plantarum strains and tracking of their gastrointestinal survival and functionality in vitro and in vivo using mCherry labeling
Some strains of lactic acid bacteria (LAB) produce riboflavin, a water-soluble vitamin of the B complex, essential for human beings. Here, we have evaluated riboflavin (B2 vitamin) production by five Lactobacillus plantarum strains isolated from chicha, a traditional maize-based fermented alcoholic beverage from north-western Argentina and their isogenic riboflavin-overproducing derivatives previously selected using roseoflavin. A direct fluorescence spectroscopic detection method to quantify riboflavin production in bacterial culture supernatants has been tested. Comparison of the efficiency for riboflavin fluorescence quantification with and without prior HPLC fractionation showed that the developed method is a rapid and easy test for selection of B2 vitamin-producing strains. In addition, it can be used for quantitative detection of the vitamin production in real time during bacterial growth. On the basis of this and previous analyses, the L. plantarum M5MA1-B2 riboflavin overproducer was selected for in vitro and in vivo studies after being fluorescently labeled by transfer of the pRCR12 plasmid, which encodes the mCherry protein. The labeling did not affect negatively the growth, the riboflavin production nor the adhesion of the strain to Caco-2 cells. Thus, L. plantarum M5MA1-B2[pRCR12] was evaluated for its survival under digestive tract stresses in the presence of microbiota in the dynamic multistage BFBL gut model and in a murine model. After exposure to both models, M5MA1-B2[pRCR12] could be recovered and detected by the pink color of the colonies. The results indicated a satisfactory resistance of the strain to gastric and intestinal stress conditions but a low colonization capability observed both in vitro and in vivo. Overall, L. plantarum M5MA1-B2 could be proposed as a probiotic strain for the development of functional foods.Fil: Mohedano, Mari Luz. Consejo Superior de Investigaciones Científicas. Centro de Investigaciones Biológicas; EspañaFil: Hernández Recio, Sara. Consejo Superior de Investigaciones Científicas. Centro de Investigaciones Biológicas; EspañaFil: Yépez, Alba. Universidad de Valencia; EspañaFil: Requena, Teresa. Consejo Superior de Investigaciones Científicas. Instituto de Investigación en Ciencias de la Alimentación; EspañaFil: Martínez Cuesta, M. Carmen. Consejo Superior de Investigaciones Científicas. Instituto de Investigación en Ciencias de la Alimentación; EspañaFil: Peláez, Carmen. Consejo Superior de Investigaciones Científicas. Instituto de Investigación en Ciencias de la Alimentación; EspañaFil: Russo, Pasquale. Università di Foggia; ItaliaFil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Spano, Giuseppe. Università di Foggia; ItaliaFil: Aznar, Rosa. Universidad de Valencia; España. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; EspañaFil: López, Paloma. Consejo Superior de Investigaciones Científicas. Centro de Investigaciones Biológicas; Españ
Pesticide Exposure Alters Follicle-Stimulating Hormone Levels in Mexican Agricultural Workers
Organophosphorous pesticides (OPs) are suspected of altering reproductive function by reducing brain acetylcholinesterase activity and monoamine levels, thus impairing hypothalamic and/or pituitary endocrine functions and gonadal processes. Our objective was to evaluate in a longitudinal study the association between OP exposure and serum levels of pituitary and sex hormones. Urinary OP metabolite levels were measured by gas–liquid chromatography, and serum pituitary and sex hormone levels by enzymatic immunoassay and radioimmunoassay in 64 men. A total of 147 urine and blood samples were analyzed for each parameter. More than 80% of the participants had at least one OP metabolite in their urine samples. The most frequent metabolite found was diethylthiophosphate (DETP; 55%), followed by diethylphosphate (DEP; 46%), dimethylthiophosphate (DMTP; 32%), and dimethyldithiophosphate (DMDTP; 31%). However, the metabolites detected at higher concentrations were DMTP, DEP, DMDTP, and dimethylphosphate. There was a high proportion of individuals with follicle-stimulating hormone (FSH) concentrations outside the range of normality (48%). The average FSH serum levels were higher during the heavy pesticide spraying season. However, a multivariate analysis of data collected in all periods showed that serum FSH levels were negatively associated with urinary concentrations of both DMTP and DMDTP, whereas luteinizing hormone (LH) was negatively associated with DMTP. We observed no significant associations between estradiol or testosterone serum levels with OP metabolites. The hormonal disruption in agricultural workers presented here, together with results from experimental animal studies, suggests that OP exposure disrupts the hypothalamic–pituitary endocrine function and also indicates that FSH and LH are the hormones most affected
Effectiveness of a telerehabilitation intervention using ReCOVery APP of long COVID patients: a randomized, 3-month follow-up clinical trial
The main objective of this study is to analyze the clinical efficacy of telerehabilitation in the recovery of Long COVID patients through ReCOVery APP for 3 months, administered in the Primary Health Care context. The second objective is to identify significant models associated with an improvement in the study variables. An open-label randomized clinical trial was conducted using two parallel groups of a total of 100 Long COVID patients. The first group follows the treatment as usual methods established by their general practitioner (control group) and the second follows the same methods and also uses ReCOVery APP (intervention group). After the intervention, no significant differences were found in favour of the group intervention. Regarding adherence, 25% of the participants made significant use of the APP. Linear regression model establishes that the time of use of ReCOVery APP predicts an improvement in physical function (b = 0.001; p = 0.005) and community social support (b = 0.004; p = 0.021). In addition, an increase in self-efficacy and health literacy also contribute to improving cognitive function (b = 0.346; p = 0.001) and reducing the number of symptoms (b = 0.226; p = 0.002), respectively. In conclusion, the significant use of ReCOVery APP can contribute to the recovery of Long COVID patients.
Trial Registration No.: ISRCTN91104012
An Overview of the Rotational Behavior of Metal--Poor Stars
The present paper describes the behavior of the rotational velocity in
metal--poor stars ([Fe/H]<-0.5 dex) in different evolutionary stages, based on
Vsini values from the literature. Our sample is comprised of stars in the field
and some Galactic globular clusters, including stars on the main sequence, the
red giant branch (RGB), and the horizontal branch (HB). The metal--poor stars
are, mainly, slow rotators, and their Vsini distribution along the HR diagram
is quite homogeneous. Nevertheless, a few moderate to high values of Vsini are
found in stars located on the main sequence and on the HB. We show that the
overall distribution of Vsini values is basically independent of metallicity
for the stars in our sample. In particular, the fast-rotating main sequence
stars in our sample present similar rotation rates as their metal-rich
counterparts, suggesting that some of them may actually be fairly young, in
spite of their low metallicity, or else that at least some of them would be
better classified as blue straggler stars. We do not find significant evidence
of evolution in Vsini values as a function of position on the RGB; in
particular, we do not confirm previous suggestions that stars close to the RGB
tip rotate faster than their less evolved counterparts. While the presence of
fast rotators among moderately cool blue HB stars has been suggested to be due
to angular momentum transport from a stellar core that has retained significant
angular momentum during its prior evolution, we find that any such transport
mechanisms must likely operate very fast as the star arrives on the zero-age HB
(ZAHB), since we do not find a link between evolution off the ZAHB and Vsini
values.
We present an extensive tabulation of all quantities discussed in this paper,
including rotation velocities, temperatures, gravitieComment: 22 pages, 10 figure
Geoarqueología y paleontología de los depósitos de Pleistoceno Superior del antiguo Arroyo Abroñigal (Cuenca de Manzanares, Madrid): el yacimiento de Puente de los Tres Ojos
La excavación arqueológica del yacimiento del Puente de los Tres Ojos, próximo a la calle Cerro Negro (Madrid), ha aportado nuevos datos para profundizar en el conocimiento de la ocupación humana y en la reconstrucción paleoambiental del valle del antiguo arroyo Abroñigal, cuyo curso fluvial funcionó como afluente del río Manzanares posiblemente desde antes del Pleistoceno Superior hasta la segunda mitad del siglo XX. En el presente artículo se incluyen los aspectos geomorfológicos y cronoestratigráficos de los niveles excavados, documentándose varias secuencias fluviales y aluviales de relleno de la margen derecha del fondo de valle del Abroñigal en su tramo inferior. Durante la excavación se registró un amplio conjunto lítico, formado en su mayoría por piezas recuperadas en niveles de arenas y gravas correspondientes a episodios fluviales de media energía, a las que hay que añadir un porcentaje menor localizado en niveles de limos arcillosos y arenas finas. La mayor parte del conjunto lítico responde a sistemas técnicos propios del Paleolítico Medio, aunque destaca la presencia testimonial de piezas del Paleolítico Superior, además de restos de fauna de mamíferos correspondientes al Pleistoceno Superior, todo ello en niveles datados por OSL entre 14.400 y 11.170 años BP aproximadament
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