Cyclosporin A inhibits PGE2 release from vascular smooth muscle cells

The influence of the fungoid undecapeptide cyclosporin A (CyA) on PGE2 release from cultured rat aortic smooth muscle cells was investigated in this study. We found that CyA time and concentration dependently (ED50:500 ng/ml) inhibited PGE2 release from the cells. CyA attenuated both basal and PGE2 release evoked by angiotensin II (10(-10)-10(-6) M), arginine vasopressin (10(-10)-10(-6) M) and ionomycin (10(-9)-10(-6) M). CyA (1 microgram/ml) did not affect the conversion of exogenous arachidonic acid (1 microM) into PGE2. The inhibitory effect of CyA was neutralized by high concentrations of the calcium ionophore ionomycin (greater than 3 X 10(-6) M). Taken together our results indicate that CyA inhibits both basal and vasoconstrictor evoked PGE2 release from vascular smooth muscle by impairing the availability of free arachidonic acid rather than by inhibiting the conversion of arachidonic acid into PGE2

The Mean Drift: Tailoring the Mean Field Theory of Markov Processes for Real-World Applications

The statement of the mean field approximation theorem in the mean field theory of Markov processes particularly targets the behaviour of population processes with an unbounded number of agents. However, in most real-world engineering applications one faces the problem of analysing middle-sized systems in which the number of agents is bounded. In this paper we build on previous work in this area and introduce the mean drift. We present the concept of population processes and the conditions under which the approximation theorems apply, and then show how the mean drift is derived through a systematic application of the propagation of chaos. We then use the mean drift to construct a new set of ordinary differential equations which address the analysis of population processes with an arbitrary size

A 3D study of the photosphere of HD 99563 - I. Pulsation analysis

We have used high-speed spectroscopy of the rapidly oscillating Ap (roAp) star HD 99563 to study the pulsation amplitude and phase behaviour of elements in its stratified atmosphere over one 2.91-d rotation cycle. We identify spectral features related to patches in the surface distribution of chemical elements and study the pulsation amplitudes and phases as the patches move across the stellar disc. The variations are consistent with a distorted non-radial dipole pulsation mode. We measure a 1.6 km s−1 rotational variation in the mean radial velocities of Hα and argue that this is the first observation of Hα abundance spots caused by He settling through suppression of convection by the magnetic field on an oblique rotator, in support of a prime theory for the excitation mechanism of roAp star pulsation. We demonstrate that HD 99563 is the second roAp star to show aspect dependence of blue-to-red running wave line profile variations in Nd iii spots

Validation of the frequency modulation technique applied to the pulsating Sct- Dor eclipsing binary star KIC 8569819

KIC 8569819 is an eclipsing binary star with an early F primary and G secondary in a 20.85-d eccentric orbit. The primary is a δ Sct–γ Dor star pulsating in both p modes and g modes. Using four years of Kepler Mission photometric data, we independently model the light curve using the traditional technique with the modelling code PHOEBE, and we study the orbital characteristics using the new frequency modulation technique. We show that both methods provide the equivalent orbital period, eccentricity and argument of periastron, thus illustrating and validating the FM technique. In the amplitude spectrum of the p-mode pulsations, we also discovered an FM signal compatible with a third body in the system, a low-mass M dwarf in an 861-d orbit around the primary pair. However, the eclipses show no timing variations, indicating that the FM signal is a consequence of the intrinsic change in pulsation frequency, thus providing a cautionary tale. Our analysis shows the potential of the FM technique using Kepler data, and we discuss the prospects to detect planets and brown dwarfs in Kepler data for A and F stars even in the absence of transits and with no spectroscopic radial velocity curves. This opens the possibility of finding planets orbiting hotter stars that cannot be found by traditional techniques

The first evidence for multiple pulsation axes: a new roAp star in the Kepler field, KIC 10195926

We have discovered a new rapidly oscillating Ap star among the Kepler Mission target stars, KIC 10195926. This star shows two pulsation modes with periods that are amongst the longest known for roAp stars at 17.1 min and 18.1 min, indicating that the star is near the terminal age main sequence. The principal pulsation mode is an oblique dipole mode that shows a rotationally split frequency septuplet that provides information on the geometry of the mode. The secondary mode also appears to be a dipole mode with a rotationally split triplet, but we are able to show within the improved oblique pulsator model that these two modes cannot have the same axis of pulsation. This is the first time for any pulsating star that evidence has been found for separate pulsation axes for different modes. The two modes are separated in frequency by 55 microHz, which we model as the large separation. The star is an alpha^2 CVn spotted magnetic variable that shows a complex rotational light variation with a period of Prot = 5.68459 d. For the first time for any spotted magnetic star of the upper main sequence, we find clear evidence of light variation with a period of twice the rotation period; i.e. a subharmonic frequency of $\nu_{\rm rot}/2$. We propose that this and other subharmonics are the first observed manifestation of torsional modes in an roAp star. From high resolution spectra we determine Teff = 7400 K, log g = 3.6 and v sin i = 21 km/s. We have found a magnetic pulsation model with fundamental parameters close to these values that reproduces the rotational variations of the two obliquely pulsating modes with different pulsation axes. The star shows overabundances of the rare earth elements, but these are not as extreme as most other roAp stars. The spectrum is variable with rotation, indicating surface abundance patches.Comment: 17 pages; 16 figures; MNRA

Deficits in explicit emotion regulation in bipolar disorder: A systematic review

Background: This study aimed to compile and synthesize studies investigating explicit emotion regulation in patients with bipolar disorder and individuals at risk of developing bipolar disorder. The importance of explicit emotion regulation arises from its potential role as a marker for bipolar disorders in individuals at risk and its potent role in therapy for bipolar disorder patients. Methods: To obtain an exhaustive compilation of studies dealing specifically with explicit emotion regulation in bipolar disorder, we conducted a systematic literature search in four databases. In the 15 studies we included in our review, the emotion-regulation strategies maintenance, distraction, and reappraisal (self-focused and situation-focused) were investigated partly on a purely behavioral level and partly in conjunction with neural measures. The samples used in the identified studies included individuals at increased risk of bipolar disorder, patients with current affective episodes, and patients with euthymic mood state. Results: In summary, the reviewed studies' results indicate impairments in explicit emotion regulation in individuals at risk for bipolar disorder, patients with manic and depressive episodes, and euthymic patients. These deficits manifest in subjective behavioral measures as well as in neural aberrations. Further, our review reveals a discrepancy between behavioral and neural findings regarding explicit emotion regulation in individuals at risk for bipolar disorders and euthymic patients. While these groups often do not differ significantly in behavioral measures from healthy and low-risk individuals, neural differences are mainly found in frontostriatal networks. Conclusion: We conclude that these neural aberrations are a potentially sensitive measure of the probability of occurrence and recurrence of symptoms of bipolar disorders and that strengthening this frontostriatal route is a potentially protective measure for individuals at risk and patients who have bipolar disorders

Nitric oxide synthase isoform III gene expression in rat liver is up-regulated by lipopolysaccharide and lipoteichoic acid

AbstractThis study was done to investigate the influence of Gram-negative and Gram-positive sepsis on the expression of the three isoforms of nitric oxide synthase (NOS) gene in rat liver and kidney. Male Sprague-Dawley rats were treated with lipopolysaccharide (LPS, 10 mg/kg i.v.) as an in vivo model for Gram-negative sepsis or lipoteichoic acid (LTA, 10 mg/kg i.v.) as an in vivo model for Gram-positive sepsis. Animals were killed 12 h and 24 h after i.v. treatment. NOS mRNA of the three isoforms was determined by RNase protection assay. NOSII gene expression was strongly induced after LPS or LTA treatment in rat liver and kidney, indicating the efficacy of this treatment to induce sepsis. We found no change of NOSI gene expression after LPS or LTA injection in rat liver and kidney. NOSIII gene expression was increased about 8-fold 12 h and about 5-fold 24 h after induction of sepsis in the rat liver whereas in the kidney there was no significant increase in NOSIII gene expression. After correction for length NOSIII mRNA was about 4- and 40-fold more abundant 12 h and 24 h after LPS treatment than NOSII mRNA in the liver, respectively. Twelve and 24 h after LTA treatment NOSIII mRNA was about 18- and 140-fold more abundant than NOSII in the liver. These findings suggest that NOSIII is an even more potent source of NO than NOSII in the liver after stimulation with LPS or LTA

The Emerging Scholarly Brain

It is now a commonplace observation that human society is becoming a coherent super-organism, and that the information infrastructure forms its emerging brain. Perhaps, as the underlying technologies are likely to become billions of times more powerful than those we have today, we could say that we are now building the lizard brain for the future organism.Comment: to appear in Future Professional Communication in Astronomy-II (FPCA-II) editors A. Heck and A. Accomazz

A spectroscopic analysis of the chemically peculiar star HD207561

In this paper we present a high-resolution spectroscopic analysis of the chemically peculiar star HD207561. During a survey programme to search for new roAp stars in the Northern hemisphere, Joshi et al. (2006) observed significant photometric variability on two consecutive nights in the year 2000. The amplitude spectra of the light curves obtained on these two nights showed oscillations with a frequency of 2.79 mHz [P~6-min]. However, subsequent follow-up observations could not confirm any rapid variability. In order to determine the spectroscopic nature of HD207561, high-resolution spectroscopic and spectro-polarimetric observations were carried out. A reasonable fit of the calculated Hbeta line profile to the observed one yields the effective temperature (Teff) and surface gravity (log g) as 7300 K and 3.7 dex, respectively. The derived projected rotational velocity (vsin i) for HD207561 is 74 km/sec indicative of a relatively fast rotator. The position of HD207561 in the H-R diagram implies that this is slightly evolved from the main-sequence and located well within the delta-Scuti instability strip. The abundance analysis indicates the star has slight under-abundances of Ca and Sc and mild over-abundances of iron-peak elements. The spectro-polarimetric study of HD207561 shows that the effective magnetic field is within the observational error of 100 gauss (G). The spectroscopic analysis revealed that the star has most of the characteristics similar to an Am star, rather than an Ap star, and that it lies in the delta-Scuti instability strip; hence roAp pulsations are not expected in HD207561, but low-overtone modes might be excited.Comment: 8 pages, 7 figures, 3 tables. Accepted for pubblication in MNRA