1,166 research outputs found
Clostridium difficile infection among veterans health administration patients
OBJECTIVETo report on the prevalence and incidence of Clostridium difficile infection (CDI) from 2009 to 2013 among Veterans Healthcare Administration patientsDESIGNA retrospective descriptive analysis of data extracted from a large electronic medical record (EMR) databaseSETTINGData were acquired from VHA healthcare records from 2009 to 2013 that included outpatient clinical visits, long-term care, and hospitalized care as well as pharmacy and laboratory information.RESULTSIn 2009, there were 10,207 CDI episodes, and in 2013, there were 12,143 CDI episodes, an increase of 19.0%. The overall CDI rate increased by 8.4% from 193 episodes per 100,000 patient years in 2009 to 209 episodes per 100,000 patient years in 2013. Of the CDI episodes identified in 2009, 58% were identified during a hospitalization, and 42% were identified in an outpatient setting. In 2013, 44% of the CDI episodes were identified in an outpatient setting.CONCLUSIONThis is one of the largest studies that has utilized timely EMR data to describe the current CDI epidemiology at the VHA. Despite an aging population with greater burden of comorbidity than the general US population, our data show that VHA CDI rates stabilized between 2011 and 2013 following increases likely attributable to the introduction of the more sensitive nucleic acid amplification tests (NAATs). The findings in this report will help establish an accurate benchmark against which both current and future VA CDI prevention initiatives can be measured.Infect. Control Hosp. Epidemiol. 2015;36(9):1038–1045</jats:sec
Interactive effects of low molecular weight carbon compounds on N2O emissions
Low molecular weight carbon (C) compounds in hotspots such as the rhizosphere can greatly affect nitrate reduction processes. Towards a better prediction of N2O emission from denitrification, we are still lacking understanding of responses to the supply of complex C compound mixtures such as rhizodeposits versus the often examined response to individually amended C compounds. In a laboratory study, we applied three C compounds, glucose, citric acid and glutamic acid, individually or as a three-compound mixture to 14NH415NO3 amended soil at 80% water-filled pore space. For the individual C compound treatments, the substrateswere enriched in 13C-C. The mixture was enriched in 13C-C either in all constituent compounds or in one of the compounds only, resulting in four different treatments. This set-up enabled quantification of the utilization of each compound for heterotrophic respiration when applied individually and in combination, and for this to be related to the dynamics of 15N-NO3- reduction to 15N-N2O. The total 15N-N2O emission from the compound mixture over 10 days was similar to the total emission predicted from the average of the individual compound treatments This could suggest potential predictability of denitrification responses to complex mixtures of C based on knowledge of its constituents. However, immediate and simultaneous peaks of 15N-N2O and 13C-CO2 fluxes from the compound mixture contrasted with observed delays in 15N-N2O and 13C-CO2 fluxes when the compounds had been applied individually. Moreover, relative contributions of the C compounds to 13C-CO2 respiration from the compound mixture were different from the predicted contributions based on their individual application. While contributions of glutamic acid-C and citric acid-C to respiration in mixture during peak 15N-N2O emission were increased, glucose utilization in the mixture treatment was significantly lower. These findings give a glimpse of the challenges we are facing when trying to predict nitrate reduction occurring in the rhizosphere where interactions between C compounds and the soil matrix, as well as within the wider heterotrophic community, determine process rates. Given that most of our understanding of the role of C in regulating nitrate reduction, is informed from single compound studies, we require more evidence on the effects and innate interactions of compound mixtures to be able to predict responses to C sources
Quantum Monte Carlo simulation of thin magnetic films
The stochastic series expansion quantum Monte Carlo method is used to study
thin ferromagnetic films, described by a Heisenberg model including local
anisotropies. The magnetization curve is calculated, and the results compared
to Schwinger boson and many-body Green's function calculations. A transverse
field is introduced in order to study the reorientation effect, in which the
magnetization changes from out-of-plane to in-plane. Since the approximate
theoretical approaches above differ significantly from each other, and the
Monte Carlo method is free of systematic errors, the calculation provides an
unbiased check of the approximate treatments. By studying quantum spin models
with local anisotropies, varying spin size, and a transverse field, we also
demonstrate the general applicability of the recent cluster-loop formulation of
the stochastic series expansion quantum Monte Carlo method.Comment: 9 pages, 12 figure
Optical linewidth of a passively mode-locked semiconductor laser
We measured the optical linewidths of a passively mode-locked quantum dot laser and show that, in agreement with theoretical predictions, the modal linewidth exhibits a parabolic dependence with the mode optical frequency. The minimum linewidth follows a Schawlow-Townes behavior with a rebroadening at high power. In addition, the slope of the parabola is proportional to the RF linewidth of the laser and can therefore provide a direct measurement of the timing jitter. Such a measurement could be easily applied to mode-locked semiconductor lasers with a fast repetition rate where the RF linewidth cannot be directly measured
Sigref – A Symbolic Bisimulation Tool Box
We present a uniform signature-based approach to compute the most popular bisimulations. Our approach is implemented symbolically using BDDs, which enables the handling of very large transition systems. Signatures for the bisimulations are built up from a few generic building blocks, which naturally correspond to efficient BDD operations. Thus, the definition of an appropriate signature is the key for a rapid development of algorithms for other types of bisimulation.
We provide experimental evidence of the viability of this approach by presenting computational results for many bisimulations on real-world instances. The experiments show cases where our framework can handle state spaces efficiently that are far too large to handle for any tool that requires an explicit state space description.
This work was partly supported by the German Research Council (DFG) as part of the Transregional Collaborative Research Center “Automatic Verification and Analysis of Complex Systems” (SFB/TR 14 AVACS). See www.avacs.org for more information
The XMM-Newton serendipitous ultraviolet source survey catalogue
The XMM-Newton Serendipitous Ultraviolet Source Survey (XMM-SUSS) is a
catalogue of ultraviolet (UV) sources detected serendipitously by the Optical
Monitor (XMM-OM) on-board the XMM-Newton observatory. The catalogue contains
ultraviolet-detected sources collected from 2,417 XMM-OM observations in 1-6
broad band UV and optical filters, made between 24 February 2000 and 29 March
2007. The primary contents of the catalogue are source positions, magnitudes
and fluxes in 1 to 6 passbands, and these are accompanied by profile
diagnostics and variability statistics. The XMM-SUSS is populated by 753,578 UV
source detections above a 3 sigma signal-to-noise threshold limit which relate
to 624,049 unique objects. Taking account of substantial overlaps between
observations, the net sky area covered is 29-54 square degrees, depending on UV
filter. The magnitude distributions peak at 20.2, 20.9 and 21.2 in UVW2, UVM2
and UVW1 respectively. More than 10 per cent of sources have been visited more
than once using the same filter during XMM-Newton operation, and > 20 per cent
of sources are observed more than once per filter during an individual visit.
Consequently, the scope for science based on temporal source variability on
timescales of hours to years is broad. By comparison with other astrophysical
catalogues we test the accuracy of the source measurements and define the
nature of the serendipitous UV XMM-OM source sample. The distributions of
source colours in the UV and optical filters are shown together with the
expected loci of stars and galaxies, and indicate that sources which are
detected in multiple UV bands are predominantly star-forming galaxies and stars
of type G or earlier.Comment: Accepted for publication in MNRA
A Luminous Be+White Dwarf Supersoft Source in the Wing of the SMC: MAXI J0158-744
We present a multi-wavelength analysis of the very fast X-ray transient MAXI
J0158-744, which was detected by MAXI/GSC on 2011 November 11. The subsequent
exponential decline of the X-ray flux was followed with Swift observations, all
of which revealed spectra with low temperatures (~100eV) indicating that MAXI
J0158-744 is a new Supersoft Source (SSS). The Swift X-ray spectra near maximum
show features around 0.8 keV that we interpret as possible absorption from
OVIII, and emission from O, Fe, and Ne lines. We obtained SAAO and ESO optical
spectra of the counterpart early in the outburst and several weeks later. The
early spectrum is dominated by strong Balmer and HeI emission, together with
weaker HeII emission. The later spectrum reveals absorption features that
indicate a B1/2IIIe spectral type, and all spectral features are at velocities
consistent with the Small Magellanic Cloud. At this distance, it is a luminous
SSS (>10^37 erg/s) but whose brief peak luminosity of >10^39 erg/s in the 2-4
keV band makes it the brightest SSS yet seen at "hard" X-rays. We propose that
MAXI J0158-744 is a Be-WD binary, and the first example to possibly enter ULX
territory. The brief hard X-ray flash could possibly be a result of the
interaction of the ejected nova shell with the B star wind in which the white
dwarf (WD) is embedded. This makes MAXI J0158-744 only the third Be/WD system
in the Magellanic Clouds, but it is by far the most luminous. The properties of
MAXI J0158-744 give weight to previous suggestions that SSS in nearby galaxies
are associated with early-type stellar systems.Comment: 15 pages, 8 figures; ApJ accepte
Cellular and humoral immune responses and protection against schistosomes induced by a radiation-attenuated vaccine in chimpanzees
The radiation-attenuated Schistosoma mansoni vaccine is highly effective in rodents and primates but has never been tested in humans, primarily for safety reasons. To strengthen its status as a paradigm for a human recombinant antigen vaccine, we have undertaken a small-scale vaccination and challenge experiment in chimpanzees (Pan troglodytes). Immunological, clinical, and parasitological parameters were measured in three animals after multiple vaccinations, together with three controls, during the acute and chronic stages of challenge infection up to chemotherapeutic cure. Vaccination induced a strong in vitro proliferative response and early gamma interferon production, but type 2 cytokines were dominant by the time of challenge. The controls showed little response to challenge infection before the acute stage of the disease, initiated by egg deposition. In contrast, the responses of vaccinated animals were muted throughout the challenge period. Vaccination also induced parasite-specific immunoglobulin M (IgM) and IgG, which reached high levels at the time of challenge, while in control animals levels did not rise markedly before egg deposition. The protective effects of vaccination were manifested as an amelioration of acute disease and overall morbidity, revealed by differences in gamma-glutamyl transferase level, leukocytosis, eosinophilia, and hematocrit. Moreover, vaccinated chimpanzees had a 46% lower level of circulating cathodic antigen and a 38% reduction in fecal egg output, compared to controls, during the chronic phase of infection
Metal transport by gas sloshing in M87
We present the results of an XMM-Newton mosaic covering the central ~200 kpc
of the nearby Virgo cluster. We focus on a strong surface brightness
discontinuity in the outskirts of the brightest cluster galaxy, M87. Using both
XMM-Newton and Suzaku, we derive accurate temperature and metallicity profiles
across this feature and show that it is a cold front probably due to sloshing
of the Virgo ICM. It is also associated with a discontinuity in the chemical
composition. The gas in the inner, bright region of the front is ~40% more
abundant in Fe than the gas outside the front, suggesting the important role of
sloshing in transporting metals through the ICM. For the first time, we provide
a quantitative estimate of the mass of Fe transported by a cold front. This
amounts to ~6% of the total Fe mass within the radial range affected by
sloshing, significantly more than the amount of metals transported by the AGN
in the same cluster core. The very low Fe abundance of only ~0.2 solar
immediately outside the cold front at a radius of 90 kpc suggests we are
witnessing first-hand the transport of higher metallicity gas into a pristine
region, whose abundance is typical of the cluster outskirts. The Mg/Fe and O/Fe
abundance ratios remain approximately constant over the entire radial range
between the centre of M87 and the faint side of the cold front, which requires
the presence of a centrally peaked distribution not only for Fe but also for
core-collapse type supernova products. This peak may stem from the star
formation triggered as the BCG assembled during the protocluster phase.Comment: accepted for publication in MNRA
Water Dynamics at Protein Interfaces: Ultrafast Optical Kerr Effect Study
The behavior of water molecules surrounding a protein can have an important bearing on its structure and function. Consequently, a great deal of attention has been focused on changes in the relaxation dynamics of water when it is located at the protein surface. Here we use the ultrafast optical Kerr effect to study the H-bond structure and dynamics of aqueous solutions of proteins. Measurements are made for three proteins as a function of concentration. We find that the water dynamics in the first solvation layer of the proteins are slowed by up to a factor of 8 in comparison to those in bulk water. The most marked slowdown was observed for the most hydrophilic protein studied, bovine serum albumin, whereas the most hydrophobic protein, trypsin, had a slightly smaller effect. The terahertz Raman spectra of these protein solutions resemble those of pure water up to 5 wt % of protein, above which a new feature appears at 80 cm–1, which is assigned to a bending of the protein amide chain
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