Renewing Community in College Park

The Calvert School served the city of College Park for more than 50 years. Now vacant, the building still sits at the heart of the historic College Park community. Adaptively reusing this well-loved building as a community center will bring new life to the building and site and provide a much-needed center for community activities in College Park. Reusing an existing building will also help to conserve economic and environmental resources, as well as preserving a visual artifact of the history and sense of community that bind the neighborhood. This thesis explores and proposes a variety of approaches to adaptive reuse and building for community, attempting to find a design strategy that suits the building, the site, the community and the proposed program, while balancing aesthetics and functionality with cultural, historical and environmental responsibility

LEED-NC version 2.2 rating system applications of common structural materials

Maher, J.E., Kramer, K.W.. LEED-NC version 2.2 rating system applications of common structural materials. 2007. Sustainable Construction Materials and Technologies, Taylor and Francis Group.Comprehensive understanding of building materials has been the basis of structural engineering. The rising environmental concern is making sustainability a crucial issue in our society. In creating a sustainable built environment, the architect usually takes the lead role with the mechanical engineer having the key responsibility for energy and water savings. Only recently have structural engineers and civil engineers begun to see the real potential of their contributions. This paper contains information pertaining to the four most common structural materials: reinforced concrete, reinforced masonry, steel, and timber. For each material, the sustainability of the material as defined by the LEED-NC Version 2.2 rating system is discussed. Information is provided on how to attain LEED points for a specific material. Whether the LEED-NC Version 2.2 rating system accurately portrays sustainability of common structural materials or needs further development is discussed in the conclusion. A comparison is provided of the four common structural materials in relation to the rating system

Slip modulus of cold-formed steel members sheathed with wood structural panels

Maher, J. E., & Kramer, K. W. (2007). LEED-NC version 2.2 rating system applications of common structural materials. Paper presented at the Sustainable Construction Materials and Technologies - International Conference on Sustainable Construction Materials and Technologies, 549-562.Cold-formed steel framing sheathed with wood structural panels is a common method of construction for wall, roof and floor systems in cold-formed steel structures. Since wood structural panels are attached with screws at relatively close spacing, a certain amount of composite behavior will be present. The benefit of composite behavior is not currently being taken advantage of in the design of these structural systems. While composite effects are present, they are not yet being accounted for in design due to a lack of statistical data. To determine the amount of composite action taking place in these systems, the slip modulus between steel and wood is required. The slip modulus reflects the amount of shear force able to be transferred through the screw connection, to either member of the composite system. This paper presents the results of a study conducted to determine values of the slip modulus for varying thicknesses of cold-formed steel and plywood sheathing. Shear tests were conducted and the slip moduli were determined based on ISO 6891 and ASTM D1761. Compared with data from a previous preliminary study performed by others, the slip modulus values determined from these tests were deemed reasonable. The determination of the slip modulus will lead to the ability to calculate a composite factor. Determination of a composite factor will allow cold-formed steel wood structural panel construction to become more economical due to the available increase in bending strength

Technology-Dependent Pedagogical Process Redesign: Leveraging Lean Methods

Purpose This research compared the efficacy of process outcomes leveraging lean methods versus traditional pedagogy applied to dental education dependent on emerging technology. The pedagogical objective was to improve system efficiency without compromising traditional outcomes of effectiveness (quality). Design/methodology/approach The research team tested the efficacy of a lean A3 framework to identify, remove waste and redesign a technology-dependent simulation laboratory course (CAD/CAM/IR Restorative Dentistry). Students were also sensitized to time-in-chair to introduce a stronger patient focus. Baseline data collected from a control group were statistically compared to the research group\u27s data after the course redesign. In addition, course time allocations were measured and then compared. Findings The results showed the interventions significantly reduced procedure cycle times without compromising quality. Additionally, the course was more efficiently conducted as measured by course time allocations. Practical implications This research demonstrated that the use of the A3 framework enhanced learning through process documentation, reengineering and systems optimization resolving issues of inefficiency associated with the CAD/CAM/IR pedagogy. This work is significant because it demonstrates the practice of using lean interventions to redesign and improve a technology-based healthcare course to maximize benefits. Originality/value This research is the first to examine how to leverage lean methods in a healthcare simulation laboratory, dependent on innovative technology, to educate and train future practitioners. This research applied statistical rigor in a controlled experiment to maximize its applicability and generalizability

David Doellinger Interview 2022

In this interview, David Doellinger describes the WOU Fallout Shelter (which was dismantled in 2022) and discusses the importance of the history of the Cold War. A physical exhibit detailing the history of WOU\u27s Fallout Shelter was created by History 404l students during Fall 2022 and captured in a PowerPoint presentation. The presentation is also included on this page

Candida albicans Induces Arginine Biosynthetic Genes in Response to Host-Derived Reactive Oxygen Species

The interaction of Candida albicans with phagocytes of the host\u27s innate immune system is highly dynamic, and its outcome directly impacts the progression of infection. While the switch to hyphal growth within the macrophage is the most obvious physiological response, much of the genetic response reflects nutrient starvation: translational repression and induction of alternative carbon metabolism. Changes in amino acid metabolism are not seen, with the striking exception of arginine biosynthesis, which is upregulated in its entirety during coculture with macrophages. Using single-cell reporters, we showed here that arginine biosynthetic genes are induced specifically in phagocytosed cells. This induction is lower in magnitude than during arginine starvation in vitro and is driven not by an arginine deficiency within the phagocyte but instead by exposure to reactive oxygen species (ROS). Curiously, these genes are induced in a narrow window of sublethal ROS concentrations. C. albicans cells phagocytosed by primary macrophages deficient in the gp91phox subunit of the phagocyte oxidase do not express the ARG pathway, indicating that the induction is dependent on the phagocyte oxidative burst. C. albicans arg pathway mutants are retarded in germ tube and hypha formation within macrophages but are not notably more sensitive to ROS. We also find that the ARG pathway is regulated not by the general amino acid control response but by transcriptional regulators similar to the Saccharomyces cerevisiae ArgR complex. In summary, phagocytosis induces this single amino acid biosynthetic pathway in an ROS-dependent manner

Process, outcome and experience of transition from child to adult mental healthcare : multiperspective study

Background Many adolescents with mental health problems experience transition of care from child and adolescent mental health services (CAMHS) to adult mental health services (AMHS). Aims As part of the TRACK study we evaluated the process, outcomes and user and carer experience of transition from CAMHS to AMHS. Method We identified a cohort of service users crossing the CAMHS/AMHS boundary over 1 year across six mental health trusts in England. We tracked their journey to determine predictors of optimal transition and conducted qualitative interviews with a subsample of users, their carers and clinicians on how transition was experienced. Results Of 154 individuals who crossed the transition boundary in 1 year, 90 were actual referrals (i.e. they made a transition to AMHS), and 64 were potential referrals (i.e. were either not referred to AMHS or not accepted by AMHS). Individuals with a history of severe mental illness, being on medication or having been admitted were more likely to make a transition than those with neurodevelopmental disorders, emotional/neurotic disorders and emerging personality disorder. Optimal transition, defined as adequate transition planning, good information transfer across teams, joint working between teams and continuity of care following transition, was experienced by less than 5% of those who made a transition. Following transition, most service users stayed engaged with AMHS and reported improvement in their mental health. Conclusions For the vast majority of service users, transition from CAMHS to AMHS is poorly planned, poorly executed and poorly experienced. The transition process accentuates pre-existing barriers between CAMHS and AMH

Effects of receptor clustering on ligand dissociation: Theory and simulations

Receptor-ligand binding is a critical first step in signal transduction and the duration of the interaction can impact signal generation. In mammalian cells, clustering of receptors may be facilitated by heterogeneous zones of lipids, known as lipid rafts. In vitro experiments show that disruption of rafts significantly alters the dissociation of fibroblast growth factor-2 (FGF-2) from heparan sulfate proteoglycans, co-receptors for FGF-2. In this paper, we develop a continuum stochastic formalism in order to (i) study how rebinding affects the dissociation of ligands from a planar substrate, and (ii) address the question of how receptor clustering influences ligand rebinding. We find that clusters reduce the effective dissociation rate dramatically when the clusters are dense and the overall surface density of receptors is low. The effect is much less pronounced in the case of high receptor density and shows non-monotonic behavior with time. These predictions are verified via lattice Monte Carlo simulations. Comparison with experimental results suggests that the theory does not capture the complete biological system. We speculate that additional co-operative mechanisms might be present in order to increase ligand retention, and present one possible ``internal diffusion'' model.Comment: Expanded text and added figures, revised version to appear in Biophys.

The sources of management innovation: when firms introduce new management practices

Management innovation is the introduction of management practices new to the firm and intended to enhance firm performance. Building on the organizational reference group literature, this article shows that management innovation is a consequence of a firm's internal context and of the external search for new knowledge. Furthermore the article demonstrates a trade-off between context and search, in that there is a negative effect on management innovation associated with their joint occurrence. Finally the article shows that management innovation is positively associated with firm performance in the form of subsequent productivity growth

Increased Orbitofrontal Brain Activation after Administration of a Selective Adenosine A2A Antagonist in Cocaine Dependent Subjects

Background: Positron Emission Tomography imaging studies provide evidence of reduced dopamine function in cocaine dependent subjects in the striatum, which is correlated with prefrontal cortical glucose metabolism, particularly in the orbitofrontal cortex. However, whether enhancement of dopamine in the striatum in cocaine dependent subjects would be associated with changes in prefrontal cortical brain activation is unknown. One novel class of medications that enhance dopamine function via heteromer formation with dopamine receptors in the striatum is the selective adenosine A2A receptor antagonists. This study sought to determine the effects administration of the selective adenosine A2A receptor antagonist SYN115 on brain function in cocaine dependent subjects. Methodology/Principle Findings: Twelve cocaine dependent subjects underwent two fMRI scans (one after a dose of placebo and one after a dose of 100 mg of SYN115) while performing a working memory task with three levels of difficulty (3, 5, and 7 digits). fMRI results showed that for 7-digit working memory activation there was significantly greater activation from SYN115 compared to placebo in portions of left (L) lateral orbitofrontal cortex, L insula, and L superior and middle temporal pole. Conclusion/Significance: These findings are consistent with enhanced dopamine function in the striatum in cocaine dependent subjects via blockade of adenosine A2A receptors producing increased brain activation in the orbitofrontal cortex and other cortical regions. This suggests that at least some of the changes in brain activation in prefrontal cortical regions in cocaine dependent subjects may be related to altered striatal dopamine function, and that enhancement of dopamine function via adenosine A2A receptor blockade could be explored further for amelioration of neurobehavioral deficits associated with chronic cocaine use