742 research outputs found

    Selection method of the project management methodology and its application

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    The task of selecting the methodology for managing a specific project is analyzed. The method, consisting of 2 stages, is suggested. At the first stage a project manager has to fill out a questionnaire. Based on the obtained results, a corresponding project management methodology is suggested. The second stage is devoted to evaluation of the work content of managing the project with the methodologies under study, the cost and risks of their application. Solution for the three-criterial optimization problem of selecting a methodology is suggested. An example of application of the method for selecting the methodology is provided for managing an IT project

    Interaction synergetics mining with rock massif

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    Purpose. To find out the physical essence of the phenomenon of zonal disintegration of rocks around underground workings. Methods. The main types of research adopted a synergistic methodological search and analysis of open thermodynamic systems in a unbalanced condition. Findings. The physical essence of the phenomenon of zonal disintegration of rocks around underground workings as a phenomenon of zonal encapsulation by an array of underground workings is detected. The processes of formation of energy fields during the formation of protective capsules around underground workings are described. The principal approaches to the management of natural factors and the procedure for their use in underground mining technologies are proposed. Originality. Underground digging call forth sine wave oscillations in energy gradients, forming a safety relief, which consists of a system of ring energy zones, the number of which increases with increasing depth and decreasing rock strength. Practical implications. The deployment of the physical essence of zonal ensheath by an array of underground diggings made it possible to create prerequisites for describing the processes and using the laws that form this phenomenal phenomenon

    Stress-strain state of the mine massif around the chambers of the second stage of mining

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    A stress-strain state of the rock mass around the chambers of the second stage of mining was analyzed with the help of thermodynamic method. This study is the question of the day as the ore reserves in the chambers of the second stage of mining are, as a rule, extracted being surrounded by the filling mass, and due to this the highest rates of the ore losses and contamination with the filling mass are observed. In connection with this, the study of the stress-strained state of the filling mass and establishment of a method for improving the massif stability presents a great interest today. A calculation scheme for modeling thermodynamic processes in the rock mass around the chambers was developed with the purpose to study the stress field and determine principles of radial stress changing in the filling mass of the surrounding chamber. A chamber in the layer at the depth of 740-840 m was simulated with the following average geotechnical conditions: depth of the extraction chamber, angle of the deposit depression, horizontal thickness of deposit, rock strength in the hanging layer against uniaxial compression, rock strength in the bottom layer against uniaxial compression, and stowing strength against uniaxial compression. The study determined areas with tensile stress in the rocks of the bottom layer, ore mass and filling mass, and their parameters (size, maximum tension) and formulated empirical equations for the dependences between radial tensions and distance to the chambers L of the second stage of mining. The areas of destructive deformation and their dimensions in the stowing mass around the chambers of the second stage of mining at the level 740-840 m were established. Maximum values are defined for the stresses acting in the stowing mass which, exceeding the ultimate strength, cause the mass failure into the space of the chamber of the second stage. In order to prevent the stowing mass failure it is recommended to make a consolidating layer of the solid stowing at the 2/3 height of the chamber in order to resist the high tensile stresses and to ensure the mass stability

    Complex application of certain micronatrients in men with androgen deficiency and pathosprimes

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    A complex approach was made for the deactivation of deuterine micronutrients, which include antioxidant and metabolic metabolism, in individuals with androgen deficiency and idiopathic pathospermia. It has been shown that is using the complex preparation Β«FEROLLΒ» for 60 days leads to increase the parameters of the spermogram to normal values on the background of normal androgen levels of blood in these patients

    TO THE QUESTION OF THE VOLTAGE STABILITY ENSURING FOR COMPLEX MONITORING SYSTEMS OF METAL’S STATUS

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    The paper considers one of the tasks that need to be solved when developing complex monitoring systems of metal’s status, which is to ensure the stability of the supply voltage, and the results of compensatory voltage stabilizer development are given. The analysis results of the adopted circuit solutions correctness are shown and the conformity of the stabilized power supply parameters to the given conditions is proved.The paper considers one of the tasks that need to be solved when developing complex monitoring systems of metal’s status, which is to ensure the stability of the supply voltage, and the results of compensatory voltage stabilizer development are given. The analysis results of the adopted circuit solutions correctness are shown and the conformity of the stabilized power supply parameters to the given conditions is proved

    Comparative analysis of standarts in the field of project management

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    УспСшноС Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡ€ΠΎΠ΅ΠΊΡ‚Π½ΠΎ-ΠΎΡ€ΠΈΠ΅Π½Ρ‚ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹Ρ… ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ ΠΏΡ€Π΅Π΄ΠΏΠΎΠ»Π°Π³Π°Π΅Ρ‚ Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΠΎΡΡ‚ΡŒ использования ΠΌΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½Ρ‹Ρ… ΠΈ Π½Π°Ρ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… стандартов с Ρ†Π΅Π»ΡŒΡŽ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΠΈ управлСния ΠΏΡ€ΠΎΠ΅ΠΊΡ‚Π°ΠΌΠΈSuccessful functioning of the project-oriented companies requires the use of the international standards in order to develop a methodology for project managemen

    Comparative analysis of standarts in the field of project management

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    УспСшноС Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡ€ΠΎΠ΅ΠΊΡ‚Π½ΠΎ-ΠΎΡ€ΠΈΠ΅Π½Ρ‚ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹Ρ… ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ ΠΏΡ€Π΅Π΄ΠΏΠΎΠ»Π°Π³Π°Π΅Ρ‚ Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΠΎΡΡ‚ΡŒ использования ΠΌΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½Ρ‹Ρ… ΠΈ Π½Π°Ρ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… стандартов с Ρ†Π΅Π»ΡŒΡŽ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΠΈ управлСния ΠΏΡ€ΠΎΠ΅ΠΊΡ‚Π°ΠΌΠΈSuccessful functioning of the project-oriented companies requires the use of the international standards in order to develop a methodology for project managemen

    ДослідТСння Π³Ρ–ΠΏΠΎΠ»Ρ–ΠΏΡ–Π΄Π΅ΠΌΡ–Ρ‡Π½ΠΈΡ… властивостСй Сстракту Ρ–ΠΌΠ±ΠΈΡ€Ρƒ Π½Π° ΠΌΠΎΠ΄Π΅Π»Ρ– Ρ†ΡƒΠΊΡ€ΠΎΠ²ΠΎΠ³ΠΎ Π΄Ρ–Π°Π±Π΅Ρ‚Ρƒ 2 Ρ‚ΠΈΠΏΡƒ, Ρ–Π½Π΄ΡƒΠΊΠΎΠ²Π°Π½ΠΎΠ³ΠΎ дСксамСтазоном

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    Aim. To study experimentally the hypolipidemic properties of Ginger extract against the background of type 2 diabetes.Materials and methods. The study of the hypolipidemic properties of Ginger extract was performed by the lipid metabolism indices on the model of type 2 diabetes induced by dexamethasone in rats aged 18 months.Results and discussion. Experimental type 2 diabetes was accompanied with disorder of the lipid metabolism, it was confirmed by the increase of the content triacylglycerides, atherogenic apoB-lipoproteins with simultaneous reduction of high-density lipoproteins and increased release of free fatty acids from the adipose tissue. Under the effect of Ginger extract in the doses of 50 and 80 mg/kg the level of free fatty acids in the blood serum decreased by 38.4 % and 38.9 %, probably due to correction of insulin resistance manifestations and preservation of the insulin control effect on lipolysis. The reliable inhibition of hypertriacylglycerolemia severity by Ginger extract in the dose of 80 mg/kg by 35.1% correlated with a decrease of apoB-LP production in the liver, and it indicated correction of diabetic dyslipidemia. At the same time, the level of the antiatherogenic fraction – high-density lipoproteins – significantly increased by 26.1 and 29.5 % under the effect of the extract in the doses of 50 and 80 mg/kg, respectively, compared to the values of animals of the control pathology. Ginger extract in the dose of 80 mg/kg showed a more expressive ability to normalize the lipid metabolism at the level of the reference drug – β€œArphasetin” herbal medicinal product.Conclusions. Introduction of Ginger extract for 14 days in the doses of 50 and 80 mg/kg on the model of typeΒ 2 diabetes induced by dexamethasone was accompanied with a reliable normalization of the lipid metabolism. The use of Ginger extract in the dose of 80 mg/kg is most pronounced at the level of the reference drug – β€œArphasetin” herbal medicinal product, corrected the pathological changes in the lipid metabolism characteristic for type 2 diabetes. It allows making a conclusion concerning the feasibility of further studies of the extract exactly in this dose and the prospects of its use as an antiatherogenic drug in the complex treatment of type 2 diabetes.ЦСль – ΡΠΊΡΠΏΠ΅Ρ€ΠΈΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½ΠΎΠ΅ исслСдованиС гиполипидСмичСских свойств экстракта имбиря Π½Π° Ρ„ΠΎΠ½Π΅ Π‘Π” 2 Ρ‚ΠΈΠΏΠ°.ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹ ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. ИсслСдованиС гиполипидСмичСских свойств экстракта имбиря ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΏΠΎ показатСлям Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° Π½Π° ΠΌΠΎΠ΄Π΅Π»ΠΈ Π‘Π” 2 Ρ‚ΠΈΠΏΠ°, ΠΈΠ½Π΄ΡƒΡ†ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ дСксамСтазоном Ρƒ крыс 18-мСсячного возраста.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ ΠΈ ΠΈΡ… обсуТдСниС. Π­ΠΊΡΠΏΠ΅Ρ€ΠΈΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½Ρ‹ΠΉ Π‘Π” 2 Ρ‚ΠΈΠΏΠ° сопровоТдался Π½Π°Ρ€ΡƒΡˆΠ΅Π½ΠΈΠ΅ΠΌ Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π°, Ρ‡Ρ‚ΠΎ ΠΏΠΎΠ΄Ρ‚Π²Π΅Ρ€ΠΆΠ΄Π°Π»ΠΎΡΡŒ ростом Ρ‚Ρ€ΠΈΠ°Ρ†ΠΈΠ»Π³Π»ΠΈΡ†Π΅Ρ€ΠΈΠ΄ΠΎΠ², содСрТания Π°Ρ‚Π΅Ρ€ΠΎΠ³Π΅Π½Π½Ρ‹Ρ… Π°ΠΏΠΎΠ’-Π»ΠΈΠΏΠΎΠΏΡ€ΠΎΡ‚Π΅ΠΈΠ½ΠΎΠ² ΠΏΡ€ΠΈ ΠΎΠ΄Π½ΠΎΠ²Ρ€Π΅ΠΌΠ΅Π½Π½ΠΎΠΌ сниТСнии Π»ΠΈΠΏΠΎΠΏΡ€ΠΎΡ‚Π΅ΠΈΠ½ΠΎΠ² высокой плотности ΠΈ усилСнии высвобоТдСния свободных ΠΆΠΈΡ€Π½Ρ‹Ρ… кислот ΠΈΠ· ΠΆΠΈΡ€ΠΎΠ²ΠΎΠΉ Ρ‚ΠΊΠ°Π½ΠΈ. Под влияниСм экстракта имбиря Π² Π΄ΠΎΠ·Π°Ρ… 50 ΠΈ 80 ΠΌΠ³/ΠΊΠ³ сниТался ΡƒΡ€ΠΎΠ²Π΅Π½ΡŒ свободных ΠΆΠΈΡ€Π½Ρ‹Ρ… кислот Π² сывороткС ΠΊΡ€ΠΎΠ²ΠΈ Π½Π° 38,4 % ΠΈ 38,9 %, вСроятно, вслСдствиС ΠΊΠΎΡ€Ρ€Π΅ΠΊΡ†ΠΈΠΈ проявлСний инсулинорСзистСнтности ΠΈ сохранСния ΡƒΠΏΡ€Π°Π²Π»ΡΡŽΡ‰Π΅Π³ΠΎ воздСйствия инсулина Π½Π° Π»ΠΈΠΏΠΎΠ»ΠΈΠ·. ДостовСрноС ΠΏΠΎΠ΄Π°Π²Π»Π΅Π½ΠΈΠ΅ выраТСнности Π³ΠΈΠΏΠ΅Ρ€Ρ‚Ρ€ΠΈΠ°Ρ†ΠΈΠ»Π³Π»ΠΈΡ†Π΅Ρ€ΠΎΠ»Π΅ΠΌΠΈΠΈ экстрактом имбиря Π² Π΄ΠΎΠ·Π΅ 80 ΠΌΠ³/ΠΊΠ³ Π½Π° 35,1 % ΠΊΠΎΡ€Ρ€Π΅Π»ΠΈΡ€ΠΎΠ²Π°Π»ΠΎ с ΡƒΠΌΠ΅Π½ΡŒΡˆΠ΅Π½ΠΈΠ΅ΠΌ ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ†ΠΈΠΈ Π°ΠΏΠΎΠ’-Π›ΠŸ Π² ΠΏΠ΅Ρ‡Π΅Π½ΠΈ, Ρ‡Ρ‚ΠΎ ΡΠ²ΠΈΠ΄Π΅Ρ‚Π΅Π»ΡŒΡΡ‚Π²ΠΎΠ²Π°Π»ΠΎ ΠΎ ΠΊΠΎΡ€Ρ€Π΅ΠΊΡ†ΠΈΠΈ диабСтичСской дислипидСмии. ΠŸΡ€ΠΈ этом ΡƒΡ€ΠΎΠ²Π΅Π½ΡŒ Π°Π½Ρ‚ΠΈΠ°Ρ‚Π΅Ρ€ΠΎΠ³Π΅Π½Π½ΠΎΠΉ Ρ„Ρ€Π°ΠΊΡ†ΠΈΠΈ – Π»ΠΈΠΏΠΎΠΏΡ€ΠΎΡ‚Π΅ΠΈΠ½ΠΎΠ² высокой плотности достовСрно ΠΏΠΎΠ²Ρ‹ΡˆΠ°Π»ΡΡ Π½Π° 26,1 ΠΈ 29,5 % ΠΏΠΎΠ΄ влияниСм экстракта Π² Π΄ΠΎΠ·Π°Ρ… 50 ΠΈ 80 ΠΌΠ³/ΠΊΠ³ соотвСтствСнно ΠΏΠΎ ΡΡ€Π°Π²Π½Π΅Π½ΠΈΡŽ с показатСлями ΠΆΠΈΠ²ΠΎΡ‚Π½Ρ‹Ρ… ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΡŒΠ½ΠΎΠΉ ΠΏΠ°Ρ‚ΠΎΠ»ΠΎΠ³ΠΈΠΈ. Экстракт имбиря Π² Π΄ΠΎΠ·Π΅ 80 ΠΌΠ³/ΠΊΠ³ проявил Π±ΠΎΠ»Π΅Π΅ Π²Ρ‹Ρ€Π°Π·ΠΈΡ‚Π΅Π»ΡŒΠ½ΡƒΡŽ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡ‚ΡŒ Π½ΠΎΡ€ΠΌΠ°Π»ΠΈΠ·ΠΎΠ²Π°Ρ‚ΡŒ ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΠΈ Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° Π½Π° ΡƒΡ€ΠΎΠ²Π½Π΅ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Π° сравнСния сбора «АрфазСтин».Π’Ρ‹Π²ΠΎΠ΄Ρ‹. Π’Π²Π΅Π΄Π΅Π½ΠΈΠ΅ экстракта имбиря Π² Ρ‚Π΅Ρ‡Π΅Π½ΠΈΠ΅ 14-Ρ‚ΠΈ суток Π² Π΄ΠΎΠ·Π°Ρ… 50 ΠΈ 80 ΠΌΠ³/ΠΊΠ³ Π½Π° ΠΌΠΎΠ΄Π΅Π»ΠΈ Π‘Π” 2 Ρ‚ΠΈΠΏΠ°, ΠΈΠ½Π΄ΡƒΡ†ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ дСксамСтазоном, ΡΠΎΠΏΡ€ΠΎΠ²ΠΎΠΆΠ΄Π°Π»ΠΎΡΡŒ достовСрной Π½ΠΎΡ€ΠΌΠ°Π»ΠΈΠ·Π°Ρ†ΠΈΠ΅ΠΉ Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π°. ΠŸΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ экстракта имбиря Π² Π΄ΠΎΠ·Π΅ 80 ΠΌΠ³/ΠΊΠ³, Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π²Ρ‹Ρ€Π°ΠΆΠ΅Π½Π½ΠΎΠ΅ Π½Π° ΡƒΡ€ΠΎΠ²Π½Π΅ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Π° сравнСния сбора «АрфазСтин», ΠΊΠΎΡ€Ρ€Π΅ΠΊΡ‚ΠΈΡ€ΠΎΠ²Π°Π»ΠΎ патологичСскиС измСнСния ΠΌΠ΅Ρ‚Π°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ° Π»ΠΈΠΏΠΈΠ΄ΠΎΠ², Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€Π½Ρ‹Π΅ для Π‘Π” 2 Ρ‚ΠΈΠΏΠ°, Ρ‡Ρ‚ΠΎ позволяСт ΡΠ΄Π΅Π»Π°Ρ‚ΡŒ Π²Ρ‹Π²ΠΎΠ΄ ΠΎ цСлСсообразности Π΄Π°Π»ΡŒΠ½Π΅ΠΉΡˆΠΈΡ… исслСдований экстракта ΠΈΠΌΠ΅Π½Π½ΠΎ Π² этой Π΄ΠΎΠ·Π΅ ΠΈ пСрспСктивности Π΅Π³ΠΎ примСнСния Π² качСствС Π°Π½Ρ‚ΠΈΠ°Ρ‚Π΅Ρ€ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ срСдства Π² комплСксном Π»Π΅Ρ‡Π΅Π½ΠΈΠΈ Π‘Π” 2 Ρ‚ΠΈΠΏΠ°.ΠœΠ΅Ρ‚Π° – Π΅ΠΊΡΠΏΠ΅Ρ€ΠΈΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½Π΅ дослідТСння Π³Ρ–ΠΏΠΎΠ»Ρ–ΠΏΡ–Π΄Π΅ΠΌΡ–Ρ‡Π½ΠΈΡ… властивостСй Скстракту Ρ–ΠΌΠ±ΠΈΡ€Ρƒ Π½Π° Ρ‚Π»Ρ– Π¦Π” 2 Ρ‚ΠΈΠΏΡƒ.ΠœΠ°Ρ‚Π΅Ρ€Ρ–Π°Π»ΠΈ Ρ‚Π° ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΈ. ДослідТСння Π³Ρ–ΠΏΠΎΠ»Ρ–ΠΏΡ–Π΄Π΅ΠΌΡ–Ρ‡Π½ΠΈΡ… властивостСй Скстракту Ρ–ΠΌΠ±ΠΈΡ€Ρƒ ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π·Π° ΠΏΠΎΠΊΠ°Π·Π½ΠΈΠΊΠ°ΠΌΠΈ Π»Ρ–ΠΏΡ–Π΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΡ–Π½Ρƒ Π½Π° ΠΌΠΎΠ΄Π΅Π»Ρ– Π¦Π” 2 Ρ‚ΠΈΠΏΡƒ, Ρ–Π½Π΄ΡƒΠΊΠΎΠ²Π°Π½ΠΎΠ³ΠΎ дСксамСтазоном Ρƒ Ρ‰ΡƒΡ€Ρ–Π² 18-місячного Π²Ρ–ΠΊΡƒ.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΈ Ρ‚Π° Ρ—Ρ… обговорСння. Π•ΠΊΡΠΏΠ΅Ρ€ΠΈΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½ΠΈΠΉ Π¦Π” 2 Ρ‚ΠΈΠΏΡƒ супроводТувався ΠΏΠΎΡ€ΡƒΡˆΠ΅Π½Π½ΡΠΌ Π»Ρ–ΠΏΡ–Π΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΡ–Π½Ρƒ, Ρ‰ΠΎ ΠΏΡ–Π΄Ρ‚Π²Π΅Ρ€Π΄ΠΆΡƒΠ²Π°Π»ΠΎΡΡŒ зростанням Ρ‚Ρ€ΠΈΠ°Ρ†ΠΈΠ»Π³Π»Ρ–Ρ†Π΅Ρ€ΠΈΠ΄Ρ–Π², вмісту Π°Ρ‚Π΅Ρ€ΠΎΠ³Π΅Π½Π½ΠΈΡ… Π°ΠΏΠΎΠ’-Π»Ρ–ΠΏΠΎΠΏΡ€ΠΎΡ‚Π΅Ρ—Π½Ρ–Π² Π·Π° ΡƒΠΌΠΎΠ²ΠΈ одночасного зниТСння Π»Ρ–ΠΏΠΎΠΏΡ€ΠΎΡ‚Π΅Ρ—Π½Ρ–Π² високої Ρ‰Ρ–Π»ΡŒΠ½ΠΎΡΡ‚Ρ– Ρ‚Π° посилСнням Π²ΠΈΠ²Ρ–Π»ΡŒΠ½Π΅Π½Π½Ρ Π²Ρ–Π»ΡŒΠ½ΠΈΡ… ΠΆΠΈΡ€Π½ΠΈΡ… кислот Π· ΠΆΠΈΡ€ΠΎΠ²ΠΎΡ— Ρ‚ΠΊΠ°Π½ΠΈΠ½ΠΈ. ΠŸΡ–Π΄ Π²ΠΏΠ»ΠΈΠ²ΠΎΠΌ Скстракту Ρ–ΠΌΠ±ΠΈΡ€Ρƒ Ρƒ Π΄ΠΎΠ·Π°Ρ… 50 Ρ‚Π° 80 ΠΌΠ³/ΠΊΠ³ зниТувався Ρ€Ρ–Π²Π΅Π½ΡŒ Π²Ρ–Π»ΡŒΠ½ΠΈΡ… ΠΆΠΈΡ€Π½ΠΈΡ… кислот Ρƒ сироватці ΠΊΡ€ΠΎΠ²Ρ– Π½Π° 38,4 % Ρ‚Π° 38,9 %, Π²Ρ–Ρ€ΠΎΠ³Ρ–Π΄Π½ΠΎ, внаслідок ΠΊΠΎΡ€Π΅ΠΊΡ†Ρ–Ρ— проявів інсулінорСзистСнтності Ρ‚Π° збСрСТСння ΠΊΠ΅Ρ€ΡƒΡŽΡ‡ΠΎΠ³ΠΎ Π²ΠΏΠ»ΠΈΠ²Ρƒ інсуліну Π½Π° Π»Ρ–ΠΏΠΎΠ»Ρ–Π·. ДостовірнС пригнічСння вираТСності Π³Ρ–ΠΏΠ΅Ρ€Ρ‚Ρ€ΠΈΠ°Ρ†ΠΈΠ»Π³Π»Ρ–Ρ†Π΅Ρ€ΠΎΠ»Π΅ΠΌΡ–Ρ— Скстрактом Ρ–ΠΌΠ±ΠΈΡ€Ρƒ дозою 80 ΠΌΠ³/ΠΊΠ³ Π½Π° 35,1 % ΠΊΠΎΡ€Π΅Π»ΡŽΠ²Π°Π»ΠΎ Π·Ρ– змСншСнням ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ†Ρ–Ρ— Π°ΠΏΠΎΠ’-Π›ΠŸ Ρƒ ΠΏΠ΅Ρ‡Ρ–Π½Ρ†Ρ–, Ρ‰ΠΎ свідчило ΠΏΡ€ΠΎ ΠΊΠΎΡ€Π΅ΠΊΡ†Ρ–ΡŽ Π΄Ρ–Π°Π±Π΅Ρ‚ΠΈΡ‡Π½ΠΎΡ— дисліпідСмії. ΠŸΡ€ΠΈ Ρ†ΡŒΠΎΠΌΡƒ Ρ€Ρ–Π²Π΅Π½ΡŒ Π°Π½Ρ‚ΠΈΠ°Ρ‚Π΅Ρ€ΠΎΠ³Π΅Π½Π½ΠΎΡ— Ρ„Ρ€Π°ΠΊΡ†Ρ–Ρ— – Π»Ρ–ΠΏΠΎΠΏΡ€ΠΎΡ‚Π΅Ρ—Π½Ρ–Π² високої Ρ‰Ρ–Π»ΡŒΠ½ΠΎΡΡ‚Ρ– достовірно підвищувався Π½Π° 26,1 Ρ‚Π° 29,5 % ΠΏΡ–Π΄ Π²ΠΏΠ»ΠΈΠ²ΠΎΠΌ Скстракту Ρƒ Π΄ΠΎΠ·Π°Ρ… 50 Ρ‚Π° 80 ΠΌΠ³/ΠΊΠ³ Π²Ρ–Π΄ΠΏΠΎΠ²Ρ–Π΄Π½ΠΎ порівняно Π· ΠΏΠΎΠΊΠ°Π·Π½ΠΈΠΊΠ°ΠΌΠΈ Ρ‚Π²Π°Ρ€ΠΈΠ½ ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΡŒΠ½ΠΎΡ— ΠΏΠ°Ρ‚ΠΎΠ»ΠΎΠ³Ρ–Ρ—. Екстракт Ρ–ΠΌΠ±ΠΈΡ€Ρƒ дозою 80 ΠΌΠ³/ΠΊΠ³ виявив Π±Ρ–Π»ΡŒΡˆ Π²ΠΈΡ€Π°Π·Π½Ρƒ Π·Π΄Π°Ρ‚Π½Ρ–ΡΡ‚ΡŒ Π½ΠΎΡ€ΠΌΠ°Π»Ρ–Π·ΡƒΠ²Π°Ρ‚ΠΈ ΠΏΠΎΠΊΠ°Π·Π½ΠΈΠΊΠΈ Π»Ρ–ΠΏΡ–Π΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΡ–Π½Ρƒ Π½Π° Ρ€Ρ–Π²Π½Ρ– ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Ρƒ порівняння Π·Π±ΠΎΡ€Ρƒ «АрфазСтин». Висновки. ВвСдСння Скстракту Ρ–ΠΌΠ±ΠΈΡ€Ρƒ протягом 14-Ρ‚ΠΈ Π΄Ρ–Π± Ρƒ Π΄ΠΎΠ·Π°Ρ… 50 Ρ‚Π° 80 ΠΌΠ³/ΠΊΠ³ Π½Π° ΠΌΠΎΠ΄Π΅Π»Ρ– Π¦Π” 2 Ρ‚ΠΈΠΏΡƒ, Ρ–Π½Π΄ΡƒΠΊΠΎΠ²Π°Π½ΠΎΠ³ΠΎ дСксамСтазоном, ΡΡƒΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΆΡƒΠ²Π°Π»ΠΎΡΡŒ Π΄ΠΎΡΡ‚ΠΎΠ²Ρ–Ρ€Π½ΠΎΡŽ Π½ΠΎΡ€ΠΌΠ°Π»Ρ–Π·Π°Ρ†Ρ–Ρ”ΡŽ Π»Ρ–ΠΏΡ–Π΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΡ–Π½Ρƒ. Застосування Скстракту Ρ–ΠΌΠ±ΠΈΡ€Ρƒ дозою 80 ΠΌΠ³/ΠΊΠ³ Π½Π°ΠΉΠ±Ρ–Π»ΡŒΡˆ Π²ΠΈΡ€Π°ΠΆΠ΅Π½ΠΎ Π½Π° Ρ€Ρ–Π²Π½Ρ– ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Ρƒ порівняння Π·Π±ΠΎΡ€Ρƒ «АрфазСтин» ΠΊΠΎΡ€Π΅Π³ΡƒΠ²Π°Π»ΠΎ ΠΏΠ°Ρ‚ΠΎΠ»ΠΎΠ³Ρ–Ρ‡Π½Ρ– Π·ΠΌΡ–Π½ΠΈ ΠΌΠ΅Ρ‚Π°Π±ΠΎΠ»Ρ–Π·ΠΌΡƒ Π»Ρ–ΠΏΡ–Π΄Ρ–Π², Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€Π½Ρ– для Π¦Π” 2 Ρ‚ΠΈΠΏΡƒ, Ρ‰ΠΎ дозволяє Π·Ρ€ΠΎΠ±ΠΈΡ‚ΠΈ висновок ΠΏΡ€ΠΎ Π΄ΠΎΡ†Ρ–Π»ΡŒΠ½Ρ–ΡΡ‚ΡŒ ΠΏΠΎΠ΄Π°Π»ΡŒΡˆΠΈΡ… Π΄ΠΎΡΠ»Ρ–Π΄ΠΆΠ΅Π½ΡŒ Скстракту самС Ρƒ Ρ†Ρ–ΠΉ Π΄ΠΎΠ·Ρ– Ρ‚Π° ΠΏΠ΅Ρ€ΡΠΏΠ΅ΠΊΡ‚ΠΈΠ²Π½Ρ–ΡΡ‚ΡŒ ΠΉΠΎΠ³ΠΎ застосування як Π°Π½Ρ‚ΠΈΠ°Ρ‚Π΅Ρ€ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ засобу Ρƒ комплСксному Π»Ρ–ΠΊΡƒΠ²Π°Π½Π½Ρ– Π¦Π” 2 Ρ‚ΠΈΠΏΡƒ.
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