9 research outputs found
Thermal Decarboxylative Nazarov Cyclization of Cyclic Enol Carbonates Involving Chirality Transfer
Access to Tetronic Acids via Silver-Catalyzed CO<sub>2</sub> Incorporation into Conjugated Ynones
Facile
and versatile access to highly functionalized tetronic acids
has been successfully achieved through the reaction of conjugated
ynones with carbon dioxide. In the presence of a base, the enolates
generated from the ynones capture CO<sub>2</sub> via a carbon–carbon
bond-forming reaction, accompanied by a 5-<i>exo-dig</i> cyclization reaction of the resulting carboxylate to the alkyne,
activated by a silver catalyst. The present method should be applicable
to the synthesis of a wide variety of tetronic acids