Bending force of LLDPE monofilaments at high temperatures measured in DMA (Dynamic Mechanical Analyzer)

The bending force of monofilaments used as pile layer in artificial turf football fields is a very important property due to the strong relation with the performance of the entire system being the force that mostly influences the deformation of monofilaments. The existing test methods for measuring this force can only be used to perform tests at room temperature. Nowadays, artificial turf surfaces are being installed worldwide, even in regions with very high values of air temperature, leading to the need of evaluating the performance of monofilaments and thus, of testing their bending force at elevated temperatures. The aim of this paper is to use the DMA's advantage of testing at high temperatures, by using a new test method developed for measuring the bending force of monofilaments at room temperature and to evaluate the results obtained. For this purpose, six different LLDPE (Low Linear Density Polyethylene) monofilaments are tested at temperatures 25 degrees C, 50 degrees C and 80 degrees C and the bending force is measured. The DMA is used successfully on performing tests at high temperatures. Considering the results, an analysis of the bending behavior of LLDPE monofilaments depending on the temperature is done. All fibers show the same trends regarding this influence, with decreasing of the bending force while increasing the temperature

Kinstate intervention in ethnic conflicts : Albania and Turkey compared

Albania and Turkey did not act in overtly irredentist ways towards their ethnic brethren in neighboring states after the end of communism. Why, nonetheless, did Albania facilitate the increase of ethnic conflict in Kosovo and Macedonia, while Turkey did not, with respect to the Turks of Bulgaria? I argue that kin-states undergoing transition are more prone to intervene in external conflicts than states that are not, regardless of the salience of minority demands in the host-state. The transition weakens the institutions of the kin-state. Experiencing limited institutional constraints, self-seeking state officials create alliances with secessionist and autonomist movements across borders alongside their own ideological, clan-based and particularistic interests. Such alliances are often utilized to advance radical domestic agendas. Unlike in Albania's transition environment, in Turkey there were no emerging elites that could potentially form alliances and use external movements to legitimize their own domestic existence or claims

Transfer factor of radionuclides from soil-to-palm oil produced from Elere palm tree plantation near Ibadan Oyo state, Nigeria

The migration of contaminants including radionuclides from soil-to-plant system is usually predicted by mathematical models commonly employed in a soil-to-plant transfer factor for activity concentration. Local palm trees found mostly in Nigeria are very tall and their fruits are used for production of red palm oil. Ibadan and its environs including Elere are underlain by crystalline basement complex which is known to be rich in natural radionuclides. Hence enhanced radioactivity and soil-toplant transfer factor influenced by physical-chemical form of the radionuclides in the soil and types of plant could be obtained. The study is aimed at determining the radioactivity levels of 40K, 238U and 232Th in the soil and palm oil; and calculating the soil to palm oil transfer factor. A total number of 20 palm trees were randomly selected in the study areas. From each palm tree, bunches of palm fruits were collected to prepare palm oil and the soil samples at the spot of the tree were also collected. The activity concentration of the natural radionuclides were determined using a single crystal 0.51cm x 0.51cmNaI (Tl) detector coupled through a Hamamatsa (R1306NSV3068) photomultiplier tube to a Multichannel Analyser, MCA (2100R:01). The activity concentrations of 40K, 238U and 232Th in palm oil ranged from 50.48 Bqkg-1 to 112.16 Bqkg-1; 6.35 Bqkg-1to 12.80 Bqkg-1and 6.08 Bqkg-1to 10.13 Bqkg-1 respectively. The activity concentrations of 40K, 232U and 232Th in the soil samples ranged from 412.43 Bqkg-1to 672.16 Bqkg-1; 10.25 Bqkg-1to17.43 Bqkg-1and 8.12 Bqkg-1to 12.48 Bqkg-1respectively. The mean transfer factors were 0.17±0.02, 0.27±0.06 and 0.28±0.02 for 40K, 238U and 232Th respectively. The 40K, 238U and 232Th radioactivity levels in the soil are comparable to the world average values of 420Bqkg-1, 32 Bqkg-1and 40 Bqkg-1respectively. The transfer factors indicated that about 17%, 27% and 28% of 40K, 238U and 232Th respectively are transferred from soil to the palm.Keywords: radionuclide, transfer factor, mathematical model, palm oil, Ibada

a pilot study, 2013

Introduction After recognition of European outbreaks of Clostridium difficile infections (CDIs) associated with the emergence of PCR ribotype 027/NAP1 in 2005, CDI surveillance at country level was encouraged by the European Centre for Disease Prevention and Control (ECDC) [1]. In 2008, an ECDC-supported European CDI survey (ECDIS) identified large intercountry variations in incidence rates and distribution of prevalent PCR ribotypes, with the outbreak-related PCR ribotype 027 being detected in 5% (range: 0–26) of the characterised isolates [2]. The surveillance period was limited to one month and the representation of European hospitals was incomplete; however, this has been the only European (comprising European Union (EU)/European Economic Area (EEA) and EU candidate countries) CDI surveillance study. The authors highlighted the need for national and European surveillance to control CDI. Yet, European countries were found to have limited capacity for diagnostic testing, particularly in terms of standard use of optimal methods and absence of surveillance protocols and a fully validated, standardised and exchangeable typing system for surveillance and/or outbreak investigation. As of 2011, 14 European countries had implemented national CDI surveillance, with various methodologies [3]. National surveillance systems have since reported a decrease in CDI incidence rate and/or prevalence of PCR ribotype 027 in some European countries [4-8]. However, CDI generally remains poorly controlled in Europe [9], and PCR ribotype 027 continues to spread in eastern Europe [10-12] and globally [13]. In 2010, ECDC launched a new project, the European C. difficile Infection Surveillance Network (ECDIS-Net), to enhance surveillance of CDI and laboratory capacity to test for CDI in Europe. The goal of ECDIS- Net was to establish a standardised CDI surveillance protocol suitable for application all over Europe in order to: (i) estimate the incidence rate and total infection rate of CDI (including recurrent CDI cases) in European acute care hospitals; (ii) provide participating hospitals with a standardised tool to measure and compare their own incidence rates with those observed in other participating hospitals; (iii) assess adverse outcomes of CDI such as complications and death; and (iv) describe the epidemiology of CDI concerning antibiotic susceptibility, PCR ribotypes, presence of tcdA, tcdB and binary toxins and detect new emerging types at local, national and European level. The primary objectives of the present study were to: (i) test the pilot protocol for the surveillance of CDI in European acute care hospitals developed by ECDIS-Net (methodology, variables and indicators); (ii) assess the feasibility and workload of collecting the required hospital data, case- based epidemiological and microbiological data; and (iii) evaluate the quality of data collected, whether in the presence or absence of existing national CDI surveillance activities. A secondary aim was to assess the relationship between patient and microbiological characteristics and in-hospital outcome of CDI to confirm the added value of collecting detailed epidemiological and microbiological data on CDI at European level

Ghrelin Modulates the fMRI BOLD Response of Homeostatic and Hedonic Brain Centers Regulating Energy Balance in the Rat

The orexigenic gut-brain peptide, ghrelin and its G-protein coupled receptor, the growth hormone secretagogue receptor 1a (GHS-R1A) are pivotal regulators of hypothalamic feeding centers and reward processing neuronal circuits of the brain. These systems operate in a cooperative manner and receive a wide array of neuronal hormone/transmitter messages and metabolic signals. Functional magnetic resonance imaging was employed in the current study to map BOLD responses to ghrelin in different brain regions with special reference on homeostatic and hedonic regulatory centers of energy balance. Experimental groups involved male, ovariectomized female and ovariectomized estradiol-replaced rats. Putative modulation of ghrelin signaling by endocannabinoids was also studied. Ghrelin-evoked effects were calculated as mean of the BOLD responses 30 minutes after administration. In the male rat, ghrelin evoked a slowly decreasing BOLD response in all studied regions of interest (ROI) within the limbic system. This effect was antagonized by pretreatment with GHS-R1A antagonist JMV2959. The comparison of ghrelin effects in the presence or absence of JMV2959 in individual ROIs revealed significant changes in the prefrontal cortex, nucleus accumbens of the telencephalon, and also within hypothalamic centers like the lateral hypothalamus, ventromedial nucleus, paraventricular nucleus and suprachiasmatic nucleus. In the female rat, the ghrelin effects were almost identical to those observed in males. Ovariectomy and chronic estradiol replacement had no effect on the BOLD response. Inhibition of the endocannabinoid signaling by rimonabant significantly attenuated the response of the nucleus accumbens and septum. In summary, ghrelin can modulate hypothalamic and mesolimbic structures controlling energy balance in both sexes. The endocannabinoid signaling system contributes to the manifestation of ghrelin’s BOLD effect in a region specific manner. In females, the estradiol milieu does not influence the BOLD response to ghrelin

Standardised surveillance of Clostridium Difficile Infection in European acute care hospitals: A pilot study, 2013

Clostridium difficile infection (CDI) remains poorly controlled in many European countries, of which several have not yet implemented national CDI surveillance. In 2013, experts from the European CDI Surveillance Network project and from the European Centre for Disease Prevention and Control developed a protocol with three options of CDI surveillance for acute care hospitals: a ‘minimal’ option (aggregated hospital data), a ‘light’ option (including patient data for CDI cases) and an ‘enhanced’ option (including microbiological data on the first 10 CDI episodes per hospital). A total of 37 hospitals in 14 European countries tested these options for a three-month period (between 13 May and 1 November 2013). All 37 hospitals successfully completed the minimal surveillance option (for 1,152 patients). Clinical data were submitted for 94% (1,078/1,152) of the patients in the light option; information on CDI origin and outcome was complete for 94% (1,016/1,078) and 98% (294/300) of the patients in the light and enhanced options, respectively. The workload of the options was 1.1, 2.0 and 3.0 person-days per 10,000 hospital discharges, respectively. Enhanced surveillance was tested and was successful in 32 of the hospitals, showing that C. difficile PCR ribotype 027 was predominant (30% (79/267)). This study showed that standardised multicountry surveillance, with the option of integrating clinical and molecular data, is a feasible strategy for monitoring CDI in Europe

Parental Marital Status as Predictor of Undergraduates’ Mental Health Status

Parenting plays a major role in the development and transformation of young adults. However, in recent years, the aptness of parents has been greatly reduced. Considering the increase of broken marriages and single parenting in Nigeria, young adults may be at risk of depreciating mental health due to unexpected emotional challenges with respect to the immediate family. This cross-sectional survey examined the mental health status of undergraduates as a function of parent’s marital status. One hundred and fifty-six undergraduates selected from three higher institutions responded to the Awaritefe Psychological Index (API), measuring mental health status. Two hypotheses were tested at p=0.05 level of significance and the results revealed that parent’s marital status did not significantly predict undergraduates’ mental health status (β=-0.076, t=0.951, p>0.05); however, the type of higher institution significantly predicted undergraduates’ mental health status (β=0.159, t= -1.985, p<0.05). Since this study revealed that the institution of learning is an effective predictor of undergraduates’ mental health status, it is recommended that institutions of learning should be made more academically conducive for undergraduates to foster better mental health

Automatic extraction of angiogenesis bioprocess from text

Motivation: Understanding key biological processes (bioprocesses) and their relationships with constituent biological entities and pharmaceutical agents is crucial for drug design and discovery. One way to harvest such information is searching the literature. However, bioprocesses are difficult to capture because they may occur in text in a variety of textual expressions. Moreover, a bioprocess is often composed of a series of bioevents, where a bioevent denotes changes to one or a group of cells involved in the bioprocess. Such bioevents are often used to refer to bioprocesses in text, which current techniques, relying solely on specialized lexicons, struggle to find

Oral particle uptake and organ targeting drives the activity of amphotericin B nanoparticles

There are very few drug delivery systems that target key organs via the oral route, as oral delivery advances normally address gastrointestinal drug dissolution, permeation, and stability. Here we introduce a nanomedicine in which nanoparticles, while also protecting the drug from gastric degradation, are taken up by the gastrointestinal epithelia and transported to the lung, liver, and spleen, thus selectively enhancing drug bioavailability in these target organs and diminishing kidney exposure (relevant to nephrotoxic drugs). Our work demonstrates, for the first time, that oral particle uptake and translocation to specific organs may be used to achieve a beneficial therapeutic response. We have illustrated this using amphotericin B, a nephrotoxic drug encapsulated within <i>N</i>-palmitoyl-<i>N</i>-methyl-<i>N</i>,<i>N</i>-dimethyl-<i>N</i>,<i>N</i>,<i>N</i>-trimethyl-6-<i>O</i>-glycol chitosan (GCPQ) nanoparticles, and have evidenced our approach in three separate disease states (visceral leishmaniasis, candidiasis, and aspergillosis) using industry standard models of the disease in small animals. The oral bioavailability of AmB-GCPQ nanoparticles is 24%. In all disease models, AmB-GCPQ nanoparticles show comparable efficacy to parenteral liposomal AmB (AmBisome). Our work thus paves the way for others to use nanoparticles to achieve a specific targeted delivery of drug to key organs via the oral route. This is especially important for drugs with a narrow therapeutic index