Acute Peripheral Inflammation Increases Plasma Concentration of Hypoglycemic Agent Nateglinide with Decreased Hepatic Drug-Metabolizing Activity in Rats

The effects of inflammation on hypoglycemic agents were evaluated in male rats with acute peripheral inflammation (API). Nateglinide (NTG) was utilized as a model compound, since it is a hepatically-metabolized compound and its metabolism is mainly mediated by CYP 2C11 enzyme. In the experiments, rats were subjected to carrageenan injection into their hind paws for API induction, and the plasma concentration profiles of NTG were then examined. In addition, pooled liver microsomes were prepared from control and API rats, and the hepatic drug-metabolizing activity toward NTG and the hepatic expression of CYP2C11 protein were evaluated. It was shown that the plasma concentration of NTG following its intravenous administration decreases at a slower rate in API rats than that in control rats. It was also indicated in the incubation study with the liver microsomes that the hepatic drug-metabolizing activity toward NTG decreases in API rats. Additionally, it was revealed in Western immunoblotting that the hepatic expression of CYP2C11 protein decreases in API rats. These findings suggest that inflammation occurring in peripheral tissues brings about a decrease in hepatic NTG metabolism by suppressing the hepatic expression of CYP2C11 protein, causing an alteration of the plasma concentration profile of NTG with its impaired elimination

The use of telephones in Sri Lanka

This article reports some findings from a survey designed to investigate the use of telephones in Sri Lanka, perceptions of the socioeconomic impact of telecommunications, and attitudes toward telecommunications policy. Although it was found that telephone subscription had significant impacts on social relations, social status and economic activity, the participants in the survey did not perceive any urgent need for investment in telecommunications.

Application for classification discriminant analysis cognitive disorders in patients encephalopathy

В статье предлагается диагностическая модель дифференциаций стадий когнитивных расстройств у пациентов с дисциркуляторной энцефалопатией, полученная в результате дискриминантного анализа данных клинических инструментальных, психологических и лабораторных исследований.У статті пропонується діагностична модель диференціацій стадій когнітивних розладів у пацієнтів з дисциркуляторною енцефалопатією, отримана в результаті дискримінантного аналізу даних клінічних інструментальних, психологічних і лабораторних досліджень.In this paper a diagnostic model for the derivation of the patients cognitive disorder stages with encephalopathy, resulting from discriminant analysis of clinical, psychological and laboratory research too is propose