Positive selection of V beta 8+ CD4-8- thymocytes by class I molecules expressed by hematopoietic cells.

A small subset of T cells of mature phenotype express the alpha/beta T cell receptor, but not CD4 and CD8 coreceptors (alpha/beta double-negative [DN] cells). The repertoire of V beta usage of alpha/beta DN cells is strongly biased towards V beta 8 expression, suggesting that the formation of the population is subject to selection. We now report that deficiency of class I expression leads to a strongly depressed frequency of V beta 8+ DN cells, but has little effect on V beta 8- DN cells. Studies of hematopoietic chimeras between class I+ and class I- mice demonstrated that expression of class I molecules by hematopoietic cells is necessary and sufficient for selection of most V beta 8 DN cells. The lack of a role for class I expression by thymic epithelial cells suggests that the mechanism of selection of these cells by class I differs significantly from the mechanism of selection of conventional T cells. Models to explain the selection of these cells as well as their possible function in vivo are discussed

The Many Faces of Modern Legal Realism

This work offers an overview of the consequences and implications of the work of the American Legal Realists. First, the article considers Brian Leiter’s naturalist understanding of the realist project and how he uses it as an occasion to argue for a generally naturalist approach to legal philosophy. Second, Frederick Schauer transforms a legal realist-like focus on the concerns of average citizens for legal enforcement to advocate for the view that coercion is central to understanding law. Third, self-styled New Legal Realists try to merge a realist-inspired search for the effects of legal rules with a more traditional respect for the importance of legal doctrine in understanding behavior within and in relation to law. Finally, with the comment, “we are all Legal Realists now”, the article discusses the ways in which the American Legal Realists have – and have not – significantly transformed legal thinking and legal education in the United States

Law and Reasons: Comments on Rodriguez-Blanco

Veronica Rodriguez-Blanco explora con minuciosidad en su detallado e importante artículo, “Reasons in Action v Triggering Reasons: A Reply to Enoch on Reason-Giving and Legal Normativity”, la naturaleza del otor- gamiento de razones, en aras de cuestionar el influyente trabajo reciente de David Enoch sobre el otorgamiento de razones y el derecho. Si bien el artículo de Rodriguez-Blanco constituye una importante contribución a la literatura en cuanto a la mejor comprensión del otorgamiento de razo- nes y la razón práctica, no está claro si el enfoque hacia las razones para la acción, reformado sobre la línea de lo que sugiere Rodríguez-Blanco, clarificaría la cuestión primordial de la que se ocupa: la manera en que los sistemas jurídicos en general o las normas jurídicas individuales le dan (o no) a los ciudadanos razones para la acción. La cuestión sobre si tenemos una obligación moral (presuntiva) general de actuar (o de abste- nerse de actuar) tal como lo disponen las normas depende en gran medi- da de si hay buenos argumentos en contra de un enfoque individualista y casuístico para responder a tales normas

Equipped for Life: Gendered Technical Training and Consumerism in Home Economics, 1920-1980

In tracing the development of technical education in American colleges and universities, historians have tended, perhaps inevitably, to concentrate on engineering departments. Those programs tell an important story: the evolution of specialized disciplines from practical, shop-oriented learning to theoretical science. Also, engineering schools were (as many still are) dominated by male students and faculty, who often connected technical expertise to masculinity