22 research outputs found
Determination of the STM tip-graphene repulsive forces by comparative STM and AFM measurements on suspended graphene
AID-Dependent Generation of Resected Double-Strand DNA Breaks and Recruitment of Rad52/Rad51 in Somatic Hypermutation
The Reform of the Italian Ministry of Cultural Heritage: Implications for Governance of the Museum System
Blue Phosphorus-MoX2 (X=S/Se/Te) heterobilayers with strain enhanced photovoltaic properties: A first-principle study
Genetic structure correlates with ethnolinguistic diversity in eastern and southern Africa
African populations are the most diverse in the world yet are sorely underrepresented in medical genetics research. Here, we examine the structure of African populations using genetic and comprehensive multi-generational ethnolinguistic data from the Neuropsychiatric Genetics of African Populations-Psychosis study (NeuroGAP-Psychosis) consisting of 900 individuals from Ethiopia, Kenya, South Africa, and Uganda. We find that self-reported language classifications meaningfully tag underlying genetic variation that would be missed with consideration of geography alone, highlighting the importance of culture in shaping genetic diversity. Leveraging our uniquely rich multi-generational ethnolinguistic metadata, we track language transmission through the pedigree, observing the disappearance of several languages in our cohort as well as notable shifts in frequency over three generations. We find suggestive evidence for the rate of language transmission in matrilineal groups having been higher than that for patrilineal ones. We highlight both the diversity of variation within Africa as well as how within-Africa variation can be informative for broader variant interpretation; many variants that are rare elsewhere are common in parts of Africa. The work presented here improves the understanding of the spectrum of genetic variation in African populations and highlights the enormous and complex genetic and ethnolinguistic diversity across Africa