Simple assessment of spatio-temporal evolution of salt marshes ecological services

A number of previous research studies have addressed the enormous role played by biodiversity and ecosystems in human well-being and have placed particular emphasis on the consequences of the reduction or loss of these services. A handful of studies have implemented practical methodologies to quantify the variability of limiting factors leading to reductions in these ecological services. The aim of this article is to document the limited number of studies that have analyzed coastal ecosystem services and acknowledge the impacts of physical changes in habitat provision. In one example, it is clear that the maintenance of salt marshes depends on sedimentary supply and consequent morphological variability in spite of the fact that there is usually no recurrent integration of habitat time-space dynamics (sediment availability) during the quantification and monetization of marsh services (i.e., monetary valuation of salt marsh services). This means that one key challenge facing the analysis of salt marsh (or other ecosystem) services in a global climate context is to predict future value, based on past trends, while at the same time guaranteeing conservation. Research in this field has been very broad and so the use of long-term evolutionary datasets is proposed here to explain future habitat provision. An empirical approximation is also presented here that accounts for service provision and enables time-space analysis. Although improvements will be required, the equation presented here represents a key first step to enable managers to cope with the constraints of resource limitations and is also applicable to other habitats.PTDC/MAR-EST/1031/2014info:eu-repo/semantics/publishedVersio

Latent tuberculosis infection and non-infectious co-morbidities: Diabetes mellitus type 2, chronic kidney disease and rheumatoid arthritis.

The prevalence of non-communicable diseases is increasing worldwide, which coincides with the persistence of infectious diseases including tuberculosis. These can synergistically affect individual and population health. Three non-communicable diseases that are relevant because of their associated morbidity, mortality and disability are type 2 diabetes mellitus, chronic kidney disease and rheumatoid arthritis. There is some evidence that patients with these conditions are at increased risk of acquiring latent tuberculosis infection (LTBI) and of this progressing to active disease. Unfortunately, evidence on accurate testing and effective prophylactic treatment in these populations is lacking. This review discusses current evidence and recommendations for management of LTBI in these patients

Assessing Human Error Against a Benchmark of Perfection

An increasing number of domains are providing us with detailed trace data on human decisions in settings where we can evaluate the quality of these decisions via an algorithm. Motivated by this development, an emerging line of work has begun to consider whether we can characterize and predict the kinds of decisions where people are likely to make errors. To investigate what a general framework for human error prediction might look like, we focus on a model system with a rich history in the behavioral sciences: the decisions made by chess players as they select moves in a game. We carry out our analysis at a large scale, employing datasets with several million recorded games, and using chess tablebases to acquire a form of ground truth for a subset of chess positions that have been completely solved by computers but remain challenging even for the best players in the world. We organize our analysis around three categories of features that we argue are present in most settings where the analysis of human error is applicable: the skill of the decision-maker, the time available to make the decision, and the inherent difficulty of the decision. We identify rich structure in all three of these categories of features, and find strong evidence that in our domain, features describing the inherent difficulty of an instance are significantly more powerful than features based on skill or time.Comment: KDD 2016; 10 page

Metallochaperones Are Needed for Mycobacterium tuberculosis and Escherichia coli Nicotinamidase-Pyrazinamidase Activity.

Mycobacterium tuberculosis nicotinamidase-pyrazinamidase (PZAse) is a metalloenzyme that catalyzes conversion of nicotinamide-pyrazinamide to nicotinic acid-pyrazinoic acid. This study investigated whether a metallochaperone is required for optimal PZAse activity. M. tuberculosis and Escherichia coli PZAses (PZAse-MT and PZAse-EC, respectively) were inactivated by metal depletion (giving PZAse-MT-Apo and PZAse-EC-Apo). Reactivation with the E. coli metallochaperone ZnuA or Rv2059 (the M. tuberculosis analog) was measured. This was repeated following proteolytic and thermal treatment of ZnuA and Rv2059. The CDC1551 M. tuberculosis reference strain had the Rv2059 coding gene knocked out, and PZA susceptibility and the pyrazinoic acid (POA) efflux rate were measured. ZnuA (200 μM) achieved 65% PZAse-EC-Apo reactivation. Rv2059 (1 μM) and ZnuA (1 μM) achieved 69% and 34.3% PZAse-MT-Apo reactivation, respectively. Proteolytic treatment of ZnuA and Rv2059 and application of three (but not one) thermal shocks to ZnuA significantly reduced the capacity to reactivate PZAse-MT-Apo. An M. tuberculosis Rv2059 knockout strain was Wayne positive and susceptible to PZA and did not have a significantly different POA efflux rate than the reference strain, although a trend toward a lower efflux rate was observed after knockout. The metallochaperone Rv2059 restored the activity of metal-depleted PZAse in vitro Although Rv2059 is important in vitro, it seems to have a smaller effect on PZA susceptibility in vivo. It may be important to mechanisms of action and resistance to pyrazinamide in M. tuberculosis Further studies are needed for confirmation.IMPORTANCE Tuberculosis is an infectious disease caused by the bacterium Mycobacterium tuberculosis and remains one of the major causes of disease and death worldwide. Pyrazinamide is a key drug used in the treatment of tuberculosis, yet its mechanism of action is not fully understood, and testing strains of M. tuberculosis for pyrazinamide resistance is not easy with the tools that are presently available. The significance of the present research is that a metallochaperone-like protein may be crucial to pyrazinamide's mechanisms of action and of resistance. This may support the development of improved tools to detect pyrazinamide resistance, which would have significant implications for the clinical management of patients with tuberculosis: drug regimens that are appropriately tailored to the resistance profile of a patient's individual strain lead to better clinical outcomes, reduced onward transmission of infection, and reduction of the development of resistant strains that are more challenging and expensive to treat

NOTES ON THE DISPLAYS AND POSSIBLE LEK BEHAVIOR OF THE FIERY TOPAZ (TOPAZA PYRA) (APODIFORMES: TROCHILIDAE)

The genus Topaza comprises two species of large hummingbirds with allopatric distributions in Amazonia. Lek behavior has already been described in almost 30 species of hummingbirds, including Crimson Topaz Topaza pella, but not for Fiery Topaz T. pyra. We describe male displays by T. pyra and how these might be possibly correlated to lek behavior, based on observations at different locations in Ecuador, Colombia, and Brazil. These behaviors are compared to the previously described behavior of T. pella and other hummingbirds, but we also describe an extremely unusual upside-down hanging behavior during male to male interactions. Furthermore, some of our observations evidence an apparent tendency for more than one male to converge on a specific perch, perhaps to compete for dominance within a group of otherwise more dispersed, probably linear song territories. 

Fractional Hamiltonian Monodromy from a Gauss-Manin Monodromy

Fractional Hamiltonian Monodromy is a generalization of the notion of Hamiltonian Monodromy, recently introduced by N. N. Nekhoroshev, D. A. Sadovskii and B. I. Zhilinskii for energy-momentum maps whose image has a particular type of non-isolated singularities. In this paper, we analyze the notion of Fractional Hamiltonian Monodromy in terms of the Gauss-Manin Monodromy of a Riemann surface constructed from the energy-momentum map and associated to a loop in complex space which bypasses the line of singularities. We also prove some propositions on Fractional Hamiltonian Monodromy for 1:-n and m:-n resonant systems.Comment: 39 pages, 24 figures. submitted to J. Math. Phy

Clinical Judgment Analysis

SUMMARY Judgment is central to the practice of medicine and occurs between making clinical observations and taking clinical decisions. Clinical judgment analysis has developed as a method of making statistically firm models of doctors' judgments. Computed models reveal the differential importance attached to items of clinical, social, or other data which are determinants of clinical decisions. These models can both reveal the causes of conflicts of judgment and may help resolve them in a way that unaided discussion cannot. Revealing experts' models to students speeds learning of diagnostic skills. Clinical judgment analysis offers a method of probing the judgments not just of students and doctors but also of patients who have shown systematic differences in their perceptions of risk and benefit. The power and relevance of clinical trials can be improved by the consistent application of judgment policies generated from both the trialists and those who will use their result

Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance.

In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB

Sarcopenia during COVID-19 lockdown restrictions: long-term health effects of short-term muscle loss.

The COVID-19 pandemic is an extraordinary global emergency that has led to the implementation of unprecedented measures in order to stem the spread of the infection. Internationally, governments are enforcing measures such as travel bans, quarantine, isolation, and social distancing leading to an extended period of time at home. This has resulted in reductions in physical activity and changes in dietary intakes that have the potential to accelerate sarcopenia, a deterioration of muscle mass and function (more likely in older populations), as well as increases in body fat. These changes in body composition are associated with a number of chronic, lifestyle diseases including cardiovascular disease (CVD), diabetes, osteoporosis, frailty, cognitive decline, and depression. Furthermore, CVD, diabetes, and elevated body fat are associated with greater risk of COVID-19 infection and more severe symptomology, underscoring the importance of avoiding the development of such morbidities. Here we review mechanisms of sarcopenia and their relation to the current data on the effects of COVID-19 confinement on physical activity, dietary habits, sleep, and stress as well as extended bed rest due to COVID-19 hospitalization. The potential of these factors to lead to an increased likelihood of muscle loss and chronic disease will be discussed. By offering a number of home-based strategies including resistance exercise, higher protein intakes and supplementation, we can potentially guide public health authorities to avoid a lifestyle disease and rehabilitation crisis post-COVID-19. Such strategies may also serve as useful preventative measures for reducing the likelihood of sarcopenia in general and in the event of future periods of isolation