524 research outputs found
Results on Plasma Focusing of High Energy Density Electron and Positron Beams
We present results from the SLAC E-150 experiment on plasma focusing of high
energy density electron and, for the first time, positron beams. We also
discuss measurements on plasma lens-induced synchrotron radiation, longitudinal
dynamics of plasma focusing, and laser- and beam-plasma interactions.Comment: LINAC 2000 paper No. THC13, Monterey, CA. Aug.21-25,2000, 3 pages, 2
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Observation of Plasma Focusing of a 28.5 GeV Positron Beam
The observation of plasma focusing of a 28.5 GeV positron beam is reported.
The plasma was formed by ionizing a nitrogen jet only 3 mm thick. Simultaneous
focusing in both transverse dimensions was observed with effective focusing
strengths of order Tesla per micron. The minimum area of the beam spot was
reduced by a factor of 2.0 +/- 0.3 by the plasma. The longitudinal beam
envelope was measured and compared with numerical calculations
A rules-based shoreface translation and sediment budgeting tool for estimating coastal change: ShoreTrans
Plasma polyunsaturated fatty acids are directly associated with cognition in overweight children but not in normal weight children
Efficacy of futibatinib, an irreversible fibroblast growth factor receptor inhibitor, in FGFR-altered breast cancer.
Several alterations in fibroblast growth factor receptor (FGFR) genes have been found in breast cancer; however, they have not been well characterized as therapeutic targets. Futibatinib (TAS-120; Taiho) is a novel, selective, pan-FGFR inhibitor that inhibits FGFR1-4 at nanomolar concentrations. We sought to determine futibatinib\u27s efficacy in breast cancer models. Nine breast cancer patient-derived xenografts (PDXs) with various FGFR1-4 alterations and expression levels were treated with futibatinib. Antitumor efficacy was evaluated by change in tumor volume and time to tumor doubling. Alterations indicating sensitization to futibatinib in vivo were further characterized in vitro. FGFR gene expression between patient tumors and matching PDXs was significantly correlated; however, overall PDXs had higher FGFR3-4 expression. Futibatinib inhibited tumor growth in 3 of 9 PDXs, with tumor stabilization in an FGFR2-amplified model and prolonged regression (\u3e 110 days) in an FGFR2 Y375C mutant/amplified model. FGFR2 overexpression and, to a greater extent, FGFR2 Y375C expression in MCF10A cells enhanced cell growth and sensitivity to futibatinib. Per institutional and public databases, FGFR2 mutations and amplifications had a population frequency of 1.1%-2.6% and 1.5%-2.5%, respectively, in breast cancer patients. FGFR2 alterations in breast cancer may represent infrequent but highly promising targets for futibatinib
Individual Oligodendrocytes Have Only a Few Hours in which to Generate New Myelin Sheaths In Vivo
The number of myelin sheaths made by individual oligodendrocytes regulates the extent of myelination, which profoundly affects central nervous system function. It remains unknown when, during their life, individual oligodendrocytes can regulate myelin sheath number in vivo. We show, using live imaging in zebrafish, that oligodendrocytes make new myelin sheaths during a period of just 5 hr, with regulation of sheath number after this time limited to occasional retractions. We also show that activation and reduction of Fyn kinase in oligodendrocytes increases and decreases sheath number per cell, respectively. Interestingly, these oligodendrocytes also generate their new myelin sheaths within the same period, despite having vastly different extents of myelination. Our data demonstrate a restricted time window relative to the lifetime of the individual oligodendrocyte, during which myelin sheath formation occurs and the number of sheaths is determined
Spectral quantification of nonlinear behaviour of the nearshore seabed and correlations with potential forcings at Duck, N.C., U.S.A
Local bathymetric quasi-periodic patterns of oscillation are identified from
monthly profile surveys taken at two shore-perpendicular transects at the USACE
field research facility in Duck, North Carolina, USA, spanning 24.5 years and
covering the swash and surf zones. The chosen transects are the two furthest
(north and south) from the pier located at the study site. Research at Duck has
traditionally focused on one or more of these transects as the effects of the
pier are least at these locations. The patterns are identified using singular
spectrum analysis (SSA). Possible correlations with potential forcing
mechanisms are discussed by 1) doing an SSA with same parameter settings to
independently identify the quasi-periodic cycles embedded within three
potentially linked sequences: monthly wave heights (MWH), monthly mean water
levels (MWL) and the large scale atmospheric index known as the North Atlantic
Oscillation (NAO) and 2) comparing the patterns within MWH, MWL and NAO to the
local bathymetric patterns. The results agree well with previous patterns
identified using wavelets and confirm the highly nonstationary behaviour of
beach levels at Duck; the discussion of potential correlations with
hydrodynamic and atmospheric phenomena is a new contribution. The study is then
extended to all measured bathymetric profiles, covering an area of 1100m
(alongshore) by 440m (cross-shore), to 1) analyse linear correlations between
the bathymetry and the potential forcings using multivariate empirical
orthogonal functions (MEOF) and linear correlation analysis and 2) identify
which collective quasi-periodic bathymetric patterns are correlated with those
within MWH, MWL or NAO, based on a (nonlinear) multichannel singular spectrum
analysis (MSSA). (...continued in submitted paper)Comment: 50 pages, 3 tables, 8 figure
An International Comparison of Implied, Realized and GARCH Volatility Forecasts
We compare the predictive ability and economic value of implied, realized, and GARCH volatility models for 13 equity indices from 10 countries. Model ranking is similar across countries, but varies with the forecast horizon. At the daily horizon, the Heterogeneous Autoregressive model offers the most accurate predictions, whereas an implied volatility model that corrects for the volatility risk premium is superior at the monthly horizon. Widely used GARCH models have inferior performance in almost all cases considered. All methods perform significantly worse over the 2008–09 crisis period. Finally, implied volatility offers significant improvements against historical methods for international portfolio diversification. © 2016 Wiley Periodicals, Inc. Jrl Fut Mar
Analytical and computational study of magnetization switching in kinetic Ising systems with demagnetizing fields
An important aspect of real ferromagnetic particles is the demagnetizing
field resulting from magnetostatic dipole-dipole interaction, which causes
large particles to break up into domains. Sufficiently small particles,
however, remain single-domain in equilibrium. This makes such small particles
of particular interest as materials for high-density magnetic recording media.
In this paper we use analytic arguments and Monte Carlo simulations to study
the effect of the demagnetizing field on the dynamics of magnetization
switching in two-dimensional, single-domain, kinetic Ising systems. For systems
in the ``Stochastic Region,'' where magnetization switching is on average
effected by the nucleation and growth of fewer than two well-defined critical
droplets, the simulation results can be explained by the dynamics of a simple
model in which the free energy is a function only of magnetization. In the
``Multi-Droplet Region,'' a generalization of Avrami's Law involving a
magnetization-dependent effective magnetic field gives good agreement with our
simulations.Comment: 29 pages, REVTeX 3.0, 10 figures, 2 more figures by request.
Submitted Phys. Rev.
Red giant masses and ages derived from carbon and nitrogen abundances
We show that the masses of red giant stars can be well predicted from their photospheric carbon and nitrogen abundances, in conjunction with their spectroscopic stellar labels log g, Teff, and [Fe/H]. This is qualitatively expected from mass-dependent post-main-sequence evolution. We here establish an empirical relation between these quantities by drawing on 1475 red giants with asteroseismic mass estimates from Kepler that also have spectroscopic labels from Apache Point Observatory Galactic Evolution Experiment (APOGEE) DR12. We assess the accuracy of our model, and find that it predicts stellar masses with fractional rms errors of about 14 per cent (typically 0.2 M⊙). From these masses, we derive ages with rms errors of 40 per cent. This empirical model allows us for the first time to make age determinations (in the range 1–13 Gyr) for vast numbers of giant stars across the Galaxy. We apply our model to ∼52 000 stars in APOGEE DR12, for which no direct mass and age information was previously available. We find that these estimates highlight the vertical age structure of the Milky Way disc, and that the relation of age with [α/M] and metallicity is broadly consistent with established expectations based on detailed studies of the solar neighbourhood
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