Exercise training and detraining process affects plasma adiponectin level in healthy and spontaneously hypertensive rats

BACKGROUND: Adiponectin levels with long-term swimming exercise have been never investigated in spontaneously hypertensive rats (SHR). OBJECTIVE: This study was aimed to investigate the effects of exercise and detraining process on the adiponectin plasma levels of spontaneously hypertensive rats (SHR) and healthy Wistar-Kyoto rats (WKY). MATERIAL AND METHODS: The rats in the exercise groups were swimming for 10 weeks, 5 days/week, one hour in a day. The detraining rats were left to be sedentary in their cages for 5 weeks after 10 weeks of exercise period. RESULTS: The plasma adiponectin levels decreased in E and SHRE groups compared to the SC and the SHR groups, respectively. In addition, blood pressure was decreased in the exercise groups vs their controls. The adiponectin level was not found to be significantly different in ED and SHRED groups compared to their controls. The blood pressure did not differ between SDC and ED groups, although in the SHRED group it was found to be lower than in SHRSD group rats. CONCLUSION: The results of this study showed that exercise reduced plasma levels of adiponectin in healthy and spontaneously hypertensive rats. However, this difference disappeared at the end of the training processes. Our results suggest, that changes in plasma adiponectin levels are not responsible for changes in blood pressure

The Discovery of the Most Metal-Rich White Dwarf: Composition of a Tidally Disrupted Extrasolar Dwarf Planet

Cool white dwarf stars are usually found to have an outer atmosphere that is practically pure in hydrogen or helium. However, a small fraction have traces of heavy elements that must originate from the accretion of extrinsic material, most probably circumstellar matter. Upon examining thousands of Sloan Digital Sky Survey spectra, we discovered that the helium-atmosphere white dwarf SDSS J073842.56+183509.6 shows the most severe metal pollution ever seen in the outermost layers of such stars. We present here a quantitative analysis of this exciting star by combining high S/N follow-up spectroscopic and photometric observations with model atmospheres and evolutionary models. We determine the global structural properties of our target star, as well as the abundances of the most significant pollutants in its atmosphere, i.e., H, O, Na, Mg, Si, Ca, and Fe. The relative abundances of these elements imply that the source of the accreted material has a composition similar to that of Bulk Earth. We also report the signature of a circumstellar disk revealed through a large infrared excess in JHK photometry. Combined with our inferred estimate of the mass of the accreted material, this strongly suggests that we are witnessing the remains of a tidally disrupted extrasolar body that was as large as Ceres.Comment: 7 pages in emulateapj, 5 figures, accepted for publication in Ap

Topology and shape optimization of induced-charge electro-osmotic micropumps

For a dielectric solid surrounded by an electrolyte and positioned inside an externally biased parallel-plate capacitor, we study numerically how the resulting induced-charge electro-osmotic (ICEO) flow depends on the topology and shape of the dielectric solid. In particular, we extend existing conventional electrokinetic models with an artificial design field to describe the transition from the liquid electrolyte to the solid dielectric. Using this design field, we have succeeded in applying the method of topology optimization to find system geometries with non-trivial topologies that maximize the net induced electro-osmotic flow rate through the electrolytic capacitor in the direction parallel to the capacitor plates. Once found, the performance of the topology optimized geometries has been validated by transferring them to conventional electrokinetic models not relying on the artificial design field. Our results show the importance of the topology and shape of the dielectric solid in ICEO systems and point to new designs of ICEO micropumps with significantly improved performance.Comment: 18 pages, latex IOP-style, 7 eps figure

Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity

The promotion of post-ischaemic motor recovery remains a major challenge in clinical neurology. Recently, plasticity-promoting effects have been described for the growth factor erythropoietin in animal models of neurodegenerative diseases. To elucidate erythropoietin's effects in the post-acute ischaemic brain, we examined how this growth factor influences functional neurological recovery, perilesional tissue remodelling and axonal sprouting of the corticorubral and corticobulbar tracts, when administered intra-cerebroventricularly starting 3 days after 30 min of middle cerebral artery occlusion. Erythropoietin administered at 10 IU/day (but not at 1 IU/day), increased grip strength of the contralesional paretic forelimb and improved motor coordination without influencing spontaneous locomotor activity and exploration behaviour. Neurological recovery by erythropoietin was associated with structural remodelling of ischaemic brain tissue, reflected by enhanced neuronal survival, increased angiogenesis and decreased reactive astrogliosis that resulted in reduced scar formation. Enhanced axonal sprouting from the ipsilesional pyramidal tract into the brainstem was observed in vehicle-treated ischaemic compared with non-ischaemic animals, as shown by injection of dextran amines into both motor cortices. Despite successful remodelling of the perilesional tissue, erythropoietin enhanced axonal sprouting of the contralesional, but not ipsilesional pyramidal tract at the level of the red and facial nuclei. Moreover, molecular biological and histochemical studies revealed broad anti-inflammatory effects of erythropoietin in both hemispheres together with expression changes of plasticity-related molecules that facilitated contralesional axonal growth. Our study establishes a plasticity-promoting effect of erythropoietin after stroke, indicating that erythropoietin acts via recruitment of contralesional rather than of ipsilesional pyramidal tract projection

First Results from Pan-STARRS1: Faint, High Proper Motion White Dwarfs in the Medium-Deep Fields

The Pan-STARRS1 survey has obtained multi-epoch imaging in five bands (Pan-STARRS1 gps, rps, ips, zps, and yps) on twelve "Medium Deep Fields", each of which spans a 3.3 degree circle. For the period between Apr 2009 and Apr 2011 these fields were observed 50-200 times. Using a reduced proper motion diagram, we have extracted a list of 47 white dwarf (WD) candidates whose Pan-STARRS1 astrometry indicates a non-zero proper motion at the 6-sigma level, with a typical 1-sigma proper motion uncertainty of 10 mas/yr. We also used astrometry from SDSS (when available) and USNO-B to assess our proper motion fits. None of the WD candidates exhibits evidence of statistically significant parallaxes, with a typical 1-sigma uncertainty of 8 mas. Twelve of these candidates are known WDs, including the high proper motion (1.7"/yr) WD LHS 291. We confirm three more objects as WDs through optical spectroscopy. Based on the Pan-STARRS1 colors, ten of the stars are likely to be cool WDs with 4170 K Teff 5000 K and cooling ages <9 Gyr. We classify these objects as likely thick disk WDs based on their kinematics. Our current sample represents only a small fraction of the Pan-STARRS1 data. With continued coverage from the Medium Deep Field Survey and the 3pi survey, Pan-STARRS1 should find many more high proper motion WDs that are part of the old thick disk and halo.Comment: 33 pages, 8 figures, submitted to Ap

Vascular endothelial growth factor induces contralesional corticobulbar plasticity and functional neurological recovery in the ischemic brain

Vascular endothelial growth factor (VEGF) is a potent angiogenic factor, which also has neuroprotective activity. In view of these dual actions on vessels and neurons, we were interested whether VEGF promotes long distance axonal plasticity in the ischemic brain. Herein, we show that VEGF promotes neurological stroke recovery in mice when delivered in a delayed way starting 3 days after middle cerebral artery occlusion. Using anterograde tract-tracing experiments that we combined with histochemical and molecular biological studies, we demonstrate that although VEGF promoted angiogenesis predominantly in the ischemic hemisphere, pronounced axonal sprouting was induced by VEGF in the contralesional, but not the ipsilesional corticobulbar system. Corticobulbar plasticity was accompanied by the deactivation of the matrix metalloproteinase MMP9 in the lesioned hemisphere and the transient downregulation of the axonal growth inhibitors NG2 proteoglycan and brevican and the guidance molecules ephrin B1/2 in the contralesional hemisphere. The regulation of matrix proteinases, growth inhibitors, and guidance molecules offers insights how brain plasticity is controlled in the ischemic brain

The Discovery of a Companion to the Lowest Mass White Dwarf

We report the detection of a radial velocity companion to SDSS J091709.55+463821.8, the lowest mass white dwarf currently known with M~0.17Msun. The radial velocity of the white dwarf shows variations with a semi-amplitude of 148.8 km/s and a period of 7.5936 hours, which implies a companion mass of M > 0.28Msun. The lack of evidence of a companion in the optical photometry forces any main-sequence companion to be smaller than 0.1Msun, hence a low mass main sequence star companion is ruled out for this system. The companion is most likely another white dwarf, and we present tentative evidence for an evolutionary scenario which could have produced it. However, a neutron star companion cannot be ruled out and follow-up radio observations are required to search for a pulsar companion.Comment: ApJ, in press. See the Press Release at http://www.cfa.harvard.edu/press/2007/pr200708.htm

The Survival of Water within Extrasolar Minor Planets

We compute that extrasolar minor planets can retain much of their internal H_2O during their host star's red giant evolution. The eventual accretion of a water-rich body or bodies onto a helium white dwarf might supply an observable amount of atmospheric hydrogen, as seems likely for GD 362. More generally, if hydrogen pollution in helium white dwarfs typically results from accretion of large parent bodies rather than interstellar gas as previously supposed, then H_2O probably constitutes at least 10% of the aggregate mass of extrasolar minor planets. One observational test of this possibility is to examine the atmospheres of externally-polluted white dwarfs for oxygen in excess of that likely contributed by oxides such as SiO_2. The relatively high oxygen abundance previously reported in GD 378 plausibly but not uniquely can be explained by accretion of an H_2O-rich parent body or bodies. Future ultraviolet observations of white dwarf pollutions can serve to investigate the hypothesis that environments with liquid water that are suitable habitats for extremophiles are widespread in the Milky Way.Comment: Astronomical Journal, in press, 24 pages, 7 figure

A Spitzer Space Telescope Study of the Debris Disks around four SDSS White Dwarfs

We present Spitzer Space Telescope data of four isolated white dwarfs that were previously known to harbor circumstellar gaseous disks. IRAC photometry shows a significant infrared excess in all of the systems, SDSS0738+1835, SDSS0845+2257, SDSS1043+0855 and SDSS1617+1620, indicative of a dusty extension to those disks. The 4.5-micron excesses seen in SDSS0738, SDSS0845, and SDSS1617 are 7.5, 5.7 and 4.5 times the white dwarf contribution, respectively. In contrast, in SDSS1043, the measured flux density at 4.5 microns is only 1.7 times the white dwarf contribution. We compare the measured IR excesses in the systems to models of geometrically thin, optically thick disks, and find that we are able to match the measured SEDs to within 3 sigma of the uncertainties, although disks with unfeasibly hot inner dust temperatures generally provide a better fit than those below the dust sublimation temperature. Possible explanations for the dearth of dust around SDSS1043+0855 are briefly discussed. Including our previous study of SDSS1228+1040, all five white dwarfs with gaseous debris disks have significant amounts of dust around them. It is evident that gas and dust can coexist around these relatively warm, relatively young white dwarfs.Comment: 20 pages, including 4 figures. Accepted to Ap

Congenital Lymphoedema, Bronchiectasis And Seizure: Case Report

A l0-year-old girl with facial anomalies, mental retardation, peripheral lymphoedema, convulsions, cerebral cortical dysgenetic changes, bronchiectasis and chronic sinusitis is presented. She had features of both yellow nail syndrome and Hennekam syndrome. We think that our case might be a new congenital lymphoedema syndrome or an intermediate form between these syndromes. East African Medical Journal Vol. 85 (3) 2008: pp. 145-14