The ethical foreign policy of the European Union: A legal appraisal.

This thesis is an attempt to analyse, in legal terms, the theory and implementation in practice of an "ethical foreign policy" by the European Union. It focuses on relations between the Union and certain developing States. The thesis is primarily composed of two distinct substantive parts. The first substantive part is composed of two chapters. This part firstly investigates which international legal rules authorise or oblige the Union, the European Community or the Member States to promote certain values in third States or in certain circumstances take action. It further examines the legal limits which under international law constrain such policies. It then goes on to examine policy and practice from a Union/Community law perspective. Here the thesis analyses: the relationship between the Union and Community pillars; the instruments available to the Union and Community in the pursuance of foreign policy objectives; and the scope of the Community and Union's competence in implementing an ethical foreign policy. The second substantive part of thesis examines practice. It analyses the importance attached to ethical values and their relationship with other priorities and objectives. Chapter Four examines relations with Myanmar, Nigeria and Pakistan. Chapter Five looks at relations with the Palestinian Authority and Israel in the overall context of the Middle East Peace Process. Chapter Six examines the Union's policy of humanitarian and emergency aid. The thesis finally attempts to draw some conclusions, as to the efficacy of the policies and instruments utilised and the approaches adopted in practice. It is argued that the Union should concentrate its efforts on certain specific rights and territories and abandon the all-encompassing policy it is currently attempting to implement

Pair production of heavy charged gauge bosons in pppp collisions at LHC

Two opposite charged new heavy gauge boson pair production at the Large Hadron Collider (LHC) is presented in this paper. These bosons are known as $W^{'}$ boson due to the reason that it is the heavy version of Standard Model's weak force carrier, the $W$ boson. The production cross section and decay width in proton-proton ($pp$) collision at \sqrts~= 8 TeV are calculated for different masses and coupling strengths of $W^{'}$. Efficiencies for different signal regions and branching ratios for different decay channels are computed. In this study, the pair production ($W^{'^{+}}W^{'^{-}}$) is considered in emerging new physics as a result of $pp$ collision at \sqrts~= 8 TeV at the LHC with final state containing two tau ($\tau$) leptons and two neutrinos (each $W^{'}$ decay to $\tau$ and its neutrino). The event selection efficiency similar to the CMS experiment is used for the mass of $W^{'}$ to set lower limits for different coupling strengths of $W^{'}$ and results are presented in this work. For heavy gauge bosons, when coupling strength is similar to that of Standard Model's $W$ boson, the mass of $W^{'}$ below 305 GeV are excluded at confidence level of $95\%$.Comment: 21 pages, 16 figure

Duplex PCR assay for the detection of avian adeno virus and chicken anemia virus prevalent in Pakistan

Avian Adeno viruses and Chicken Anemia Viruses cause serious economic losses to the poultry industry of Pakistan each year. Timely and efficient diagnosis of the viruses is needed in order to practice prevention and control strategies. In the first part of this study, we investigated broilers, breeder and Layer stocks for morbidity and mortality rates due to AAV and CAV infections and any co-infections by examining signs and symptoms typical of their infestation or post mortem examination. In the second part of the study, we developed a duplex PCR assay for the detection of AAV and CAV which is capable to simultaneously detect both the viral types prevalent in Pakistan with high sensitivity and 100% specificity

Can retail investors induce corporate green innovation? -Evidence from Baidu Search Index

China's rapid economic development has caused some environmental damage in recent years. The popularity of the Internet has enriched the ways for investors to obtain information, which would exert an impact on corporate environmental behavior. Focusing on micro-enterprise green innovation from the perspective of informal regulation, this paper investigates the impact of investor attention on corporate green innovation. This study takes Chinese A-share listed companies from 2011 to 2018 as samples, constructs panel fixed-effects models and adopts multiple linear, Logistic and Tobit regressions. This article finds that investor attention, measured by the web search index, can significantly improve corporate green innovation. The conclusion is still valid after a series of robust tests. Besides, mechanism tests reveal that investor attention can promote corporate green innovation by improving the implementation efficiency of punitive environmental regulation, the use efficiency of environmental subsidies, and by increasing the reputation cost of enterprises. In additional tests, this paper further clarifies that investors' attention to negative public opinion can play a better role in environmental governance, and reveals the reason why investors are motivated to improve corporate green innovation. This research puts forward a unique perspective, which extends the understanding of informal environmental regulation and enriches research on green innovation at the micro-enterprise level, promoting the cross research of finance and environmental protection. © 2022 The Author(s

Physiological and cell ultrastructure disturbances in wheat seedlings generated by Chenopodium murale hairy root exudate.

Chenopodium murale L. is an invasive weed species significantly interfering with wheat crop. However, the complete nature of its allelopathic influence on crops is not yet fully understood. In the present study, the focus is made on establishing the relation between plant morphophysiological changes and oxidative stress, induced by allelopathic extract. Phytotoxic medium of C. murale hairy root clone R5 reduced the germination rate (24% less than control value) of wheat cv. Nataša seeds, as well as seedling growth, diminishing shoot and root length significantly, decreased total chlorophyll content, and induced abnormal root gravitropism. The R5 treatment caused cellular structural abnormalities, reflecting on the root and leaf cell shape and organization. These abnormalities mostly included the increased number of mitochondria and reorganization of the vacuolar compartment, changes in nucleus shape, and chloroplast organization and distribution. The most significant structural changes were observed in cell wall in the form of amoeboid protrusions and folds leading to its irregular shape. These structural alterations were accompanied by an oxidative stress in tissues of treated wheat seedlings, reflected as increased level of H2O2 and other ROS molecules, an increase of radical scavenging capacity and total phenolic content. Accordingly, the retardation of wheat seedling growth by C. murale allelochemicals may represent a consequence of complex activity involving both cell structure alteration and physiological processes.This is a post-peer-review, pre-copyedit version of an article published in Protoplasma. The final authenticated version is available online at: [http://dx.doi.org/10.1007/s00709-018-1250-0

Cumulative Prognostic Score Predicting Mortality in Patients Older Than 80 Years Admitted to the ICU.

OBJECTIVES: To develop a scoring system model that predicts mortality within 30 days of admission of patients older than 80 years admitted to intensive care units (ICUs). DESIGN: Prospective cohort study. SETTING: A total of 306 ICUs from 24 European countries. PARTICIPANTS: Older adults admitted to European ICUs (N = 3730; median age = 84 years [interquartile range = 81-87 y]; 51.8% male). MEASUREMENTS: Overall, 24 variables available during ICU admission were included as potential predictive variables. Multivariable logistic regression was used to identify independent predictors of 30-day mortality. Model sensitivity, specificity, and accuracy were evaluated with receiver operating characteristic curves. RESULTS: The 30-day-mortality was 1562 (41.9%). In multivariable analysis, these variables were selected as independent predictors of mortality: age, sex, ICU admission diagnosis, Clinical Frailty Scale, Sequential Organ Failure Score, invasive mechanical ventilation, and renal replacement therapy. The discrimination, accuracy, and calibration of the model were good: the area under the curve for a score of 10 or higher was .80, and the Brier score was .18. At a cut point of 10 or higher (75% of all patients), the model predicts 30-day mortality in 91.1% of all patients who die. CONCLUSION: A predictive model of cumulative events predicts 30-day mortality in patients older than 80 years admitted to ICUs. Future studies should include other potential predictor variables including functional status, presence of advance care plans, and assessment of each patient's decision-making capacity

Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study.

BACKGROUND: The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after admission to the ICU. This study aimed to evaluate the influence of modelling approach on the association between the CFS score and short-term mortality and quantify the prognostic value of frailty in this context. METHODS: We analysed data from two multicentre prospective cohort studies which enrolled intensive care unit patients ≥ 80 years old in 26 countries. The primary outcome was mortality within 30-days from admission to the ICU. Logistic regression models for both ICU and 30-day mortality included the CFS score as either a categorical, continuous or dichotomous variable and were adjusted for patient's age, sex, reason for admission to the ICU, and admission Sequential Organ Failure Assessment score. RESULTS: The median age in the sample of 7487 consecutive patients was 84 years (IQR 81-87). The highest fraction of new prognostic information from frailty in the context of 30-day mortality was observed when the CFS score was treated as either a categorical variable using all original levels of frailty or a nonlinear continuous variable and was equal to 9% using these modelling approaches (p < 0.001). The relationship between the CFS score and mortality was nonlinear (p < 0.01). CONCLUSION: Knowledge about a patient's frailty status adds a substantial amount of new prognostic information at the moment of admission to the ICU. Arbitrary simplification of the CFS score into fewer groups than originally intended leads to a loss of information and should be avoided. Trial registration NCT03134807 (VIP1), NCT03370692 (VIP2)