Updated precision measurement of the average lifetime of B hadrons

The measurement of the average lifetime of B hadrons using inclusively reconstructed secondary vertices has been updated using both an improved processing of previous data and additional statistics from new data. This has reduced the statistical and systematic uncertainties and gives \tau_{\mathrm{B}} = 1.582 \pm 0.011\ \mathrm{(stat.)} \pm 0.027\ \mathrm{(syst.)}\ \mathrm{ps.} Combining this result with the previous result based on charged particle impact parameter distributions yields \tau_{\mathrm{B}} = 1.575 \pm 0.010\ \mathrm{(stat.)} \pm 0.026\ \mathrm{(syst.)}\ \mathrm{ps.

Proliferating or Differentiating Stimuli Act on Different Lipid-dependent Signaling Pathways in Nuclei of Human Leukemia Cells

Previous results have shown that the human promyelocytic leukemia HL-60 cell line responds to either proliferating or differentiating stimuli. When these cells are induced to proliferate, protein kinase C (PKC)-βII migrates toward the nucleus, whereas when they are exposed to differentiating agents, there is a nuclear translocation of the α isoform of PKC. As a step toward the elucidation of the early intranuclear events that regulate the proliferation or the differentiation process, we show that in the HL-60 cells, a proliferating stimulus (i.e., insulin-like growth factor-I [IGF-I]) increased nuclear diacylglycerol (DAG) production derived from phosphatidylinositol (4,5) bisphosphate, as indicated by the inhibition exerted by 1-O-octadeyl-2-O-methyl-sn-glycero-3-phosphocholine and U-73122 (1-[6((17β-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-1H-pyrrole-2,5-dione), which are pharmacological inhibitors of phosphoinositide-specific phospholipase C. In contrast, when HL-60 cells were induced to differentiate along the granulocytic lineage by dimethyl sulfoxide, we observed a rise in the nuclear DAG mass, which was sensitive to either neomycin or propranolol, two compounds with inhibitory effect on phospholipase D (PLD)-mediated DAG generation. In nuclei of dimethyl sulfoxide-treated HL-60 cells, we observed a rise in the amount of a 90-kDa PLD, distinct from PLD1 or PLD2. When a phosphatidylinositol (4,5) bisphosphate-derived DAG pool was generated in the nucleus, a selective translocation of PKC-βII occurred. On the other hand, nuclear DAG derived through PLD, recruited PKC-α to the nucleus. Both of these PKC isoforms were phosphorylated on serine residues. These results provide support for the proposal that in the HL-60 cell nucleus there are two independently regulated sources of DAG, both of which are capable of acting as the driving force that attracts to this organelle distinct, DAG-dependent PKC isozymes. Our results assume a particular significance in light of the proposed use of pharmacological inhibitors of PKC-dependent biochemical pathways for the therapy of cancer disease

The evolution of magma during continental rifting: New constraints from the isotopic and trace element signatures of silicic magmas from Ethiopian volcanoes

Magma plays a vital role in the break-up of continental lithosphere. However, significant uncertainty remains about how magma-crust interactions and melt evolution vary during the development of a rift system. Ethiopia captures the transition from continental rifting to incipient sea-floor spreading and has witnessed the eruption of large volumes of silicic volcanic rocks across the region over ∼45 Ma. The petrogenesis of these silicic rocks sheds light on the role of magmatism in rift development, by providing information on crustal interactions, melt fluxes and magmatic differentiation. We report new trace element and Sr–Nd–O isotopic data for volcanic rocks, glasses and minerals along and across active segments of the Main Ethiopian (MER) and Afar Rifts. Most δ18Odata for mineral and glass separates from these active rift zones fall within the bounds of modelled fractional crystallization trajectories from basaltic parent magmas (i.e., 5.5–6.5h) with scant evidence for assimilation of Pan-African Precambrian crustal material (δ18Oof 7–18h). Radiogenic isotopes (εNd= 0.92–6.52; 87Sr/86Sr = 0.7037–0.7072) and incompatible trace element ratios (Rb/Nb 100 km3), and estimate that crystal cumulates fill at least 16–30% of the volume generated by crustal extension under the axial volcanoes of the MER and Manda Hararo Rift Segment (MHRS) of Afar. At Erta Ale only ∼1% of the volume generated due to rift extension is filled by cumulates, supporting previous seismic evidence for a greater role of plate stretching in mature rifts at the onset of sea-floor spreading. We infer that ∼45 Ma of magmatism has left little fusible Pan-African material to be assimilated beneath the magmatic segments and the active segments are predominantly composed of magmatic cumulates with δ18O indistinguishable from mantle-derived melts. We predict that the δ18Oof silicic magmas should converge to mantle values as the rift continues to evolve. Although current data are limited, a comparison with ∼30 Ma ignimbrites (with δ18Oup to 8.9h) supports this inference, evidencing greater crustal assimilation during initial stages of rifting and at times of heightened magmatic flux

Search for the Standard Model Higgs boson at LEP in the year 2000

Searches for the Standard Model Higgs boson have been performed in the data collected by the DELPHI experiment at LEP in the year 2000 at centre-of-mass energies between 200 and 209 GeV corresponding to a total integrated luminosity of 224 pb-1. No evidence for a Higgs signal is observed in the kinematically accessible mass range, and a 95% CL lower mass limit of 114.3 GeV/c2 is set, to be compared with an expected median limit of 113.5 GeV/c2 for these data. © 2001 Elsevier Science B.V

Search for charged Higgs bosons in e+ e- collisions at s**(1/2) = 189-GeV - 202-GeV

A search for pair-produced charged Higgs bosons was performed in the high energy data collected by the DELPHI detector at LEP II at centre-of-mass energies from 189 GeV to 202 GeV. The three different final states, \tau \nu \tau \nu, c \bar s \bar c s and c \bar s \tau \nu were considered. New methods were applied to reject wrong hadronic jet pairings and for the tau identification, where a discriminator based on tau polarisation and polar angles was used. No excess of data compared to the expected Standard Model processes was observed and the existence of a charged Higgs boson with mass lower than 71.5 GeV/c^2 is excluded at the 95% confidence level.Comment: 19 pages, 6 figure

Search for neutralino pair production at √s = 189 GeV

A search for pair-production of neutralinos at a LEP centre-of-mass energy of 189 GeV gave no evidence for a signal. This limits the neutralino production cross-section and excludes regions in the parameter space of the Minimal Supersymmetric Standard Model (MSSM)