An evaluation of a metric method for sex estimation using the clavicle, humerus, radius, and ulna

Sex estimation is important in both forensic and bioarchaeological contexts for the construction of a biological profile, which might aid in the identification process in forensic cases or answer demographic questions in archaeological contexts. The os coxa is generally considered the best indicator of sex, given its reproductive functionality in females, although it is not always available for analysis, thus presenting a need for alternative methods of sex estimation. The present research aims to validate the previous study by Albanese (2013), which examined the use of the clavicle, humerus, radius, and ulna. Albanese (2013) applied logistic regression analysis to the osteometric data and achieved allocation accuracies between 87.4% and 97.5%. A sample size of 400, comprised of American Whites and American Blacks from the William M. Bass Donated Skeletal Collection, was utilized in the present study. The present study applies both discriminant function analysis and logistic regression analysis to a total of 20 measurements collected from the clavicle, humerus, radius, and ulna, including three variant measurements that were proposed by Albanese (2013), and a set discriminant functions and logistic regression equations were produced to classify individuals as male or female. Allocation accuracies as high as 100% were produced by the logistic regression equation that utilized all measurements. Discriminant analysis was applied to each of the bones individually, and the results indicated that the humerus exhibited the most sexual dimorphism and had the highest allocation accuracies (95.0% for males and 97.0% for females). Measurements that exhibited the greatest degree of sexual dimorphism were those representative of joint size such as the maximum diameter of the radial head, the vertical diameter of the humeral head, and the epicondylar breadth of the humerus. A set of equations were produced through discriminant function analysis, which are representative of various recovery scenarios and are meant to provide the examiner with sets of equations that might be applicable to a particular case. Because of its high allocation accuracies and its applicability to contemporary American White and Black populations, the methodology should be useful in forensic contexts within the United States. Sex estimation is important in both forensic and bioarchaeological contexts for the construction of a biological profile, which might aid in the identification process in forensic cases or answer demographic questions in archaeological contexts. The os coxa is generally considered the best indicator of sex, given its reproductive functionality in females, although it is not always available for analysis, thus presenting a need for alternative methods of sex estimation. The present research aims to validate the previous study by Albanese (2013), which examined the use of the clavicle, humerus, radius, and ulna. Albanese (2013) applied logistic regression analysis to the osteometric data and achieved allocation accuracies between 87.4% and 97.5%. A sample size of 400, comprised of American Whites and American Blacks from the William M. Bass Donated Skeletal Collection, was utilized in the present study. The present study applies both discriminant function analysis and logistic regression analysis to a total of 20 measurements collected from the clavicle, humerus, radius, and ulna, including three variant measurements that were proposed by Albanese (2013), and a set discriminant functions and logistic regression equations were produced to classify individuals as male or female. Allocation accuracies as high as 100% were produced by the logistic regression equation that utilized all measurements. Discriminant analysis was applied to each of the bones individually, and the results indicated that the humerus exhibited the most sexual dimorphism and had the highest allocation accuracies (95.0% for males and 97.0% for females). Measurements that exhibited the greatest degree of sexual dimorphism were those representative of joint size such as the maximum diameter of the radial head, the vertical diameter of the humeral head, and the epicondylar breadth of the humerus. A set of equations were produced through discriminant function analysis, which are representative of various recovery scenarios and are meant to provide the examiner with sets of equations that might be applicable to a particular case. Because of its high allocation accuracies and its applicability to contemporary American White and Black populations, the methodology should be useful in forensic contexts within the United States

Irish Travellers and the Transformative Nature of Media Representation

The Travellers, a nomadic group of people indigenous to Ireland, have long been marginalized in Irish society as a result of discrimination. The Travellers themselves have had a history of working to keep themselves separate from the settled Irish, essentially maintaining their own ethnic identity. Traveller culture has undergone a number of changes since the 1960s, a period of increasing urbanization and economic transformation in Ireland. With the changes in both Traveller culture and Irish society as a whole, there has been a corresponding shift to a more positive relationship between the media (newspapers, documentaries, and commercial films and television) and this marginalized group of people. This shift is largely due to a transformation in the Travellers’ self-perception along with their discovery of the importance of self-promotion and the recognition of the media as a tool through which to channel this self-presentation to the larger Irish society

Detailed Profiling of the Tumor Microenvironment in Ethnic Breast Cancer, Using Tissue Microarrays and Multiplex Immunofluorescence

Breast cancer poses a global health challenge, yet the influence of ethnicity on the tumor microenvironment (TME) remains understudied. In this investigation, we examined immune cell infiltration in 230 breast cancer samples, emphasizing diverse ethnic populations. Leveraging tissue microarrays (TMAs) and core samples, we applied multiplex immunofluorescence (mIF) to dissect immune cell subtypes across TME regions. Our analysis revealed distinct immune cell distribution patterns, particularly enriched in aggressive molecular subtypes triple-negative and HER2-positive tumors. We observed significant correlations between immune cell abundance and key clinicopathological parameters, including tumor size, lymph node involvement, and patient overall survival. Notably, immune cell location within different TME regions showed varying correlations with clinicopathologic parameters. Additionally, ethnicities exhibited diverse distributions of cells, with certain ethnicities showing higher abundance compared to others. In TMA samples, patients of Chinese and Caribbean origin displayed significantly lower numbers of B cells, TAMs, and FOXP3-positive cells. These findings highlight the intricate interplay between immune cells and breast cancer progression, with implications for personalized treatment strategies. Moving forward, integrating advanced imaging techniques, and exploring immune cell heterogeneity in diverse ethnic cohorts can uncover novel immune signatures and guide tailored immunotherapeutic interventions, ultimately improving breast cancer management.</p

Development of a European Centre of Excellence (Coe) for Research in Continuing Professional Development (UPGRADE)

The European Centre of Excellence (CoE) for Research in Continuing Professional Development (UPGRADE) is a pan-European network of researchers, clinicians, regulators, educators, and professional bodies, established in 2020 through a consensus group of experts, who defined its mission, vision, values, aims and objectives. The Centre’s aim is to advance the science of Continuing Professional Development (CPD) for healthcare professionals through research and dissemination of best practices for CPD. Debate among UPGRADE partners and interchange of research data will yield best practices across countries to optimise quality CPD programmes. Collaboration, information exchange and communication among CPD experts will be facilitated through UPGRADE via an online Community of Inquiry (CoI). UPGRADE aims to evolve as a driving force network of academics and health professional leaders in research, education, professional regulation, and clinical practice whose collaborative work ensures quality and safe person-centred care. UPGRADE members are from 22 European countries, represented by strategic leaders in diverse sectors of health, policy, academia, and professional organisations. Three research-working groups constitute the pillars of UPGRADE, which addresses gaps in research, collect and create critical databases, and solidify the effectiveness of CPD

A genetic history of the Balkans from Roman frontier to Slavic migrations

[Summary] The rise and fall of the Roman Empire was a socio-political process with enormous ramifications for human history. The Middle Danube was a crucial frontier and a crossroads for population and cultural movement. Here, we present genome-wide data from 136 Balkan individuals dated to the 1st millennium CE. Despite extensive militarization and cultural influence, we find little ancestry contribution from peoples of Italic descent. However, we trace a large-scale influx of people of Anatolian ancestry during the Imperial period. Between ∼250 and 550 CE, we detect migrants with ancestry from Central/Northern Europe and the Steppe, confirming that “barbarian” migrations were propelled by ethnically diverse confederations. Following the end of Roman control, we detect the large-scale arrival of individuals who were genetically similar to modern Eastern European Slavic-speaking populations, who contributed 30%–60% of the ancestry of Balkan people, representing one of the largest permanent demographic changes anywhere in Europe during the Migration Period.We thank the funding agencies for this study: PGC2018-0955931-B-100 grant (MCIU/AEI/FEDER, UE) of the Spanish Ministry of Science of Innovation (C.L.-F.), PID2021-124590NB-100 grant of the Spanish Ministry of Science of Innovation (C.L.-F.), fellowship from “la Caixa” Foundation (ID 100010434), code LCF/BQ-ES11/10000073 (I.O.), grant “Ayudas para contratos Ramón y Cajal” funded by MCIN/AEI/10.13039/501100011033 and by “ESF Investing in your future” (I.O.), FPI-2019 (Spanish Ministry of Science of Innovation, BDNS ID: 476421) (P.C.), NSERC Discovery grant (Canada) RGPIN-2018-05989 (M.G.), Ministry of Science and Education of the Republic of Croatia (grant 533-03-19-0002) (M.N.), National Institutes of Health funding (HG012287) (D.R.), John Templeton Foundation (grant 61220) (D.R.), gifts from J.-F. Clin (D.R. and I.O.), the Allen Discovery Center, a Paul G. Allen Frontiers Group advised program of the Paul G. Allen Family Foundation (D.R.), and the Howard Hughes Medical Institute (D.R.).Peer reviewe

A qualitative systematic review of family caregivers’ experiences of artificial nutrition and hydration at home: A meta-ethnography

Background: Artificial nutrition and hydration (AN&H) may be provided toindividuals in the home environment, and family caregivers are often involved in the management of this intervention. This experience can have multiple consequences for families. Aims: The aim of this meta-ethnography is to explore and synthesize the personal experiences of family caregivers providing care to a person receiving home AN&H. Methods & Procedures: A comprehensive search of the literature was conducted without any time limitations applied. Seven stages of meta-ethnography were followed. Public and patient involvement was incorporated into the development of the line of argument synthesis in this review. This review is reported following the eMERGe guidelines and it was registered in PROSPERO. Main Contribution: A total of 22 studies were included representing the experiences of 336 family caregivers. Two main themes emerged: (1) sink or swim, being thrown in at the deep end; and (2) professional support as a bedrock. The first theme represents the experiences from the very start of home AN&H when the family caregivers may be overwhelmed with the level of skills they have to acquire. With time, family caregivers perceived the benefits, but also the challenges, associated with managing home AN&H. If a person receiving home AN&H was able to continue with some oral intake, it had a positive impact on family caregivers’ experiences. The second theme represents the influence of professional support on the lived experience of family caregivers managing home AN&H. This support should be individualized, comprehensive, and co-created with the family caregiver and the person receiving home AN&H. Conclusions & Implications: This review concluded that caring for a person receiving home AN&H can be very challenging for family caregivers. Family caregivers require personalized support from a multidisciplinary team of healthcare professionals to acquire skills, competence and confidence in this new role. Speech and language therapists are important members of this multidisciplinary team because they can facilitate a continuation of oral intake as appropriate.</p

Restricted reproductive rights and risky sexual behaviour: how political disenfranchisement relates to women’s sense of control, well-being and sexual health

Few studies have investigated the role of disenfranchisement and denial of agency in women’s sexual health. To address this, a cross-sectional study of disenfranchisement, control (general and reproductive control) and health was conducted in Ireland, where abortion is severely restricted. Multiple mediation models (N = 513 women) indicated that general but not reproductive control mediates the association between disenfranchisement and psychological well-being. Additionally, serial mediation shows disenfranchisement is associated with lower sense of control, which is linked to poorer well-being and risky sexual behaviour. Disenfranchisement arising from socio-political contexts may have important implications for women’s sexual health

A blood biomarker and clinical correlation cohort study protocol to diagnose sports-related concussion and monitor recovery in elite rugby

Introduction In professional rugby, sports-related concussion (SRC) remains the most frequent time loss injury. Therefore, accurately diagnosing SRC and monitoring player recovery, through a multi-modal assessment process, is critical to SRC management. In this protocol study, we aim to assess SRC over multiple time points post-injury to determine the value of multi-modal assessments to monitor player recovery. This is of significance to minimise premature return-to-play and, ultimately, to reduce the long-term effects associated with SRC. The study will also establish the logistics of implementing such a study in a professional setting to monitor a player’s SRC recovery. Methods and analysis All players from the participating professional rugby club within the Irish Rugby Football Union are invited to participate in the current study. Player assessment includes head injury assessment (HIA), neuropsychometric assessment (ImPACT), targeted biomarker analysis and untargeted biomarker analysis. Baseline HIA, ImPACT, and blood draws are performed prior to the start of playing season. During the baseline tests, player’s complete consent forms and an SRC history questionnaire. Subsequently, any participant that enters the HIA process over the playing season due to a suspected SRC will be clinically assessed (HIA and ImPACT) and their blood will be drawn within 3 days of injury, 6 days post-injury, and 13 days post-injury. Ethics and dissemination Ethical approval was attained from the Science and Engineering Research Ethics Committee, University of Limerick (Approval Code: 2018_06_11_S&E). On completion of the study, further manuscripts will be published to present the results of the tests and their ability to measure player recovery from SRC. Trial registration number NCT04485494

Large-scale migration into Britain during the Middle to Late Bronze Age

Present-day people from England and Wales harbour more ancestry derived from Early European Farmers (EEF) than people of the Early Bronze Age . To understand this, we generated genome-wide data from 793 individuals, increasing data from the Middle to Late Bronze and Iron Age in Britain by 12-fold, and Western and Central Europe by 3.5-fold. Between 1000 and 875 BC, EEF ancestry increased in southern Britain (England and Wales) but not northern Britain (Scotland) due to incorporation of migrants who arrived at this time and over previous centuries, and who were genetically most similar to ancient individuals from France. These migrants contributed about half the ancestry of Iron Age people of England and Wales, thereby creating a plausible vector for the spread of early Celtic languages into Britain. These patterns are part of a broader trend of EEF ancestry becoming more similar across central and western Europe in the Middle to Late Bronze Age, coincident with archaeological evidence of intensified cultural exchange . There was comparatively less gene flow from continental Europe during the Iron Age, and Britain's independent genetic trajectory is also reflected in the rise of the allele conferring lactase persistence to ~50% by this time compared to ~7% in central Europe where it rose rapidly in frequency only a millennium later. This suggests that dairy products were used in qualitatively different ways in Britain and in central Europe over this period. [Abstract copyright: © 2021. The Author(s), under exclusive licence to Springer Nature Limited.