New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Alternative Formulas for Distributing Parental Incomes at Divorce

The current study applied five formulas for distributing parental incomes at divorce to 414 court case records in Minnesota and evaluated which formulas and actual court orders provided sufficient incomes for male and female-headed households. The study further explored influences of pre-divorce gross income levels, household/genders, and lengths of marriage on the post-divorce income-to-needs ratios (ITN) produced by the five formulas and actual court orders, using MANOVA. Results were interpreted using distributive justice principles of equity, needs, and contributions. Males have higher ITN with each alternative, except the income-sharing formula. The actual court orders and the income-sharing formula produce the largest discrepancy between male and female ITN and the highest percentage of females living below poverty level guidelines. Copyright Springer Science+Business Media, Inc. 2006divorce, income distributions, spousal support.,