Career Engine

Everyone\u27s learning is increasing in this competitive environment, to the point that professional chances are becoming scarce. Companies desire the greatest personnel in their areas. It was difficult to find persons who were bright enough to be recruited at the time. Companies’ attempts to find qualified employees are also increasing. The purpose of this application is to provide a system that allows employers and candidates to communicate with one another. The idea is to speed up the recruiting process by facilitating contact between interested parties. A career engine is a website that offers recruiters and job seekers with online information. Our application helps both job searchers and recruiters choose the finest company for their workers. For job seekers, the employment site presents a list of companies based on their educational credentials, experience, and interests. Furthermore, it offers appropriate candidates from a pool of shortages to recruiters. In this project, we utilized MySQL to store the data, and the frontend is constructed using HTML5, CSS3, Bootstrap, JavaScript, and the backend for PHP is made with the MVC CodeIgniter framework. In our application, we use the technological stacks listed above. Our application presented three responsibilities: job searchers, recruiters, and administrators. The responsibility of the job seeker is to apply for the position and offer feedback to the business. The following recruiter\u27s role is to publicize job vacancies, contact job seekers, and conduct interviews on their behalf. All users, including job seekers, recruiters, and job listings, must be tracked by the administrator

Gliquidone

The title compound {systematic name: N-cyclo­hexyl­carba­moyl-4-[2-(7-meth­oxy-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetra­hydro­isoquinolin-2-yl)eth­yl]benzene­sulfonamide}, C27H33N3O6S, displays an intra­molecular N—H⋯O=S inter­action, as well as inter­molecular N—H⋯O=C hydrogen bonds. The latter inter­actions lead to the formation of hydrogen-bonded chains parallel to the c axis. The conformation of the sulfonyl­urea fragment is in agreement with a recent theoretical study [Kasetti et al. (2010 ▶). J. Phys. Chem. B, 114, 11603–11610]

Personality traits and pre-treatment beliefs and cognitions predicting patient adherence to continuous positive airway pressure : a systematic review

Adherence to Continuous Positive Airway Pressure for obstructive sleep apnoea (OSA) can be improved by behavioural interventions which modify patients’ beliefs and cognitions about OSA, CPAP, and themselves. We have conducted the first systematic review of the literature on beliefs and cognitions held before starting treatment, and personality (which influences the former) that predict the decision to purchase or start CPAP, or CPAP adherence one month or more after CPAP initiation. A systematic search and screen of articles identified 21 eligible publications from an initial 1317. Quality assessment performed using an adapted Newcastle-Ottawa Scale demonstrated that 13 (62%) studies were poor quality and only seven (33%) were high quality. Eighteen factors, such as self-efficacy (confidence) in using CPAP and value placed on health predicted CPAP adherence; however, for only six (33%), utility as an intervention target is known, from calculation of individual predictive power. Studies did not use new behavioural frameworks effective at explaining adherence behaviours, nor did they interview patients to collect in-depth data on barriers and facilitators of CPAP use. Future studies cannot have these limitations if high quality evidence is to be generated for intervention development, which is currently sparse as highlighted by this review

CRISPR-Cas9–based treatment of myocilin-associated glaucoma

Primary open-angle glaucoma (POAG) is a leading cause of irreversible vision loss worldwide, with elevated intraocular pressure (IOP) a major risk factor. Myocilin (MYOC) dominant gain-of-function mutations have been reported in ∼4% of POAG cases. MYOC mutations result in protein misfolding, leading to endoplasmic reticulum (ER) stress in the trabecular meshwork (TM), the tissue that regulates IOP. We use CRISPR-Cas9–med iated genome editing in cultured human TM cells and in a MYOC mouse model of POAG to knock down expression of mutant MYOC, resulting in relief of ER stress. In vivo genome editing results in lower IOP and prevents further glaucomatous damage. Importantly, using an ex vivo human organ culture system, we demonstrate the feasibility of human genome editing in the eye for this important disease. Keywords: myocilin; CRISPR; glaucoma; trabecular meshwork; genome editingNational Institutes of Health (U.S.) (Grant R01 EY024259)National Institutes of Health (U.S.) (Grant R01 EY026177)National Institutes of Health (U.S.) (Grant R00 EY022077

The SuperFGD Prototype charged particle beam tests

A novel scintillator detector, the SuperFGD, has been selected as the main neutrino target for an upgrade of the T2K experiment ND280 near detector. The detector design will allow nearly 4π coverage for neutrino interactions at the near detector and will provide lower energy thresholds, significantly reducing systematic errors for the experiment. The SuperFGD is made of optically-isolated scintillator cubes of size 10×10×10 mm3, providing the required spatial and energy resolution to reduce systematic uncertainties for future T2K runs. The SuperFGD for T2K will have close to two million cubes in a 1920 × 560 × 1840 mm3 volume. A prototype made of 24 × 8 × 48 cubes was tested at a charged particle beamline at the CERN PS facility. The SuperFGD Prototype was instrumented with readout electronics similar to the future implementation for T2K . Results on electronics and detector response are reported in this paper, along with a discussion of the 3D reconstruction capabilities of this type of detector. Several physics analyses with the prototype data are also discussed, including a study of stopping protons

First measurement of electron neutrino appearance in NOvA

We report results from the first search for νμ→νe transitions by the NOvA experiment. In an exposure equivalent to 2.74×1020 protons on target in the upgraded NuMI beam at Fermilab, we observe 6 events in the Far Detector, compared to a background expectation of 0.99±0.11(syst) events based on the Near Detector measurement. A secondary analysis observes 11 events with a background of 1.07±0.14(syst). The 3.3σ excess of events observed in the primary analysis disfavors 0.1π<δCP<0.5π in the inverted mass hierarchy at the 90% C.L

First measurement of muon-neutrino disappearance in NOvA

This paper reports the first measurement using the NOvA detectors of νμ disappearance in a νμ beam. The analysis uses a 14 kton-equivalent exposure of 2.74×1020 protons-on-target from the Fermilab NuMI beam. Assuming the normal neutrino mass hierarchy, we measure Δm232=(2.52+0.20−0.18)×10−3  eV2 and sin2θ23 in the range 0.38–0.65, both at the 68% confidence level, with two statistically degenerate best-fit points at sin2θ23=0.43 and 0.60. Results for the inverted mass hierarchy are also presented

Search for electron antineutrino appearance in a long-baseline muon antineutrino beam

Electron antineutrino appearance is measured by the T2K experiment in an accelerator-produced antineutrino beam, using additional neutrino beam operation to constrain parameters of the Pontecorvo-Maki-Nakagawa-Sakata (PMNS) mixing matrix. T2K observes 15 candidate electron antineutrino events with a background expectation of 9.3 events. Including information from the kinematic distribution of observed events, the hypothesis of no electron antineutrino appearance is disfavored with a significance of 2.40σ and no discrepancy between data and PMNS predictions is found. A complementary analysis that introduces an additional free parameter which allows non-PMNS values of electron neutrino and antineutrino appearance also finds no discrepancy between data and PMNS predictions