An ALMA survey of sub-millimetre galaxies in the extended chandra deep field south: The far-infrared properties of SMGs

We exploit Atacama Large Millimeter Array (ALMA) 870 μm observations of sub-millimetre sources in the Extended Chandra Deep Field South to investigate the far-infrared properties of high-redshift sub-millimetre galaxies (SMGs). Using the precisely located 870 μm ALMA positions of 99 SMGs, together with 24μm and radio imaging, we deblend the Herschel/SPIRE imaging to extract their far-infrared fluxes and colours. The median redshifts for ALMA LESS (ALESS) SMGs which are detected in at least two SPIRE bands increases with wavelength of the peak in their spectral energy distributions (SEDs), with z = 2.3 ± 0.2, 2.5 ± 0.3 and 3.5 ± 0.5 for the 250, 350 and 500 μm peakers, respectively. 34 ALESS SMGs do not have a >3σ counterpart at 250, 350 or 500 μm. These galaxies have a median photometric redshift derived from the rest-frame UV–mid-infrared SEDs of z = 3.3 ± 0.5, which is higher than the full ALESS SMG sample; z = 2.5 ± 0.2. We estimate the far-infrared luminosities and characteristic dust temperature of each SMG, deriving LIR = (3.0 ± 0.3) × 1012 L⊙ (SFR = 300 ± 30 M⊙ yr−1) and Td = 32 ± 1 K. The characteristic dust temperature of these high-redshift SMGs is ΔTd = 3–5 K lower than comparably luminous galaxies at z = 0, reflecting the more extended star formation in these systems. We show that the contribution of S870 μm ≥ 1 mJy SMGs to the cosmic star formation budget is 20 per cent of the total over the redshift range z ∼ 1–4. Adopting an appropriate gas-to-dust ratio, we estimate a typical molecular mass of the ALESS SMGs of MH2 = (4.2 ± 0.4) × 1010 M⊙. Finally, we show that SMGs with S870 μm > 1 mJy (LIR ≳ 1012 L⊙) contain ∼ 10 per cent of the z ∼ 2 volume-averaged H2 mass density

Priming of microglia in a DNA-repair deficient model of accelerated aging

AbstractAging is associated with reduced function, degenerative changes, and increased neuroinflammation of the central nervous system (CNS). Increasing evidence suggests that changes in microglia cells contribute to the age-related deterioration of the CNS. The most prominent age-related change of microglia is enhanced sensitivity to inflammatory stimuli, referred to as priming. It is unclear if priming is due to intrinsic microglia ageing or induced by the ageing neural environment. We have studied this in Ercc1 mutant mice, a DNA repair-deficient mouse model that displays features of accelerated aging in multiple tissues including the CNS. In Ercc1 mutant mice, microglia showed hallmark features of priming such as an exaggerated response to peripheral lipopolysaccharide exposure in terms of cytokine expression and phagocytosis. Specific targeting of the Ercc1 deletion to forebrain neurons resulted in a progressive priming response in microglia exemplified by phenotypic alterations. Summarizing, these data show that neuronal genotoxic stress is sufficient to switch microglia from a resting to a primed state

Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data

Background: Recently an important role for synovial pathology in the initiation and progression of knee osteoarthritis (OA) has been emphasised. This study aimed to examine whether ultrasonographydetected synovial changes (USSCs) associate with knee pain (KP) in a community population. Methods: A case-control study was conducted to compare people with early KP (n=298), established KP (n=100) or no KP (n=94) at baseline. Multinomial logistic regression was used to estimate odds ratio (OR) and 95% confidence interval (CI) between groups adjusted for radiographic osteoarthritis (ROA) severity and other confounding factors. After one year 255 participants with early and established KP completed the followup questionnaire for changes in KP. Logistic regression with adjustment was used to determine predictors of KP worsening. Results: At baseline, effusion was associated with early (OR 2.64, 95%CI 1.57 to 4.45) and established KP (OR 5.07, 95%CI 2.74 to 9.38). Synovial hypertrophy was also associated with early (OR 5.43, 95%CI 2.12 to 13.92) and established KP (OR 13.27, 95%CI 4.97 to 35.43). The association with effusion diminished when adjusted for ROA. Power Doppler signal was uncommon (early KP 3%, established KP 2%, controls 0%). Baseline effusion predicted worsening of knee pain at one year (OR 1.95, 95% CI 1.05 to 3.64). However, after adjusting for ROA, the prediction was insignificant (aORs 0.95, 95%CI 0.44 to 2.02). Conclusion: US effusion and synovial hypertrophy are associated with KP, but only effusion predicts KP worsening. However, the association/prediction are not independent from ROA. Power Doppler signal is uncommon in people with KP. Further study is needed to understand whether synovitis is directly involved in different types of KP

HDL Interfere with the Binding of T Cell Microparticles to Human Monocytes to Inhibit Pro-Inflammatory Cytokine Production

BACKGROUND: Direct cellular contact with stimulated T cells is a potent mechanism that induces cytokine production in human monocytes in the absence of an infectious agent. This mechanism is likely to be relevant to T cell-mediated inflammatory diseases such as rheumatoid arthritis and multiple sclerosis. Microparticles (MP) generated by stimulated T cells (MPT) display similar monocyte activating ability to whole T cells, isolated T cell membranes, or solubilized T cell membranes. We previously demonstrated that high-density lipoproteins (HDL) inhibited T cell contact- and MPT-induced production of IL-1beta but not of its natural inhibitor, the secreted form of IL-1 receptor antagonist (sIL-1Ra). METHODOLOGY/PRINCIPAL FINDINGS: Labeled MPT were used to assess their interaction with monocytes and T lymphocytes by flow cytometry. Similarly, interactions of labeled HDL with monocytes and MPT were assessed by flow cytometry. In parallel, the MPT-induction of IL-1beta and sIL-1Ra production in human monocytes and the effect of HDL were assessed in cell cultures. The results show that MPT, but not MP generated by activated endothelial cells, bond monocytes to trigger cytokine production. MPT did not bind T cells. The inhibition of IL-1beta production by HDL correlated with the inhibition of MPT binding to monocytes. HDL interacted with MPT rather than with monocytes suggesting that they bound the activating factor(s) of T cell surface. Furthermore, prototypical pro-inflammatory cytokines and chemokines such as TNF, IL-6, IL-8, CCL3 and CCL4 displayed a pattern of production induced by MPT and inhibition by HDL similar to IL-1beta, whereas the production of CCL2, like that of sIL-1Ra, was not inhibited by HDL. CONCLUSIONS/SIGNIFICANCE: HDL inhibit both MPT binding to monocytes and the MPT-induced production of some but not all cytokines, shedding new light on the mechanism by which HDL display their anti-inflammatory functions

X-ray stacking of Lyman break galaxies in the 4 Ms CDF-S: X-ray luminosities and star formation rates across cosmic time

Context. Lyman break galaxies (LBGs) are widely thought to be prototypical young galaxies in the early universe, particularly representative of those undergoing massive events of star formation. Therefore, LBGs should produce significant amounts of X-ray emission. Aims. We aim to trace the X-ray luminosity of LBGs across cosmic time and from that derive constraints on their star formation history. Methods. We utilize the newly released 4 Ms mosaic obtained with the Chandra X-ray Observatory, the deepest X-ray image to date, alongside with the superb spectroscopic data sets available in the CDF-S survey region to construct large but nearly uncontaminated samples of LBGs across a wide range of redshift (0.5 < z < 4.5) which can be used as input samples for stacking experiments. This approach allows us to trace the X-ray emission of LBGs to even lower, previously unreachable, flux density limits (~10 -18 mW m -2) and therefore to larger redshifts. Results. We reliably detect soft-band X-ray emission from all our input redshift bins except for the highest redshift (z ~ 4) one. From that we derive rest-frame 2-10 keV luminosities and infer star formation rates and stellar masses. We find that star formation in LBGs peaks at a redshift of z peak 3.5 and then decreases quickly. We also see a characteristic peak in the specific star formation rate (sSFR = SFR/M -) at this redshift. Furthermore, we calculate the contribution of LBGs to the total cosmic star formation rate density (SFRD) and find that the contribution of LBGs is negligible. Therefore, we conclude that most of the star formation in the early universe takes place in lower luminosity galaxies as suggested by hierarchical structure formation models

A 3D cellular context for the macromolecular world

We report the outcomes of the discussion initiated at the workshop entitled A 3D Cellular Context for the Macromolecular World and propose how data from emerging three-dimensional (3D) cellular imaging techniques—such as electron tomography, 3D scanning electron microscopy and soft X-ray tomography—should be archived, curated, validated and disseminated, to enable their interpretation and reuse by the biomedical community

A Single Gene Target of an ETS-Family Transcription Factor Determines Neuronal CO2-Chemosensitivity

Many animals possess neurons specialized for the detection of carbon dioxide (CO2), which acts as a cue to elicit behavioral responses and is also an internally generated product of respiration that regulates animal physiology. In many organisms how such neurons detect CO2 is poorly understood. We report here a mechanism that endows C. elegans neurons with the ability to detect CO2. The ETS-5 transcription factor is necessary for the specification of CO2-sensing BAG neurons. Expression of a single ETS-5 target gene, gcy-9, which encodes a receptor-type guanylate cyclase, is sufficient to bypass a requirement for ets-5 in CO2-detection and transforms neurons into CO2-sensing neurons. Because ETS-5 and GCY-9 are members of gene families that are conserved between nematodes and vertebrates, a similar mechanism might act in the specification of CO2-sensing neurons in other phyla

Reliability and validity of ultrasound imaging of features of knee osteoarthritis in the community

<p>Abstract</p> <p>Background</p> <p>Radiographs are the main outcome measure in epidemiological studies of osteoarthritis (OA). Ultrasound imaging has unique advantages in that it involves no ionising radiation, is easy to use and visualises soft tissue structures. Our objective was to measure the inter-rater reliability and validity of ultrasound imaging in the detection of features of knee OA.</p> <p>Methods</p> <p>Eighteen participants from a community cohort, had both knees scanned by two trained musculoskeletal sonographers, up to six weeks apart. Inter-rater reliability for osteophytes, effusion size and cartilage thickness was calculated by estimating Kappa (κ) and Intraclass correlation coefficients (ICC), as appropriate. A measure of construct validity was determined by estimating κ between the two imaging modalities in the detection of osteophytes.</p> <p>Results</p> <p><it>Reliability: </it>κ for osteophyte presence was 0.77(right femur), 0.65(left femur) and 0.88 for both tibia. ICCs for effusion size were 0.70(right) and 0.85(left). Moderate to substantial agreement was found in cartilage thickness measurements. <it>Validity: </it>For osteophytes, κ was moderate to excellent at 0.52(right) and 0.75(left).</p> <p>Conclusion</p> <p>Substantial to excellent agreement was found between ultrasound observers for the presence of osteophytes and measurement of effusion size; it was moderate to substantial for femoral cartilage thickness. Moderate to substantial agreement was observed between ultrasound and radiographs for osteophyte presence.</p

VizieR Online Data Catalog: An ALMA survey of ECDFS submillimeter galaxies (Simpson+, 2014)

In this study we undertake a multi-wavelength analysis of the ALMA-detected submm galaxies from the catalog presented by Hodge et al. (2013, J/ApJ/768/91) (see also Karim et al. 2013MNRAS.432....2K). To briefly summarize the observations, we obtained 120 s integrations of 122 of the original 126 LESS submm sources, initially identified using the LABOCA camera on the APEX telescope (Weiss et al. 2009, J/ApJ/707/1201). These Cycle 0 observations used the compact configuration, yielding a median synthesized beam of ~1.6"x1.2". The observing frequency was matched to the original LESS survey, 344 GHz (Band 7), and we reach a typical rms across our velocity-integrated maps of 0.4 mJy/beam. (3 data files)

Enhanced star formation rates in AGN hosts with respect to inactive galaxies from PEP-Herschel observations

We compare the average star formation (SF) activity in X-ray selected AGN hosts with mass-matched control inactive galaxies,including star forming and quiescent sources, at 0.5<z<2.5. Recent observations carried out by PACS, the 60-210um Herschel photometric camera, in GOODS-S, GOODS-N and COSMOS allow us to unbiasedly estimate the far-IR luminosity, and hence the SF properties, of the two samples. Accurate AGN host stellar masses are measured by decomposing their total emission into the stellar and nuclear components. We find a higher average SF activity in AGN hosts with respect to non-AGNs. The level of SF enhancement is modest (~0.26dex at ~3sigma) at low X-ray luminosities (Lx10sigma) for bright AGNs. However, when comparing to star forming galaxies only, AGN hosts are broadly consistent with the locus of their `main sequence'. We investigate the relative far-IR luminosity distributions of active and inactive galaxies, and find a higher fraction of PACS detected, hence normal and highly star forming systems among AGN hosts. Although different interpretations are possible, we explain our findings as a consequence of a twofold AGN growth path: faint AGNs evolve through secular processes, with instantaneous AGN accretion not tightly linked to the current total SF in the host, while luminous AGNs co-evolve with their hosts through periods of enhanced AGN activity and SF, possibly through major mergers. While an increased SF with respect to non-AGNs of similar mass is expected in the latter, we interpret the modest SF offsets measured in low-Lx AGN hosts as either a) generated by non-synchronous accretion and SF histories in a merger scenario or b) due to possible connections between instantaneous SF and accretion that can be induced by smaller scale (non-major merger) mechanisms. Far-IR luminosity distributions favour the latter scenario.Comment: Final versio