Magnetic-field asymmetry of electron wave packet transmission in bent channels capacitively coupled to a metal gate

We study the electron wave packet moving through a bent channel. We demonstrate that the packet transmission probability becomes an uneven function of the magnetic field when the electron packet is capacitively coupled to a metal plate. The coupling occurs through a non-linear potential which translates a different kinetics of the transport for opposite magnetic field orientations into a different potential felt by the scattered electron

Personal and Perceived Peer Use of and Attitudes Toward Alcohol Among University and College Students in Seven EU Countries: Project SNIPE.

The objective of this study was to explore perceptions of peer substance use and related attitudes among European students. Challenging perceptions about peer substance use has become the basis of a form of prevention and intervention known as the social norms approach, which can be delivered using personalized online feedback. This article reports baseline alcohol use and attitudes data for university students across Europe collected as part of the Social Norms Intervention for the prevention of Polydrug usE project (Project SNIPE)

Student estimations of peer alcohol consumption: links between the Social Norms Approach and the Health Promoting University concept.

The Social Norms Approach, with its focus on positive behaviour and its consensus orientation, is a health promotion intervention of relevance to the context of a Health Promoting University. In particular, the approach could assist with addressing excessive alcohol consumption

Normative perceptions of cannabis use amongst European University students: associations between perceived peer use and peer attitudes with personal use and attitudes.

Objective: Perceptions of peer behavior and attitudes exert considerable social pressure on young adults to use substances. This study investigated whether European students perceive their peers’ cannabis use and approval of cannabis use to be higher than their own personal behaviors and attitudes, and whether estimations of peer use and attitudes are associated with personal use and attitudes. Method: University students (n = 4131) from Belgium, Denmark, Germany, the Slovak Republic, Spain, Turkey and the United Kingdom completed an online survey as part of the Social Norms Intervention for Polysubstance usE in students (SNIPE) project, a feasibility study of a web-based normative feedback intervention for substance use. The survey assessed students’ (1) personal substance use and attitudes, and (2) perceptions of their peers’ cannabis use (descriptive norms) and attitudes (injunctive norms). Results: Although most respondents (92%) did not personally use cannabis in the past two months, the majority of students thought that the majority of their peers were using cannabis and that their peers had more permissive attitudes towards cannabis than themselves. Controlling for students’ age, sex, study year and religious beliefs, perceived peer descriptive norms were associated with personal cannabis use (OR: 1.42; 95% CI: 1.22, 1.64) and perceived injunctive norms were associated with personal attitudes towards cannabis use (OR: 1.46; 95% CI: 1.09, 1.94). Conclusions: European students appear to possess similar discrepancies between personal and perceived peer norms for cannabis use and attitudes as found in North American students. Interventions which address such discrepancies may be effective in reducing cannabis use. Keywords: cannabis, social norms, student health, social influenc

Pigmentary retinopathy can indicate the presence of pathogenic LAMP2 variants even in somatic mosaic carriers with no additional signs of Danon disease

PURPOSE: Danon disease (DD) is a rare X-linked disorder caused by pathogenic variants in LAMP2. DD primarily manifests as a severe cardiomyopathy. An early diagnosis is crucial for patient survival. The aim of the study was to determine the usefulness of ocular examination for identification of DD. METHODS: Detailed ocular examination in 10 patients with DD (3 males, 7 females) and a 45-year-old asymptomatic female somatic mosaic carrier of a LAMP2 disease-causing variant. RESULTS: All patients with manifest cardiomyopathy had pigmentary retinopathy with altered autofluorescence and diffuse visual field loss. Best corrected visual acuity (BCVA) was decreased (<0.63) in 8 (40%) out of 20 eyes. The severity of retinal pathology increased with age, resulting in marked cone-rod involvement overtime. Spectral-domain optical coherence tomography in younger patients revealed focal loss of photoreceptors, disruption and deposition at the retinal pigment epithelium/Bruch's membrane layer (corresponding to areas of marked increased autofluorescence), and hyperreflective foci in the outer nuclear layer. Cystoid macular oedema was seen in one eye. In the asymptomatic female with somatic mosaicism, the BCVA was 1.0 bilaterally. An abnormal autofluorescence pattern in the left eye was present; while full-field electroretinography was normal. CONCLUSIONS: Detailed ocular examination may represent a sensitive and quick screening tool for the identification of carriers of LAMP2 pathogenic variants, even in somatic mosaicism. Hence, further investigation should be undertaken in all patients with pigmentary retinal dystrophy as it may be a sign of a life-threatening disease

Stellar Half-Mass Radii of 0.5<z<2.30.5<z<2.3 Galaxies: Comparison with JWST/NIRCam Half-Light Radii

We use CEERS JWST/NIRCam imaging to measure rest-frame near-IR light profiles of $>$500 $M_\star>10^{10}~M_\odot$ galaxies in the redshift range $0.5<z<2.3$. We compare the resulting rest-frame 1.5-2$\mu$m half-light radii ($R_{\rm{NIR}}$) with stellar half-mass radii (\rmass) derived with multi-color light profiles from CANDELS HST imaging. In general agreement with previous work, we find that $R_{\rm{NIR}}$ and \rmass~are up to 40\%~smaller than the rest-frame optical half-light radius $R_{\rm{opt}}$. The agreement between $R_{\rm{NIR}}$ and \rmass~is excellent, with negligible systematic offset ($<$0.03 dex) up to $z=2$ for quiescent galaxies and up to $z=1.5$ for star-forming galaxies. We also deproject the profiles to estimate \rmassd, the radius of a sphere containing 50\% of the stellar mass. We present the $R-M_\star$ distribution of galaxies at $0.5<z<1.5$, comparing $R_{\rm{opt}}$, \rmass~and \rmassd. The slope is significantly flatter for \rmass~and \rmassd~ compared to $R_{\rm{opt}}$, mostly due to downward shifts in size for massive star-forming galaxies, while \rmass~and \rmassd~do not show markedly different trends. Finally, we show rapid size evolution ($R\propto (1+z)^{-1.7\pm0.1}$) for massive ($M_\star>10^{11}~M_\odot$) quiescent galaxies between $z=0.5$ and $z=2.3$, again comparing $R_{\rm{opt}}$, \rmass~and \rmassd. We conclude that the main tenets of the size evolution narrative established over the past 20 years, based on rest-frame optical light profile analysis, still hold in the era of JWST/NIRCam observations in the rest-frame near-IR.Comment: Submitted to ApJ. Comments welcom

The Evolution of Bat Vestibular Systems in the Face of Potential Antagonistic Selection Pressures for Flight and Echolocation

PMCID: PMC3634842This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

EuroFlow Standardized Approach to Diagnostic Immunopheneotyping of Severe PID in Newborns and Young Children

The EuroFlow PID consortium developed a set of flow cytometry tests for evaluation of patients with suspicion of primary immunodeficiency (PID). In this technical report we evaluate the performance of the SCID-RTE tube that explores the presence of recent thymic emigrants (RTE) together with T-cell activation status and maturation stages and discuss its applicability in the context of the broader EuroFlow PID flow cytometry testing algorithm for diagnostic orientation of PID of the lymphoid system. We have analyzed peripheral blood cells of 26 patients diagnosed between birth and 2 years of age with a genetically defined primary immunodeficiency disorder: 1