Sosiaalinen pääoma nuorisorikollisuuden näkökulmasta

Tiivistelmä. Tämän tutkielman tavoitteena on selvittää nuoren rikollisen sosiaalisen pääoman muodostumiseen liittyviä tekijöitä ja sosiaalisen pääoman yhteyttä nuoren rikollisuuteen. Tutkielmamme on kuvaileva kirjallisuuskatsaus, jossa luomme tietoa yhdistelemällä aiheeseen liittyvää kirjallisuutta sekä tutkimuksia. Aineistomme pohjautuu pääosin kriminologiseen ja sosiologiseen kirjallisuuteen sekä tutkimukseen. Näkökulmamme tutkielmassa on sosiaalisen pääoman käsitteessä. Tutkielmassa määritelty sosiaalisen pääoman käsite on monimuotoinen ilmiö, josta on olemassa useita eri teorioita. Sosiaalisen pääoman käsitteen määrittelemisessä tukeudumme kolmen tunnetun teoreetikon (James J. Coleman, Robert D. Putnam ja Pierre Bourdieu) määritelmään. Näiden kolmen teoreetikon määritelmät sosiaalisesta pääomasta ovat useimmin käytettyjä aiheen tutkimuksissa. Rikollisuuden problematiikka on myös oleellisessa osassa tutkielmassamme käsitteiden muodossa. Kirjallisuuskatsaus osoittaa, että sosiaaliset verkostot ovat merkittävässä asemassa nuoren sosiaalisen pääoman muodostumisessa. Läheiset sosiaaliset suhteet ovat positiivisessa yhteydessä sosiaalisen pääoman muodostumisen kannalta sukupuolesta riippumatta. Tytöt kuitenkin omaavat sosiaalisia suhteita poikia enemmän. Nuorilla rikollisilla sosiaalisten suhteiden verkosto on jäänyt väljäksi, jonka vuoksi sosiaalinen pääoma on niukempi. Heikolla sosiaalisella pääomalla on havaittu olevan yhteys rikolliseen eli antisosiaaliseen käytökseen. Sosiaalisen pääoman tekijöistä perhe, koulu ja vertaisryhmä toimivat joko rikollisuutta ehkäisevänä tai riskiä lisäävänä tekijöinä. Vanhempien ja opettajan antama kontrolli ja tuki ovat positiivisia sosiaalisen pääoman vaikuttajia, joilla voidaan ehkäistä riskiä rikollisuuteen. Koulun ja opettajan tuki nousevat erityisen tärkeiksi silloin, kun nuoren saama tuki muualta on heikkoa. Tyypillistä nuorten rikollisuudelle on sen tapahtuminen ryhmässä. Ryhmät voivat välittää joko negatiivista tai positiivista sosiaalista pääomaa eli toimia hyväksyvästi rikosten tekemiselle tai päinvastoin. Nuoren omat asenteet rikosten tekoa kohtaan ja ryhmästä saadut vaikutteet ovat yhteydessä siihen, alkaako nuori tehdä rikoksia

Chromatin modifier developmental pluripotency associated factor 4 (DPPA4) is a candidate gene for alcohol-induced developmental disorders

Peer reviewe

Whole mitochondrial genomes unveil the impact of domestication on goat matrilineal variability

Background: The current extensive use of the domestic goat (Capra hircus) is the result of its medium size and high adaptability as multiple breeds. The extent to which its genetic variability was influenced by early domestication practices is largely unknown. A common standard by which to analyze maternally-inherited variability of livestock species is through complete sequencing of the entire mitogenome (mitochondrial DNA, mtDNA). Results: We present the first extensive survey of goat mitogenomic variability based on 84 complete sequences selected from an initial collection of 758 samples that represent 60 different breeds of C. hircus, as well as its wild sister species, bezoar (Capra aegagrus) from Iran. Our phylogenetic analyses dated the most recent common ancestor of C. hircus to ~460,000 years (ka) ago and identified five distinctive domestic haplogroups (A, B1, C1a, D1 and G). More than 90 % of goats examined were in haplogroup A. These domestic lineages are predominantly nested within C. aegagrus branches, diverged concomitantly at the interface between the Epipaleolithic and early Neolithic periods, and underwent a dramatic expansion starting from ~12–10 ka ago. Conclusions: Domestic goat mitogenomes descended from a small number of founding haplotypes that underwent domestication after surviving the last glacial maximum in the Near Eastern refuges. All modern haplotypes A probably descended from a single (or at most a few closely related) female C. aegagrus. Zooarchaelogical data indicate that domestication first occurred in Southeastern Anatolia. Goats accompanying the first Neolithic migration waves into the Mediterranean were already characterized by two ancestral A and C variants. The ancient separation of the C branch (~130 ka ago) suggests a genetically distinct population that could have been involved in a second event of domestication. The novel diagnostic mutational motifs defined here, which distinguish wild and domestic haplogroups, could be used to understand phylogenetic relationships among modern breeds and ancient remains and to evaluate whether selection differentially affected mitochondrial genome variants during the development of economically important breeds

In vitro fertilization does not increase the incidence of de novo copy number alterations in fetal and placental lineages

Although chromosomal instability (CIN) is a common phenomenon in cleavage-stage embryogenesis following in vitro fertilization (IVF)1,2,3, its rate in naturally conceived human embryos is unknown. CIN leads to mosaic embryos that contain a combination of genetically normal and abnormal cells, and is significantly higher in in vitro-produced preimplantation embryos as compared to in vivo-conceived preimplantation embryos4. Even though embryos with CIN-derived complex aneuploidies may arrest between the cleavage and blastocyst stages of embryogenesis5,6, a high number of embryos containing abnormal cells can pass this strong selection barrier7,8. However, neither the prevalence nor extent of CIN during prenatal development and at birth, following IVF treatment, is well understood. Here we profiled the genomic landscape of fetal and placental tissues postpartum from both IVF and naturally conceived children, to investigate the prevalence and persistence of large genetic aberrations that probably arose from IVF-related CIN. We demonstrate that CIN is not preserved at later stages of prenatal development, and that de novo numerical aberrations or large structural DNA imbalances occur at similar rates in IVF and naturally conceived live-born neonates. Our findings affirm that human IVF treatment has no detrimental effect on the chromosomal constitution of fetal and placental lineages

Three Thousand Years of Continuity in the Maternal Lineages of Ancient Sheep (Ovis aries) in Estonia

lthough sheep (Ovis aries) have been one of the most exploited domestic animals in Estonia since the Late Bronze Age, relatively little is known about their genetic history. Here, we explore temporal changes in Estonian sheep populations and their mitochondrial genetic diversity over the last 3000 years. We target a 558 base pair fragment of the mitochondrial hypervariable region in 115 ancient sheep from 71 sites in Estonia (c. 1200 BC – AD 1900s), 19 ancient samples from Latvia, Russia, Poland and Greece (6800 BC – AD 1700), as well as 44 samples of modern Kihnu native sheep breed. Our analyses revealed: (1) 49 mitochondrial haplotypes, associated with sheep haplogroups A and B; (2) high haplotype diversity in Estonian ancient sheep; (3) continuity in mtDNA haplotypes through time; (4) possible population expansion during the first centuries of the Middle Ages (associated with the establishment of the new power regime related to 13th century crusades); (5) significant difference in genetic diversity between ancient populations and modern native sheep, in agreement with the beginning of large-scale breeding in the 19th century and population decline in local sheep. Overall, our results suggest that in spite of the observed fluctuations in ancient sheep populations, and changes in the natural and historical conditions, the utilisation of local sheep has been constant in the territory of Estonia, displaying matrilineal continuity from the Middle Bronze Age through the Modern Period, and into modern native sheep

Pitfalls in machine learning-based assessment of tumor-infiltrating lymphocytes in breast cancer: a report of the international immuno-oncology biomarker working group

The clinical significance of the tumor-immune interaction in breast cancer is now established, and tumor-infiltrating lymphocytes (TILs) have emerged as predictive and prognostic biomarkers for patients with triple-negative (estrogen receptor, progesterone receptor, and HER2-negative) breast cancer and HER2-positive breast cancer. How computational assessments of TILs might complement manual TIL assessment in trial and daily practices is currently debated. Recent efforts to use machine learning (ML) to automatically evaluate TILs have shown promising results. We review state-of-the-art approaches and identify pitfalls and challenges of automated TIL evaluation by studying the root cause of ML discordances in comparison to manual TIL quantification. We categorize our findings into four main topics: (1) technical slide issues, (2) ML and image analysis aspects, (3) data challenges, and (4) validation issues. The main reason for discordant assessments is the inclusion of false-positive areas or cells identified by performance on certain tissue patterns or design choices in the computational implementation. To aid the adoption of ML for TIL assessment, we provide an in-depth discussion of ML and image analysis, including validation issues that need to be considered before reliable computational reporting of TILs can be incorporated into the trial and routine clinical management of patients with triple-negative breast cancer. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland

Pitfalls in machine learning‐based assessment of tumor‐infiltrating lymphocytes in breast cancer: a report of the international immuno‐oncology biomarker working group

The clinical significance of the tumor-immune interaction in breast cancer (BC) has been well established, and tumor-infiltrating lymphocytes (TILs) have emerged as a predictive and prognostic biomarker for patients with triple-negative (estrogen receptor, progesterone receptor, and HER2 negative) breast cancer (TNBC) and HER2-positive breast cancer. How computational assessment of TILs can complement manual TIL-assessment in trial- and daily practices is currently debated and still unclear. Recent efforts to use machine learning (ML) for the automated evaluation of TILs show promising results. We review state-of-the-art approaches and identify pitfalls and challenges by studying the root cause of ML discordances in comparison to manual TILs quantification. We categorize our findings into four main topics; (i) technical slide issues, (ii) ML and image analysis aspects, (iii) data challenges, and (iv) validation issues. The main reason for discordant assessments is the inclusion of false-positive areas or cells identified by performance on certain tissue patterns, or design choices in the computational implementation. To aid the adoption of ML in TILs assessment, we provide an in-depth discussion of ML and image analysis including validation issues that need to be considered before reliable computational reporting of TILs can be incorporated into the trial- and routine clinical management of patients with TNBC

Analysis of viscous fluid flow in a pressure-swirl atomizer using large-eddy simulation

A computational fluid dynamics study is carried out on the inner nozzle flow and onset of liquid sheet instability in a large-scale pressure-swirl atomizer with asymmetric inflow configuration for high viscosity fluids. Large-eddy simulations (LES) of the two-phase flow indicate the unsteady flow character inside the nozzle and its influence on liquid sheet formation. A novel geometric volume-of-fluid (VOF) method by Roenby et al. (2016), termed isoAdvector, is applied for sharp interface capturing. We carry out a Reynolds number sweep (420 ≤ Re ≤ 5300) in order to investigate the link between the asymmetric inner nozzle flow and liquid sheet characteristics in laminar, transitional and fully turbulent conditions. Inside the nozzle, the numerical simulations reveal counter-rotating Dean vortices, flow impingement locations, and strong asymmetric flow features at all investigated Reynolds numbers. A helical, rotating gaseous core is observed when Re ≥ 1660. For laminar flow (Re=420), an S-shaped liquid film isobserved, while the gas core presence at Re ≥ 1660 results in a hollow cone liquid sheet. For the intermediate value Re=830, the numerical simulations indicate a liquid sheet of mixed type. Consequences of the inflow asymmetry and Reynolds number to the uniformity of the injected liquid mass distribution and liquid sheet instability are pointed out.Peer reviewe

Chromatin modifier developmental pluripotency associated factor 4 (DPPA4) is a candidate gene for alcohol-induced developmental disorders

Peer reviewe