SpK: A fast atomic and microphysics code for the high-energy-density regime

SpK is part of the numerical codebase at Imperial College London used to model high energy density physics (HEDP) experiments. SpK is an efficient atomic and microphysics code used to perform detailed configuration accounting calculations of electronic and ionic stage populations, opacities and emissivities for use in post-processing and radiation hydrodynamics simulations. This is done using screened hydrogenic atomic data supplemented by the NIST energy level database. An extended Saha model solves for chemical equilibrium with extensions for non-ideal physics, such as ionisation potential depression, and non thermal equilibrium corrections. A tree-heap (treap) data structure is used to store spectral data, such as opacity, which is dynamic thus allowing easy insertion of points around spectral lines without a-priori knowledge of the ion stage populations. Results from SpK are compared to other codes and descriptions of radiation transport solutions which use SpK data are given. The treap data structure and SpK’s computational efficiency allows inline post-processing of 3D hydrodynamics simulations with a dynamically evolving spectrum stored in a treap

On Type IIn/Ia-CSM supernovae as exemplified by SN 2012ca

We present the complete set of ultra-violet, optical and near-infrared photometry and spectroscopy for SN 2012ca, covering the period from 6 d prior to maximum light, until 531 d after maximum. The spectroscopic time series for SN 2012ca is essentially unchanged over 1.5 yr, and appear to be dominated at all epochs by signatures of interaction with a dense circumstellar medium (CSM) rather than the underlying supernova (SN). SN 2012ca is a member of the set of type of the ambiguous IIn/Ia-CSM SNe, the nature of which have been debated extensively in the literature. The two leading scenarios are either a Type Ia SN exploding within a dense CSM from a non-degenerate, evolved companion, or a core-collapse SN from a massive star. While some members of the population have been unequivocally associated with Type Ia SNe, in other cases the association is less certain. While it is possible that SN 2012ca does arise from a thermonuclear SN, this would require a relatively high (between 20 and 70 per cent) efficiency in converting kinetic energy to optical luminosity, and a massive (∼2.3–2.6 M$_{⊙}$) circumstellar medium. On the basis of energetics, and the results of simple modelling, we suggest that SN 2012ca is more likely associated with a core-collapse SN. This would imply that the observed set of similar SNe to SN 2012ca is in fact originated by two populations, and while these are drawn from physically distinct channels, they can have observationally similar properties.This work is based on observations collected at the European Organization for Astronomical Research in the Southern hemisphere, Chile as part of PESSTO, (the Public ESO Spectroscopic Survey for Transient Objects Survey) ESO program 188.D-3003, 191.D-0935. It is also based on observations taken at the Panchromatic Robotic Optical Monitoring and Polarimetry Telescope (PROMPT) through the CNTAC proposal CN2012A-103; the Australian National University 2.3m Telescope and the Swift satellite. This work makes use of observations from the LCOGT network. Funded by the European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013)/ERC Grant agreement n° [291222] (SJS). This work was partly supported by the European Union FP7 programme through ERC grant number 320360. SB and AP acknowledge the PRIN-INAF 2011 project ‘Transient Universe: from ESO Large to PESSTO’. Support for GP is provided by the Ministry of Economy, Development, and Tourism's Millennium Science Initiative through grant IC120009, awarded to The Millennium Institute of Astrophysics, MAS. This research has made use of the NASA/IPAC Extragalactic Database (NED) which is operated by the Jet Propulsion Laboratory, California Institute of Technology, under contract with the National Aeronautics and Space Administration.This is the final version of the article. It first appeared from Oxford Univeristy Pres via http://dx.doi.org/10.1093/mnras/stw82

Eradication of chronic myeloid leukemia stem cells: a novel mathematical model predicts no therapeutic benefit of adding G-CSF to imatinib

Imatinib mesylate induces complete cytogenetic responses in patients with chronic myeloid leukemia (CML), yet many patients have detectable BCR-ABL transcripts in peripheral blood even after prolonged therapy. Bone marrow studies have shown that this residual disease resides within the stem cell compartment. Quiescence of leukemic stem cells has been suggested as a mechanism conferring insensitivity to imatinib, and exposure to the Granulocyte-Colony Stimulating Factor (G-CSF), together with imatinib, has led to a significant reduction in leukemic stem cells in vitro. In this paper, we design a novel mathematical model of stem cell quiescence to investigate the treatment response to imatinib and G-CSF. We find that the addition of G-CSF to an imatinib treatment protocol leads to observable effects only if the majority of leukemic stem cells are quiescent; otherwise it does not modulate the leukemic cell burden. The latter scenario is in agreement with clinical findings in a pilot study administering imatinib continuously or intermittently, with or without G-CSF (GIMI trial). Furthermore, our model predicts that the addition of G-CSF leads to a higher risk of resistance since it increases the production of cycling leukemic stem cells. Although the pilot study did not include enough patients to draw any conclusion with statistical significance, there were more cases of progression in the experimental arms as compared to continuous imatinib. Our results suggest that the additional use of G-CSF may be detrimental to patients in the clinic

Methods for specifying the target difference in a randomised controlled trial : the Difference ELicitation in TriAls (DELTA) systematic review

Peer reviewedPublisher PD

The rise and fall of an extraordinary Ca-rich transient: The discovery of ATLAS19dqr/SN 2019bkc

This work presents the observations and analysis of ATLAS19dqr/SN 2019bkc, an extraordinary rapidly evolving transient event located in an isolated environment, tens of kiloparsecs from any likely host. Its light curves rise to maximum light in 5-6 d and then display a decline of Δm15 ∼ 5 mag. With such a pronounced decay, it has one of the most rapidly evolving light curves known for a stellar explosion. The early spectra show similarities to normal and "ultra-stripped" type Ic SNe, but the early nebular phase spectra, which were reached just over two weeks after explosion, display prominent calcium lines, marking SN 2019bkc as a Ca-rich transient. The Ca emission lines at this phase show an unprecedented and unexplained blueshift of 10 000-12 000 km s-1. Modelling of the light curve and the early spectra suggests that the transient had a low ejecta mass of 0.2-0.4 M⊙ and a low kinetic energy of (2-4) × 1050 erg, giving a specific kinetic energy Ek/Mej ∼ 1 [1051 erg]/M⊙. The origin of this event cannot be unambiguously defined. While the abundance distribution used to model the spectra marginally favours a progenitor of white dwarf origin through the tentative identification of Ar II, the specific kinetic energy, which is defined by the explosion mechanism, is found to be more similar to an ultra-stripped core-collapse events. SN 2019bkc adds to the diverse range of physical properties shown by Ca-rich events. © ESO 2020

LSQ14efd: observations of the cooling of a shock break-out event in a type Ic Supernova

We present the photometric and spectroscopic evolution of the type Ic supernova LSQ14efd, discovered by the La Silla QUEST survey and followed by PESSTO. LSQ14efd was discovered few days after explosion and the observations cover up to ~100 days. The early photometric points show the signature of the cooling of the shock break-out event experienced by the progenitor at the time of the supernova explosion, one of the first for a type Ic supernova. A comparison with type Ic supernova spectra shows that LSQ14efd is quite similar to the type Ic SN 2004aw. These two supernovae have kinetic energies that are intermediate between standard Ic explosions and those which are the most energetic explosions known (e.g. SN 1998bw). We computed an analytical model for the light-curve peak and estimated the mass of the ejecta 6.3 +/- 0.5 Msun, a synthesized nickel mass of 0.25 Msun and a kinetic energy of Ekin = 5.6 +/- 0.5 x 10^51 erg. No connection between LSQ14efd and a GRB event could be established. However we point out that the supernova shows some spectroscopic similarities with the peculiar SN-Ia 1999ac and the SN-Iax SN 2008A. A core-collapse origin is most probable considering the spectroscopic, photometric evolution and the detection of the cooling of the shock break-out

Superluminous supernovae from PESSTO

We present optical spectra and light curves for three hydrogen-poor superluminous supernovae followed by the Public ESO Spectroscopic Survey of Transient Objects (PESSTO). Time series spectroscopy from a fewdays aftermaximum light to 100 d later shows them to be fairly typical of this class, with spectra dominated by Ca II, MgII, FeII, and Si II, which evolve slowly over most of the post-peak photospheric phase. We determine bolometric light curves and apply simple fitting tools, based on the diffusion of energy input by magnetar spin-down, Ni-56 decay, and collision of the ejecta with an opaque circumstellar shell. We investigate how the heterogeneous light curves of our sample (combined with others from the literature) can help to constrain the possible mechanisms behind these events. We have followed these events to beyond 100-200 d after peak, to disentangle host galaxy light from fading supernova flux and to differentiate between the models, which predict diverse behaviour at this phase. Models powered by radioactivity require unrealistic parameters to reproduce the observed light curves, as found by previous studies. Both magnetar heating and circumstellar interaction still appear to be viable candidates. A large diversity is emerging in observed tail-phase luminosities, with magnetar models failing in some cases to predict the rapid drop in flux. This would suggest either that magnetars are not responsible, or that the X-ray flux from the magnetar wind is not fully trapped. The light curve of one object shows a distinct rebrightening at around 100 d after maximum light. We argue that this could result either from multiple shells of circumstellar material, or from a magnetar ionization front breaking out of the ejecta.</p

The conceptualisation of health and disease in veterinary medicine

<p>Abstract</p> <p>Background</p> <p>The concept of health, as well as the concept of disease, is central in veterinary medicine. However, the definitions "health" and "disease" are not generally acknowledged by veterinarians. The aim of this study was to examine how the concepts "health" and "disease" are defined in veterinary textbooks.</p> <p>Methods</p> <p>Veterinary textbooks in several disciplines were investigated, but only textbooks with explicit definitions of the concepts were selected for examination.</p> <p>Results</p> <p>Eighty out of the 500 relevant books within veterinary medicine were written for non-veterinarians. Eight percent of the books had an explicit definition of health and/or disease. More frequently, textbooks written for non veterinarians did have definitions of health or disease, compared to textbooks written for professionals. A division of health definitions in five different categories was suggested, namely:</p> <p>1. Health as normality, 2. Health as biological function, 3. Health as homeostasis, 4. Health as physical and psychological well-being and 5. Health as productivity including reproduction.</p> <p>Conclusion</p> <p>Few veterinary textbooks had any health or disease definition at all. Furthermore, explicit definitions of health stated by the authors seemed to have little impact on how health and disease are handled within the profession. Veterinary medicine would probably gain from theoretical discussions about health and disease.</p