164 research outputs found
The Microchannel X-ray Telescope on Board the SVOM Satellite
We present the Micro-channel X-ray Telescope (MXT), a new narrow-field (about
1{\deg}) telescope that will be flying on the Sino-French SVOM mission
dedicated to Gamma-Ray Burst science, scheduled for launch in 2021. MXT is
based on square micro pore optics (MPOs), coupled with a low noise CCD. The
optics are based on a "Lobster Eye" design, while the CCD is a focal plane
detector similar to the type developed for the seven eROSITA telescopes. MXT is
a compact and light (<35 kg) telescope with a 1 m focal length, and it will
provide an effective area of about 45 cmsq on axis at 1 keV. The MXT PSF is
expected to be better than 4.2 arc min (FWHM) ensuring a localization accuracy
of the afterglows of the SVOM GRBs to better than 1 arc min (90\% c.l. with no
systematics) provided MXT data are collected within 5 minutes after the
trigger. The MXT sensitivity will be adequate to detect the afterglows for
almost all the SVOM GRBs as well as to perform observations of non-GRB
astrophysical objects. These performances are fully adapted to the SVOM science
goals, and prove that small and light telescopes can be used for future small
X-ray missions.Comment: 6 pages, 6 figures, proceedings of the conference "Swift: 10 years of
Discovery", Rome, December 2-5, 2014. To be published by Po
Spectral performance of the Microchannel X-ray Telescope on board the SVOM mission
The Microchannel X-ray Telescope (MXT) is an innovative compact X-ray
instrument on board the SVOM astronomical mission dedicated to the study of
transient phenomena such as gamma-ray bursts. During 3 weeks, we have tested
the MXT flight model at the Panter X-ray test facility under the nominal
temperature and vacuum conditions that MXT will undergo in-flight. We collected
data at series of characteristic energies probing the entire MXT energy range,
from 0.28 keV up to 9 keV, for multiple source positions with the center of the
point spread function (PSF) inside and outside the detector field of view
(FOV). We stacked the data of the positions with the PSF outside the FOV to
obtain a uniformly illuminated matrix and reduced all data sets using a
dedicated pipeline. We determined the best spectral performance of MXT using an
optimized data processing, especially for the energy calibration and the charge
sharing effect induced by the pixel low energy thresholding. Our results
demonstrate that MXT is compliant with the instrument requirement regarding the
energy resolution (<80 eV at 1.5 keV), the low and high energy threshold, and
the accuracy of the energy calibration (20 eV). We also determined the
charge transfer inefficiency (~) of the detector and modeled its
evolution with energy prior to the irradiation that MXT will undergo during its
in-orbit lifetime. Finally, we measured the relation of the energy resolution
as function of the photon energy. We determined an equivalent noise charge of
4.9 0.2 e- rms for the MXT detection chain and a Fano factor of 0.131
0.003 in silicon at 208 K, in agreement with previous works. This
campaign confirmed the promising scientific performance that MXT will be able
to deliver during the mission lifetime.Comment: 20 pages, 10 figures, accepted for publication in Experimental
Astronom
The Effects Combining Cryocompression Therapy following an Acute Bout of Resistance Exercise on Performance and Recovery
Compression and cold therapy used separately have shown to reduce negative effects of tissue damage. The combining compression and cold therapy (cryocompression) as a single recovery modality has yet to be fully examined. To examine the effects of cryocompression on recovery following a bout of heavy resistance exercise, recreationally resistance trained men (n =16) were recruited, matched, and randomly assigned to either a cryocompression group (CRC) or control group (CON). Testing was performed before and then immediately after exercise, 60 minutes, 24 hours, and 48 hours after a heavy resistance exercise workout (barbell back squats for 4 sets of 6 reps at 80% 1RM, 90 sec rest between sets, stiff legged deadlifts for 4 sets of 8 reps at 1.0 X body mass with 60 sec rest between sets, 4 sets of 10 eccentric Nordic hamstring curls, 45 sec rest between sets). The CRC group used the CRC system for 20-mins of cryocompression treatment immediately after exercise, 24 hours, and 48 hours after exercise. CON sat quietly for 20-mins at the same time points. Muscle damage [creatine kinase], soreness (visual analog scale, 0-100), pain (McGill Pain Q, 0-5), fatigue, sleep quality, and jump power were significantly (p \u3c 0.05) improved for CRC compared to CON at 24 and 48 hours after exercise. Pain was also significantly lower for CRC compared to CON at 60-mins post exercise. These findings show that cryocompression can enhance recovery and performance following a heavy resistance exercise workout
The Scientific Performance of the Microchannel X-ray Telescope on board the SVOM Mission
The Microchannel X-ray Telescope (MXT) will be the first focusing X-ray
telescope based on a "Lobster-Eye" optical design to be flown on Sino-French
mission SVOM. SVOM will be dedicated to the study of Gamma-Ray Bursts and more
generally time-domain astrophysics. The MXT telescope is a compact (focal
length ~ 1.15 m) and light (< 42 kg) instrument, sensitive in the 0.2--10 keV
energy range. It is composed of an optical system, based on micro-pore optics
(MPOs) of 40 micron pore size, coupled to a low-noise pnCDD X-ray detector. In
this paper we describe the expected scientific performance of the MXT
telescope, based on the End-to-End calibration campaign performed in fall 2021,
before the integration of the SVOM payload on the satellite.Comment: 22 pages, 12 figures, accepted for publication in Experimental
Astronom
The COSPIX mission: focusing on the energetic and obscured Universe
Tracing the formation and evolution of all supermassive black holes,
including the obscured ones, understanding how black holes influence their
surroundings and how matter behaves under extreme conditions, are recognized as
key science objectives to be addressed by the next generation of instruments.
These are the main goals of the COSPIX proposal, made to ESA in December 2010
in the context of its call for selection of the M3 mission. In addition,
COSPIX, will also provide key measurements on the non thermal Universe,
particularly in relation to the question of the acceleration of particles, as
well as on many other fundamental questions as for example the energetic
particle content of clusters of galaxies. COSPIX is proposed as an observatory
operating from 0.3 to more than 100 keV. The payload features a single long
focal length focusing telescope offering an effective area close to ten times
larger than any scheduled focusing mission at 30 keV, an angular resolution
better than 20 arcseconds in hard X-rays, and polarimetric capabilities within
the same focal plane instrumentation. In this paper, we describe the science
objectives of the mission, its baseline design, and its performances, as
proposed to ESA.Comment: 7 pages, accepted for publication in Proceedings of Science, for the
25th Texas Symposium on Relativistic Astrophysics (eds. F. Rieger & C.
van Eldik), PoS(Texas 2010)25
Durability of bioprosthetic aortic valves in patients under the age of 60 years - Rationale and design of the international INDURE registry
Background: There is an ever-growing number of patients requiring aortic valve replacement (AVR). Limited data is available on the long-term outcomes and structural integrity of bioprosthetic valves in younger patients undergoing surgical AVR. Methods: The INSPIRIS RESILIA Durability Registry (INDURE) is a prospective, open-label, multicentre, international registry with a follow-up of 5 years to assess clinical outcomes of patients younger than 60 years who undergo surgical AVR using the INSPIRIS RESILIA aortic valve. INDURE will be conducted across 20-22 sites in Europe and Canada and intends to enrol minimum of 400 patients. Patients will be included if they are scheduled to undergo AVR with or without concomitant root replacement and/or coronary bypass surgery. The primary objectives are to 1) determine VARC-2 defined time-related valve safety at one-year (depicted as freedom from events) and 2) determine freedom from stage 3 structural valve degeneration (SVD) presenting as morphological abnormalities and severe haemodynamic valve degeneration at 5 years. Secondary objectives include the assessment of the haemodynamic performance of the valve, all stages of SVD, potential valve-in-valve procedures, clinical outcomes (in terms of New York Heart Association [NYHA] function class and freedom from valve-related rehospitalisation) and change in patient quality-of-life. Discussion: INDURE is a prospective, multicentre registry in Europe and Canada, which will provide much needed data on the long-term performance of bioprosthetic valves in general and the INSPIRIS RESILIA valve in particular. The data may help to gather a deeper understanding of the longevity of bioprosthetic valves and may expand the use of bioprosthetic valves in patients under the age of 60 years. Trial registration: ClinicalTrials.gov identifier: NCT03666741 (registration received September, 12th, 2018)
Maternal Malaria and Gravidity Interact to Modify Infant Susceptibility to Malaria
BACKGROUND: In endemic areas, placental malaria due to Plasmodium falciparum is most frequent and severe in first-time mothers, and increases the risk of infant mortality in their offspring. Placental malaria may increase the susceptibility of infants to malaria parasitemia, but evidence for this effect is inconclusive. METHODS AND FINDINGS: During 2002–2004, we monitored parasitemia in 453 infants, including 69 who were born to mothers with placental malaria, in a region of northeastern Tanzania where malaria transmission is intense. We used a Cox proportional hazards model to evaluate the time from birth to first parasitemia, and a generalized estimating equations logistic regression model to evaluate risk of any parasitemia throughout the first year of life. Compared with infants whose mothers did not have placental malaria at delivery (“PM-negative”), offspring of mothers with placental malaria at delivery (“PM-positive”) were 41% more likely to experience their first parasitemia at a younger age (adjusted hazard ratio [AHR] = 1.41, 95% confidence interval [CI] 1.01–1.99). The odds of parasitemia throughout infancy were strongly modified by the interaction between placental malaria and gravidity (p for interaction = 0.008, Type 3 likelihood ratio test). Offspring of PM-negative primigravidae had lower odds of parasitemia during infancy (adjusted odds ratio [AOR] = 0.67, 95% CI 0.50–0.91) than offspring of PM-negative multigravidae, and offspring of PM-positive primigravidae had the lowest odds (AOR = 0.21, 95% CI 0.09–0.47). In contrast, offspring of PM-positive multigravidae had significantly higher odds of parasitemia (AOR = 1.59, 95% CI 1.16–2.17). CONCLUSION: Although parasitemia is more frequent in primigravid than multigravid women, the converse is true in their offspring, especially in offspring of PM-positive women. While placental malaria is known to increase mortality risk for first-born infants, it surprisingly reduced their risk of parasitemia in this study. Placental malaria of multigravidae, on the other hand, is a strong risk factor for parasitemia during infancy, and therefore preventive antimalarial chemotherapy administered to multigravid women close to term may reduce the frequency of parasitemia in their offspring
Reconstruction of SARS-CoV-2 outbreaks in a primary school using epidemiological and genomic data.
peer reviewedMathematical modelling studies have shown that repetitive screening can be used to mitigate SARS-CoV-2 transmission in primary schools while keeping schools open. However, not much is known about how transmission progresses within schools and whether there is a risk of importation to households. During the academic year 2020-2021, a prospective surveillance study using repetitive screening was conducted in a primary school and associated households in Liège (Belgium). SARS-CoV-2 screening was performed via throat washing either once or twice a week. We used genomic and epidemiological data to reconstruct the observed school outbreaks using two different models. The outbreaker2 model combines information on the generation time and contact patterns with a model of sequence evolution. For comparison we also used SCOTTI, a phylogenetic model based on the structured coalescent. In addition, we performed a simulation study to investigate how the accuracy of estimated positivity rates in a school depends on the proportion of a school that is sampled in a repetitive screening strategy. We found no difference in SARS-CoV-2 positivity between children and adults and children were not more often asymptomatic compared to adults. Both models for outbreak reconstruction revealed that transmission occurred mainly within the school environment. Uncertainty in outbreak reconstruction was lowest when including genomic as well as epidemiological data. We found that observed weekly positivity rates are a good approximation to the true weekly positivity rate, especially in children, even when only 25% of the school population is sampled. These results indicate that, in addition to reducing infections as shown in modelling studies, repetitive screening in school settings can lead to a better understanding of the extent of transmission in schools during a pandemic and importation risk at the community level
Durability of bioprosthetic aortic valves in patients under the age of 60 years - Rationale and design of the international INDURE registry
Background: There is an ever-growing number of patients requiring aortic valve replacement (AVR). Limited data is available on the long-term outcomes and structural integrity of bioprosthetic valves in younger patients undergoing surgical AVR. Methods: The INSPIRIS RESILIA Durability Registry (INDURE) is a prospective, open-label, multicentre, international registry with a follow-up of 5 years to assess clinical outcomes of patients younger than 60 years who undergo surgical AVR using the INS
RNASeq analysis of differentiated keratinocytes reveals a massive response to late events during human papillomavirus type 16 infection, including loss of epithelial barrier function.
The human papillomavirus (HPV) replication cycle is tightly linked to epithelial cell differentiation. To examine HPV-associated changes in the keratinocyte transcriptome, RNAs isolated from undifferentiated and differentiated cell populations of normal, spontaneously immortalised, keratinocytes (NIKS), and NIKS stably transfected with HPV16 episomal genomes (NIKS16), were compared using RNASeq. HPV16 infection altered expression of 2862 cellular genes. Next, to elucidate the role of keratinocyte gene expression in late events during the viral life cycle, RNASeq was carried out on triplicate differentiated populations of NIKS (uninfected) and NIKS16 (infected). Of the top 966 genes altered (>log2 = 1.8, 3.5-fold change) 670 genes were downregulated and 296 genes were up-regulated. HPV down-regulated many genes involved in epithelial barrier function that involves structural resistance to the environment and immunity to infectious agents. For example, HPV infection repressed expression of the differentiated keratinocyte-specific pattern recognition receptor TLR7, the Langerhans cell chemoattractant, CCL20, and proinflammatory cytokines, IL1A and IL1B. However, IRF1, IFNκ and viral restriction factors (IFIT1, 2, 3, 5, OASL, CD74, RTP4) were up-regulated. HPV infection abrogated gene expression associated with the physical epithelial barrier, including keratinocyte cytoskeleton, intercellular junctions and cell adhesion. qPCR and western blotting confirmed changes in expression of seven of the most significantly altered mRNAs. Expression of three genes showed statistically significant changes during cervical disease progression in clinical samples. Taken together, the data indicate that HPV infection manipulates the differentiating keratinocyte transcriptome to create an environment conducive to productive viral replication and egress.IMPORTANCE Human papillomavirus (HPV) genome amplification and capsid formation takes place in differentiated keratinocytes. The viral life cycle is intimately associated with host cell differentiation. Deep sequencing (RNASeq) of RNA from undifferentiated and differentiated uninfected and HPV16-positive keratinocytes showed that almost 3000 genes were differentially expressed in keratinocyte due to HPV16 infection. Strikingly, the epithelial barrier function of differentiated keratinocytes, comprising keratinocyte immune function and cellular structure, was found to be disrupted. These data provide new insights into virus-host interaction crucial for production of infectious virus and reveal that HPV infection remodels keratinocytes for completion of the virus replication cycle
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