Rossby and Magnetic Prandtl Number Scaling of Stellar Dynamos

Rotational scaling relationships are examined for the degree of equipartition between magnetic and kinetic energies in stellar convection zones. These scaling relationships are approached from two paradigms, with first a glance at scaling relationship built upon an energy-balance argument and second a look at a force-based scaling. The latter implies a transition between a nearly-constant inertial scaling when in the asymptotic limit of minimal diffusion and magnetostrophy, whereas the former implies a weaker scaling with convective Rossby number. Both scaling relationships are then compared to a suite of 3D convective dynamo simulations with a wide variety of domain geometries, stratifications, and range of convective Rossby numbers.Comment: 15 pages, 6 figures, accepted in Ap

A model of rotating convection in stellar and planetary interiors: II -- gravito-inertial wave generation

Gravito-inertial waves are excited at the interface of convective and radiative regions and by the Reynolds stresses in the bulk of the convection zones of rotating stars and planets. Such waves have notable asteroseismic signatures in the frequency spectra of rotating stars, particularly among rapidly rotating early-type stars, which provides a means of probing their internal structure and dynamics. They can also transport angular momentum, chemical species, and energy from the excitation region to where they dissipate in radiative regions. To estimate the excitation and convective parameter dependence of the amplitude of those waves, a monomodal model for stellar and planetary convection as described in Paper I is employed, which provides the magnitude of the rms convective velocity as a function of rotation rate. With this convection model, two channels for wave driving are considered: excitation at a boundary between convectively stable and unstable regions and excitation due to Reynolds-stresses. Parameter regimes are found where the sub-inertial waves may carry a significant energy flux, depending upon the convective Rossby number, the interface stiffness, and the wave frequency. The super-inertial waves can also be enhanced, but only for convective Rossby numbers near unity. Interfacially excited waves have a peak energy flux near the lower cutoff frequency when the convective Rossby number of the flows that excite them are below a critical Rossby number that depends upon the stiffness of the interface, whereas that flux decreases when the convective Rossby number is larger than this critical Rossby number.Comment: 18 pages, 6 figures, accepted in Ap

How tidal waves interact with convective vortices in rapidly rotating planets and stars

Context. The dissipation of tidal inertial waves in planetary and stellar convective regions is one of the key mechanisms that drive the evolution of star–planet and planet–moon systems. This dissipation is particularly efficient for young low-mass stars and gaseous giant planets, which are rapid rotators. In this context, the interaction between tidal inertial waves and turbulent convective flows must be modelled in a realistic and robust way. In the state-of-the-art simulations, the friction applied by convection on tidal waves is commonly modeled as an effective eddy viscosity. This approach may be valid when the characteristic length scales of convective eddies are smaller than those of the tidal waves. However, it becomes highly questionable in the case where tidal waves interact with potentially stable large-scale vortices such as those observed at the poles of Jupiter and Saturn. The large-scale vortices are potentially triggered by convection in rapidly-rotating bodies in which the Coriolis acceleration forms the flow in columnar vortical structures along the direction of the rotation axis. Aims. We investigate the complex interactions between a tidal inertial wave and a columnar convective vortex. Methods. We used a quasi-geostrophic semi-analytical model of a convective columnar vortex, which is validated by numerical simulations. First, we carried out linear stability analysis using both numerical and asymptotic Wentzel–Kramers–Brillouin–Jeffreys (WKBJ) methods. We then conducted linear numerical simulations of the interactions between a convective columnar vortex and an incoming tidal inertial wave. Results. The vortex we consider is found to be centrifugally stable in the range –Ωp ≤ Ω0 ≤ 3.62Ωp and unstable outside this range, where Ω0 is the local rotation rate of the vortex at its center and Ωp is the global planetary (stellar) rotation rate. From the linear stability analysis, we find that this vortex is prone to centrifugal instability with perturbations with azimuthal wavenumbers m = {0,1, 2}, which potentially correspond to eccentricity, obliquity, and asynchronous tides, respectively. The modes with m > 2 are found to be neutral or stable. The WKBJ analysis provides analytic expressions of the dispersion relations for neutral and unstable modes when the axial (vertical) wavenumber is sufficiently large. We verify that in the unstable regime, an incoming tidal inertial wave triggers the growth of the most unstable mode of the vortex. This would lead to turbulent dissipation. For stable convective columns, the wave-vortex interaction leads to the mixing of momentum for tidal inertial waves while it creates a low-velocity region around the vortex core and a new wave-like perturbation in the form of a progressive wave radiating in the far field. The emission of this secondary wave is the strongest when the wavelength of the incoming wave is close to the characteristic size (radius) of the vortex. Incoming tidal waves can also experience complex angular momentum exchanges locally at critical layers of stable vortices. Conclusions. The interaction between tidal inertial waves and large-scale coherent convective vortices in rapidly-rotating planets (stars) leads to turbulent dissipation in the unstable regime and complex behaviors such as mixing of momentum and radiation of new waves in the far field or wave-vortex angular momentum exchanges in the stable regime. These phenomena cannot be modeled using a simple effective eddy viscosity

Design and development of the Australian and New Zealand (ANZ) myeloma and related diseases registry

© 2016 The Author(s). Background: Plasma cell dyscrasias (PCD) are a spectrum of disorders resulting from the clonal expansion of plasma cells, ranging from the pre-malignant condition monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM). MM generates a significant burden of disease on the community and it is predicted that it will increase in both incidence and prevalence owing to an ageing population and longer survival secondary to new therapeutic options. Robust and comprehensive clinical data are currently lacking but are required to define current diagnostic, investigational and management patterns in Australia and New Zealand (ANZ) for comparison to both local and international guidelines for standards of care. A clinical registry can provide this information and subsequently support development of strategies to address any differences, including providing a platform for clinical trials. The Myeloma and Related Diseases Registry (MRDR) was developed to monitor and explore variations in practices, processes and outcomes in ANZ and provide benchmark outcomes nationally and internationally for PCD. This paper describes the MRDR aims, development and implementation and discusses challenges encountered in the process. Methods: The MRDR was established in 2012 as an online database for a multi-centre collaboration across ANZ, collecting prospective data on patients with a diagnosis of MGUS, MM, solitary plasmacytoma or plasma cell leukaemia. Development of the MRDR required multi-disciplinary team participation, IT and biostatistical support as well as financial resources. Results: More than 1250 patients have been enrolled at 23 sites to date. Here we describe how database development, data entry and securing ethics approval have been major challenges for participating sites and the coordinating centre, and our approaches to resolving them. Now established, the MRDR will provide clinically relevant and credible monitoring, therapy and 'real world' outcome data, to support the conduction of high quality studies. In addition, the Myeloma 1000 sub-study is establishing a repository of paired peripheral blood specimens from registry patients to study mechanisms underlying disease progression. Conclusion: Establishment of the MRDR has been challenging, but it is a valuable investment that will provide a platform for coordinated national and international collaboration for clinical research in PCD in ANZ

Renal impairment at diagnosis in myeloma: Patient characteristics, treatment, and impact on outcomes. Results trom the Australia and New Zealand myeloma and related diseases registry

Background: Renal impairment (RI) is a common complication of multiple myeloma (MM) and remains a poor prognostic factor despite improved survival with newer therapies. Patients and Methods: We evaluated baseline characteristics, treatment, and outcomes of newly diagnosed MM patients with RI at diagnosis in the Australia and New Zealand Myeloma and Related Diseases Registry over 5 years to April 2018; we compared patients with RI (estimated glomerular filtration rate [eGFR

Multisite spectroscopic seismic study of the beta Cep star V2052 Oph: inhibition of mixing by its magnetic field

We used extensive ground-based multisite and archival spectroscopy to derive observational constraints for a seismic modelling of the magnetic beta Cep star V2052 Ophiuchi. The line-profile variability is dominated by a radial mode (f_1=7.14846 d^{-1}) and by rotational modulation (P_rot=3.638833 d). Two non-radial low-amplitude modes (f_2=7.75603 d^{-1} and f_3=6.82308 d^{-1}) are also detected. The four periodicities that we found are the same as the ones discovered from a companion multisite photometric campaign (Handler et al. 2012) and known in the literature. Using the photometric constraints on the degrees l of the pulsation modes, we show that both f_2 and f_3 are prograde modes with (l,m)=(4,2) or (4,3). These results allowed us to deduce ranges for the mass (M \in [8.2,9.6] M_o) and central hydrogen abundance (X_c \in [0.25,0.32]) of V2052 Oph, to identify the radial orders n_1=1, n_2=-3 and n_3=-2, and to derive an equatorial rotation velocity v_eq \in [71,75] km s^{-1}. The model parameters are in full agreement with the effective temperature and surface gravity deduced from spectroscopy. Only models with no or mild core overshooting (alpha_ov \in [0,0.15] local pressure scale heights) can account for the observed properties. Such a low overshooting is opposite to our previous modelling results for the non-magnetic beta Cep star theta Oph having very similar parameters, except for a slower surface rotation rate. We discuss whether this result can be explained by the presence of a magnetic field in V2052 Oph that inhibits mixing in its interior.Comment: 12 pages, 6 figures and 5 tables; accepted for publication in MNRAS on 2012 August 1

Redeployment-based drug screening identifies the anti-helminthic niclosamide as anti-myeloma therapy that also reduces free light chain production

Despite recent therapeutic advancements, multiple myeloma (MM) remains incurable and new therapies are needed, especially for the treatment of elderly and relapsed/refractory patients. We have screened a panel of 100 off-patent licensed oral drugs for anti-myeloma activity and identified niclosamide, an anti-helminthic. Niclosamide, at clinically achievable non-toxic concentrations, killed MM cell lines and primary MM cells as efficiently as or better than standard chemotherapy and existing anti-myeloma drugs individually or in combinations, with little impact on normal donor cells. Cell death was associated with markers of both apoptosis and autophagy. Importantly, niclosamide rapidly reduced free light chain (FLC) production by MM cell lines and primary MM. FLCs are a major cause of renal impairment in MM patients and light chain amyloid and FLC reduction is associated with reversal of tissue damage. Our data indicate that niclosamides anti-MM activity was mediated through the mitochondria with rapid loss of mitochondrial membrane potential, uncoupling of oxidative phosphorylation and production of mitochondrial superoxide. Niclosamide also modulated the nuclear factor-κB and STAT3 pathways in MM cells. In conclusion, our data indicate that MM cells can be selectively targeted using niclosamide while also reducing FLC secretion. Importantly, niclosamide is widely used at these concentrations with minimal toxicity

Design, baseline characteristics, and retention of African American light smokers into a randomized trial involving biological data

<p>Abstract</p> <p>Background</p> <p>African Americans experience significant tobacco-related health disparities despite the fact that over half of African American smokers are light smokers (use ≤10 cigarettes per day). African Americans have been under-represented in smoking cessation research, and few studies have evaluated treatment for light smokers. This paper describes the study design, measures, and baseline characteristics from <it>Kick It at Swope III </it>(KIS-III), the first treatment study of bupropion for African American light smokers.</p> <p>Methods</p> <p>Five hundred forty African American light smokers were randomly assigned to receive bupropion (150mg bid) (n = 270) or placebo (n = 270) for 7 weeks. All participants received written materials and health education counseling. Participants responded to survey items and provided blood samples for evaluation of phenotype and genotype of CYP2A6 and CYP2B6 enzymes involved in nicotine and bupropion metabolism. Primary outcome was cotinine-verified 7-day point prevalence smoking abstinence at Week 26 follow-up.</p> <p>Results</p> <p>Of 2,628 individuals screened, 540 were eligible, consented, and randomized to treatment. Participants had a mean age of 46.5 years and 66.1% were women. Participants smoked an average of 8.0 cigarettes per day, had a mean exhaled carbon monoxide of 16.4ppm (range 1-55) and a mean serum cotinine of 275.8ng/ml. The mean Fagerström Test for Nicotine Dependence was 3.2, and 72.2% of participants smoked within 30 minutes of waking. The average number of quit attempts in the past year was 3.7 and 24.2% reported using pharmacotherapy in their most recent quit attempt. Motivation and confidence to quit were high.</p> <p>Conclusion</p> <p>KIS-III is the first study designed to examine both nicotine and bupropion metabolism, evaluating CYP2A6 and CYP2B6 phenotype and genotype in conjunction with psychosocial factors, in the context of treatment of African American light smokers. Of 1629 smokers screened for study participation, only 18 (1.1%) were ineligible to participate in the study because they refused blood draws, demonstrating the feasibility of recruiting and enrolling African American light smokers into a clinical treatment trial involving biological data collection and genetic analyses. Future evaluation of individual factors associated with treatment outcome will contribute to advancing tailored tobacco use treatment with the goal of enhancing treatment and reducing health disparities for African American light smokers.</p> <p>Trial Registration</p> <p>ClinicalTrials.gov: <a href="URL">NCT00666978</a></p