156 research outputs found

    Análisis cualitativo y cuantitativo de la oferta de piscinas cubiertas en las Comunidades Autónomas españolas

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    La natación recreativa es la actividad físico-deportiva con mayor volumen de practicantes en España. Esta actividad se ha visto favorecida en los últimos años por el progresivo incremento de la oferta de piscinas cubiertas, siendo este espacio el que presenta mayor intensidad de uso. Distintos estudios han destacado la asociación positiva entre la disponibilidad de instalaciones deportivas y los niveles de actividad física de la población. El análisis cuantitativo y cualitativo de la oferta de piscinas cubiertas en las Comunidades Autónomas puede resultar un excelente indicador del grado de desarrollo de estas instalaciones en la consecución de un entorno social más saludable. Para ello, se seleccionaron 12 variables por un grupo de expertos que permitieran el análisis de la oferta de piscinas cubiertas en las regiones, y mediante el análisis con un Indicador Sintético de Piscinas Cubiertas (ISPC) se clasificó a las Comunidades Autónomas en 4 niveles de desarrollo (Bajo, Medio-Bajo, Medio Alto y Alto). Los resultados ofrecen una gran disparidad entre las regiones en sus dotaciones de piscinas cubiertas, fruto de las diferentes inversiones políticas, culturas deportivas y realidades sociales, situándose en los primeros puestos las Comunidades Autónomas con mayor práctica deportiva. Este estudio puede servir de herramienta para una mejor planificación deportiva de las Autonomías y entidades promotoras del deporte. Palabras clave: piscinas cubiertas, indicador sintético, planificación deportiva, posicionamiento, comunidades autónomas. The physical-sport activity more practiced in Spain is the recreational swimming. In recent years, this activity has been amplified by the progressive increment of indoor pools, being these types of spaces, the ones that present more use. Different studies have manifested the positive association between the availability of sports facilities and levels of population’s physical activity. The qualitative and quantitative analysis of the offer of indoor swimming pools in Autonomous Communities can result an excellent indicator of the degree of development of these facilities, to achieve a healthy social context. For this study, 12 variables by a group of experts were selected to permit the analysis of the offer of indoor swimming pools in the Autonomous Communities. With the analysis of a Synthetic Indicator of Indoor Pools (ISPC), was classified each Autonomous Community into 4 levels of development (Low, Lower-Middle, Upper-Medium and Upper). The results demonstrate the great disparities between Autonomous Communities with regards of their resources in indoor swimming pools, which has been produced from different political investments, sports cultures and social realities, being in the first positions the Autonomous Communities with higher levels sports practice. This study can be a useful tool for better sports planning’s in Autonomies and also for companies of the sport. Key words: indoor pools, synthetic indicator, sports planning, ranking, autonomous communities

    Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners

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    This article belongs to the Special Issue TGF-beta/BMP Signaling PathwayEndoglin is a 180-kDa glycoprotein receptor primarily expressed by the vascular endothelium and involved in cardiovascular disease and cancer. Heterozygous mutations in the endoglin gene (ENG) cause hereditary hemorrhagic telangiectasia type 1, a vascular disease that presents with nasal and gastrointestinal bleeding, skin and mucosa telangiectases, and arteriovenous malformations in internal organs. A circulating form of endoglin (alias soluble endoglin, sEng), proteolytically released from the membrane-bound protein, has been observed in several inflammation-related pathological conditions and appears to contribute to endothelial dysfunction and cancer development through unknown mechanisms. Membrane-bound endoglin is an auxiliary component of the TGF-ß receptor complex and the extracellular region of endoglin has been shown to interact with types I and II TGF-ß receptors, as well as with BMP9 and BMP10 ligands, both members of the TGF-ß family. To search for novel protein interactors, we screened a microarray containing over 9000 unique human proteins using recombinant sEng as bait. We find that sEng binds with high affinity, at least, to 22 new proteins. Among these, we validated the interaction of endoglin with galectin-3, a secreted member of the lectin family with capacity to bind membrane glycoproteins, and with tripartite motif-containing protein 21 (TRIM21), an E3 ubiquitin-protein ligase. Using human endothelial cells and Chinese hamster ovary cells, we showed that endoglin co-immunoprecipitates and co-localizes with galectin-3 or TRIM21. These results open new research avenues on endoglin function and regulation.This work was supported by grants from Ministerio de Ciencia, Innovación y Universidades of Spain (SAF2013-43421-R to CB and SAF2017-84183-R to MQ), Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER; ISCIII-CB06/07/0038 to CB and contract CNV-234-PRF-360 to LR-L) and Consejo Superior de Investigaciones Científicas (CSIC; 201920E022 to CB). JC-V was supported by a postdoctoral contract co-funded by Consejo Superior de Investigaciones Científicas, Ministerio de Ciencia, Innovación y Universidades and the European Social Fund (ESF). CIBERER and CIBERNED are initiatives of the Instituto de Salud Carlos III (ISCIII) of Spain supported by European Regional Development (FEDER) funds

    Real-time 2.5  Gbit/s spatial circuit switching on W-band wireless links

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    A spatial circuit switching system based on a beam steering application for W-band wireless links is proposed and experimentally demonstrated. The system enables two simultaneous transmissions of a 2.5 Gbit∕s data signal over a carrier of 81 GHz, while allowing the receiver to dynamically switch between them. The performance of the system is tested with the real-time measurements of the BER, achieving values below the FEC limit for 7% of overhead and serving to prove the viability of wireless spatial circuit switching in the next generation of wireless access networks

    Andalucía transversal: sistema de información activa del espacio público en Andalucía

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    Andalucía Transversal [2] es un laboratorio de investigación activa sobre Espacio Público, apoyado en las infraestructuras de datos existentes, donde se pretende articular la información espacial para dar soporte a la formulación, implementación y evaluación de políticas públicas a diferentes niveles en el Paisaje Urbano de Andalucía. La presente actividad investigadora se enmarca en la segunda convocatoria de ayudas de I+D+i (G-GI3001/IDIU) de la Agencia de Obra Pública de la Junta de Andalucía, cofinanciadas con fondos europeos. Andalucía Transversal rescata una serie de iniciativas y documentos de investigación activa sobre territorio, paisaje, patrimonio y espacio público, en los que un grupo de profesionales de diferentes disciplinas y entornos, pertenecientes a la universidad, a la administración pública y a la empresa privada, lleva trabajando los últimos diez años. La metodología utilizada es en código abierto, transdisciplinar, más global que puramente urbanística o arquitectónica. El modelo empleado es experimental, integrador, centrado en el usuario y de carácter transversal. Redescubrir el Espacio Público en Andalucía supone intervenir en la re-activación de la ciudad histórica y de la ciudad en tránsito. Las preguntas centrales a las que se han de responder son: ¿Cómo son los nuevos lugares de lo público en Andalucía? ¿Cómo se puede ayudar a resolver los conflictos planteados en los nuevos espacios públicos? ¿Cómo se pueden orientar las políticas institucionales sobre espacios públicos? ¿Cómo se puede facilitar la colaboración entre los técnicos, los políticos y los ciudadanos en los proyectos de intervención sobre los espacios públicos? ¿Cómo se puede favorecer la apropiación de los ciudadanos de los espacios públicos? ¿Cómo se puede incrementar y mejorar la participación de los ciudadanos en la decisión sobre los espacios públicos? ¿Cuáles son sus conexiones y sus pautas evolutivas? ¿Es posible definirlas desde nuestras disciplinas y cómo? O bien, ¿Estamos ante un proceso de cambio y transformación que demanda nuevas metodologías y herramientas de acción?Tópico 1: Aspectos teóricos, históricos, legales, económicos y tecnológicos de la protección, conservación y valoración de los bienes del patrimonio cultural tangible. Planificación y gestión sostenible de los bienes del patrimonio cultural (arquitectónico, ingenieril, arqueológico) y paisajístico. Circuitos turísticos culturale

    Moisture content modeling and effective moisture diffusivity determination during convective solar drying of blackberry (rubus spp) and basil (Ocimum basilicum L.)

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    [EN] The goal of reducing energy consumption (EC), losses and waste (FL) in the food processing is a challenges in the worldwide. The use of active solar greenhouse dryers (GHD) for EC and FL reductions has increased due to its capacity, and low operating costs. In this work the effective diffusivity (Deff) and the moisture content modeling were analized for basil (Ocimum basilicum) and blackberry pulp (Rubus rosoideae) dried in a conventional stove (CD) and an GHD coupled to an additional air solar heating system (SCHa). The loss of water and the drying rate in food materials dehydrated in the GHD is consistent with the increment or decrement of temperature during the solar day. The Deff values for basil and blackberry pulp was ranged between -1.1044x10-7 and -3.9167x10-9. The solar energy obtained in the GHD supplied the heating requirements. In general, the Page’s model was the best fit for the drying kinetics for basil and blackberry pulp.López-Ortiz, A.; Gallardo-Brígido, JC.; Silva-Norman, A.; Pilatowsky-Figueroa, I.; García-Valladares, O.; Rodríguez-Ramírez, J. (2018). Moisture content modeling and effective moisture diffusivity determination during convective solar drying of blackberry (rubus spp) and basil (Ocimum basilicum L.). En IDS 2018. 21st International Drying Symposium Proceedings. Editorial Universitat Politècnica de València. 505-512. https://doi.org/10.4995/IDS2018.2018.7841OCS50551

    Study of the break-up channel in 11Li+208Pb collisions at energies around the Coulomb barrier

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    We present a study of 11Li+208 Pb collisions at energies around the Coulomb barrier (Elab = 24.3 and 29.8 MeV), measured at the post-accelerated beam facility, ISAC II, at TRIUMF (Vancouver, Canada). A remarkably large yield of 9Li has been observed, a result that is attributed to the weak binding of the 11Li nucleus. The angular distribution of this 9Li yield, relative to the elastic one, has been analysed in terms of first-order semiclassical calculations as well as four-body and three-body Continuum-Discretized Coupled-Channels (CDCC) calculations, based on a three-body and di-neutron model of the 11Li nucleus, respectively. The calculations reproduce well the trend of the data and support the existence of a large concentration of B (E1) strength at very low excitation energies. The connection of this large B (E1) with a possible low-lying dipole resonance is discussed

    Bioremediation of Olive Mill Wastewater sediments in evaporation ponds through in situ composting assisted by bioaugmentation

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    The common method for the disposal of olive oil mill wastewater (OMW) has been its accumulation in evaporation ponds where OMW sediments concentrate. Due to the phytotoxic and antimicrobial effect of OMW, leaks from ponds can pollute soils and water bodies. This work focuses on the search for microorganisms that can be used as inocula for bioremediation of polluted matrices in OMW ponds by means of in situ composting. Two fungi isolated from OMW sediments, Aspergillus ochraceus H2 and Scedosporium apiospermum H16, presented suitable capabilities for this use as a consortium. Composting eliminated the phyto- and ecotoxicity of OMW sediments by depleting their main toxic components. Inoculation with the fungal consortium improved the bioremediation efficacy of the technique by hastening the decrease of phytotoxicity and ecotoxicity and enhancing phytostimulant property of compost produced. This procedure constitutes a promising strategy for bioremediation of OMW polluted sites

    Experimental study of He6+Be9 elastic scattering at low energies

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    New data for the He6+Be9 reaction at Elab=16.2 and 21.3 MeV have been taken and analyzed. The effect of the collective couplings to the excited states of the target has been studied by means of coupled-channels calculations, using a double-folding potential for the bare interaction between the colliding nuclei, supplemented with a phenomenological imaginary part of Woods-Saxon type. In addition, three- and four-body continuum-discretized coupled-channels calculations have been performed to investigate the effect of the projectile breakup on the elastic scattering. Both effects, the coupling to target and projectile excited states, are found to affect significantly the elastic scattering. The trivial local polarization potential extracted from the continuum-discretized coupled-channels calculations indicates that continuum couplings produce a repulsive real part and a long-range imaginary part in the projectile-target interaction. © 2011 American Physical Society.This work has been partially supported by the Spanish Ministerio de Ciencia e Innovacion´ under Projects FPA2009-07653 and PCI2006-A7-0654 and by the Spanish Consolider-Ingenio 2010 Programme CPAN (CSD2007-00042).Peer Reviewe

    Multicentric Standardization of Protocols for the Diagnosis of Human Mitochondrial Respiratory Chain Defects

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    The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Institutional Review Board of each institution: IBC U737 (C0000128), HCL U722 (HCB2017/0808), 12O U723 (CEI:18/487), VH U701 (PR(IR)63/2016) and UPO U729 (C.I. 2768-N-21)The quantification of mitochondrial respiratory chain (MRC) enzymatic activities is essential for diagnosis of a wide range of mitochondrial diseases, ranging from inherited defects to secondary dysfunctions. MRC lesion is frequently linked to extended cell damage through the generation of proton leak or oxidative stress, threatening organ viability and patient health. However, the intrinsic challenge of a methodological setup and the high variability in measuring MRC enzymatic activities represents a major obstacle for comparative analysis amongst institutions. To improve experimental and statistical robustness, seven Spanish centers with extensive experience in mitochondrial research and diagnosis joined to standardize common protocols for spectrophotometric MRC enzymatic measurements using minimum amounts of sample. Herein, we present the detailed protocols, reference ranges, tips and troubleshooting methods for experimental and analytical setups in different sample preparations and tissues that will allow an international standardization of common protocols for the diagnosis of MRC defects. Methodological standardization is a crucial step to obtain comparable reference ranges and international standards for laboratory assays to set the path for further diagnosis and research in the field of mitochondrial diseasesThis work was supported by Instituto de Salud Carlos III (ISCIII), grants FIS PI17/00021, PI17/00359, PI18/00498, PI18/00451, PI18/01374, PI19/01772, PI20/00541, PI21/00229, PI21/00381 and PI21/00935 (ISCIII-FEDER “Cofinanciado por la Unión Europea”), Fundació Privada Cellex, Junta de Andalucía (UPO-1262247) and Ministerio de Ciencia e Innovación (MCINN) grant PID2019-110320RBI00. All participant centers are integrated in the Centro de Investigación Biomédica en Red (CIBER), Sección de Enfermedades Raras (CIBERER, an initiative of ISCIII), which is the founder of this present methodological stud
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