Design of the Front End Electronics for the Infrared Camera of JEM-EUSO, and manufacturing and verification of the prototype model

The Japanese Experiment Module (JEM) Extreme Universe Space Observatory (EUSO) will be launched and attached to the Japanese module of the International Space Station (ISS). Its aim is to observe UV photon tracks produced by ultra-high energy cosmic rays developing in the atmosphere and producing extensive air showers. The key element of the instrument is a very wide-field, very fast, large-lense telescope that can detect extreme energy particles with energy above $10^{19}$ eV. The Atmospheric Monitoring System (AMS), comprising, among others, the Infrared Camera (IRCAM), which is the Spanish contribution, plays a fundamental role in the understanding of the atmospheric conditions in the Field of View (FoV) of the telescope. It is used to detect the temperature of clouds and to obtain the cloud coverage and cloud top altitude during the observation period of the JEM-EUSO main instrument. SENER is responsible for the preliminary design of the Front End Electronics (FEE) of the Infrared Camera, based on an uncooled microbolometer, and the manufacturing and verification of the prototype model. This paper describes the flight design drivers and key factors to achieve the target features, namely, detector biasing with electrical noise better than $100 \mu$V from $1$ Hz to $10$ MHz, temperature control of the microbolometer, from $10^{\circ}$C to $40^{\circ}$C with stability better than $10$ mK over $4.8$ hours, low noise high bandwidth amplifier adaptation of the microbolometer output to differential input before analog to digital conversion, housekeeping generation, microbolometer control, and image accumulation for noise reduction

Magnetocaloric effect in random magnetic anisotropy materials

In this letter we report the results of entropy variations in random anisotropy magnets composed of TbxY1−xAl2, with x=0.15, 0.20, 0.25, 0.35, 0.40, and 0.50. We discovered large entropy variation associated with the spin glass to paramagnetictransition. Both temperature transition and entropy changes were studied at different temperatures and with different compositions. Our conclusion is that these materials are suitable candidates for use as magnetic refrigerants in a temperature range below 40 K

MODELOS DE GESTIÓN DEL CONOCIMIENTO QUE INTEGREN TECNOLOGÍAS E-LEARNING EN LA EDUCACIÓN SUPERIOR

La Universidad de la Amazonia cuenta con personas que tienen un conocimiento tácito individual en el área de la programación de computadores, los cuales desempeñan el rol de docente. Los docentes socializan este conocimiento a sus estudiantes mediante un trabajo magistral en el aula de clase, complementado con trabajos en grupo y exposiciones, generando de esta forma un conocimiento público o lo que también se conoce como conocimiento tácito colectivo.Sin embargo, como se ha evidenciado mediante un estudio inicial, tanto los docentes como los estudiantes del área de programación no tienen la cultura de exteriorizar este conocimiento, por ejemplo, mediante la documentación de sus experiencias de clase. Esto ocasiona, entre otros los siguientes problemas: desde el punto de vista de los docentes: (i) no existe una socialización de las experiencias lo que ocasiona que cada semestre se cometan los mismos errores en los procesos de enseñanza; (ii) los conocimientos tácitos de los docentes son difíciles de formalizar, comunicar y transferir. Desde el punto de vista de los estudiantes: (i) se denotan altos porcentajes de pérdida de la asignatura de programación básica; (ii) no se tiene a disposición medios educativos diferentes a la clase magistral impartida por el docente, lo que genera falta de motivación en el estudio.Una de las estrategias que puede ayudar a solventar estos problemas es lo que se conoce como un modelo de gestión del conocimiento. La integración de herramientas e-learning en la gestión del conocimiento facilita los procesos de captura, organización, almacenamiento y transferencia de información, para posteriormente acceder a ella  y gestionarla.Este artículo es de revisión del estado del arte de la temática Modelos de gestión del conocimiento en la educación

Experimental measurement of the quality factor of a Fabry-P\'erot open-cavity axion haloscope

The axion is a hypothetical boson arising from the most natural solution to the problem of charge and parity symmetry in the strong nuclear force. Moreover, this pseudoscalar emerges as a dark matter candidate in a parameter space extending several decades in mass. The Dark-photons \& Axion-Like particles Interferometer (DALI) is a proposal to search for axion dark matter in a range that remains under-examined. Currently in a design and prototyping phase, this haloscope is a multilayer Fabry-P\'erot interferometer. A proof-of-principle experiment is performed to observe the resonance in a prototype. The test unveils a quality factor per open cavity of a few hundred over a bandwidth of the order of dozens of megahertz. The result elucidates a physics potential to find the, so far elusive, axion, in a sector which can simultaneously solve the symmetry problem in the strong interaction and the enigma of dark matter.Comment: 5 pages, 6 figure

Plan de responsabilidad social para la empresa hidrosanitarias NMC en la ciudad de Ibagué - Tolima.

Anexo A. Enlace al Código de Ética: https://editor.reedsy.com/s/EY98m35 Anexo B. Formato de Recolección de Información - Diseño encuesta aplicada a directivos: https://forms.gle/ExEBvWh7mLXyUjJW8 - Diseño encuesta aplicada a colaboradores: https://forms.gle/1FMTykR1NDjSBczu6En la presente investigación se realiza el Plan estratégico de responsabilidad social empresarial (RSE) para la empresa Hidrosanitarias NMC, contando con la colaboración de los grupos de interés (Stakeholders), realizando un reconocimiento a los diferentes temas que permiten hacer una conceptualización y teorización de lo que representa actuar con responsabilidad social empresarial, los elementos que comprenden la ética empresarial, la planeación estratégica que incluye las acciones que favorezcan al medio ambiente y el desarrollo de sus operaciones, las labores sociales y todo aquello que genera beneficios para los stakeholders y así estar contribuyendo económicamente en el desarrollo de la región. Se realiza un diagnóstico integral a cada una de las áreas, identificando como el problema crítico de la empresa el Incumplimiento de las prácticas y políticas ambientales, para lo cual mediante un análisis con la matriz de marco lógico se busca plantear objetivos estratégicos para superar y/o mitigar los problemas y de esta forma proponer un Plan estratégico de responsabilidad social para la empresa, que contribuye a procesos internos, mejorar su imagen y el reconocimiento de esta empresa en el entorno comercial por sus acciones y buenas prácticas empresariales. Se presenta una propuesta de Plan de acción y seguimiento para la empresa Hidrosanitarias NMC para así dar cumplimiento de las prácticas y políticas ambientales dentro de los temas fundamentales de la ISO 26000.In this research, the strategic plan of corporate social responsibility for the company Hidrosanitarias NMC is carried out, with the collaboration of the stakeholders, making a recognition of the different topics that allow a conceptualization and theorization of what it represents to act with corporate social responsibility, the elements that comprise business ethics, strategic planning that includes actions that favor the environment and the development of its operations, social work and everything that generates benefits for stakeholders and thus be contributing economically in the development of the region. A comprehensive diagnosis is made in each of the areas, identifying as the critical problem of the company the non-compliance of environmental practices and policies, for which by means of an analysis with the logical framework matrix seeks to propose strategic objectives to overcome and/or mitigate the problems and thus propose a strategic plan of social responsibility for the company, which contributes to internal processes, improve its image and the recognition of this company in the business environment for its actions and good business practices. A proposal for an action and follow-up plan for Hidrosanitarias NMC is presented in order to comply with environmental practices and policies within the fundamental topics of ISO 26000

Silibinin suppresses EMT-driven erlotinib resistance by reversing the high miR-21/low miR-200c signature in vivo

The flavolignan silibinin was studied for its ability to restore drug sensitivity to EGFR-mutant NSCLC xenografts with epithelial-to-mesenchymal transition (EMT)-driven resistance to erlotinib. As a single agent, silibinin significantly decreased the tumor volumes of erlotinib-refractory NSCLC xenografts by approximately 50%. Furthermore, the complete abrogation of tumor growth was observed with the co-treatment of erlotinib and silibinin. Silibinin fully reversed the EMT-related high miR-21/low miR-200c microRNA signature and repressed the mesenchymal markers SNAIL, ZEB, and N-cadherin observed in erlotinib-refractory tumors. Silibinin was sufficient to fully activate a reciprocal mesenchymal-to-epithelial transition (MET) in erlotinib-refractory cells and prevent the highly migratogenic phenotype of erlotinib-resistant NSCLC cells. Given that the various mechanisms of resistance to erlotinib result from EMT, regardless of the EGFR mutation status, a water-soluble, silibinin-rich milk thistle extract might be a suitable candidate therapy for upcoming clinical trials aimed at preventing or reversing NSCLC progression following erlotinib treatment

Multi-Targeted Molecular Effects of Hibiscus sabdariffa Polyphenols: An Opportunity for a Global Approach to Obesity

Improper diet can alter gene expression by breaking the energy balance equation and changing metabolic and oxidative stress biomarkers, which can result in the development of obesity-related metabolic disorders. The pleiotropic effects of dietary plant polyphenols are capable of counteracting by modulating different key molecular targets at the cell, as well as through epigenetic modifications. Hibiscus sabdariffa (HS)-derived polyphenols are known to ameliorate various obesity-related conditions. Recent evidence leads to propose the complex nature of the underlying mechanism of action. This multi-targeted mechanism includes the regulation of energy metabolism, oxidative stress and inflammatory pathways, transcription factors, hormones and peptides, digestive enzymes, as well as epigenetic modifications. This article reviews the accumulated evidence on the multiple anti-obesity effects of HS polyphenols in cell and animal models, as well as in humans, and its putative molecular targets. In silico studies reveal the capacity of several HS polyphenols to act as putative ligands for different digestive and metabolic enzymes, which may also deserve further attention. Therefore, a global approach including integrated and networked omics techniques, virtual screening and epigenetic analysis is necessary to fully understand the molecular mechanisms of HS polyphenols and metabolites involved, as well as their possible implications in the design of safe and effective polyphenolic formulations for obesity.Some of the investigations described in this review have been partially or fully supported by competitive public grants from the following institutions: AGL2011-29857-C03-03 and IDI-20120751 grants (Spanish Ministry of Science and Innovation); projects AGL2015-67995-C3-1-R, AGL2015-67995-C3-2-R and AGL2015-67995-C3-3-R from the Spanish Ministry of Economy and Competitiveness (MINECO); and PROMETEO/2012/007, PROMETEO/2016/006, ACOMP/2013/093, ACIF/2010/162, ACIF/2015/158 and ACIF/2016/230 grants from Generalitat Valenciana and CIBER (CB12/03/30038, Fisiopatologia de la Obesidad y la Nutricion, CIBERobn, Instituto de Salud Carlos III, Spain)

Evaluation of 12 GWAS-drawn SNPs as biomarkers of rheumatoid arthritis response to TNF inhibitors. A potential SNP association with response to etanercept

Research in rheumatoid arthritis (RA) is increasingly focused on the discovery of biomarkers that could enable personalized treatments. The genetic biomarkers associated with the response to TNF inhibitors (TNFi) are among the most studied. They include 12 SNPs exhibiting promising results in the three largest genome-wide association studies (GWAS). However, they still require further validation. With this aim, we assessed their association with response to TNFi in a replication study, and a meta-analysis summarizing all nonredundant data. The replication involved 755 patients with RA that were treated for the first time with a biologic drug, which was either infliximab (n = 397), etanercept (n = 155) or adalimumab (n = 203). Their DNA samples were successfully genotyped with a single-base extension multiplex method. Lamentably, none of the 12 SNPs was associated with response to the TNFi in the replication study (p > 0.05). However, a drug-stratified exploratory analysis revealed a significant association of the NUBPL rs2378945 SNP with a poor response to etanercept (B = -0.50, 95% CI = -0.82, -0.17, p = 0.003). In addition, the metaanalysis reinforced the previous association of three SNPs: rs2378945, rs12142623, and rs4651370. In contrast, five of the remaining SNPs were less associated than before, and the other four SNPs were no longer associated with the response to treatment. In summary, our results highlight the complexity of the pharmacogenetics of TNFi in RA showing that it could involve a drug-specific component and clarifying the status of the 12 GWAS-drawn SNPsThis work was supported by the Instituto de Salud Carlos III (ISCIII, Spain) through grants PI14/01651, PI17/01606 and RD16/0012/0014 to AG and PI12/01909 to JJG-R. These grants are partially financed by the European Regional Development Fund of the EU (FEDER

Sustained low disease activity measured by ASDAS slow radiographic spinal progression in axial spondyloarthritis patients treated with TNF-inhibitors: data from REGISPONSERBIO

Background To evaluate the influence of the disease activity on radiographic progression in axial spondyloarthritis (axSpA) patients treated with TNF inhibitors (TNFi). Methods The study included 101 axSpA patients from the Spanish Register of Biological Therapy in Spondyloarthritides (REGISPONSERBIO), which had clinical data and radiographic assessment available. Patients were classified into 2 groups based on the duration of TNFi treatment at baseline: (i) long-term treatment (>= 4 years) and (ii) no long-term treatment (= 2 mSASSS units. At inclusion, approximately half of the patients (45.5%) were receiving long-term treatment with TNFi (>= 4 years). In this group of subjects, a significant difference in averaged Ankylosing Spondylitis disease Activity Score (ASDAS) across follow-up was found between progressors and non-progressors (2.33 vs 1.76, p=0.027, respectively). In patients not under long-term TNFi treatment (54.5%) though, no significant ASDAS differences were observed between progressors and non-progressors until the third year of follow-up. Furthermore, no significant differences were found in progression status, when disease activity was measured by Bath Ankylosing spondylitis Disease Activity Index (BASDAI) and C reactive protein (CRP). Conclusions Patients on long-term TNFi treatment with a mean sustained low disease activity measures by ASDAS presented lower radiographic progression than those with active disease

Evaluation of 12 GWAS-drawn SNPs as biomarkers of rheumatoid arthritis response to TNF inhibitors. A potential SNP association with response to etanercept

Research in rheumatoid arthritis (RA) is increasingly focused on the discovery of biomarkers that could enable personalized treatments. The genetic biomarkers associated with the response to TNF inhibitors (TNFi) are among the most studied. They include 12 SNPs exhibiting promising results in the three largest genome-wide association studies (GWAS). However, they still require further validation. With this aim, we assessed their association with response to TNFi in a replication study, and a meta-analysis summarizing all non-redundant data. The replication involved 755 patients with RA that were treated for the first time with a biologic drug, which was either infliximab (n = 397), etanercept (n = 155) or adalimumab (n = 203). Their DNA samples were successfully genotyped with a single-base extension multiplex method. Lamentably, none of the 12 SNPs was associated with response to the TNFi in the replication study (p > 0.05). However, a drug-stratified exploratory analysis revealed a significant association of the NUBPL rs2378945 SNP with a poor response to etanercept (B = -0.50, 95% CI = -0.82, -0.17, p = 0.003). In addition, the meta-analysis reinforced the previous association of three SNPs: rs2378945, rs12142623, and rs4651370. In contrast, five of the remaining SNPs were less associated than before, and the other four SNPs were no longer associated with the response to treatment. In summary, our results highlight the complexity of the pharmacogenetics of TNFi in RA showing that it could involve a drug-specific component and clarifying the status of the 12 GWAS-drawn SNP