152 research outputs found

    On the leakage-power modeling for optimal server operation

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    Leakage power consumption is a com- ponent of the total power consumption in data cen- ters that is not traditionally considered in the set- point temperature of the room. However, the effect of this power component, increased with temperature, can determine the savings associated with the careful management of the cooling system, as well as the re- liability of the system. The work presented in this paper detects the need of addressing leakage power in order to achieve substantial savings in the energy consumption of servers. In particular, our work shows that, by a careful detection and management of two working regions (low and high impact of thermal- dependent leakage), energy consumption of the data- center can be optimized by a reduction of the cooling budget

    Evaluación del Programa Piloto de Dispensación de Medicamentos en Dosis Personalizada en Galicia

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    ResumenObjetivoEvaluar, desde una perspectiva económica, los resultados del Programa Piloto de Dispensación de Medicamentos en Dosis Personalizada en Galicia.Pacientes y métodosEstudio retrospectivo de las 35.923 recetas de antibióticos (amoxicilina, amoxicilina/clavulánico, claritromicina, cefuroxima axetilo y ciprofloxacino) en dosis personalizada generadas en el programa de 12 meses de duración en el que participaron 292 médicos de familia de 46 unidades de atención primaria del Servicio Gallego de Salud y 167 oficinas de farmacia.ResultadosEl 60,57% de los tratamientos prescritos no se ajustaba de manera exacta a las presentaciones disponibles en el mercado. El ahorro, en número de unidades, de la dispensación en dosis personalizada frente a la convencional fue del 14,32%. El ahorro económico fue del 29,94%, lo que supondría un 0,46% de la facturación en Galicia. La inclusión de 2 presentaciones nuevas en amoxicilina y amoxicilina/ clavulánico (de 15 y 21 comprimidos) y de una en los otros 3 (cefuroxima y ciprofloxacino de 14 comprimidos y claritromicina de 16) evitaría el 86,5% de las unidades sobrantes.ConclusionesEl importante sobrante de tratamientos prescritos (1.800.000 dosis de antibiótico en 2004 para el caso de Galicia) podría reducirse con la dispensación en dosis personalizada y, parcialmente, con la entrada en el mercado de nuevas presentaciones.AbstractObjectiveTo quantify, from an economic perspective, the results of the Pilot Program of Dispensation of Medicines in Unitary Dose in Galicia, Spain.Patients and methodsRetrospective study from 35,923 antibiotic prescriptions in customized doses corresponding to 5 active principles (amoxicillin, amoxicilin/clavulanic, claritromicin, cefuroxima axetil and ciprofloxacin). The program, which worked during 12 months, included 292 physicians from 46 units of primary care of the Galician Health Service and 167 offices of pharmacy.Results60.57% of the prescribed treatments did not adjust xactly to the conventional presentations existing in the market. Savings in units of antibiotic of the dispensation in customized doses forehead to the conventional one has been of 14.32%. Registered economic saving has been of 29.94%. The inclusion of 2 new presentations in amoxiciline and amoxiciline/ clavulanic (of 15 and 21 tablets) and of one in the other 3 (cefuroxima and ciprofloxacine of 14 tablets and claritromicine of 16) would avoid 86.5% of the leftover units without having to implement individualized dispensation.ConclusionsAn important antibiotic stock is being generated in the domestic medicine kits as a result of the leftovers of prescribed treatments that in the case of Galicia are equivalent to more than 1,800,000 doses of antibiotic in 2004. This problem could be reduced with the dispensation in customized dose and partially with new presentations

    Flue gas adsorption by single-wall carbon nanotubes: A Monte Carlo study

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    Adsorption of flue gases by single-wall carbon nanotubes (SWCNT) has been studied by means of Monte Carlo simulations. The flue gas is modeled as a ternary mixture of N2, CO2, and O2, emulating realistic compositions of the emissions from power plants. The adsorbed flue gas is in equilibrium with a bulk gas characterized by temperature T , pressure p, and mixture composition. We have consid- ered different SWCNTs with different chiralities and diameters in a range between 7 and 20 Å. Our results show that the CO2 adsorption properties depend mainly on the bulk flue gas thermodynamic conditions and the SWCNT diameter. Narrow SWCNTs with diameter around 7 Å show high CO2 adsorption capacity and selectivity, but they decrease abruptly as the SWCNT diameter is increased. For wide SWCNT, CO2 adsorption capacity and selectivity, much smaller in value than for the narrow case, decrease mildly with the SWCNT diameter. In the intermediate range of SWCNT diameters, the CO2 adsorption properties may show a peculiar behavior, which depend strongly on the bulk flue gas conditions. Thus, for high bulk CO2 concentrations and low temperatures, the CO2 adsorption capacity remains high in a wide range of SWCNT diameters, although the corresponding selectivity is moderate. We correlate these findings with the microscopic structure of the adsorbed gas inside the SWCNTs.Ministerio de Economía y Competitividad MAT2013-42934-R y FIS2012-3245

    Users, content and platforms: A multidimensional approach to the research of news sharing

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    The sharing of news on the internet and social media has been a growing area of research for scholars. As early as 2011, the Pew Research Center in the U.S. suggested that “if searching for news was the most important development of the last decade, sharing news may be among the most important of the next” (Olmstead, Mitchell & Rosenstiel, 2011, p. 10). Just a few years later, a review of the literature identified 461 peer-reviewed articles on the topic from 2004 to 2014 (Kümpel, Karnowski & Keyling, 2015). No doubt that number has risen since then, particularly given concerns about the circulation of mis and dis-information on social media. It is important to note that the sharing of news is a 21st century online phenomenon. Through the ages, people have found ways to disseminate, discuss and dissect the news, from adding their own commentary to the blank pages of eighteenth-century newspapers in England (Singer et al., 2011) to meeting in parks in Paris to hear about the latest scandals at the court of Louis XV (Hermida, 2014).Ciencias de la Comunicació

    Data Mining of Polymer Phase Transitions upon Temperature Changes by Small and Wide-Angle X-ray Scattering Combined with Raman Spectroscopy

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    The complex physical transformations of polymers upon external thermodynamic changes are related to the molecular length of the polymer and its associated multifaceted energetic balance. The understanding of subtle transitions or multistep phase transformation requires real-time phenomenological studies using a multi-technique approach that covers several length-scales and chemical states. A combination of X-ray scattering techniques with Raman spectroscopy and Differential Scanning Calorimetry was conducted to correlate the structural changes from the conformational chain to the polymer crystal and mesoscale organization. Current research applications and the experimental combination of Raman spectroscopy with simultaneous SAXS/WAXS measurements coupled to a DSC is discussed. In particular, we show that in order to obtain the maximum benefit from simultaneously obtained high-quality data sets from different techniques, one should look beyond traditional analysis techniques and instead apply multivariate analysis. Data mining strategies can be applied to develop methods to control polymer processing in an industrial context. Crystallization studies of a PVDF blend with a fluoroelastomer, known to feature complex phase transitions, were used to validate the combined approach and further analyzed by MVA

    El consumo de psicofármacos en pacientes que acuden a Atención Primaria en el Principado de Asturias (España)

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    En este estudio se analiza el consumo de psicofármacos en los pacientes que acuden a los centros de Atención Primaria del Principado de Asturias, así como las variables relacionadas con el uso de estas sustancias. La muestra se compuso de 602 personas seleccionadas mediante un muestreo por conglomerados en dos etapas. Los resultados señalan que el 37,9% de los pacientes consume psicofármacos. El consumo de estos medicamentos es significativamente superior en las mujeres, en las amas de casa, en los desempleados y en las personas con bajo nivel educativo. Los trastornos de ansiedad, del sueño y los síntomas depresivos son los motivos más frecuentes. El 28% de la muestra cumplía los criterios de dependencia a este tipo de sustancias. Estos resultados indican unas tasas de consumo muy elevadas y sugieren la necesidad de la puesta en marcha de estrategias que reduzcan el uso de psicofármacos en esta población

    Rare variants in genes of the cholesterol pathway are present in 60% of patients with acute myocardial infarction

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    [Abstract] Acute myocardial infarction (AMI) is a pandemic in which conventional risk factors are inadequate to detect who is at risk early in the asymptomatic stage. Although gene variants in genes related to cholesterol, which may increase the risk of AMI, have been identified, no studies have systematically screened the genes involved in this pathway. In this study, we included 105 patients diagnosed with AMI with an elevation of the ST segment (STEMI) and treated with primary percutaneous coronary intervention (PPCI). Using next-generation sequencing, we examined the presence of rare variants in 40 genes proposed to be involved in lipid metabolism and we found that 60% of AMI patients had a rare variant in the genes involved in the cholesterol pathway. Our data show the importance of considering the wide scope of the cholesterol pathway in order to assess the genetic risk related to AMI.Insituto de Salud Carlos III; PI18/0173

    Quantification of cells expressing mesenchymal stem cell markers in healthy and osteoarthritic synovial membranes

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    [Abstract] Objective. To quantify cells expressing mesenchymal stem cell (MSC) markers in synovial mem- branes from human osteoarthritic (OA) and healthy joints. Methods. Synovial membranes from OA and healthy joints were digested with collagenase and the isolated cells were cultured. Synovial membrane-derived cells were phenotypically characterized for differentiation experiments using flow cytometry to detect the expression of mesenchymal markers (CD29, CD44, CD73, CD90, CD105, CD117, CD166, and STRO-1) and hematopoietic markers (CD34 and CD45). Chondrogenesis was assessed by staining for proteoglycans and collagen type II, adipogenesis by using a stain for lipids, and osteogenesis by detecting calcium deposits. Coexpression of CD44, CD73, CD90, and CD105 was determined using immunofluorescence. Results. Cells expressing MSC markers were diffusely distributed in OA synovial membranes; in healthy synovial membrane these cells were localized in the subintimal zone. More numerous MSC markers in OA synovial membranes were observed in cells also expressing the CD90 antigen. FACS analysis showed that more than 90% of OA synovial membrane-derived cells were positive for CD44, CD73, and CD90, and negative for CD34 and CD45. OA synovial membrane-derived cells were also positive for CD29 (85.23%), CD117 (72.35%), CD105 (45.5%), and STRO-1 (49.46%). Micropellet analyses showed that the culture of cells with transforming growth factor-ß3 stimulated proteoglycan and collagen type II synthesis. Conclusion. Synovial membranes from patients with OA contain more cells positive for CD44, CD90, and CD105 antigens than those from joints with undamaged cartilage
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