Uso de Minería de Datos Para la Determinación de Perfiles Socioeconómicos y Sanitarios en la UNCAus

El proyecto PI N° 91, aprobado por Res. N° 332/18 CS, se desarrolla con el fin de obtener información relevante que detecte variables relacionadas con los frecuentes problemas de salud en la ciudad de Presidencia Roque Sáenz Peña (Chaco, Argentina) y su área de influencia, relacionando los pacientes con su hábitat, ecología y salud. Para ello se trabaja con la información proveniente de las actividades curriculares de vinculación comunitaria que la carrera de Medicina de la UNCAus (Universidad Nacional del Chaco Austral) realiza en los distintos barrios de dicha ciudad y su zona de influencia; con dicha información se construye un almacén de datos (data warehouse) que es estudiado con técnicas de minería de datos (data mining), especialmente técnicas de agrupamiento (clusterización) y de árboles de decisión, a los efectos de conseguir los perfiles característicos relacionados con los distintos tipos de diagnósticos; en un principio se buscan modelos descriptivos de minería de datos, para pasar en el futuro a modelos predictivos, lo cual permitiría disponer de conocimiento que permitiría mejorar la toma de decisiones en cuanto a campañas de salud hacia la población de los barrios de la ciudad de P. R. Sáenz Peña. Project PI N ° 91, approved by Res. N ° 332/18 CS, was developed in order to obtain relevant information that detects variables related to frequent health problems in the city of Presidencia Roque Sáenz Peña (Chaco, Argentina) and its area of influence, relating patients to their habitat, ecology, and health. For this, we work with the information coming from the curricular activities based on the relationship with the community that the Medicine undergraduate degree program of the UNCAus (National University of Chaco Austral) carries out in the different neighborhoods of the said city and its area of influence. With this information, a data warehouse was built and studied with data mining techniques, especially clustering techniques and decision trees, in order to achieve the characteristic profiles related to the different types of diagnosis. Initially, descriptive data mining models was sought and moved on to predictive models in the future. This would result to knowledge that would lead to better decision-making regarding health campaigns towards the population of the neighborhoods of the city of P.R. Sáenz Peña

The architecture of an empirical genotype-phenotype map

Recent advances in high‐throughput technologies are bringing the study of empirical genotype‐phenotype (GP) maps to the fore. Here, we use data from protein‐binding microarrays to study an empirical GP map of transcription factor (TF) ‐binding preferences. In this map, each genotype is a DNA sequence. The phenotype of this DNA sequence is its ability to bind one or more TFs. We study this GP map using genotype networks, in which nodes represent genotypes with the same phenotype, and edges connect nodes if their genotypes differ by a single small mutation. We describe the structure and arrangement of genotype networks within the space of all possible binding sites for 525 TFs from three eukaryotic species encompassing three kingdoms of life (animal, plant, and fungi). We thus provide a high‐resolution depiction of the architecture of an empirical GP map. Among a number of findings, we show that these genotype networks are “small‐world” and assortative, and that they ubiquitously overlap and interface with one another. We also use polymorphism data from Arabidopsis thaliana to show how genotype network structure influences the evolution of TF‐binding sites in vivo. We discuss our findings in the context of regulatory evolution

La cobertura de la burbuja inmobiliaria en la prensa española (2003-2013). Un análisis de las opiniones de las fuentes políticas y expertos

: Este estudio analiza las opiniones de políticos y expertos publicadas en cinco diarios españoles (los tres principales periódicos nacionales -El País, El Mundo y ABC-, y los dos principales periódicos financieros -Expansión y Cinco Días-) antes y después de la explosión de la burbuja inmobiliaria española. La metodología básica del estudio es el análisis de contenido, cuantitativo y cualitativo, de informaciones publicadas en los diarios citados entre 2003 y 2013. El trabajo se centra en el análisis estadístico de coincidencias y divergencias en las declaraciones y opiniones de esas fuentes en torno a la naturaleza, causas y consecuencias de la burbuja. La hipótesis general de la investigación es que antes de la crisis, especialmente entre los políticos, no hubo un verdadero debate sobre la amenaza de una burbuja del sector inmobiliario, ni sobre sus posibles causas y consecuencias probables, con lo que dominó en la opinión autorizada un consenso “negacionista”.This study compiles and analyzes data on views of politicians and economists reported in news articles published in five Spanish dailies (the three leading national newspapers –El País, El Mundo and ABC-, and the two leading financial newspapers –Expansión and Cinco Días–). Quantitative content analysis will be used as the basic methodology for research. This content analysis will be focused on the coincidences and divergences between the nature, structure and frames of the opinions and comments on the bubble made by these policy makers and experts in two different periods, before and after the bubble burst. The general hypothesis of the research is that before the crisis –especially among politicians– there was not a real discussion on the threat of a housing bubble, its causes and probable consequences, but a quite orchestrated “negationist” consensus

Multidimensional evaluation of the pain profile as prognostic factor in individuals with hip or knee osteoarthritis receiving total joint replacement:protocol of a 2-year longitudinal prognostic cohort study

INTRODUCTION: Knee and hip osteoarthritis are two highly prevalent musculoskeletal pain conditions. Unsuccessful rates after hip/knee replacement range from 10% to 20%. Subjects with sensitisation manifestations are vulnerable to worse clinical outcomes. Most studies have analysed outcomes up to 1 year after surgery. The aim of this 2-year longitudinal study will be to evaluate sensory-related, psychological and psychophysical pain sensitisation manifestations and a potential epigenetic biomarker as prognostic clinical outcomes for the development of chronic postoperative pain after knee or hip replacement.METHODS AND ANALYSIS: A prospective longitudinal study with a 2-year follow-up period will be conducted. The prognostic variables will include pain, function, related-disability, anxiety, depression, quality of life, sensitisation-associated symptoms, kinesiophobia, neuropathic pain and catastrophising, and expectative of the intervention will be assessed before surgery. We will also evaluate the presence of the Val158Met polymorphism as a possible epigenetic marker. Clinical outcomes including pain, related-disability and self-perceived satisfaction, sensitisation-associated symptoms and neuropathic pain will be assessed 3, 6, 12, 18 and 24 months after surgery. These variables will be used to construct three prediction models: (1) pain and function, (2) sensitisation-associated symptomatology and (3) neuropathic pain features classifying those patients in responders and non-responders. Data from knee or hip osteoarthritis will be analysed separately. Statistical analyses will be conducted with logistic regressions.ETHICS AND DISSEMINATION: The study has been approved by the Ethics Committee of both institutions involved (Hospital Universitario Fundación Alcorcón (HUFA) 19-141 and Universidad Rey Juan Carlos (URJC) 0312201917319). Participants will sign the written informed consent before their inclusion. Study results will be disseminated through peer-reviewed publications and presentations at scientific meetings.</p

Debris Flows Occurrence in the Semiarid Central Andes under Climate Change Scenario

This review paper compiles research related to debris flows and hyperconcentrated flows in the central Andes (30°–33° S), updating the knowledge of these phenomena in this semiarid region. Continuous records of these phenomena are lacking through the Andean region; intense precipitations, sudden snowmelt, increased temperatures on high relief mountain areas, and permafrost degradation are related to violent flow discharges. Documented catastrophic consequences related to these geoclimatic events highlight the need to improve their understanding in order to prepare the Andean communities for this latent danger. An amplified impact is expected not only due to environmental changes potentially linked to climate change but also due to rising exposure linked to urban expansion toward more susceptible or unstable areas. This review highlights as well the need for the implementation of preventive measures to reduce the negative impacts and vulnerability of the Andean communities in the global warming context.Fil: Moreiras, Stella Maris. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: Sepúlveda, Sergio A.. Universidad de Chile; Chile. Universidad de O’higgins; ChileFil: Correas Gonzalez, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: Lauro, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: Vergara Dal Pont, Iván Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales. Universidad Nacional del Comahue. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales; ArgentinaFil: Jeanneret, Pilar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: Junquera Torrado, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: Cuevas, Jaime G.. Universidad de La Serena; ChileFil: Maldonado, Antonio. Universidad de La Serena; ChileFil: Antinao, José L.. Indiana University; Estados UnidosFil: Lara, Marisol. Universidad de Chile; Chil

Novel Phenazine 5,10-Dioxides Release •OH in Simulated Hypoxia and Induce Reduction of Tumour Volume In Vivo

Phenazine 5,10-dioxides (PDOs) are a new class of bioreductive cytotoxins, which could act towards tumours containing hypoxic regions. The PDOs selective-hypoxic bioreduction was probed in vitro; however, the mechanism of action has not been completely explained. Besides, PDOs in vivo antitumour activities have not been demonstrated hitherto. We study the mechanism of hypoxic/normoxic cytotoxicity of PDO representative members. Electron spin resonance is used to confirm •OH production, alkaline comet assay to determine genotoxicity, and gel electrophoresis and flow cytometry to analyze DNA fragmentation and cell cycle distribution. Chemically induced rat breast tumours are employed to evaluate in vivo activities. For the most selective cytotoxin, 7(8)-bromo-2-hydroxyphenazine 5,10-dioxide (PDO1), exclusive hypoxic •OH production is evidenced, while for the unselective ones, •OH is produced in both conditions (normoxia and simulated hypoxia). In normoxia (Caco-2 cells), PDO1 induces cell-cycle arrest and DNA fragmentation but does not significantly induce apoptosis neither at IC50 nor IC80. No difference in the comet-assay scores are observed in normoxia and simulated hypoxia being the unselective 2-amino-7(8)-bromophenazine 5,10-dioxide (PDO2) the most genotoxic. The in vivo efficacy with the absence of systemic toxicity of PDO1 and PDO2 is checked out. Results from this study highlight the potential of PDOs as new therapeutics for cancer

Comparing the microstructure and photovoltaic performance of 3 perylene imide acceptors with similar energy levels but different packing tendencies

[Abstract] While it is widely recognized that microstructure plays an important role in the performance of organic photovoltaics (OPV), systematic studies are often challenging, as varying the molecular packing through typical chemical means (such as sidechain tuning) often affects the molecular energy levels, thus preventing a clear correlation. In this work we present the synthesis of three perylene imide (PI) based electron acceptors with almost identical energy levels, but distinct packing tendencies. We confirm our initial hypothesis by measuring solution and solid-state absorption, and cyclic voltammetry as well as characterizing the films by grazing incidence wide angle X-ray scattering (GIWAXS). In a second step, we repeat the characterization of the three materials in blends with two polymer donors, namely PCDTBT or PBDBT, whose energy levels are well aligned with those of the PI acceptors, and which, additionally, exhibit different degrees of structural order. We show how the initial strong difference between acceptors is partially blurred in blends, but still critical. Finally, we correlate our structural data with OPV devices made with the corresponding six blends. Our data suggest that a good donor acceptor marriage should ensure good energy alignment but also exhibit complementary crystallization tendencies of the two components.Ministerio de Ciencia e Innovación; CEX2019-000917-SMinisterio de Ciencia e Innovación; PGC2018-095411-B-I00Ministerio de Ciencia e Innovación; PID2019-106268GB-C33MInisterio de Ciencia e Innovación; PID2019-110305GB-I00Universidad Complutense de Madrid; INV.GR.00.1819.10759Universidad Complutense de Madrid; CT20/19-CT21/19/PEJD-2018-POST/IND-8661PAIJunta de Andalucía; UMA18-FEDERJA-08

Determinación de perfiles socioeconómicos y sanitarios de las personas atendidas en las campañas efectuadas como actividades curriculares de la carrera de Medicina de la UNCAus en su área de influencia

El proyecto PI N° 91, aprobado por Res. N° 332/18 CS, se desarrolla con el fin de obtener información relevante que detecte variables relacionadas con los frecuentes problemas de salud de la ciudad de Presidencia Roque Sáenz Peña (Chaco, Argentina) y su área de influencia, relacionando los pacientes con su hábitat, ecología y salud. Para ello se trabaja con la información proveniente de las actividades curriculares de vinculación comunitaria que la carrera de Medicina de la UNCAus (Universidad Nacional del Chaco Austral) realiza en los distintos barrios de la ciudad y zona de influencia; con dicha información se construye un almacén de datos (data warehouse) que es estudiado con técnicas de minería de datos, especialmente técnicas de agrupamiento (clusterización) y de árboles de decisión, a los efectos de conseguir los perfiles característicos relacionados con los distintos tipos de diagnósticos; se buscan modelos descriptivos y predictivos de minería de datos, lo cual permitiría disponer de conocimiento que permitiría mejorar la toma de decisiones en cuanto a campañas de salud hacia la población de las zonas.Red de Universidades con Carreras en Informátic

Does stroke volume increase during an incremental exercise? A systematic review

Introduction: Cardiac output increases during incremental-load exercise to meet metabolic skeletal muscle demand. This response requires a fast adjustment in heart rate and stroke volume. The heart rate is well known to increase linearly with exercise loadhowever, data for stroke volume during incremental-load exercise are unclear. Our objectives were to (a) review studies that have investigated stroke volume on incremental load exercise and (b) summarize the findings for stroke volume, primarily at maximal-exercise load. Methods: A comprehensive review of the Cochrane Library's, Embase, Medline, SportDiscus, PubMed, and Web of Sci-ence databases was carried out for the years 1985 to the present. The search was performed between February and June 2014 to find studies evaluating changes in stroke volume during incremental-load exercise. Controlled and uncontrolled trials were evaluated for a quality score. Results: The stroke volume data in maximal-exercise load are inconsistent. There is evidence to hypothesis that stroke volume increases during maximal-exercise load, but other lines of evidence indicate that stroke volume reaches a plateau under these circumstances, or even decreases. Conclusion: The stroke volume are unclear, include contradictory evidence. Additional studies with standardized reporting for subjects (e.g., age, gender, physical fitness, and body position), exercise test protocols, and left ventricular function are required to clarify the characteristics of stroke volume during incremental maximal-exercise load.National Council for Scientific [479395/2012-8]Universidade Federal de São Paulo, Laboratório de Fisiologia e Fisiopatologia Cardíaca, São Paulo, SP, BrazilUniversidade Nove de Julho, Programa de Pós-Graduação em Biofotônica Aplicada a Ciências da Saúde, São Paulo, SP, BrazilLaboratorio de Fisiologia Transacional dos Programas de Pos Graduacao em Educacao Fisica e Ciências do En-velhecimento, São Paulo, SP, BrasilUniversidade Nove de Julho, Programa de Pós-Graduação em Medicina, São Paulo, SP, BrazilUniversidade Federal do Mato Grosso, Programa de Mestrado em Educação Física, Cuiabá, MT, BrazilUniversidade Federal de São Paulo, Laboratório de Fisiologia e Fisiopatologia Cardíaca, São Paulo, SP, BrazilNational Council for Scientific: 479395/2012-8Web of Scienc

Prevalencia serológica de parainfluenza tipo 3 en ovinos de algunos municipios de Boyacá y Cundinamarca.

Dado que en Colombia existe muy poca información sobre la magnitud y difusión del virus Parainfluenza 3 (P.I. 3), se realizó un estudió en Boyacá (Valle de Sogamoso) y Cundinamarca, con el objetivo de establecer la presencia de anticuerpos inhibidores de la hemaglutinación para el virus mencionado. De acuerdo a un modelo de distribución binomial se obtuvo una muestra de 160 animales para cada área, obteniéndose una prevalencia serológica puntual de 1.25. En el valle de Sogamoso se encontraron 2 reactores positivos a P.I.3, al igual que en las granjas de Cundinamarca, con título 1:20. La prevalencia encontrada se considera baja al compararla con la establecida en otros países, sin embargo, indica la exposición anterior al virus de P.I.3. Se recomienda investigar la presencia del virus y de agentes bacterianos como Pasteurella haemolytica y Mycoplasma ovipneumoniae en las poblaciones ovinas y caprinas relativamente importantes de Nariño, Santanderes y GuajiraOvinos-Ganado ovino - Ovis arie