Problemas no cotidiano do trabalho e sua relação com o cuidado de si e o cuidado do outro

The authors analyse daily problems of the nurses’ work and the coping strategies used, building knowledge about self care and care of the others in administrative spaces that emphasize freedom and autonomy, relating this (re)construction process to their health process Starting from semi-structured interviews with nurses of a University Hospital, it was possible to identify problems related to human and material resources, team relationship and nurses’ own characteristics of subjectivity. There is a perception of greater freedom and autonomy related to administration, although the nurses perceive negative aspects about the boundaries of the freedom exercises, with commitment to the care of the otherSe pretendió analisar los problemas del cotidiano del trabajo de enfermeras y estrategias de enfrentamiento, produciendose conocimientos a cerca del cuidado de si y el cuidado del otro, en espacios que preconizan la libertad y la autonomía, relacionando este proceso de (re) construcción a su proceso de salud. A partir de entrevistas semi-estructuradas con enfermeras de un hospital universitario, fué posible identificar problemas relacionados a recursos humanos y materiales, relacionamientos en el equipo y las propias características de subjectividad de las enfermeras. Hay una percepción de mayor liberdad y autonomía en relación a la administración, a pesar de perceberense aspectos negativos cuanto al ejercicio de la liberdad, con comprometimiento del cuidado del otro.Analisam-se problemas do cotidiano do trabalho das enfermeiras e estratégias de enfrentamento, produzindo conhecimentos acerca do cuidado de si e do cuidado do outro, em espaços administrativos que preconizam a liberdade e a autonomia, relacionando este processo de (re)construção ao seu processo de saúde. A partir de entrevistas semi-estruturadas com enfermeiras de um Hospital Universitário, foi possível identificar problemas relacionados a recursos humanos e materiais, relacionamento na equipe e às próprias características de subjetividade das enfermeiras. Há uma percepção de maior liberdade e autonomia em relação à administração, apesar de perceberem aspectos negativos, quanto aos limites do exercício da liberdade, com comprometimento do cuidado do outro

Intratumoral virotherapy with 4-1BBL armed modified vaccinia Ankara eradicates solid tumors and promotes protective immune memory

Background Human cancers are extraordinarily heterogeneous in terms of tumor antigen expression, immune infiltration and composition. A common feature, however, is the host ' s inability to mount potent immune responses that prevent tumor growth effectively. Often, naturally primed CD8(+) T cells against solid tumors lack adequate stimulation and efficient tumor tissue penetration due to an immune hostile tumor microenvironment. Methods To address these shortcomings, we cloned tumor-associated antigens (TAA) and the immune-stimulatory ligand 4-1BBL into the genome of modified vaccinia Ankara (MVA) for intratumoral virotherapy. Results Local treatment with MVA-TAA-4-1BBL resulted in control of established tumors. Intratumoral injection of MVA localized mainly to the tumor with minimal leakage to the tumor-draining lymph node. In situ infection by MVA-TAA-4-1BBL triggered profound changes in the tumor microenvironment, including the induction of multiple proinflammatory molecules and immunogenic cell death. These changes led to the reactivation and expansion of antigen-experienced, tumor-specific cytotoxic CD8(+) T cells that were essential for the therapeutic antitumor effect. Strikingly, we report the induction of a systemic antitumor immune response including tumor antigen spread by local MVA-TAA-4-1BBL treatment which controlled tumor growth at distant, untreated lesions and protected against local and systemic tumor rechallenge. In all cases, 4-1BBL adjuvanted MVA was superior to MVA. Conclusion Intratumoral 4-1BBL-armed MVA immunotherapy induced a profound reactivation and expansion of potent tumor-specific CD8(+) T cells as well as favorable proinflammatory changes in the tumor microenvironment, leading to elimination of tumors and protective immunological memory

Synthesizing the scientific evidence to inform the development of the post-2020 Global Framework on Biodiversity

Fil: Díaz, Sandra. Universidad Nacional de Córdoba; Argentina.Fil: Broadgate, Wendy. Future Earth; Suecia.Fil: Declerck, Fabrice. Bioversity International; Italia.Fil: Dobrota, Susanna. Future Earth; Suecia.Fil: Krug, Cornelia. bioDISCOVERY; Suecia.Fil: Moersberg, Hannah. Future Earth; Francia.Fil: Obura, David. Coastal Oceans Research and Development – Indian Ocean; Kenya.Fil: Spehn, Eva. Forum Biodiversity; Suiza.Fil: Tewksbury, Joshua. Future Earth; Estados Unidos.Fil: Verburg, Peter. Vrije Universiteit Amsterdam; Países Bajos.Fil: Zafra Calvo, Noelia. Future Earth; Suecia.Fil: Bellon, Mauricio. Comisión Nacional para el Conocimiento y Uso de la Biodiversidad; México.Fil: Burgess, Neil. United Nations Environment Programme World Conservation Monitoring Centre; Reino Unido.Fil: Cariño, Joji. Forest Peoples Programme; Reino Unido.Fil: Castañeda Alvarez, Nora. Global Crop Diversity Trust; Alemania.Fil: Cavender-Bares, Jeannine. University of Minnesota; Estados Unidos.Fil: Chaplin Kramer, Rebecca. Stanford University; Estados Unidos.Fil: De Meester, Luc. Katholieke Universiteit Leuven; Bélgica.Fil: Dulloo, Ehsan. Consultative Group for International Agricultural Research; Francia.Fil: Fernández-Palacios, José María. Universidad de La Laguna; España.Fil: Garibaldi, Lucas A. Universidad Nacional de Río Negro. Instituto de Investigaciones en Recursos Naturales, Agroecología y Desarrollo Rural; Argentina.Fil: Garibaldi, Lucas A. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Recursos Naturales, Agroecología y Desarrollo Rural; Argentina.Fil: Hill, Samantha. United Nations Environment Programme World Conservation Monitoring Centre; Reino Unido.Fil: Isbell, Forest. University of Minnesota; Estados Unidos.Fil: Leadley, Paul. Université Paris-Saclay; Francia.Fil: Liu, Jianguo. Michigan State University; Estados Unidos.Fil: Mace, Georgina M. University College London; Reino Unido.Fil: Maron, Martine. The University of Queensland; Australia.Fil: Martín-López, Berta. Leuphana University Lüneburg; Alemania.Fil: McGowan, Philip. University of Newcastle; Australia.Fil: Pereira, Henrique. German Centre for Integrative Biodiversity Research; Alemania.Fil: Purvis, Andy. Imperial College London. Grand Challenges in Ecosystems and the Environment; Reino Unido.Fil: Reyes-García, Victoria. Universidad Autónoma de Barcelona; España.Fil: Rocha, Juan. Future Earth; Suecia.Fil: Rondinini, Carlo. Sapienza-Università di Roma; Italia.Fil: Shannon, Lynne. University of Cape Town; Sudáfrica.Fil: Shaw, Rebecca. World Wildlife Fund; Estados Unidos.Fil: Shin, Yunne Jai. University of Cape Town. Marine Research Institute. Department of Biological Sciences; Sudáfrica.Fil: Snelgrove, Paul. Memorial University of Newfoundland; Canadá.Fil: Strassburg, Bernardo. International Institute for Sustainability; Brasil.Fil: Subramanian, Suneetha.United Nations University; Japón.Fil: Visconti, Piero. International Institute for Applied Systems Analysis; Austria.Fil: Watson, James. Wildlife Conservation Society; Estados Unidos.Fil: Zanne, Amy. The George Washington University; Estados Unidos.Fil: Bruford, Michael. Cardiff University; Gales.Fil: Colli, Licia. Università Cattolica del Sacro Cuore; Italia.Fil: Azeredo de Dornelas, Maria. University of St Andrews; Escocia.Fil: Bascompte, Jordi. Universität Zürich; Suiza.Fil: Forest, Felix. Royal Botanic Gardens; Reino Unido.Fil: Hoban, Sean. The Morton Arboretum; Estados Unidos.Fil: Jones, Sarah. Consultative Group for International Agricultural Research; Francia.Fil: Jordano, Pedro. Consejo Superior de Investigaciones Científicas; España.Fil: Kassen, Rees. University of Ottawa; Canadá.Fil: Khoury, Colin. Consultative Group for International Agricultural Research; Francia.Fil: Laikre, Linda. Stockholms Universitet; Suecia.Fil: Maxted, Nigel. University of Birmingham; Reino Unido.Fil: Miloslavich, Patricia. Universidad Simón Bolívar; Venezuela.Fil: Moreno Mateos, David. Basque Centre for Climate Change; España.Fil: Ogden, Rob. The University of Edinburgh; Reino Unido.Fil: Segelbacher, Gernot. Albert-Ludwigs-Universität Freiburg; Alemania.Fil: Souffreau, Caroline. Katholieke Universiteit Leuven; Bélgica.Fil: Svenning, Jens Christian. Aarhus University; Dinamarca.Fil: Vázquez, Ella. Universidad Nacional Autónoma de México; México.This report is the result of a meeting which aimed to offer scientific guidance to the development under the Convention on Biological Diversity (CBD) of the post-2020 Global Biodiversity Framework focussing on its contribution to the 2030 Mission and 2050 Vision. We provide a synthesis of the scientific and technical justification, evidence base and feasibility for outcome-oriented goals on nature and its contributions to people, including biodiversity at different levels from genes to biomes. The report is structured to respond to the Zero Draft of the post-2020 Global Biodiversity Framework

The 16th Data Release of the Sloan Digital Sky Surveys: First Release from the APOGEE-2 Southern Survey and Full Release of eBOSS Spectra

This paper documents the 16th data release (DR16) from the Sloan Digital Sky Surveys (SDSS), the fourth and penultimate from the fourth phase (SDSS-IV). This is the first release of data from the Southern Hemisphere survey of the Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2); new data from APOGEE-2 North are also included. DR16 is also notable as the final data release for the main cosmological program of the Extended Baryon Oscillation Spectroscopic Survey (eBOSS), and all raw and reduced spectra from that project are released here. DR16 also includes all the data from the Time Domain Spectroscopic Survey and new data from the SPectroscopic IDentification of ERosita Survey programs, both of which were co-observed on eBOSS plates. DR16 has no new data from the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey (or the MaNGA Stellar Library "MaStar"). We also preview future SDSS-V operations (due to start in 2020), and summarize plans for the final SDSS-IV data release (DR17)

The 16th Data Release of the Sloan Digital Sky Surveys: First Release from the APOGEE-2 Southern Survey and Full Release of eBOSS Spectra

This paper documents the 16th data release (DR16) from the Sloan Digital Sky Surveys (SDSS), the fourth and penultimate from the fourth phase (SDSS-IV). This is the first release of data from the Southern Hemisphere survey of the Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2); new data from APOGEE-2 North are also included. DR16 is also notable as the final data release for the main cosmological program of the Extended Baryon Oscillation Spectroscopic Survey (eBOSS), and all raw and reduced spectra from that project are released here. DR16 also includes all the data from the Time Domain Spectroscopic Survey and new data from the SPectroscopic IDentification of ERosita Survey programs, both of which were co-observed on eBOSS plates. DR16 has no new data from the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey (or the MaNGA Stellar Library "MaStar"). We also preview future SDSS-V operations (due to start in 2020), and summarize plans for the final SDSS-IV data release (DR17)

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Problemas no cotidiano do trabalho e sua relação com o cuidado de si e o cuidado do outro

The authors analyse daily problems of the nurses’ work and the coping strategies used, building knowledge about self care and care of the others in administrative spaces that emphasize freedom and autonomy, relating this (re)construction process to their health process Starting from semi-structured interviews with nurses of a University Hospital, it was possible to identify problems related to human and material resources, team relationship and nurses’ own characteristics of subjectivity. There is a perception of greater freedom and autonomy related to administration, although the nurses perceive negative aspects about the boundaries of the freedom exercises, with commitment to the care of the otherSe pretendió analisar los problemas del cotidiano del trabajo de enfermeras y estrategias de enfrentamiento, produciendose conocimientos a cerca del cuidado de si y el cuidado del otro, en espacios que preconizan la libertad y la autonomía, relacionando este proceso de (re) construcción a su proceso de salud. A partir de entrevistas semi-estructuradas con enfermeras de un hospital universitario, fué posible identificar problemas relacionados a recursos humanos y materiales, relacionamientos en el equipo y las propias características de subjectividad de las enfermeras. Hay una percepción de mayor liberdad y autonomía en relación a la administración, a pesar de perceberense aspectos negativos cuanto al ejercicio de la liberdad, con comprometimiento del cuidado del otro.Analisam-se problemas do cotidiano do trabalho das enfermeiras e estratégias de enfrentamento, produzindo conhecimentos acerca do cuidado de si e do cuidado do outro, em espaços administrativos que preconizam a liberdade e a autonomia, relacionando este processo de (re)construção ao seu processo de saúde. A partir de entrevistas semi-estruturadas com enfermeiras de um Hospital Universitário, foi possível identificar problemas relacionados a recursos humanos e materiais, relacionamento na equipe e às próprias características de subjetividade das enfermeiras. Há uma percepção de maior liberdade e autonomia em relação à administração, apesar de perceberem aspectos negativos, quanto aos limites do exercício da liberdade, com comprometimento do cuidado do outro