Hydrogenation and dehydrogenation of Tetralin and Naphthalene to explore heavy oil upgrading using NiMo/Al₂O₃ and CoMo/Al₂O₃ catalysts heated with steel balls via induction

This paper reports the hydrogenation and dehydrogenation of tetralin and naphthalene as model reactions that mimic polyaromatic compounds found in heavy oil. The focus is to explore complex heavy oil upgrading using NiMo/Al2O3 and CoMo/Al2O3 catalysts heated inductively with 3 mm steel balls. The application is to augment and create uniform temperature in the vicinity of the CAtalytic upgrading PRocess In-situ (CAPRI) combined with the Toe-to-Heel Air Injection (THAI) process. The effect of temperature in the range of 210–380 °C and flowrate of 1–3 mL/min were studied at catalyst/steel balls 70% (v/v), pressure 18 bar, and gas flowrate 200 mL/min (H2 or N2). The fixed bed kinetics data were described with a first-order rate equation and an assumed plug flow model. It was found that Ni metal showed higher hydrogenation/dehydrogenation functionality than Co. As the reaction temperature increased from 210 to 300 °C, naphthalene hydrogenation increased, while further temperature increases to 380 °C caused a decrease. The apparent activation energy achieved for naphthalene hydrogenation was 16.3 kJ/mol. The rate of naphthalene hydrogenation was faster than tetralin with the rate constant in the ratio of 1:2.5 (tetralin/naphthalene). It was demonstrated that an inductively heated mixed catalytic bed had a smaller temperature gradient between the catalyst and the surrounding fluid than the conventional heated one. This favored endothermic tetralin dehydrogenation rather than exothermic naphthalene hydrogenation. It was also found that tetralin dehydrogenation produced six times more coke and caused more catalyst pore plugging than naphthalene hydrogenation. Hence, hydrogen addition enhanced the desorption of products from the catalyst surface and reduced coke formation

Viscous Three-Dimensional Simulation of Flow in an Axial Low Pressure Compressor at Engine Icing Operating Points

Viscous three-dimensional simulations of the Honeywell ALF502R-5 low pressure compressor (sometimes called a booster) using the NASA Glenn code GlennHT have been carried out. A total of ten simulations were produced. Five operating points are investigated, with each point run with two different wall thermal conditions. These operating points are at, or near, points where engine icing has been determined to be likely. In the future, the results of this study will be used for further analysis such as predicting collection efficiency of ice particles and ice growth rates at various locations in the compressor. A mixing plane boundary condition is used between each blade row, resulting in convergence to steady state within each blade row. The k-omega turbulence model of Wilcox, combined with viscous grid spacing near the wall on the order of one, is used to resolve the turbulent boundary layers. For each of the operating points, heat transfer coefficients are generated on the blades and walls. The heat transfer coefficients are produced by running the operating point with two different wall thermal conditions and then solving simultaneously for the heat transfer coefficient and adiabatic wall temperature at each point. Average Nusselt numbers are calculated for the most relevant surfaces. The values are seen to scale with Reynolds number to approximately a power of 0.7. Additionally, images of surface distribution of Nusselt number are presented. Qualitative comparison between the five operating points show that there is relatively little change in the character of the distribution. The dominant observed effect is that of an overall scaling, which is expected due to Reynolds number differences. One interesting aspect about the Nusselt number distribution is observed on the casing (outer diameter) downstream of the exit guide vanes (EGVs). The Nusselt number is relatively high between the pairs of EGVs, with two lower troughs downstream of each EGV trailing edge. This is of particular interest since rather complex ice shapes have been observed in that region

Impossible protest: noborders in Calais

Since the closure of the Red Cross refugee reception centre in Sangatte, undocumented migrants in Calais hoping to cross the border to Britain have been forced to take refuge in a number of squatted migrant camps, locally known by all as ‘the jungles.’ Unauthorised shanty-like residences built by the migrants themselves, living conditions in the camps are very poor. In June 2009, European ‘noborder’ activists set up a week-long protest camp in the area with the intention of confronting the authorities over their treatment of undocumented migrants. In this article, we analyse the June 2009 noborder camp as an instance of ‘immigrant protest.’ Drawing on ethnographic materials and Jacques Rancière's work on politics and aesthetics, we construct a typology of forms of border control through which to analyse the different ways in which the politics of the noborder camp were staged, performed and policed. Developing a critique of policing practices which threatened to make immigrant protest ‘impossible’, we highlight moments of protest which, through the affirmation of an ‘axiomatic’ equality, disrupted and disarticulated the borders between citizens and non-citizens, the political and non-political

A trivariate additive regression model with arbitrary link functions and varying correlation matrix

In many empirical situations, modelling simultaneously three or more outcomes as well as their dependence structure can be of considerable relevance. Copulae provide a powerful framework to build multivariate distributions and allow one to view the specification of the marginal responses’ equations and their dependence as separate but related issues. We propose a generalizationof the trivariate additive probit model where the link functions can in principle be derived from any parametric distribution and the parameters describing the residual association between the responses can be made dependent on several types of covariate effects (such as linear, nonlinear, random, and spatial effects). All the coefficients of the model are estimated simultaneously within a penalized likelihood framework that uses a trust region algorithm with integrated automatic multiple smoothing parameter selection. The effectiveness of the model is assessed in simulation as well as empirically by modelling jointly three adverse birth binary outcomes in North Carolina. The approach can be easily employed via the gjrm() function in the R package GJRM

Small Molecule-Induced Cytosolic Activation of Protein Kinase Akt Rescues Ischemia-Elicited Neuronal Death

Elevating Akt activation is an obvious clinical strategy to prevent progressive neuronal death in neurological diseases. However, this endeavor has been hindered because of the lack of specific Akt activators. Here, from a cell-based high-throughput chemical genetic screening, we identified a small molecule SC79 that inhibits Akt membrane translocation, but paradoxically activates Akt in the cytosol. SC79 specifically binds to the PH domain of Akt. SC79-bound Akt adopts a conformation favorable for phosphorylation by upstream protein kinases. In a hippocampal neuronal culture system and a mouse model for ischemic stroke, the cytosolic activation of Akt by SC79 is sufficient to recapitulate the primary cellular function of Akt signaling, resulting in augmented neuronal survival. Thus, SC79 is a unique specific Akt activator that may be used to enhance Akt activity in various physiological and pathological conditions

Comparative epigenomics in distantly related teleost species identifies conserved cis-regulatory nodes active during the vertebrate phylotypic period

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months. After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International).The complex relationship between ontogeny and phylogeny has been the subject of attention and controversy since von Baer's formulations in the 19th century. The classic concept that embryogenesis progresses from clade general features to species-specific characters has often been revisited. It has become accepted that embryos from a clade show maximum morphological similarity at the so-called phylotypic period (i.e., during mid-embryogenesis). According to the hourglass model, body plan conservation would depend on constrained molecular mechanisms operating at this period. More recently, comparative transcriptomic analyses have provided conclusive evidence that such molecular constraints exist. Examining cis-regulatory architecture during the phylotypic period is essential to understand the evolutionary source of body plan stability. Here we compare transcriptomes and key epigenetic marks (H3K4me3 and H3K27ac) from medaka (Oryzias latipes) and zebrafish (Danio rerio), two distantly related teleosts separated by an evolutionary distance of 115-200 Myr. We show that comparison of transcriptome profiles correlates with anatomical similarities and heterochronies observed at the phylotypic stage. Through comparative epigenomics, we uncover a pool of conserved regulatory regions (≈700), which are active during the vertebrate phylotypic period in both species. Moreover, we show that their neighboring genes encode mainly transcription factors with fundamental roles in tissue specification. We postulate that these regulatory regions, active in both teleost genomes, represent key constrained nodes of the gene networks that sustain the vertebrate body plan.The Andalusian government (JA) supported A.F-.M. as scientific manager of the Aquatic Vertebrates Platform at CABD. J.W.C. was supported by a studentship from The Institute of Cancer Research. Spanish and Andalusian government grants BFU2010-14839, CSD2007-00008, and P08-CVI-3488 to J.L.G-.S.; and BFU2011-22916 and P11-CVI-7256 to J.R.M-.M. supported this work.Peer Reviewe

Mixed Binary-Continuous Copula Regression Models with Application to Adverse Birth Outcomes

Bivariate copula regression allows for the flexible combination of two arbitrary, continuous marginal distributions with regression effects being placed on potentially all parameters of the resulting bivariate joint response distribution. Motivated by a study examining the risk factors of adverse birth outcomes, we consider mixed binary-continuous responses that extend this framework to the situation where one response variable is discrete (more precisely binary) while the other response remains continuous. Utilizing the latent continuous representation of binary regression models, we implement a penalized likelihood based approach for the resulting class of copula regression models and employ it in the context of modelling jointly gestational age and the presence/absence of low birth weight. The analysis strongly benefits from the flexible specification of regression effects including nonlinear effects of continuous covariates and spatial effects. Our results imply that racial and spatial inequalities in the risk factors for infant mortality are even greater than previously suggested

An unsustainable state: contrasting food practices and state policies in the Czech Republic

This paper brings together consideration of food policies and practices and of post-socialist transition to raise neglected questions about means of nurturing more sustainable food systems in the developed world. The last three decades have been marked by the growing salience of food as a political and scholarly concern. While market-based alternative food systems have been heralded for their potential to promote environmental sustainability, the benefits of non-market practices such as household food self-provisioning and barter have been assumed rather than being the focus of research. In the western context, both types of food consumption have positive connotations. Although food self-provisioning in European post-socialist societies is a more wide-spread practice than in western societies, it has been on the periphery of research. The existing literature has conceptualised them as ‘coping strategies’ or as a legacy of irregular supply of goods in the state socialist era. Drawing on empirical research in the Czech Republic, we are proposing a novel approach to the phenomenon of household food production in post-socialist societies as a practice compliant with principles of sustainability. First, we highlight the large extent and social inclusivity of food self-provisioning in Czech society to demonstrate how post-socialist societies are a repository of a rich set of sustainability-promoting consumption practices in relation to food systems. Second, we show that international and domestic policy actors in these societies have ignored these alternative, socially inclusive and environmentally effective practices in favour of far less effective market-based sustainability oriented food policy initiatives. The paper promotes a more integrated view of non-market and market approaches in the pursuit of more sustainable food systems