Getting to ground: integrating community-driven climate adaptation into Washington’s Floodplain by Design and Shoreline Master Programs.

Over the past few years, state and federal agencies, and communities, have accelerated efforts to adapt to impacts from a changing climate; projects collectively termed as “climate adaptation.” While planners and researchers have developed numerous climate change vulnerability assessments and climate adaptation plans, few concrete examples exist of decisions and on-the-ground action that address impacts of climate change. Working with communities throughout Washington, The Nature Conservancy connects local decision makers with the research community to catalyze on-the-ground adaptation. In this talk, we will highlight examples of our engagement through the Floodplains by Design and Shoreline Master Programs. Floodplains by Design is a public-private partnership working to reduce flood risk and improve community resilience in Puget Sound’s coastal floodplains communities. The program is catalyzing local adaptation actions through supporting inclusive reach scale planning and bringing available climate science into project designs. For the Pacific County example, we will describe the essential role of connecting the dots between the science and mapping of coastal vulnerability, to outreach and policy analysis - all ingredients for project success. Across the two projects, we will synthesize our insights about key elements and hurdles for creating effective conduits to move climate adaptation beyond planning and into action. There is not a “one-size-fits-all” approach to responding to climate change. It is critical to understand the social and ecological context of each place, so that climate information can be tailored to address the specific needs of stakeholders and decision-makers

The TB structural genomics consortium: a decade of progress

The TB Structural Genomics Consortium is a worldwide organization of collaborators whose mission is the comprehensive structural determination and analyses of Mycobacterium tuberculosis proteins to ultimately aid in tuberculosis diagnosis and treatment. Congruent to the overall vision, Consortium members have additionally established an integrated facilities core to streamline M. tuberculosis structural biology and developed bioinformatics resources for data mining. This review aims to share the latest Consortium developments with the TB community, including recent structures of proteins that play significant roles within M. tuberculosis. Atomic resolution details may unravel mechanistic insights and reveal unique and novel protein features, as well as important protein-protein and protein-ligand interactions, which ultimately lead to a better understanding of M. tuberculosis biology and may be exploited for rational, structure-based therapeutics design.Nicholas Chim ... John Bruning ... et al