Poronienie i ciąża obumarła w aspekcie prawa – udział położnej w opiece nad pacjentką w sytuacji utraty ciąży = Miscarriage and pregnancy degenerated in terms of law - part midwife in the care of the patient in case of pregnancy loss

Stadnicka Sabina Katarzyna, Bień Agnieszka, Gdańska Paulina, Piechowska Joanna. Poronienie i ciąża obumarła w aspekcie prawa – udział położnej w opiece nad pacjentką w sytuacji utraty ciąży = Miscarriage and pregnancy degenerated in terms of law - part midwife in the care of the patient in case of pregnancy loss. Journal of Education, Health and Sport. 2016;6(9):379-390. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.62008 http://ojs.ukw.edu.pl/index.php/johs/article/view/3841 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2016; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.08.2016. Revised 25.08.2016. Accepted: 06.09.2016. Poronienie i ciąża obumarła w aspekcie prawa – udział położnej w opiece nad pacjentką w sytuacji utraty ciąży Miscarriage and pregnancy degenerated in terms of law - part midwife in the care of the patient in case of pregnancy loss Sabina Katarzyna Stadnicka, mgr położnictwa, doktorantka, Katedra i Zakład Pielęgniarstwa Pediatrycznego, Wydział Nauk o Zdrowiu Uniwersytetu Medycznego w Lublinie Agnieszka Bień, dr n. med., adiunkt, Zakład Podstaw Położnictwa, Wydział Nauk o Zdrowiu Uniwersytetu Medycznego w Lublinie Paulina Gdańska, mgr psychologii, I Katedra i Klinika Położnictwa i Ginekologii Warszawskiego Uniwersytetu Medycznego Joanna Piechowska, mgr położnictwa, doktorantka, Zakład Podstaw Położnictwa, Wydział Nauk o Zdrowiu Uniwersytetu Medycznego w Lublinie Streszczenie Niekorzystne zakończenie ciąży ma charakter niezwykle złożony i delikatny. Utrata ciąży na skutek poronienia jest wydarzeniem biomedycznym wywierającym ogromny wpływ na funkcjonowanie psychiczne. Nowe Rozporządzenie Ministra Zdrowia z dnia 1 grudnia 2015r. wprowadza dokładnie określone standardy postępowań okołoporodowych w opiece nad pacjentkami w sytuacji niepowodzeń położniczych. Celem publikacji jest pokazanie istotności wprowadzenia standardów. Odpowiedni przekaz niepomyślnych wiadomości, poprawna komunikacja a także udzielenie wsparcia może załagodzić psychologiczne skutki niepomyślnej sytuacji. Słowa kluczowe: ciąża, poronienie, strata, przepisy prawa, zdrowie psychiczne Abstract Unfavorable termination of pregnancy is a very complex and delicate. Pregnancy loss due to miscarriage is an event biomedical exerting a huge influence on the functioning of mental health. The new Minister of Health of 1 December 2015. introduces precisely defined standards proceedings perinatal care for female patients in an obstetric failures. The aim of the publication is to show the significance of the introduction of standards. The corresponding message bad news, the correct communication and assistance can alleviate the psychological effects of unfavorable situation. Key words: pregnancy, miscarriage, loss, law, mental healt

Low-Temperature Spectra of the Analogues of 10-Hydroxybenzo[<i>h</i>]quinoline as an Indication of Barrierless ESIPT

The absorption and fluorescence spectra of two analogues of 10-hydroxybenzo­[<i>h</i>]­quinoline (10-HBQ), namely, 1-hydroxy-7-methylbenzo­[<i>c</i>]­acridine (HMBA) and 4-hydroxybenzo­[<i>c</i>]­phenanthridine (HBPA), were studied in <i>n</i>-alkane matrices at 5 K. Considerable energy separation between the onsets of the spectra and broadening of the bands was an indication that intramolecular proton transfer (ESIPT) takes place at such a low temperature. DFT and ab initio methods were used to calculate the electronic transition energies and oscillator strengths and the vibronic structure of the electronic spectra. Shortcomings in our knowledge of the shape of the potential energy surface for ESIPT systems are highlighted in the context of the discussion of the shape of the electronic spectra. The π-expansion of the 10-HBQ chromophore achieved by adding a benzene moiety at various positions adjacent to the pyridine ring led to compounds possessing diverse photophysical properties, ranging from the non-ESIPT strongly fluorescent molecule of 10-hydroxy-1-azaperylene to weakly emitting (or nonemitting) molecules, where ESIPT occurs very efficiently

12-Hydroxy-1-azaperyleneLimiting Case of the ESIPT System: Enol–Keto Tautomerization in S₀ and S₁ States

Absorption, fluorescence, and fluorescence excitation spectra of 12-hydroxy-1-azaperylene (<b>HAP</b>) and 1-azaperylene were studied in <i>n</i>-alkane matrices at 5 K. Two stable tautomers of <b>HAP</b>, each of them in <i>n</i>-nonane embedded in two sites, were identified and attributed to the enol and keto forms. Theoretical calculations of the energy and vibrational structure of the spectra suggest that tautomer <b>A</b>, with the (0, 0) transition energy at 18 980 ± 10 cm^–1 (and 19 060 ± 10 cm^–1 in the high energy site), should be identified as the keto form, whereas tautomer <b>B</b>, with the (0, 0) energy at 19 200 ± 20 cm^–1 (19 290 ± 20 cm^–1), as the enol form. Observation of absorption and fluorescence of both tautomeric forms and lack of large Stokes shift of fluorescence of the keto form classify HAP as the limiting case of the excited-state intramolecular proton transfer system

Excited State Intramolecular Proton Transfer in Electron-Rich and Electron-Poor Derivatives of 10-Hydroxybenzo[<i>h</i>]quinoline

Eight previously inaccessible derivatives of 10-hydroxybenzo­[<i>h</i>]­quinoline were prepared via a straightforward strategy comprising formation of the benzo­[<i>h</i>]­quinoline skeleton followed by C–H acetoxylation at position 10. The occurrence of excited state intramolecular proton transfer (ESIPT) was detected in all cases since emission was observed only from the excited keto-tautomer. Studies on derivatives bearing both electron-donating and electron-withdrawing groups adjacent to the pyridine ring allowed us to identify some design patterns giving rise to NIR emission and large Stokes shifts. For a derivative of 10-hydroxybenzo­[<i>c</i>]­acridine, emission at 745 nm was observed, one of the lowest energy fluorescence ever reported for ESIPT system. On the basis of time-resolved measurements, proton transfer was found to be extremely fast with time constants in the range (0.08–0.45 ps)

Tropinone-Derived Alkaloids as Potent Anticancer Agents: Synthesis, Tyrosinase Inhibition, Mechanism of Action, DFT Calculation, and Molecular Docking Studies

A new series of hybrid compounds with tropinone and thiazole rings in the structure was designed and synthesized as potential anticancer agents. They were tested against human multiple myeloma (RPMI 8226), lung carcinoma (A549), breast adenocarcinoma (MDA-MB-231), and mouse skin melanoma (B16-F10) cell lines. Toxicity was tested on human normal skin fibroblasts (HSF) and normal colon fibroblasts (CCD-18Co). The growth inhibition mechanism of the most active derivative was analyzed through investigation of its effect on the distribution of cell cycle phases and ability to induce apoptosis and necrosis in RPMI 8226 and A549 cancer cells. The tyrosinase inhibitory potential was assessed, followed by molecular docking studies. Compounds 3a&ndash;3h show high anticancer activity against MDA-MB-231 and B16-F10 cell lines with IC50 values of 1.51&ndash;3.03 &micro;M. Moreover, the cytotoxic activity of the investigated compounds against HSF and CCD-18Co cells was 8&ndash;70 times lower than against the cancer cells or no toxicity was shown in our tests, with derivative 3a being particularly successful. The mechanism of action of compound 3a in RPMI 8226 cell was shown to be through induction of cell death through apoptosis. The derivatives show ability to inhibit the tyrosinase activity with a mixed mechanism of inhibition. The final molecular docking results showed for IC50 distinct correlation with experiment