Определение скорости перемещения деформаций растяжений в массиве при подземной выемке угля

Приведена швидкість переміщення деформацій в непорушеному масиві. Встановлено, що швидкість в породах середнього ступеня метаморфізму складає 15 м/добу. Середня швидкість переміщення деформацій в сланцях – 10 м/добу, в піщаниках – 15 м/добу. При повторній підробці швидкість переміщення деформацій складає 17 м/добу.Deformation’s speed travel in the virgin rock massif is given in this article. It has been determined that deformation’s speed in the rocks of medium-scale metamorphism was 15 meters over the entire circadian period. The average speed of deformation’s travel in the shale rocks is 10 meters over the entire circadian period and in the sandstone is 15 meters over the entire circadian period. During the recurring undermining the speed travel of deformations is 17 meters over the entire circadian period

Vascular Ehlers-Danlos Syndrome: A Comprehensive Natural History Study in a Dutch National Cohort of 142 Patients

BACKGROUND: Vascular Ehlers-Danlos syndrome (vEDS) is a rare connective tissue disorder with a high risk for arterial, bowel, and uterine rupture, caused by heterozygous pathogenic variants in COL3A1. The aim of this cohort study is to provide further insights into the natural history of vEDS and describe genotype-phenotype correlations in a Dutch multicenter cohort to optimize patient care and increase awareness of the disease. METHODS: Individuals with vEDS throughout the Netherlands were included. The phenotype was charted by retrospective analysis of molecular and clinical data, combined with a one-time physical examination. RESULTS: A total of 142 individuals (50% female) participated the study, including 46 index patients (32%). The overall median age at genetic diagnosis was 41.0 years. More than half of the index patients (54.3%) and relatives (53.1%) had a physical appearance highly suggestive of vEDS. In these individuals, major events were not more frequent (P=0.90), but occurred at a younger age (P=0.01). A major event occurred more often and at a younger age in men compared with women (P<0.001 and P=0.004, respectively). Aortic aneurysms (P=0.003) and pneumothoraces (P=0.029) were more frequent in men. Aortic dissection was more frequent in individuals with a COL3A1 variant in the first quarter of the collagen helical domain (P=0.03). CONCLUSIONS: Male sex, type and location of the COL3A1 variant, and physical appearance highly suggestive of vEDS are risk factors for the occurrence and early age of onset of major events. This national multicenter cohort study of Dutch individuals with vEDS provides a valuable basis for improving guidelines for the diagnosing, follow-up, and treatment of individuals with vEDS

The GEOTRACES Intermediate Data Product 2014

The GEOTRACES Intermediate Data Product 2014 (IDP2014) is the first publicly available data product of the international GEOTRACES programme, and contains data measured and quality controlled before the end of 2013. It consists of two parts: (1) a compilation of digital data for more than 200 trace elements and isotopes (TEIs) as well as classical hydrographic parameters, and (2) the eGEOTRACES Electronic Atlas providing a strongly inter-linked on-line atlas including more than 300 section plots and 90 animated 3D scenes. The IDP2014 covers the Atlantic, Arctic, and Indian oceans, exhibiting highest data density in the Atlantic. The TEI data in the IDP2014 are quality controlled by careful assessment of intercalibration results and multi-laboratory data comparisons at cross-over stations. The digital data are provided in several formats, including ASCII spreadsheet, Excel spreadsheet, netCDF, and Ocean Data View collection. In addition to the actual data values the IDP2014 also contains data quality flags and 1-? data error values where available. Quality flags and error values are useful for data filtering. Metadata about data originators, analytical methods and original publications related to the data are linked to the data in an easily accessible way. The eGEOTRACES Electronic Atlas is the visual representation of the IDP2014 data providing section plots and a new kind of animated 3D scenes. The basin-wide 3D scenes allow for viewing of data from many cruises at the same time, thereby providing quick overviews of large-scale tracer distributions. In addition, the 3D scenes provide geographical and bathymetric context that is crucial for the interpretation and assessment of observed tracer plumes, as well as for making inferences about controlling processes

Dietary protein affects gene expression and prevents lipid accumulation in the liver in mice

High protein (HP) diets are suggested to positively modulate obesity and associated increased prevalence of non-alcoholic fatty liver (NAFLD) disease in humans and rodents. The aim of our study was to detect mechanisms by which a HP diet affects hepatic lipid accumulation

Fasted and postprandial plasma values.

<p>Fasted plasma triglyceride concentration after Triton WR1339 injection (A). Hepatic VLDL production rate is lower after 1 week of HF-NP feeding (mean ± SEM). Plasma concentrations 2 hours postprandial to a standardised meal indicating increased TG (B) and BHB (C) in HP-fed mice in comparison with NP-fed mice. Effects of increased dietary protein (P) and fat (F) within one time point were tested using general linear model with P and F as fixed factors. * represents values significantly different from the reference group (ref.) as determined by one way ANOVA: *p≤0.05, **p≤0.01, ***p≤0.001. # represents significant difference from all other groups as determined using one way ANOVA.</p

Diet Compositions.¹

1<p>All dietary components were purchased (sources given below) or prepared by UPAE (Unité de Préparation des Aliments Expérimentaux, French National Institute of Agronomic Research, INRA, Jouy en Josas, France).</p>2<p>Nutrinov, Rennes, France.</p>3<p>Cerestar, Haubourdin, France.</p>4<p>Eurosucre, Paris, France.</p>5<p>Bailly SA, Aulnay-sous-bois, France.</p>6<p>ICN biochemicals, Cleveland, OH.</p>7<p>Medias filtrants Durieux, Torcy, France.</p

Hepatic steatosis.

<p>In mice fed the LF-NP and HF-NP large amounts of lipid droplets can be detected after 1 week and 12 weeks of dietary intervention. Mice fed the high protein diets (LF-HP and HF-HP) these lipid droplets are almost absent. (A) Oil red O staining of representative 5 µm liver sections of the 8 groups. Pictures were taken with a light microscope at 20x magnification. Bar represents 50 µm. (B) Hepatic triglycerides (mean expressed in mg/g liver) are decreased by HP feeding after 1 and 12 weeks and increased by HF feeding after 12 weeks. Effects of increased dietary protein (P) and fat (F) within one time point were tested using general linear model with P and F as fixed factors. * represents values significantly different from the reference group (ref.) as determined by one way ANOVA: *p≤0.05, **p≤0.01, ***p≤0.001.</p

Body composition and food intake.

<p>Whereas cumulative food intake (A) did not differ (mean ± SD), <i>ad libitum</i> fed C57BL/6J mice (n = 10 per group) in the HF-NP group developed a higher body weight (B) compared to the other groups (mean ± SEM). Epididymal adipose tissue mass (C) and plasma leptin (D) are likewise increased in the HF-NP group. Effects of increased dietary protein (P) and fat (F) within one time point were tested using general linear model with P and F as fixed factors. * represents values significantly different from the reference group (ref.) as determined by one way ANOVA: *p≤0.05, **p≤0.01, ***p≤0.001.</p

Enrichment map for HP versus NP feeding to identify biological functions.

<p>The map displays the enriched gene-sets in HP fed vs. NP fed mice, independent of background diet and time. Nodes represent gene-sets while edges represent overlapping genes. Gene-sets that did not pass the enrichment significance threshold (p≤0.005 and false discovery rate (FDR) ≤0.1) are not shown. Red node colour represents enrichment in HP fed animals (or induction by HP diet), whereas green represents enrichment in NP fed animals (or suppression by HP diet). Clusters of functionally related gene-sets were manually circled and assigned a label.</p