Be wary of simple solutions to complex problems

Wiebers & Feigin purport to show that the current Covid-19 outbreak provides evidence to support a variety of public policy recommendations. Closer examination of their argument reveals a number of flaws, including a failure to adequately define terms, acknowledge counterevidence, identify value-driven trade-offs and acknowledge the logical implications of their reasoning. Scientists should attempt to address these concerns when offering public policy advice

Dairy production in India: Animal welfare implications and public perceptions

TOPIC ONE: Dairy consumption in India. Key points: 1) India is the world's largest dairy consumer. 2) Fluid milk and ghee makes up 3/4 of all dairy products consumed. 3) India's growing population, affluence, demographic changes, and liberalized trade policies are expected to contribute to increased dairy demand.TOPIC TWO: Dairy production in India. Key points: 1) Launched in 1970, Operation Flood spread the cooperative dairy model throughout India and vastly increased dairy production. 2) Today, India is world's largest milk producer with more than 80 million farmers and 500 million cattle. 3) Both cattle and buffalo are raised for milk production but productivity per animal is very low. 4) Most dairy farms are very small, but large commercial dairies are increasing. 5) Most dairy goes through unorganized markets; organized sector consist of cooperatives and private companies.TOPIC THREE: How animal welfare is assessed on dairy farms, and the major dairy animal welfare challenges in India. Key points: 1) Size of a farm is not associated with welfare status of the animals on that farm. 2) Most animal welfare challenges faced by dairy animals in India relate to lack of basic animal care, poor/uncomfortable housing, tethering and abandonment. 3) As dairy production in India intensifies, animal welfare will likely improve, but new animal welfare issues will emerge.TOPIC FOUR: India's unique socio-cultural context and how this shapes public debate about dairy cattle welfare. Key points: 1) Cattle has sacred status. 2) India is home to the D'harmic religions which place high value on the principle of non-harm to animals (Ahimsa). 3) Cattle slaughter is banned or restricted in many states, leading farmers to abandon unproductive cattle. 4) Indians appear divided on the implications of intensified dairy farming for animal welfare.TOPIC FIVE: Recommendations for front-line persons interested in the animal welfare implications of the Indian dairy sector. 1) Prioritize public outreach to most receptive demographic (younger, educated, affluent, females, pet owners). 2) Conduct pilot studies to benchmark dairy animal welfare and actual consumer demand for animal-friendly products. 3) Organize symposia where farmers, dairy scientists, animal ethicists and religious authorities can discuss relationship between dairy farming, animal welfare, and religion in India. 4) Focus on animal welfare issues, not farm size/type

Genome mapping of quantitative trait loci (QTL) controlling domestication traits of intermediate wheatgrass (Thinopyrum intermedium).

Allohexaploid (2n = 6x = 42) intermediate wheatgrass (Thinopyrum intermedium), abbreviated IWG, is an outcrossing perennial grass belonging to the tertiary gene pool of wheat. Perenniality would be valuable option for grain production, but attempts to introgress this complex trait from wheat-Thinopyrum hybrids have not been commercially successful. Efforts to breed IWG itself as a dual-purpose forage and grain crop have demonstrated useful progress and applications, but grain yields are significantly less than wheat. Therefore, genetic and physical maps have been developed to accelerate domestication of IWG. Herein, these maps were used to identify quantitative trait loci (QTLs) and candidate genes associated with IWG grain production traits in a family of 266 full-sib progenies derived from two heterozygous parents, M26 and M35. Transgressive segregation was observed for 17 traits related to seed size, shattering, threshing, inflorescence capacity, fertility, stem size, and flowering time. A total of 111 QTLs were detected in 36 different regions using 3826 genotype-by-sequence markers in 21 linkage groups. The most prominent QTL had a LOD score of 15 with synergistic effects of 29% and 22% over the family means for seed retention and percentage of naked seeds, respectively. Many QTLs aligned with one or more IWG gene models corresponding to 42 possible domestication orthogenes including the wheat Q and RHT genes. A cluster of seed-size and fertility QTLs showed possible alignment to a putative Z self-incompatibility gene, which could have detrimental grain-yield effects when genetic variability is low. These findings elucidate pathways and possible hurdles in the domestication of IWG

Contemporary Africa through the theory of Louis Dumont

Abstract This article responds to a trend in recent anthropological scholarship in Africa that has overemphasized a lack of social organization following the advancement of neoliberal reforms across the continent. Using a theoretical framework informed by the theory of Louis Dumont, I show that social organization remains an important analytical topic in times of crisis, and that this is best apprehended through an analysis of values. The ethnographic focus of this article is Pentecostal Christianity as it is practiced on the Zambian Copperbelt. In this particular African context, Pentecostalism is animated by an overarching value that I call "moving," which is in turn made up to two sub-values: charisma and prosperity. By exploring how Pentecostal believers navigate the hierarchical relationship between these two sub-values, we are given a clear picture of the social world that Pentecostal adherence makes possible

Molecular Cytogenetic Analysis and Resequencing of Contactin Associated Protein-Like 2 in Autism Spectrum Disorders

Autism spectrum disorders (ASD) are a group of related neurodevelopmental syndromes with complex genetic etiology.1 We identified a de novo chromosome 7q inversion disrupting Autism susceptibility candidate 2 (AUTS2) and Contactin Associated Protein-Like 2 (CNTNAP2) in a child with cognitive and social delay. We focused our initial analysis on CNTNAP2 based on our demonstration of disruption of Contactin 4 (CNTN4) in a patient with ASD;2 the recent finding of rare homozygous mutations in CNTNAP2 leading to intractable seizures and autism;3 and in situ and biochemical analyses reported herein that confirm expression in relevant brain regions and demonstrate the presence of CNTNAP2 in the synaptic plasma membrane fraction of rat forebrain lysates. We comprehensively resequenced CNTNAP2 in 635 patients and 942 controls. Among patients, we identified a total of 27 nonsynonymous changes; 13 were rare and unique to patients and 8 of these were predicted to be deleterious by bioinformatic approaches and/or altered residues conserved across all species. One variant at a highly conserved position, I869T, was inherited by four affected children in three unrelated families, but was not found in 4010 control chromosomes (p = 0.014). Overall, this resequencing data demonstrated a modest nonsignificant increase in the burden of rare variants in cases versus controls. Nonethless, when viewed in light of two independent studies published in this issue of AJHG showing a relationship between ASD and common CNTNAP2 alleles,4,5 the cytogenetic and mutation screening data suggest that rare variants may also contribute to the pathophysiology of ASD, but place limits on the magnitude of this contribution

Adaptive Variation in Beach Mice Produced by Two Interacting Pigmentation Genes

Little is known about the genetic basis of ecologically important morphological variation such as the diverse color patterns of mammals. Here we identify genetic changes contributing to an adaptive difference in color pattern between two subspecies of oldfield mice (Peromyscus polionotus). One mainland subspecies has a cryptic dark brown dorsal coat, while a younger beach-dwelling subspecies has a lighter coat produced by natural selection for camouflage on pale coastal sand dunes. Using genome-wide linkage mapping, we identified three chromosomal regions (two of major and one of minor effect) associated with differences in pigmentation traits. Two candidate genes, the melanocortin-1 receptor (Mc1r) and its antagonist, the Agouti signaling protein (Agouti), map to independent regions that together are responsible for most of the difference in pigmentation between subspecies. A derived mutation in the coding region of Mc1r, rather than change in its expression level, contributes to light pigmentation. Conversely, beach mice have a derived increase in Agouti mRNA expression but no changes in protein sequence. These two genes also interact epistatically: the phenotypic effects of Mc1r are visible only in genetic backgrounds containing the derived Agouti allele. These results demonstrate that cryptic coloration can be based largely on a few interacting genes of major effect

Le Forum, Vol. 43 No. 1

https://digitalcommons.library.umaine.edu/francoamericain_forum/1099/thumbnail.jp

Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth

Resident macrophages densely populate the normal arterial wall, yet their origins and the mechanisms that sustain them are poorly understood. Here we use gene-expression profiling to show that arterial macrophages constitute a distinct population among macrophages. Using multiple fate-mapping approaches, we show that arterial macrophages arise embryonically from CX3CR1+ precursors and postnatally from bone marrow–derived monocytes that colonize the tissue immediately after birth. In adulthood, proliferation (rather than monocyte recruitment) sustains arterial macrophages in the steady state and after severe depletion following sepsis. After infection, arterial macrophages return rapidly to functional homeostasis. Finally, survival of resident arterial macrophages depends on a CX3CR1-CX3CL1 axis within the vascular niche