[Cu(tn)]3[Cr(CN)6]2·3H2O: a unique two-dimensional Cu–Cr cyano-bridged ferromagnet (tn = 1,3-diaminopropane)

Reaction of the two-coordinate ‘assembling complex-ligand’ [Cu(tn)]2+ with the building block [Cr(CN)6]32 leads to a unique two-dimensional Cu–Cr cyano-bridged ferromagnet with unusual m3- and m4-bridging [Cu(tn)]2+ units.Gomez Garcia, Carlos Jose, [email protected]

Heptanuclear hydroxo-bridged copper cluster of the dicubane-like type: structural and magnetic characterisations of [Cu7(OH)6Cl2(pn)6(H2O)2](C(CN)3)4Cl2 (pn = 1,3-diaminopropane)

A new polynuclear copper(II) complex [Cu7(OH)6Cl2- (pn)6(H2O)2](C(CN)3)4Cl2 with hydroxo-bridging ligands has been prepared; the centrosymmetric cluster cation can be described as two Cu4O3Cl distorted cubane units sharing one copper cation.Clemente Juan, Juan Modesto, [email protected] ; Gomez Garcia, Carlos Jose, [email protected] ; Coronado Miralles, Eugenio, [email protected]

Photoinduced HS state in the first spin-crossover chain containing a cyanocarbanion as bridging ligand

A new polymeric approach, based on cyanocarbanion ligands, for the design of spin crossover (SCO) compounds led us to the compound [Fe(abpt)2(tcpd)] (1) (tcpd^2 = (C[C(CN)2|3)^2 , abpt = 4-amino-3,5-bis(pyridin-2-yl)-1,2,4-triazole) which has been characterised as the first SCO molecular chain involving a cyanocarbanion as bridging ligand.Gomez Garcia, Carlos Jose, [email protected]

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.

Thyroid dysfunction is an important public health problem, which affects 10% of the general population and increases the risk of cardiovascular morbidity and mortality. Many aspects of thyroid hormone regulation have only partly been elucidated, including its transport, metabolism, and genetic determinants. Here we report a large meta-analysis of genome-wide association studies for thyroid function and dysfunction, testing 8 million genetic variants in up to 72,167 individuals. One-hundred-and-nine independent genetic variants are associated with these traits. A genetic risk score, calculated to assess their combined effects on clinical end points, shows significant associations with increased risk of both overt (Graves' disease) and subclinical thyroid disease, as well as clinical complications. By functional follow-up on selected signals, we identify a novel thyroid hormone transporter (SLC17A4) and a metabolizing enzyme (AADAT). Together, these results provide new knowledge about thyroid hormone physiology and disease, opening new possibilities for therapeutic targets

MATERIAUX MOLECULAIRES A BASE DE DONNEURS ORGANIQUES ET D'ANIONS INORGANIQUES MAGNETIQUES (SYNTHESES, STRUCTURES ET PROPRIETES)

BREST-BU Droit-Sciences-Sports (290192103) / SudocSudocFranceF

Sport et politique -Analyse de trois événements vécus par l’A.S. Saint-Etienne-

National audienc

A copper(II) coordination polymer based on flexible spacer ligands: Synthesis, crystal structure, and magnetic properties of the adipato complex [Cu4(bpy)4(adip)3](tcnp)2 [bpy=C10H8N2; ; ]

International audienceOne-pot reaction of copper(II) chloride dihydrate CuCl2 · 2H2O with sodium adipate Na2adip (adip2-=O2C(CH2)4CO22-) in the presence of 2,2′-bipyridyl (bpy = C10H8N2) and potassium 1,1,3,3-tetracyano-2-ethoxypropenide (tcnp-=(NC)2CC(OEt)C(CN)2-) gives the new compound [Cu4(bpy)4(adip)3](tcnp)2 (1), which was characterized by single crystal X-ray diffraction analysis. Each metal ion presents an elongated square pyramidal CuN2O3 environment, with an oxygen atom in apical position and a base plane involving almost equivalent bond lengths. The structure can be described as a pseudo dinuclear species in which two Cu(bpy) units are triply bridged by two unsymmetrical bridging oxygen atoms of two carboxylate groups with a κ-μ-bridging mode and by an almost symmetrical OCO unit with a bidentate syn–syn κ:κ–μ-bridging mode. Such coordination modes generate the tetranuclear Cu2(adip)2Cu2 units which are bound by a symmetrical adipate ligand through a κ-μ-bridging mode to lead to infinite chains involving a succession of Cu2 units alternatively bridged by one or two aliphatic chains of adipate ligands. Magnetic measurements exhibit a maximum in the χm versus T plot (at ∼15.2 K), which is characteristic of weak antiferromagnetic exchange interactions between the Cu(II) ions bridged by the carboxylate groups. Fit of the magnetic data with appropriate model led to J value of −7.74 cm−1 (the Hamiltonian is written as H = −2JSaSb)

New coordination polymers with a 2,2-dicyano-1-ethoxyethenolate (dcne-) bridging ligand

International audienceNew polymeric materials [M(dcne)2(H2O)2] with M = MnII (1), FeII (2), CoII (3), NiII (4) and ZnII (5) and [Cu(dcne)2(H2O)] (6) (dcne- = [(CN)2CC(O)OEt)]- = 2,2-dicyano-1-ethoxyethenolate anion) have been synthesised and characterised by infrared spectroscopy, X-ray crystallography and magnetic measurements. In these compounds, each organic ligand acts in a bridging mode with its two nitrogen atoms bound to two different metal cations. In compounds 1-5, each metal cation has a pseudo-octahedral cis-MN4O2 environment with four nitrogen atoms from four different organic ligands and two oxygen atoms from two water molecules. In compound 6, only one water molecule is coordinated and each copper(II) cation presents a CuN4O distorted trigonal bipyramid environment with a perfectly planar CuN2O equatorial plane. In all compounds the molecular arrangement involves 12-membered M(dcne)2M dimetallacycles that share a M atom forming chains running along the [101] direction with alternated, almost orthogonal, dimetallacycles. The intra-chain M ⋯ M distances (7.4270(2) Å in 3, 7.4628(2) Å in 5 and 7.2299(3) Å in 6) are longer than the inter-chain ones (6.0430(4) Å in 3, 6.0907(3) Å in 5 and 5.9648(5) Å in 6). The chains are connected by hydrogen bonds between the coordinated water molecules and the terminal oxygen atom of the organic ligand, giving rise to a 3D structure. Magnetic measurements show very weak antiferromagnetic coupling between metal centres that can be satisfactorily reproduced with a regular antiferromagnetic classical spin chain model

Unprecedented reactions of alkynes with η 2 -CS 2 metal complexes

International audienceAlkynes react with [Mo(η5-C5H5)2(η2-CS2)](1) to afford heterocycle derivatives [(η5-C5H5)2[graphic omitted]R][(2) R = CF3; (3) R = CO2Me] and [(η5-C5H5)2[graphic omitted]R][(4) R = CO2Me], and both (2) and (3) react with HC[triple bond, length half m-dash]C–CN to yield [(η5-C5H5)[graphic omitted]R}][(5) R = CO2Me; (6) R = CF3], while treatment of (1) with HC[triple bond, length half m-dash]C–CN gives an unprecedented metallacycle [(η5-C5H5)2Mo(C10H3N3S2)](7), corresponding to the addition of three alkynes to CS2; the structures of (4), (5), and (7) have been established by X-ray crystallograph