Data assimilation for hydraulic state estimation of a development project

International audienceAssurer la sûreté hydraulique sur les aménagements du Rhône est la priorité pour la Compagnie Nationale du Rhône. Cela signifie qu'il est indispensable de respecter les consignes d'exploitation sur les aménagements. Pour la régulation automatique des aménagements, le calcul de la commande prédictive s'appuie sur les mesures en cote en certains points caractéristiques ainsi que sur les débits aux ouvrages. De ce fait, lors de pannes de capteurs ou bien lors de forts phénomènes transitoires (tels que des arrêts ou démarrages de turbines), la régulation est perturbée. Suite à la présente étude, la solution proposée pour corriger les observations et mettre à jour les lignes d'eau intervenant dans le calcul des commandes, est la mise en place d'une méthode d'assimilation de données de type filtre de Kalman. Cette méthode est optimale dans le sens où elle assure la minimisation de l'erreur d'estimation. Mais cela n'est pas suffisant pour certaines applications industrielles. C'est pourquoi les notions de détectabilité et de convergence ont été approfondies. Cette étude a permis de déterminer des conditions suffisantes qui assurent une erreur de l'estimation convergente vers une moyenne nulle. Pour tester la mise en place d'une telle méthode, celle-ci a été implémentée sur l'outil de test industriel appelé " plateforme de simulation ". Des exemples de scénarios habituellement difficiles pour les régulations automatiques, telles que la perte de capteur et l'arrêt brutal d'une turbine sont présentés. Ils permettent de démontrer l'apport de la solution proposée. / Ensure the safety of development projects of the Rhône is the priority of the Compagnie Nationale du Rhône. That means it is essential to respect the water levels at some set points along the river. To regulate its development projects, the computation of the predictive control is based on measurements at the characteristic points as well as flows at the hydraulic facilities. Thus, when failures of sensors occur or during strong transients (such as stopping or starting the turbines), the regulation process can be disturbed. Following this study, the new solution suggested to detect sensor defaults, to correct the observations and to update the water profiles involved in the calculation of control actions, is based on a data assimilation method (Kalman Filter). This method is optimal because it ensures minimizing the estimation error. But this property is not sufficient for our industrial application. This is why the notions of detectability and convergence have been studied into detail. This study has identified sufficient conditions that ensure the error of the estimate to converge towards a nil average. In order to test and validate such a method, it has been implemented into the industrial test tool called "simulation platform." Examples of usually difficult scenarios simulating a loss of sensor and an unexpected stopping of a turbine are presented in this document. It allows demonstrating the benefits of the presented solution

MetNH3 Whim Bog Intercomparison Off-line ammonia metrology intercomparison

There is no regular quality assurance programme for ammonia passive samplers despite widespread use of these samplers across Europe and the rest of the world. In order to improve standards and begin to embed quality assurance in the measurement of ambient ammonia using passive samplers, within the EMRP MetNH3 project a passive sampler intercomparison was planned to enable side-by side exposure of the samplers to varying levels of ammonia in the field. From this experiment and in parallel the NPL CATFAC experiment (also within MetNH3), sufficient information and protocols could be developed. The method and infrastructure developed will then be available for future studies

Limits on the production of scalar leptoquarks from Z (0) decays at LEP

A search has been made for pairs and for single production of scalar leptoquarks of the first and second generations using a data sample of 392000 Z0 decays from the DELPHI detector at LEP 1. No signal was found and limits on the leptoquark mass, production cross section and branching ratio were set. A mass limit at 95% confidence level of 45.5 GeV/c2 was obtained for leptoquark pair production. The search for the production of a single leptoquark probed the mass region above this limit and its results exclude first and second generation leptoquarks D0 with masses below 65 GeV/c2 and 73 GeV/c2 respectively, at 95% confidence level, assuming that the D0lq Yukawa coupling alpha(lambda) is equal to the electromagnetic one. An upper limit is also given on the coupling alpha(lambda) as a function of the leptoquark mass m(D0)

EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI) : Study protocol for a multicentre, observational trial

More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362