112 research outputs found
The Response of the Sweat Glands to Some Locally Acting Agents in Human Subjects1
- Publication venue
- The Williams and Wilkins Co. Published by Elsevier Inc.
- Publication date
- 30/06/1950
- Field of study
Novel genetic loci associated with hippocampal volume
- Author
- Abramovic L. (Lucija)
- Adams H.H.H. (Hieab)
- Agartz I. (Ingrid)
- Alhusaini S. (Saud)
- Almasy L. (Laura)
- Ames D.J. (David)
- Amin N. (Najaf)
- Amouyel P. (Philippe)
- Andersson M. (Micael)
- Andreassen O.A. (Ole)
- Arepalli S. (Sampath)
- Arfanakis K. (Konstantinos)
- Arias-Vásquez A. (Alejandro)
- Aribisala B. (Benjamin)
- Armstrong N.J. (Nicola J.)
- Assareh A.A.
- Athanasiu L. (Lavinia)
- Axelsson T. (Tomas)
- Barral S. (Sandra)
- Bastin M.E. (Mark)
- Becker D.M. (Diane M.)
- Becker J.T. (James)
- Beecham A.H. (Ashley)
- Beiser A. (Alexa)
- Bennett D.A. (David A.)
- Bernard M. (Manon)
- Bis J.C. (Joshua)
- Björnsson A. (Asgeir)
- Blangero J. (John)
- Blanton S.H. (Susan H.)
- Bohlken M.M. (Marc M.)
- Bokhoven H. (Hans) van
- Boks M.P.M. (Marco)
- Boomsma D.I. (Dorret)
- Braber A. (Anouk) den
- Bralten L.B.C. (Linda)
- Brickman A.M. (Adam M.)
- Brodaty H. (Henry)
- Brouwer R.M. (Rachel)
- Brug M.P. (Marcel) van der
- Brunner H.G.
- Buckner M.
- Buitelaar J.K. (Jan)
- Bulayeva K. (Kazima)
- Cahn W. (Wiepke)
- Calhoun V.D. (Vince)
- Cannon D.M. (Dara)
- Carmichael O. (Owen)
- Cavalleri G. (Gianpiero)
- Chakravarty M.M. (M. Mallar)
- Chauhan G. (Ganesh)
- Chen Q. (Qiang)
- Cheng C.-Y. (Ching-Yu)
- Ching C.R.K. (Christopher)
- Chouraki V. (Vincent)
- Cichon S. (Sven)
- Cookson M.R. (Mark)
- Corvin A. (Aiden)
- Craen A.J. (Anton) de
- Crespo-Facorro B. (Benedicto)
- Crivello F. (Fabrice)
- Cuellar-Partida G. (Gabriel)
- Curran J.E. (Joanne)
- Czisch M. (Michael)
- Dale A.M. (Anders)
- Davies G.E. (Gareth)
- Deary I.J. (Ian)
- Debette S. (Stéphanie)
- DeCarli C. (Charles)
- Delanty N.
- Depondt C. (Chantal)
- Desrivières S. (Sylvane)
- DeStefano A.L. (Anita)
- Dillman A. (Allissa)
- Djurovic S. (Srdjan)
- Doan N.T. (Nhat Trung)
- Donohoe D.J. (Dennis)
- Drevets D.A. (Douglas)
- Duggirala R. (Ravi)
- Duijn C.M. (Cornelia) van
- Dyer M.D. (Matthew)
- Ehrlich S.M. (Stefan)
- Eijk K.R. (Kristel) van
- Ent D. (Dennis) van 't
- Enzinger C. (Christian)
- Erk S.
- Erp T.G.M. (Theo G.) van
- Espeseth T. (Thomas)
- Fedko I.O. (Iryna O.)
- Fernández G. (Guillén)
- Ferrucci L. (Luigi)
- Fisher S.E. (Simon)
- Fleischman D. (Debra)
- Ford I. (Ian)
- Fornage M. (Myriam)
- Foroud T. (Tatiana)
- Fox P.T. (Peter)
- Francks C. (Clyde)
- Franke B. (Barbara)
- Fukunaga M. (Masaki)
- Geus E.J.C. (Eco) de
- Gibbs J.R. (J. Raphael)
- Giddaluru S. (Sudheer)
- Glahn D.C. (David)
- Goldman A.L. (Aaron L.)
- Gollub R.L. (Randy)
- Gottesman R.F. (Rebecca)
- Grabe H.J. (Hans Jörgen)
- Green R.C. (Robert C.)
- Grimm O. (Oliver)
- Griswold M.D. (Michael)
- Gruber O. (Oliver)
- Guadalupe T. (Tulio)
- Gudnason V. (Vilmundur)
- Guelfi S. (Sebastian)
- Gutman B.A. (Boris A.)
- Göring H.H.H. (Harald H.)
- Hansell N.K. (Narelle)
- Hardy J. (John)
- Haren N.E.M. (Neeltje E.) van
- Hartman C.A. (C.)
- Hashimoto R. (Ryota)
- Hass J. (Johanna)
- Haukvik U.K. (Unn)
- Hegenscheid K. (Katrin)
- Heinz J. (Judith)
- Hernandez D.G. (Dena)
- Hernández M.C.V. (Maria C. Valdés)
- Heslenfeld D.J. (Dirk)
- Hibar D.P. (Derrek)
- Ho B.-C. (Beng-Choon)
- Hoehn D. (David)
- Hoekstra P.J. (Pieter)
- Hofer E. (Edith)
- Hoffmann W. (Wolfgang)
- Hofman A. (Albert)
- Holmes A.J. (Avram)
- Holsboer F. (Florian)
- Homuth G. (Georg)
- Hoogman M. (Martine)
- Hosten N. (Norbert)
- Hottenga J.J. (Jouke Jan)
- Huentelman M.J. (Matthew)
- Håberg A.K. (Asta K.)
- Ikeda M. (Masashi)
- Ikram M.K. (Kamran)
- Ikram M.K. (M. Kamran)
- Jack C.R. (Clifford R.)
- Jager P.L. (Philip) de
- Jahanshad N. (Neda)
- Janowitz D. (Deborah)
- Jenkinson S. (Sarah)
- Jia T. (Tianye)
- Johnson R. (Robert)
- Jukema J.W.
- Jönsson E.G. (Erik G.)
- Jørgensen K.N. (Kjetil N.)
- Kahn R. (René)
- Kanai R. (Ryota)
- Karbalai N. (Nazanin)
- Kasperaviciute D. (Dalia)
- Kim S. (Shinseog)
- Klein M. (Marieke)
- Kloszewska I. (Iwona)
- Knopman D.S. (David S.)
- Kochunov P. (Peter)
- Kraemer B. (Bernd)
- Kwok J.B. (John B.)
- Launer L.J. (Lenore)
- Lawrie S. (Stephen)
- Le Hellard S. (Stephanie)
- Lee P.H. (Phil)
- Lee S.J. (Sven) van der
- Lemaître H. (Herve)
- Liewald D.C.M. (David)
- Liu X. (Xinmin)
- Longo D.L. (Dan L.)
- Longstreth Jr W.T.
- Loohuis L.M.O. (Loes M. Olde)
- Lopez L.M. (Lorna)
- Lopez O.L. (Oscar L.)
- Lovestone S. (Simon)
- Luciano M. (Michelle)
- Lugt A. (Aad) van der
- MacAre C. (Christine)
- Marquand A.F. (Andre F.)
- Martin N.G. (Nicholas)
- Martinez O. (Oliver)
- Martinot J.-L. (Jean-Luc)
- Matarin M. (Mar)
- Mather R.
- Mattay V.S. (Venkata S.)
- Mattheisen M. (Manuel)
- McDonald C. (Colm)
- McIntosh A.M. (Andrew)
- McKay D.R. (David R.)
- McMahon F.J. (Francis J.)
- McMahon K.L. (Katie L.)
- Mecocci P. (Patrizia)
- Medland S.E. (Sarah)
- Melle I. (Ingrid)
- Meyer-Lindenberg A. (Andreas)
- Milaneschi Y. (Yuri)
- Mohnke S. (Sebastian)
- Montgomery G.W. (Grant W.)
- Morris D.W. (Derek W)
- Mosley T.H. (Thomas H.)
- Muñoz Maniega S. (Susana)
- Mühleisen T.W. (Thomas)
- Müller-Myhsok B. (B.)
- Nalls M.A. (Michael)
- Nauck M. (Matthias)
- Nho K. (Kwangsik)
- Nichols T.E. (Thomas)
- Niessen W.J. (Wiro)
- Nugent A.C. (Allison)
- Nyberg L. (Lars)
- Nyquist P. (Paul)
- Nöthen M.M. (Markus)
- Ohi K. (Kazutaka)
- Olvera R.L. (Rene)
- Oosterlaan J. (Jaap)
- Ophoff R.A. (Roel)
- Pandolfo M. (Massimo)
- Papmeyer M. (Martina)
- Paus T. (Tomas)
- Pausova Z. (Zdenka)
- Penninx B.W.J.H. (Brenda)
- Pike G.B. (G. Bruce)
- Pirpamer L. (Lukas)
- Pol H.H.
- Potkin S.G. (Steven)
- Psaty B.M. (Bruce)
- Pütz B. (Benno)
- Ramasamy A. (Adaikalavan)
- Rentería M.E. (Miguel)
- Reppermund S.
- Richards J.S. (Jennifer S.)
- Rietschel M. (Marcella)
- Risacher S.L. (Shannon)
- Roffman J.L. (Joshua)
- Roiz-Santiañez R. (Roberto)
- Rommelse N. (Nanda)
- Ropele S. (Stefan)
- Rose E.J. (Emma)
- Rotter J.I. (Jerome I.)
- Royle N.A. (Natalie)
- Rundek T. (Tatjana)
- Ryten M. (Mina)
- Sacco R.L. (Ralph L.)
- Sachdev P.S. (Perminder)
- Saremi A. (Arvin)
- Satizabal C.L. (Claudia)
- Saykin A.J. (Andrew)
- Schmaal L. (Lianne)
- Schmidt H. (Helena)
- Schmidt R. (Reinhold)
- Schofield C.J. (Christopher)
- Schork N.J. (Nicholas)
- Schumann G. (Gunter)
- Seiferth N. (Nina)
- Seshadri S. (Sudha)
- Shen L. (Li)
- Shin J. (Jean)
- Shumskaya E. (Elena)
- Sigursson S. (Sigurdur)
- Simmons A. (Andrew)
- Singleton A. (Andrew)
- Sisodiya S.M. (Sanjay)
- Smith A.V. (Albert Vernon)
- Smith C. (Colin)
- Smoller J.W.
- Soininen H. (H.)
- Sprooten R. (Roy)
- Steen V.M. (Vidar)
- Stein J.L.
- Stott D.J. (David J.)
- Strike L.T. (Lachlan)
- Sussmann J. (Jessika)
- Sämann P.G. (Philipp)
- Teumer A. (Alexander)
- Thalamuthu A. (Anbupalam)
- Thompson P.M. (Paul)
- Toga A.W. (Arthur W.)
- Tol M.J.D. (Marie-José) van
- Tordesillas-Gutierrez D. (Diana)
- Toro R. (Roberto)
- Trabzuni D. (Danyah)
- Traynor B. (Bryan)
- Trompet S. (Stella)
- Troncoso J.C. (Juan)
- Tsolaki M. (Magda)
- Tzourio C. (Christophe)
- Uitterlinden A.G. (André)
- Vaidya D. (Dhananjay)
- van der Grond J. (Jeroen)
- Van Der Meer D. (Dennis)
- Van Donkelaar M.M.J. (Marjolein M. J.)
- Van Rooij D. (Daan)
- Vardarajan B.N. (Badri)
- Vellas B. (Bruno)
- Veltman D.J. (Dick)
- Vernooij M.W. (Meike)
- Völzke H. (Henry)
- Walter H.J. (Henrik)
- Walton E. (Esther)
- Wardlaw J. (Joanna)
- Wassink A.M.J. (Annemarie)
- Weale M.E. (Michael)
- Wee N.J. (Nic) van der
- Weinberger D.R. (Daniel R.)
- Weiner M.W. (Michael W.)
- Wen W. (Wei)
- Westlye L.T. (Lars)
- Westman E. (Eric)
- Whelan C.D. (Christopher)
- White T.J.H. (Tonya)
- Windham B.G. (Gwen)
- Winkler A.M. (Anderson)
- Wittfeld K. (Katharina)
- Woldehawariat G. (Girma)
- Wolfers T. (Thomas)
- Wong T.Y. (Tien Y.)
- Wright C.B. (Clinton B.)
- Wright M.J. (Margaret)
- Yanek L.R. (Lisa)
- Yang J. (Jingyun)
- Zielke R.H. (Ronald H.)
- Zijdenbos A.P.
- Zonderman A.B.
- Zubicaray G.I. (Greig) de
- Zwiers M.P. (Marcel)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 18/01/2017
- Field of study
The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg =-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness
Genetic architecture of subcortical brain structures in 38,851 individuals
- Author
- Abramovic Lucija
- Adams Hieab H. H.
- Agartz Ingrid
- Alhusaini Saud
- Ames David
- Amin Najaf
- Amouyel Philippe
- Andersson Micael
- Andreassen Ole A.
- Arfanakis Konstantinos
- Arias-Vasquez Alejandro
- Aribisala Benjamin S.
- Armstrong Nicola J.
- Assareh Amelia A.
- Athanasiu Lavinia
- Axelsson Tomas
- Bastin Mark E.
- Becker Diane M.
- Becker James T.
- Beiser Alexa S.
- Bennett David A.
- Bernard Manon
- Bis Joshua C.
- Bohlken Marc M.
- Boks Marco P.
- Boomsma Dorret
- Bralten Janita
- Brodaty Henry
- Brouwer Rachel M.
- Brunner Han G.
- Buckner Randy L.
- Buitelaar Jan K.
- Bulayeva Kazima B.
- Burkhardt Ralph
- Cahn Wiepke
- Calhoun Vince D.
- Carmichael Owen
- Cavalleri Gianpiero L.
- Chakravarty M. Mallar
- Chauhan Ganesh
- Chen Christopher
- Chen Qiang
- Cheng Ching-Yu
- Cheung Joshua W.
- Ching Christopher R. K.
- Cichon Sven
- Crespo-Facorro Benedicto
- Crivello Fabrice
- Cuellar-Partida Gabriel
- Dale Anders M.
- Davies Gareth E.
- de Geus Eco J. C.
- De Jager Philip L.
- de Zubicaray Greig
- Deary Ian J.
- Debette Stephanie
- DeCarli Charles
- Delanty Norman
- den Braber Anouk
- Depondt Chantal
- Desrivieres Sylvane
- DeStefano Anita L.
- Djurovic Srdjan
- Ehrlich Stefan
- Eicher John D.
- Erk Susanne
- Espeseth Thomas
- Fedko Iryna O.
- Fernandez Guilln
- Filippi Irina
- Fisher Simon E.
- Fleischman Debra A.
- Fletcher Evan
- Fornage Myriam
- Foroud Tatiana M.
- Francks Clyde
- Franke Barbara
- Giddaluru Sudheer
- Goldman Aaron L.
- Gollub Randy L.
- Grabe Hans J.
- Green Robert C.
- Greve Douglas N.
- Grimm Oliver
- Groenewold Nynke A.
- Gruber Oliver
- Guadalupe Tulio
- Gudnason Vilmundur
- Haberg Asta K.
- Hagenaars Saskia P.
- Hansell Narelle K.
- Harris Tamara B.
- Hartman Catharina A.
- Haukvik Unn K.
- Hegenscheid Katrin
- Heinz Andreas
- Hernandez Maria C. Valdes
- Heslenfeld Dirk J.
- Hibar Derrek P.
- Hilal Saima
- Himali Jayandra J.
- Ho Beng-Choon
- Hoehn David
- Hoekstra Pieter J.
- Hofer Edith
- Hoffmann Wolfgang
- Hofman Albert
- Holmes Avram J.
- Holsboer Florian
- Homuth Georg
- Hoogman Martine
- Hosten Norbert
- Hottenga Jouke-Jan
- Hu Yanhui
- Huentelman Matthew
- Ikram M. Arfan
- Ikram M. Kamran
- Ipser Jonathan C.
- Jack Clifford R. Jr.
- Jahanshad Neda
- Janowitz Deborah
- Jia Tianye
- Jian Xueqiu
- Johnson Andrew D.
- Jones Hannah J.
- Jonsson Erik G.
- Kahn Rene S.
- Kanai Ryota
- Kasperaviciute Dalia
- Kim Sungeun
- Klein Marieke
- Kloszewska Iwona
- Knol Maria J.
- Koen Nastassja
- Koh Jia Yu
- Kraemer Bernd
- Kwok John B. J.
- Launer Lenore J.
- Lawrie Stephen M.
- Le Hellard Stephanie
- Lee Phil H.
- Lee Tom
- Lemaitre Herve
- Li Shuo
- Liewald David C. M.
- Lin Honghuang
- Loeffler Markus
- Longstreth William T. Jr.
- Loohuis Loes M. Olde
- Lopez Oscar L.
- Lovestone Simon
- Luciano Michelle
- Macare Christine
- Maillard Pauline
- Marquand Andre F.
- Martin Nicholas G.
- Martinot Jean-Luc
- Masouleh Shahrzad Kharabian
- Matarin Mar
- Mather Karen A.
- Mattay Venkata S.
- Mattheisen Manuel
- Mazoyer Bernard
- McIntosh Andrew M.
- McMahon Katie L.
- Mecocci Patrizia
- Medland Sarah E.
- Melle Ingrid
- Meyer-Lindenberg Andreas
- Milaneschi Yuri
- Mirza-Schreiber Nazanin
- Mohnke Sebastian
- Montgomery Grant W.
- Mosley Thomas H.
- Muehleisen Thomas W.
- Mueller-Myhsok Bertram
- Nauck Matthias
- Nhat Trung Doan
- Nho Kwangsik
- Niessen Wiro J.
- Noethen Markus M.
- Nyberg Lars
- Nyquist Paul A.
- Oosterlaan Jaap
- Ophoff Roel A.
- Pandolfo Massimo
- Papmeyer Martina
- Paus Tomas
- Pausova Zdenka
- Penninx Brenda W. J. H.
- Pike G. Bruce
- Pol Hilleke E. Hulshoff
- Potkin Steven G.
- Psaty Bruce M.
- Puetz Benno
- Rentera Miguel E.
- Reppermund Simone
- Richards Jennifer S.
- Rietschel Marcella
- Risacher Shannon L.
- Roffman Joshua L.
- Roiz-Santianez Roberto
- Romanczuk-Seiferth Nina
- Rommelse Nanda
- Roshchupkin Gennady
- Rotter Jerome
- Saba Yasaman
- Sachdev Perminder S.
- Saemann Philipp G.
- Saremi Arvin
- Sargurupremraj Muralidharan
- Satizabal Claudia L.
- Saykin Andrew J.
- Schmaal Lianne
- Schmidt Helena
- Schmidt Reinhold
- Schofield Peter R.
- Scholz Markus
- Schork Andrew J.
- Schroeter Matthias L.
- Schumann Gunter
- Seshadri Sudha
- Shen Li
- Shin Jean
- Shulman Joshua M.
- Shumskaya Elena
- Simmons Andrew
- Singh Baljeet
- Sisodiya Sanjay M.
- Smith Albert
- Smith George Davey
- Smoller Jordan W.
- Soininen Hilkka
- Steen Vidar M.
- Stein Dan J.
- Stein Jason L.
- Stevens Allison
- Strike Lachlan T.
- Sussmann Jessika E.
- Teumer Alexander
- Thalamuthu Anbupalam
- Thompson Paul M.
- Toga Arthur W.
- Tordesillas-Gutierrez Diana
- Toro Roberto
- Tsolaki Magda
- Turner Jessica A.
- Tzourio Christophe
- Uitterlinden Andre G.
- van Bokhoven Hans
- van der Lee Sven J.
- van der Meer Dennis
- van der Wee Nic J. A.
- van Donkelaar Marjolein M. J.
- van Duijn Cornelia M.
- van Eijk Kristel R.
- van Erp Theo G. M.
- van Haren Neeltje E. M.
- van Rooij Daan
- van Tol Marie-Jose
- van't Ent Dennis
- Vellas Bruno
- Veltman Dick J.
- Vernooij Meike W.
- Villringer Arno
- Vinke Louis N.
- Voelzke Henry
- Walter Henrik
- Walton Esther
- Wardlaw Joanna M.
- Wassink Thomas H.
- Weinberger Daniel R.
- Weiner Michael W.
- Wen Wei
- Westlye Lars T.
- Westman Eric
- Whelan Christopher D.
- White Charles C.
- White Tonya
- Witte A. Veronica
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wong Tien Yin
- Wright Margaret J.
- Yanek Lisa R.
- Yang Jingyun
- Yang Qiong
- Zwiers Marcel P.
- Publication venue
- Ludwig-Maximilians-Universität München
- Publication date
- 01/01/2019
- Field of study
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease
Genetic architecture of subcortical brain structures in 38,851 individuals
- Author
- Abramovic Lucija
- Adams Hieab H. H.
- Agartz Ingrid
- Alhusaini Saud
- Ames David
- Amin Najaf
- Amouyel Philippe
- Andersson Micael
- Andreassen Ole A.
- Arfanakis Konstantinos
- Arias-Vasquez Alejandro
- Aribisala Benjamin S.
- Armstrong Nicola J.
- Assareh Amelia A.
- Athanasiu Lavinia
- Axelsson Tomas
- Bastin Mark E.
- Becker Diane M.
- Becker James T.
- Beiser Alexa S.
- Bennett David A.
- Bernard Manon
- Bis Joshua C.
- Bohlken Marc M.
- Boks Marco P.
- Boomsma Dorret I.
- Bralten Janita
- Brodaty Henry
- Brouwer Rachel M.
- Brunner Han G.
- Buckner Randy L.
- Buitelaar Jan K.
- Bulayeva Kazima B.
- Burkhardt Ralph
- Cahn Wiepke
- Calhoun Vince D.
- Carmichael Owen
- Cavalleri Gianpiero L.
- Chakravarty M. Mallar
- Chauhan Ganesh
- Chen Christopher
- Chen Qiang
- Cheng Ching-Yu
- Cheung Joshua W.
- Ching Christopher R. K.
- Cichon Sven
- Crespo-Facorro Benedicto
- Crivello Fabrice
- Cuellar-Partida Gabriel
- Dale Anders M.
- Davey Smith George
- Davies Gareth E.
- de Geus Eco J. C.
- De Jager Philip L.
- De Zubicaray Greig I.
- Deary Ian J.
- Debette Stéphanie
- Decarli Charles
- Delanty Norman
- Den Braber Anouk
- Depondt Chantal
- Desrivières Sylvane
- Destefano Anita L.
- Djurovic Srdjan
- Doan Nhat Trung
- Ehrlich Stefan
- Eicher John D.
- Erk Susanne
- Espeseth Thomas
- Fedko Iryna O.
- Fernández Guillén
- Filippi Irina
- Fisher Simon E.
- Fleischman Debra A.
- Fletcher Evan
- Fornage Myriam
- Foroud Tatiana M.
- Francks Clyde
- Franke Barbara
- Giddaluru Sudheer
- Goldman Aaron L.
- Gollub Randy L.
- Grabe Hans J.
- Green Robert C
- Greve Douglas N.
- Grimm Oliver
- Groenewold Nynke A.
- Gruber Oliver
- Guadalupe Tulio
- Gudnason Vilmundur
- Hagenaars Saskia P.
- Hansell Narelle K.
- Harris Tamara B.
- Hartman Catharina A.
- Haukvik Unn K.
- Hegenscheid Katrin
- Heinz Andreas
- Heslenfeld Dirk J.
- Hibar Derrek P.
- Hilal Saima
- Himali Jayandra J.
- Ho Beng-Choon
- Hoehn David
- Hoekstra Pieter J.
- Hofer Edith
- Hoffmann Wolfgang
- Hofman Albert
- Holmes Avram J.
- Holsboer Florian
- Homuth Georg
- Hoogman Martine
- Hosten Norbert
- Hottenga Jouke-Jan
- Hu Yanhui
- Huentelman Matthew
- Hulshoff Pol Hilleke E.
- Håberg Asta K.
- Ikram M. Arfan
- Ikram M. Kamran
- Ipser Jonathan C.
- Jack Clifford R.
- Jahanshad Neda
- Janowitz Deborah
- Jia Tianye
- Jian Xueqiu
- Johnson Andrew D.
- Jones Hannah J.
- Jönsson Erik G.
- Kahn René S.
- Kanai Ryota
- Kasperaviciute Dalia
- Kharabian Masouleh Shahrzad
- Kim Sungeun
- Klein Marieke
- Kloszewska Iwona
- Knol Maria J.
- Koen Nastassja
- Koh Jia Yu
- Kraemer Bernd
- Kwok John B. J.
- Launer Lenore J.
- Lawrie Stephen M.
- Le Hellard Stephanie
- Lee Phil H.
- Lee Tom V.
- Lemaître Hervé
- Li Shuo
- Liewald David C. M.
- Lin Honghuang
- Loeffler Markus
- Longstreth William T.
- Lopez Oscar L.
- Lovestone Simon
- Luciano Michelle
- Macare Christine
- Maillard Pauline
- Marquand Andre F.
- Martin Nicholas G.
- Martinot Jean-Luc
- Matarin Mar
- Mather Karen A.
- Mattay Venkata S.
- Mattheisen Manuel
- Mazoyer Bernard
- McIntosh Andrew M.
- McMahon Katie L.
- Mecocci Patrizia
- Medland Sarah E.
- Melle Ingrid
- Meyer-Lindenberg Andreas
- Milaneschi Yuri
- Mirza-Schreiber Nazanin
- Mohnke Sebastian
- Montgomery Grant W.
- Mosley Thomas H.
- Mühleisen Thomas W.
- Müller-Myhsok Bertram
- Nauck Matthias
- Nho Kwangsik
- Niessen Wiro J.
- Nyberg Lars
- Nyquist Paul A.
- Nöthen Markus M.
- Olde Loohuis Loes M.
- Oosterlaan Jaap
- Ophoff Roel A.
- Pandolfo Massimo
- Papmeyer Martina
- Paus Tomas
- Pausova Zdenka
- Penninx Brenda W. J. H.
- Pike G. Bruce
- Potkin Steven G.
- Psaty Bruce M.
- Pütz Benno
- Rentería Miguel E.
- Reppermund Simone
- Richards Jennifer S.
- Rietschel Marcella
- Risacher Shannon L.
- Roffman Joshua L.
- Roiz-Santiañez Roberto
- Romanczuk-Seiferth Nina
- Rommelse Nanda
- Roshchupkin Gennady V.
- Rotter Jerome I.
- Saba Yasaman
- Sachdev Perminder S.
- Saremi Arvin
- Sargurupremraj Muralidharan
- Satizabal Claudia L.
- Saykin Andrew J.
- Schmaal Lianne
- Schmidt Helena
- Schmidt Reinhold
- Schofield Peter R.
- Scholz Markus
- Schork Andrew J.
- Schroeter Matthias L.
- Schumann Gunter
- Seshadri Sudha
- Shen Li
- Shin Jean
- Shulman Joshua M.
- Shumskaya Elena
- Simmons Andrew
- Singh Baljeet
- Sisodiya Sanjay M.
- Smith Albert V.
- Smoller Jordan W.
- Soininen Hilkka
- Steen Vidar M.
- Stein Dan J.
- Stein Jason L.
- Stevens Allison
- Strike Lachlan T.
- Sussmann Jessika E.
- Sämann Philipp G.
- Teumer Alexander
- Thalamuthu Anbupalam
- Thompson Paul M.
- Toga Arthur W.
- Tordesillas-Gutierrez Diana
- Toro Roberto
- Tsolaki Magda
- Turner Jessica A.
- Tzourio Christophe
- Uitterlinden André G.
- Valdés Hernández Maria C.
- Van Bokhoven Hans
- Van Der Lee Sven J.
- van der Meer Dennis
- Van Der Wee Nic J. A.
- Van Donkelaar Marjolein M. J.
- Van Duijn Cornelia M.
- Van Eijk Kristel R.
- Van Erp Theo G. M.
- Van Haren Neeltje E. M.
- Van Rooij Daan
- Van Tol Marie-Jose
- van ‘t Ent Dennis
- Vellas Bruno
- Veltman Dick J.
- Vernooij Meike W.
- Villringer Arno
- Vinke Louis N.
- Völzke Henry
- Walter Henrik
- Walton Esther
- Wardlaw Joanna M.
- Wassink Thomas H.
- Weinberger Daniel R.
- Weiner Michael W.
- Wen Wei
- Westlye Lars T.
- Westman Eric
- Whelan Christopher D.
- White Charles C.
- White Tonya
- Witte A. Veronica
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wong Tien Yin
- Wright Margaret J.
- Yanek Lisa R.
- Yang Jingyun
- Yang Qiong
- Zwiers Marcel P.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease
Novel genetic loci underlying human intracranial volume identified through genome-wide association
- Author
- Abramovic Lucija
- Adams Hieab H H
- Agartz Ingrid
- Aggarwal Neelum T
- Alhusaini Saud
- Almasy Laura
- Ames David
- Amin Najaf
- Amouyel Philippe
- Andersson Micael
- Andreassen Ole A
- Arepalli Sampath
- Arfanakis Konstantinos
- Arias-Vasquez Alejandro
- Aribisala Benjamin S
- Armstrong Nicola J
- Assareh Amelia A
- Athanasiu Lavinia
- Axelsson Tomas
- Barral Sandra
- Bastin Mark E
- Becker Diane M
- Becker James T
- Beecham Ashley H
- Beiser Alexa
- Bennett David A
- Bernard Manon
- Bis Joshua C
- Blangero John
- Blanken Laura M E
- Blanton Susan H
- Bohlken Marc M
- Boks Marco P
- Boomsma Dorret I
- Braber Anouk Den
- Bralten Janita
- Brickman Adam M
- Brodaty Henry
- Brouwer Rachel M
- Brunner Han G
- Buckner Randy L
- Buitelaar Jan K
- Bulayeva Kazima B
- Cahn Wiepke
- Calhoun Vince D
- Cannon Dara M
- Carmichael Owen
- Cavalleri Gianpiero L
- Chakravarty M Mallar
- Chauhan Ganesh
- Chen Christopher
- Chen Qiang
- Cheng Ching-Yu
- Ching Christopher R K
- Chouraki Vincent
- Cichon Sven
- Cookson Mark R
- Corvin Aiden
- Crespo-Facorro Benedicto
- Cuellar-Partida Gabriel
- Curran Joanne E
- Czisch Michael
- Dale Anders M
- Davies Gareth E
- De Craen Anton J M
- De Geus Eco J C
- De Jager Philip L
- De Zubicaray Greig I
- Deary Ian J
- Debette Stéphanie
- Decarli Charles
- Delanty Norman
- Depondt Chantal
- Desrivières Sylvane
- Destefano Anita L
- Dillman Allissa
- Djurovic Srdjan
- Doan Nhat Trung
- Donohoe Gary
- Drevets Wayne C
- Duggirala Ravi
- Dyer Thomas D
- Ehrlich Stefan
- Erk Susanne
- Espeseth Thomas
- Evans Denis A
- Fedko Iryna O
- Fernández Guillén
- Ferrucci Luigi
- Filippi Irina
- Fisher Simon E
- Fleischman Debra A
- Ford Ian
- Fornage Myriam
- Foroud Tatiana M
- Fox Peter T
- Francks Clyde
- Franke Barbara
- Fukunaga Masaki
- Ge Tian
- Gibbs J Raphael
- Giddaluru Sudheer
- Glahn David C
- Goldman Aaron L
- Gollub Randy L
- Gottesman Rebecca F
- Grabe Hans J
- Green Robert C
- Greven Corina U
- Grimm Oliver
- Griswold Michael E
- Gruber Oliver
- Guadalupe Tulio
- Gudnason Vilmundur
- Guelfi Sebastian
- Göring Harald H H
- Hansell Narelle K
- Hardy John
- Hartman Catharina A
- Hashimoto Ryota
- Hass Johanna
- Haukvik Unn K
- Hegenscheid Katrin
- Heinz Andreas
- Hernandez Dena G
- Hernández Maria C Valdés
- Heslenfeld Dirk J
- Hibar Derrek P
- Hilal Saima
- Ho Beng-Choon
- Hoehn David
- Hoekstra Pieter J
- Hofer Edith
- Hoffmann Wolfgang
- Hofman Albert
- Holmes Avram J
- Holsboer Florian
- Homuth Georg
- Hoogman Martine
- Hosten Norbert
- Hottenga Jouke-Jan
- Ikeda Masashi
- Ikram M Arfan
- Ikram M Kamran
- Jack Clifford R
- Jahanshad Neda
- Janowitz Deborah
- Jenkinson Mark
- Jia Tianye
- Johnson Robert
- Jukema J Wouter
- Jönsson Erik G
- Kahn René S
- Kanai Ryota
- Kasperaviciute Dalia
- Kim Sungeun
- Klein Marieke
- Kloszewska Iwona
- Knopman David S
- Kochunov Peter
- Kraemer Bernd
- Kwok John B
- Launer Lenore J
- Lawrie Stephen M
- Le Hellard Stephanie
- Lee Phil H
- Lemaître Hervé
- Liao Jiemin
- Liewald David C M
- Liu Xinmin
- Longo Dan L
- Longstreth
- Loohuis Loes M Olde
- Lopez Lorna M
- Lopez Oscar L
- Lovestone Simon
- Luciano Michelle
- Macare Christine
- Maniega Susana Muñoz
- Marquand Andre
- Martin Nicholas G
- Martinez Oliver
- Martinot Jean-Luc
- Matarin Mar
- Mather Karen A
- Mattay Venkata S
- Mattheisen Manuel
- Mazoyer Bernard
- McDonald Colm
- McIntosh Andrew M
- McKay David R
- McMahon Francis J
- McMahon Katie L
- McWhirter Rebekah
- Mecocci Patrizia
- Medland Sarah E
- Melle Ingrid
- Meyer-Lindenberg Andreas
- Milaneschi Yuri
- Mirza-Schreiber Nazanin
- Mohnke Sebastian
- Montgomery Grant W
- Morris Derek W
- Mosley Thomas H
- Muetzel Ryan L
- Mühleisen Thomas W
- Müller-Myhsok Bertram
- Nalls Michael A
- Nauck Matthias
- Nho Kwangsik
- Nichols Thomas E
- Niessen Wiro J
- Nugent Allison C
- Nyberg Lars
- Nyquist Paul A
- Nöthen Markus M
- Ohi Kazutaka
- Olvera Rene L
- Oosterlaan Jaap
- Ophoff Roel A
- Pandolfo Massimo
- Papmeyer Martina
- Pappa Irene
- Paus Tomas
- Pausova Zdenka
- Penninx Brenda W J H
- Pike G Bruce
- Pirpamer Lukas
- Pol Hilleke E Hulshoff
- Potkin Steven G
- Psaty Bruce M
- Pudas Sara
- Pütz Benno
- Rajan Kumar B
- Ramasamy Adaikalavan
- Rentería Miguel E
- Reppermund Simone
- Richards Jennifer S
- Rietschel Marcella
- Risacher Shannon L
- Roffman Joshua L
- Roiz-Santiañez Roberto
- Romanczuk-Seiferth Nina
- Rommelse Nanda
- Rose Emma J
- Rotter Jerome I
- Royle Natalie A
- Rundek Tatjana
- Ryten Mina
- Sacco Ralph L
- Sachdev Perminder S
- Satizabal Claudia L
- Saykin Andrew J
- Schmaal Lianne
- Schmidt Helena
- Schmidt Reinhold
- Schofield Peter R
- Schork Andrew J
- Schumann Gunter
- Seshadri Sudha
- Shen Li
- Shin Jean
- Shumskaya Elena
- Sigurdsson Sigurdur
- Simmons Andy
- Singleton Andrew
- Sisodiya Sanjay M
- Smith Albert V
- Smith Colin
- Smoller Jordan W
- Soininen Hilkka
- Sprooten Emma
- Srikanth Velandai
- Steen Vidar M
- Stein Jason L
- Stott David J
- Strike Lachlan T
- Sussmann Jessika E
- Sämann Philipp G
- Teumer Alexander
- Thalamuthu Anbupalam
- Thompson Paul M.
- Thomson Russell
- Tiemeier Henning
- Toga Arthur W
- Tordesillas-Gutierrez Diana
- Toro Roberto
- Trabzuni Daniah
- Traynor Bryan J
- Trompet Stella
- Troncoso Juan
- Turner Jessica A
- Tzourio Christophe
- Uitterlinden Andre G
- Vaidya Dhananjay
- Van Bokhoven Hans
- Van Der Brug Marcel
- Van Der Grond Jeroen
- Van Der Lee Sven J
- Van Der Lugt Aad
- Van Der Meer Dennis
- Van Der Wee Nic J A
- Van Donkelaar Marjolein M J
- Van Duijn Cornelia M
- Van Eijk Kristel R
- Van Erp Theo G M
- Van Haren Neeltje E M
- Van Rooij Daan
- Van Tol Marie-Jose
- Van't Ent Dennis
- Vardarajan Badri N
- Veltman Dick J
- Vernooij Meike W
- Völzke Henry
- Walter Henrik
- Walton Esther
- Wardlaw Joanna M
- Wassink Thomas H
- Weale Michael E
- Weinberger Daniel R
- Weiner Michael W
- Wen Wei
- Westlye Lars T
- Westman Eric
- Whelan Christopher D
- White Tonya
- Windham Beverly G
- Winkler Anderson M
- Wittfeld Katharina
- Woldehawariat Girma
- Wolf Christiane
- Wolfers Thomas
- Wong Tien Y
- Wright Clinton B
- Wright Margaret J
- Xu Bing
- Yanek Lisa R
- Yang Jingyun
- Zielke H Ronald
- Zijdenbos Alex
- Zonderman Alan B
- Zwiers Marcel P
- Publication venue
- Publication date
- 01/01/2016
- Field of study
Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five novel loci for intracranial volume and confirmed two known signals. Four of the loci are also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (ρgenetic=0.748), which indicated a similar genetic background and allowed for the identification of four additional loci through meta-analysis (Ncombined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, Parkinson’s disease, and enriched near genes involved in growth pathways including PI3K–AKT signaling. These findings identify biological underpinnings of intracranial volume and provide genetic support for theories on brain reserve and brain overgrowth
The genetic architecture of the human cerebral cortex
- Author
- Adams Hieab H. H.
- Agartz Ingrid
- Alhusaini Saud
- Almeida Marcio A. A.
- Alnaes Dag
- Alvim Marina K. M.
- Ames David
- Amlien Inge K.
- Anderson Tim J.
- Andersson Micael
- Andreassen Ole A.
- Ard Tyler
- Arias-Vasquez Alejandro
- Armstrong Nicola J.
- Artiges Eric
- Ashley-Koch Allison
- Assareh Amelia A.
- Atkins Joshua R.
- Ayesa-Arriola Rosa
- Bastin Mark E.
- Baune Bernhard T.
- Beckham Jean C.
- Belger Aysenil
- Bernard Manon
- Bis Joshua C.
- Blangero John
- Boomsma Dorret I.
- Bralten Janita
- Brandt Christine L.
- Brodaty Henry
- Brouwer Rachel M.
- Brown Gregory G.
- Brunner Han G.
- Buckner Randy L.
- Buimer Elizabeth E. L.
- Buitelaar Jan K.
- Bulow Robin
- Burger Christian
- Bustillo Juan R.
- Cahn Wiepke
- Cairns Murray J.
- Calhoun Vince
- Cannon Dara M.
- Carr Vaughan J.
- Caseras Xavier
- Caspers Svenja
- Cavalleri Gianpiero L.
- Cendes Fernando
- Chakravarty Mallar
- Chen Qiang
- Cheung Joshua W.
- Ching Christopher R. K.
- Cichon Sven
- Colodro-Conde Lucia
- Corvin Aiden
- Couvy-Duchesne Baptiste
- Crespo-Facorro Benedicto
- Curran Joanne E.
- Dale Anders M.
- Dalrymple-Alford John C.
- Dalvie Shareefa
- Dannlowski Udo
- Davies Gareth E.
- de Araujo Tania K.
- de Geus Eco J. C.
- de Zubicaray Greig I.
- de Zwarte Sonja M. C.
- Deary Ian J.
- Debette Stephanie
- Decarli Charles
- Degenhardt Franziska
- Delanty Norman
- den Braber Anouk
- Dennis Michelle F.
- Depondt Chantal
- Desrivieres Sylvane
- Dietsche Bruno
- Djurovic Srdjan
- Doherty Colin P.
- Dohm Katharina
- Donohoe Gary
- Ehrlich Stefan
- Engelbrecht Hannah-Ruth
- Erk Susanne
- Espeseth Thomas
- Espiritu Ryan
- Fan Chun Chieh
- Fedko Iryna O.
- Fernandez Guillen
- Fisher Simon E.
- Flor Herta
- Foley Sonya F.
- Ford Judith M.
- Fornage Myriam
- Forstner Andreas J.
- Francks Clyde
- Franke Barbara
- Fukunaga Masaki
- Garijo Daniel
- Garrett Melanie E.
- Ge Tian
- Giddaluru Sudheer
- Gil Yolanda
- Glahn David C.
- Goldman Aaron L.
- Gollub Randy L.
- Gowland Penny A.
- Grabe Hans J.
- Grasby Katrina L.
- Green Melissa J.
- Green Robert C.
- Groenewold Nynke A.
- Grotegerd Dominik
- Gruber Oliver
- Gudnason Vilmundur
- Gurholt Tiril P.
- Gutman Boris A.
- Haberg Asta K.
- Hansell Narelle K.
- Hariri Ahmad R.
- Harris Mathew A.
- Harrison Marc B.
- Hartman Catharina A.
- Hashimoto Ryota
- Haswell Courtney C.
- Hauser Michael
- Hausler Alexander N.
- Heindel Walter
- Heinz Andreas
- Henskens Frans A.
- Herms Stefan
- Heslenfeld Dirk J.
- Hibar Derrek P.
- Hillegers Manon H. J.
- Ho Beng-Choon
- Ho New Fei
- Hoehn David
- Hoekstra Pieter J.
- Hofer Edith
- Hoffmann Per
- Hoffmann Wolfgang U.
- Holleran Laurena
- Holmes Avram J.
- Holsboer Florian
- Homuth Georg
- Hong L. Elliot
- Hoogman Martine
- Hopkins William D.
- Hosten Norbert
- Hottenga Jouke-Jan
- Ikeda Masashi
- Ikram M. Arfan
- Jack Clifford R.
- Jahanshad Neda
- Jang MiHyun
- Janowitz Deborah
- Jansen Andreas
- Jansen Iris E.
- Jernigan Terry L.
- Jia Tianye
- Jockwitz Christiane
- Jonsson Erik G.
- Kahn Rene S.
- Kanai Ryota
- Karama Sherif
- Kasperaviciute Dalia
- Kaufmann Tobias
- Kelly Sinead
- Kennedy Martin A.
- Kikuchi Masataka
- Kimbrel Nathan A.
- Kircher Tilo T. J.
- Klein Marieke
- Knapp Michael
- Knodt Annchen R.
- Kochunov Peter
- Kolskar Knut
- Koops Sanne
- Kramer Bernd
- Krug Axel
- Kwok John B. J.
- Lam Max
- Lancaster Thomas M.
- Launer Lenore
- Le Hellard Stephanie
- Lee Phil H.
- Lett Tristram A.
- Lewis Lindsay B.
- Lim Kelvin O.
- Lind Penelope A.
- Longstreth W. T.
- Loohuis Loes M. Olde
- Lopes-Cendes Iscia
- Lopez Oscar L.
- Loughland Carmel M.
- Luciano Michelle
- Luykx Jurjen J.
- Macciardi Fabio
- Marquand Andre F.
- Martin Nicholas G.
- Martinot Jean-Luc
- Martinot Marie-Laure Paillere
- Mathalon Daniel H.
- Mather Karen A.
- Mathias Samuel R.
- Mattay Venkata S.
- Matthews Sarah
- Mazoyer Bernard
- McDonald Colm
- McEwen Sarah C.
- McMahon Katie L.
- McMahon Mary Agnes B.
- Medland Sarah E.
- Melle Ingrid
- Melzer Tracy R.
- Meyer-Lindenberg Andreas
- Michie Patricia T.
- Milaneschi Yuri
- Mirza-Schreiber Nazanin
- Moreira Jose C. V.
- Morey Rajendra A.
- Morris Derek W.
- Mosley Thomas H.
- Mota Nina R.
- Mowry Bryan
- Mueller Bryon A.
- Mueller-Myhsok Bertram
- Muhleisen Thomas W.
- Najt Pablo
- Nakahara Soichiro
- Nauck Matthias
- Nhat Trung Doan
- Nho Kwangsik
- Noethen Markus M.
- Nordvik Jan E.
- Nyberg Lars
- O'Leary Daniel S.
- Oosterlaan Jaap
- Opel Nils
- Ophoff Roel A.
- Orfanos Dimitri Papadopoulos
- Painter Jodie N.
- Pantelis Christos
- Paus Tomas
- Pausova Zdenka
- Pearson John F.
- Penninx Brenda W. J. H.
- Pike G. Bruce
- Pitcher Toni L.
- Pizzagalli Fabrizio
- Pol Hilleke E. Hulshoff
- Polderman Tinca J. C.
- Posthuma Danielle
- Preda Adrian
- Putz Benno
- Quide Yann
- Quinlan Erin B.
- Ragothaman Anjanibhargavi
- Rashid Faisal M.
- Rasser Paul E.
- Ratnakar Varun
- Reay William R.
- Redlich Ronny
- Reinbold Celine S.
- Reppermund Simone
- Repple Jonathan
- Richard Genevieve
- Riedel Brandalyn C.
- Rietschel Marcella
- Risacher Shannon L.
- Rocha Cristiane S.
- Roffman Joshua L.
- Roshchupkin Gennady V.
- Rowland Laura M.
- Sachdev Perminder S.
- Salminen Lauren
- Samann Philipp G.
- Saremi Arvin
- Satizabal Claudia L.
- Saykin Andrew J.
- Schall Ulrich
- Schlag Fenja
- Schmaal Lianne
- Schmidt Reinhold
- Schofield Peter R.
- Schumann Gunter
- Scott Rodney J.
- Secolin Rodrigo
- Seshadri Sudha
- Shapland Chin Yang
- Shatokhina Natalia
- Shen Li
- Shin Jean
- Shumskaya Elena
- Sim Kang
- Sisodiya Sanjay M.
- Smoller Jordan W.
- Sommer Iris E.
- Sonderby Ida E.
- Sprooten Emma
- St Pourcain Beate
- Steen Vidar M.
- Stein Dan J.
- Stein Jason L.
- Strike Lachlan T.
- Tansey Katherine E.
- Teumer Alexander
- Thalamuthu Anbupalam
- Thomopoulos Sophia I.
- Thompson Paul M.
- Toga Arthur W.
- Tooney Paul A.
- Tordesillas-Gutierrez Diana
- Torres Fabio R.
- Trollor Julian N.
- Turner Jessica A.
- Uhlmann Anne
- Vallerga Costanza L.
- van der Meer Dennis
- Van der Wee Nic J. A.
- van Donkelaar Marjolein M. J.
- van Eijk Liza
- van Erp Theo G. M.
- van Haren Neeltje E. M.
- van Rooij Daan
- Van Son Jaqueline Mayoral
- van Tol Marie-Jose
- van't Ent Dennis
- Veldink Jan H.
- Veltman Dick J.
- Verhoef Ellen
- Volzke Henry
- Voyvodic James T.
- Walter Henrik
- Walton Esther
- Wang Mingyuan
- Wang Yunpeng
- Wardlaw Joanna M.
- Weber Bernd
- Weinberger Daniel R.
- Wen Wei
- Westlye Lars T.
- Whelan Christopher D.
- Whelan Robert
- White Tonya
- Witt Stephanie H.
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wright Margaret J.
- Wu Jing Qin
- Yamamori Hidenaga
- Yang Qiong
- Yasuda Clarissa L.
- Zaremba Dario
- Zhang Zuo
- Zhou Juan
- Zhu Alyssa H.
- Zsembik Leo C. P.
- Zwiers Marcel P.
- Publication venue
- Ludwig-Maximilians-Universität München
- Publication date
- 01/01/2020
- Field of study
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
The genetic architecture of the human cerebral cortex
- Author
- Adams Hieab H H
- Adams Hieab H H
- Agartz Ingrid
- Ahlijanian Michael
- Ahmad Shahzad
- Ainscough Susan
- Aisen Paul
- Albers Colleen S
- Albert Marilyn
- Alhusaini Saud
- Allard Joanne
- Almeida Marcio A A
- Alnæs Dag
- Alvim Marina K M
- Ames David
- Ames David
- Amin Najaf
- Amlien Inge K
- Amouyel Philippe
- Ances Beau
- Anderson Karen
- Anderson Tim J
- Andersson Micael
- Andreassen Ole A
- Andreassen Ole A
- Apostolova Liana
- Ard Tyler
- Arias-Vasquez Alejandro
- Armstrong Nicola J
- Armstrong Nicola J
- Arnedo Vanessa
- Arnold Steven E
- Artiges Eric
- Artiges Eric
- Ashley-Koch Allison
- Assaly Michele
- Assareh Amelia A
- Asthana Sanjay
- Atkins Joshua R
- Aydin Semiha
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- Teng Edmond
- Teodoro Liberty
- Tetrud James
- Teumer Alexander
- Teumer Alexander
- Thai Gaby
- Thal Leon
- Thalamuthu Anbupalam
- Thalamuthu Anbupalam
- Thomas Cathi-Ann
- Thomopoulos Sophia I
- Thompson Paul
- Thompson Paul M
- Tingus Kathleen
- Tinklenberg Jared
- Todd Gretchen
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- Toga Arthur W
- Toga Arthur W
- Tolosa Eduardo
- Tooney Paul A
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- Tremont Geoffrey
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- Trollor Julian N
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- Umek Robert
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- van der Brug Marcel
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- Van der Wee Nic J A
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- van Eijk Liza
- van Erp Theo G M
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- van Noort Betteke
- van Rooij Daan
- van Tol Marie-José
- Vanderswag Helen
- Varma Pradeep
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- Vemuri Prashanthi
- Venkov Heli
- Verhoef Ellen
- Vernooij Meike W
- Villena Teresa
- Villringer Arno
- Voyvodic James T
- Völker Uwe
- Völzke Henry
- Walter Henrik
- Walter Henrik
- Walter Sarah
- Walton Esther
- Wang Mingyuan
- Wang Yunpeng
- Ward Chad
- Wardlaw Joanna M
- Wardlaw Joanna M
- Weber Bernd
- Weinberger Daniel R
- Weiner Michael
- Weiner Michael W
- Weintraub Sandra
- Wen Wei
- Wen Wei
- Westlye Lars T
- Whelan Christopher D
- Whelan Robert
- Whelan Robert
- White Tonya
- Willeke Diana
- Williams Karen
- Williams Steve
- Wilson Renee
- Winkfield David
- Witbracht Megan
- Witt Stephanie H
- Witte A Veronica
- Wittfeld Katharina
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wolk David A
- Womack Kyle
- Wong Terence Z
- Woo Ellen
- Wright Margaret J
- Wright Margaret J
- Wu Chuang-Kuo
- Wu Jing Qin
- Wurster Isabel
- Xia Rui
- Yamamori Hidenaga
- Yanez Beatriz
- Yang Mia
- Yang Qiong
- Yang Qiong
- Yankey Jon
- Yasuda Clarissa L
- Yeh Randy
- Yesavage Jerome
- Zamrini Edward
- Zare Habil
- Zaremba Dario
- Zhang Zuo
- Zhou Juan
- Zhu Alyssa H
- Zimmerman Earl A
- Ziolkowski Jaimie
- Zsembik Leo C P
- Zwiers Marcel P
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
Exploration of Shared Genetic Architecture Between Subcortical Brain Volumes and Anorexia Nervosa
- Author
- Abramovic Lucija
- Adams Hieab HH
- Adan Roger
- Agartz Ingrid
- Alfredsson Lars
- Alhusaini Saud
- Almasy Laura
- Ames David
- Andersson Micael
- Ando Tetsuya
- Andreassen Ole
- Andreassen Ole A
- Anttila Verneri
- Arepalli Sampath
- Arias-Vasquez Alejandro
- Aribisala Benjamin S
- Armstrong Nicola J
- Aschauer Harald
- Ashbrook David G
- Assareh Amelia A
- Athanasiu Lavinia
- Baker Jessica
- Barrett Jeffrey
- Bastin Mark E
- Batury V-L
- Becker James T
- Bencko Vladimir
- Bergen Andrew
- Bernard Manon
- Berrettini Wade
- Birgegard Andreas
- Bis Joshua C
- Blangero John
- Bohlken Marc M
- Boks Marco P
- Boni Claudette
- Boomsma Dorret I
- Bralten Janita
- Brandt Harry
- Breen Gerome
- Brodaty Henry
- Brouwer Rachel M
- Brown Andrew A
- Brunner Han G
- Buckner Randy L
- Buitelaar Jan K
- Bulayeva Kazima B
- Bulik CM
- Bulik Cynthia M
- Bulik-Sullivan Brendan
- Burghardt Roland
- Cahn Wiepke
- Calhoun Vince D
- Cannon Dara M
- Carlberg Laura
- Carless Melanie A
- Cassina Matteo
- Cavalleri Gianpiero L
- Chakravarty M Mallar
- Chauhan Ganesh
- Chen Qiang
- Cheung J
- Ching Christopher RK
- Cichon Carolyn Cesta Sven
- Cichon Sven
- Clementi Maurizio
- Cohen-Woods Sarah
- Coleman Joni
- Cone Roger
- Cookson Mark R
- Corvin Aiden
- Courtet Philippe
- Crawford Steven
- Crespo-Facorro Benedicto
- Crow Scott
- Crowley Jim
- Cuellar-Partida Gabriel
- Curran Joanne E
- Czisch Michael
- Dale Anders M
- Danner Unna
- Davies Gareth E
- Davis Oliver
- de Geus Eco JC
- de Zubicaray Greig I
- de Zwaan Martina
- Deary Ian J
- Dedoussis George
- Degortes Daniela
- Delanty Norman
- Den Braber Anouk
- Depondt Chantal
- DeSocio Janiece
- Desrivieres Sylvane
- Dick Danielle
- Dikeos Dimitris
- Dillman Allissa
- Dina Christian
- Ding Bo
- Djurovic Srdjan
- Dmitrzak-Weglarz Monika
- Docampo Elisa
- Donohoe Gary
- Drevets Wayne C
- Duggirala Ravi
- Duncan Laramie
- Dyer Thomas D
- Ebling Maritza
- Egberts Karin
- Ehrlich Stefan
- Ehrlich Stefan
- Ehrlich Stefan
- Erk Susanne
- Escaramis Georgia
- Esko Tonu
- Espeseth Thomas
- Espeseth Thomas
- Estivill Xavier
- Favaro Angela
- Fedko Iryna O
- Fernandez Guillen
- Fernandez-Aranda Fernando
- Ferrucci Luigi
- Fichter Manfred
- Finan Chris
- Fischer Krista
- Fischl Bruce
- Fisher Simon E
- Floyd James
- Focker Manuel
- Foretova Lenka
- Foroud Tatiana M
- Forzan Monica
- Fox Caroline
- Fox Peter T
- Francks Clyde
- Franke Barbara
- Franklin Christopher
- Fukunaga Masaki
- Gallinger Valerie Gaborieau Steven
- Gambaro Giovanni
- Gaspar Helena
- Gibbs J Raphael
- Giddaluru Sudheer
- Giegling Ina
- Glahn David C
- Goldman Aaron L
- Goldstein Jackie
- Gollub Randy L
- Gonidakis Fragiskos
- Goring Harald HH
- Gorwood Philip
- Grabe Hans J
- Gratacos Monica
- Green Robert C
- Greve Douglas
- Grimm Oliver
- Grp ENIGMA Genetics Working
- Gruber Oliver
- Guadalupe Tulio
- Gudnason Vilmundur
- Guelfi Sebastian
- Guillaume Sebastien
- Guo Yiran
- Hager Reinmar
- Hakobjan Marina MH
- Hakonarson Hakon
- Halmi Katherine
- Hansell Narelle K
- Hardy John
- Harrison Rebecca
- Hartberg Cecilie B
- Hartman Catharina A
- Hashimoto Ryota
- Hass Johanna
- Hatzikotoulas Konstantinos
- Haukvik Unn K
- Hauser Joanna
- Hebebrand Johannes
- Hegenscheid Katrin
- Heinz Andreas
- Heister Angelien JGAM
- Helder Sietske
- Hendriks Judith
- Herms Stefan
- Hernandez Dena G
- Hernandez Maria C Valdes
- Herpertz-Dahlmann Beate
- Herzog Wolfgang
- Heslenfeld Dirk J
- Hibar D
- Hibar Derrek P
- Hilliard Christopher
- Hinney Anke
- Ho Beng-Choon
- Hoekstra Pieter J
- Hoffmann Wolfgang
- Hohn David
- Holmes Avram J
- Holsboer Florian
- Homuth Georg
- Hoogman Martine
- Hosten Norbert
- Hottenga Jouke-Jan
- Huckins Laura
- Hudson James
- Huemer Julia
- Ikeda Masashi
- Ikram M Arfan
- Imgart Hartmut
- Inoko Hidetoshi
- Jahanshad N
- Jahanshad Neda
- Jamain Sigrid Jall Stephane
- Janout Vladimir
- Janowitz Deborah
- Jenkinson Mark
- Jia Tianye
- Jimenez-Murcia Susana
- Johnson Craig
- Johnson Robert
- Jonsson Erik G
- Jordan Jenny
- Jr Jack Clifford R
- Jr Kent Jack W
- Julia Antonio
- Jureus Anders
- Kahn Rene S
- Kalsi Gursharan
- Kaminska Debora
- Kanai Ryota
- Kaplan Allan
- Kaprio Jaakko
- Karhunen Leila
- Karwautz Andreas
- Kas Martien
- Kasperaviciute Dalia
- Kaye Walter
- Keil Maria
- Kennedy James
- Kennedy Martin
- Keski-Rahkonen Anna
- Kiezebrink Kirsty
- Kim Sungeun
- Kim Youl-Ri
- Klareskog Lars
- Klein Marieke
- Kloszewska Iwona
- Klump Kelly
- Knudsen Gun Peggy
- Kochunov Peter
- Koeleman Bobby
- Koubek Doris
- Kraemer Bernd
- Kwok John B
- La Via Maria
- Landen Mikael
- Launer Lenore J
- Lawrie Stephen M
- Le Hellard Stephanie
- Le Hellard Stephanie
- Leboyer Marion
- Lee Phil H
- Levitan Robert
- Li Dong
- Lichtenstein Paul
- Liewald David CM
- Lilenfeld Lisa
- Lissowska Jolanta
- Liu Xinmin
- Longo Dan L
- Longstreth WT
- Loohuis Loes M Olde
- Lopez Lorna M
- Lovestone Simon
- Lu Lu
- Luciano Michelle
- Lundervold Astri
- Luting Xue
- Macare Christine
- Magistretti Pierre
- Maj Mario
- Makkinje Remco RR
- Mannik Katrin
- Marsal Sara
- Martin Nicholas
- Martin Nicholas G
- Matarin Mar
- Mather Karen A
- Mattay Venkata S
- Mattheisen Manuel
- Mattingsdal Morten
- Mazoyer Bernard
- McDevitt Sara
- McDonald Colm
- McGuffin Peter
- McIntosh Andrew M
- Mckay David R
- McMahon Francis J
- McMahon Katie L
- Mecocci Patrizia
- Medland Sarah E
- Meisenzahl Eva
- Melle Ingrid
- Merl Elisabeth
- Metspalu Andres
- Meulenbelt Ingrid
- Meyer-Lindenberg Andreas
- Micali Nadia
- Milaneschi Yuri
- Mitchell James
- Mitchell Karen
- Mohnke Sebastian
- Monteleone Alessio Maria
- Monteleone Palmiero
- Montgomery Grant
- Montgomery Grant W
- Morris Derek W
- Mortensen Preben
- Mostert Jeanette C
- Mueller Timo
- Mueller-Myhsok Bertram
- Muhleisen Thomas W
- Munn-Chernoff Melissa
- Naber Marlies AM
- Nacmias Benedetta
- Nalls Michael A
- Nauck Matthias
- Navratilova Marie
- Needham Margaret
- Nho Kwangsik
- Nichols Thomas E
- Nilsson Ida
- Nilsson Lars G
- Norring Claes
- Nothen Markus M
- Ntalla Ioanna
- Nugent Allison C
- Nyberg Lars
- Nyquist Paul
- O'Toole Julie
- Ohi Kazutaka
- Olvera Rene L
- Ophoff Roel
- Ophoff Roel A
- Palotie Aarno
- Pandolfo Massimo
- Pantel Jacques
- Papezova Hana
- Papmeyer Martina
- Paus Tomas
- Pausova Zdenka
- Penninx Brenda WJH
- Perez-Iglesias Rocio
- Perica Vesna Boraska
- PGC-ED
- Pike G Bruce
- Pinto Richard Parker Dalila
- Pol Hilleke E Hulshoff
- Potkin Steven G
- Putz Benno
- Rabionet Raquel
- Raevuori Anu
- Rajewski Andrzej
- Ramasamy Adaikalavan
- Ramoz Nicolas
- Rayner N William
- Reichborn-Kjennerud Ted
- Reinvang Ivar
- Renteria Miguel E
- Reppermund Simone
- Ricca Valdo
- Rietschel Marcella
- Ripatti Samuli
- Ripke Stephan
- Risacher Shannon L
- Ritschel Franziska
- Roberts Marion
- Roffman Joshua L
- Roiz-Santianez Roberto
- Romanczuk-Seiferth Nina
- Rose Emma J
- Rosen Glenn D
- Rotondo Alessandro
- Rujescu Dan
- Rujescu Dan
- Rybakowski Filip
- Ryten Mina
- Sachdev Perminder S
- Salami Alireza
- Samann Philipp G
- Santonastaso Paolo
- Satizabal Claudia L
- Saykin Andrew J
- Scherag Andre
- Scherer Stephen
- Schmaal Lianne
- Schmidt Helena
- Schmidt Reinhold
- Schmidt Ulrike
- Schnell Knut
- Schofield Peter R
- Schork Andrew J
- Schork Nicholas
- Schosser Alexandra
- Schumann Gunter
- Scott Laura
- Seiler Stephan
- Seitz J
- Seitz Jochen
- Seshadri Sudha
- Shen Li
- Shin Jean
- Simmons Andrew
- Singleton Andrew
- Sisodiya Sanjay M
- Slachtova Lenka
- Sladek Robert
- Slagboom P Eline
- Slof-Op't Landt Margarita
- Slopien Agnieszka
- Smith Colin
- Smith Tosha
- Smoller Jordan W
- Soininen Hilkka
- Soranzo Nicole
- Sorbi Sandro
- Southam Lorraine
- Sprooten Emma
- Steen Vidar
- Steen Vidar M
- Stein Jason L
- Strengman Eric
- Strike Lachlan T
- Strober Michael
- Sussmann Jessika E
- Szatkiewicz Jin
- Szeszenia-Dabrowska Neonila
- Tachmazidou Ioanna
- Tenconi Elena
- Teumer Alexander
- Thalamuthu Anbupalam
- Thompson Paul M
- Thompson PM
- Thornton Laura
- Toga Arthur W
- Toro Roberto
- Tortorella Alfonso
- Tozzi Federica
- Trabzuni Daniah
- Traynor Bryan J
- Treasure Janet
- Troncoso Juan
- Tschop Matthias
- Tsitsika Artemis
- Turner Jessica A
- Tziouvas Konstantinos
- van Bokhoven Hans
- van der Brug Marcel
- van der Lee Sven J
- van der Marel Saskia SL
- van der Wee Nic JA
- van Donkelaar Marjolein MJ
- van Duijn Cornelia M
- van Eijk Kristel R
- van Elburg Annemarie
- van Furth Eric
- van Haren Neeltje EM
- van Hulzen Kimm JE
- van Tol Marie-Jose
- van't Ent Dennis
- Veltman Dick J
- Vinke Louis N
- Volzke Henry
- Wade Tracey
- Wagner Gudrun
- Walter Henrik
- Walters Raymond
- Walters Raymond K
- Walton E
- Walton Esther
- Walton Esther
- Wardlaw Joanna M
- Wassink Thomas H
- Watson Hunna
- Weale Michael E
- Weinberger Daniel R
- Weiner Michael W
- Wen Wei
- Westlye Lars T
- Westman Eric
- Whelan Christopher D
- White Tonya
- Wichmann H-Erich
- Widen Elisabeth
- Williams Robert W
- Winkler Anderson M
- Wittfeld Katharina
- Woldehawariat Girma
- Wolf Christiane
- Woodside D Blake
- Wright Margaret J
- Yanek Lisa R
- Yanovski Jack
- Yao Shuyang
- Yilmaz Z
- Yilmaz Zeynep
- Zerwas Stephanie
- Zielke Ronald H
- Zipfel Stephan
- Zonderman Alan B
- Zwiers Marcel P
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/07/2019
- Field of study
Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
- Author
- Aarsland Dag
- Aarsland Dag
- Abdelnour Carla
- Abraham Richard
- Abraham Richard
- Adarmes-Gómez A.D.
- Adarmes-Gómez Ad
- Aguilera N.
- Aguilera Nuria
- Ahmad Shahzad
- Al-Chalabi Ammar
- Al-Chalabi Ammar
- Alarcon E.
- Alarcón-Martín E.
- Alarcón-Martín Emilio
- Alcolea Daniel
- Alegret M.
- Alegret Montserrat
- Alonso M.D.
- Alvarez Ignacio
- Alvarez Victoria
- Ambati Aditya
- Amer-Ferrer G.
- Amin Najaf
- Amouyel Philippe
- Amouyel Philippe
- Amouyel Phillippe
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Andreoni Simona
- Annuar Azlina Ahmad
- Antequera M.
- Anthoula Tsolaki
- Antikainen Riitta
- Antonell Anna
- Antúnez C.
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Arfan Ikram M.
- Arias Pastor Alfonso
- Ariel Prestia Federico
- Armstrong Nicola J.
- Arosio Beatrice
- Arosio Beatrice
- Assogna Francesca
- Athanasiu Lavinia
- Athanasiu Lavinia
- Au Wing-Lok
- Bahrami Shahram
- Bailly Henri
- Banaj Nerisa
- Baquero M.
- Baquero Miquel
- Bass Nicholas J.
- Bass Nick
- Bastiani Patrizia
- Bayer Anthony
- Becker Tim
- Belezhanska Diyana
- Bellenguez Céline
- Bellenguez Céline
- Bellenguez Céline
- Belloy Michael E.
- Belén Pastor Ana
- Ben-Shlomo Yoav
- Benussi Alberto
- Benussi Luisa
- Benussi Luisa
- Bergh Sverre
- Bernal M.
- Bernardo-Harrington Mateus
- Berr Claudine
- Berr Claudine
- Besse Céline
- Bessi Valentina
- Binetti Giuliano
- Bizarro Alessandra
- Bjerke Maria
- Blennow Kaj
- Blesa R.
- Blesa Rafael
- Boada M.
- Boada M.
- Boada Mercè
- Boada Mercè
- Boecker Henning
- Boland Anne
- Boland Anne
- Borroni Barbara
- Borroni Barbara
- Boschi Silvia
- Bosnes Ingunn
- Bossù Paola
- Brayne Carol
- Brayne Carol
- Bresner Catherine
- Brice Alexis
- Brodaty Henry
- Brookes Keeley J.
- Brown Kristelle
- Brown Kristelle S.
- Bråthen Geir
- Bråthen Geir
- Buendia M.
- Buendia Mar
- Buiza-Rueda D.
- Buiza-Rueda Dolores
- Bullido M.J.
- Bullido María J.
- Bullido María J.
- Burguera J.A.
- Burholt Vanessa
- BÛrger Katharina
- Caffarra Paolo
- Calero M.
- Calero Miguel
- campion Dominique
- Campos-Martin Rafael
- Cano A.
- Carracedo A.
- Carracedo Ángel
- Carrillo F.
- Carrillo F.
- Carrion-Claro M.
- Carrión-Claro M.
- Casajeros M.J.
- Castaño Eduardo M.
- Castillo Morales Atahualpa
- Cañabate P.
- Cañabate Pilar
- Cecchetti Roberta
- Cervera-Carles Laura
- Chan Anne Y.Y.
- Chao Yinxia
- Chapuis Julien
- Charbonnier Camille
- Chen Ling
- Chen Yongping
- Chene Geneviève
- Chew Elaine Guo Yan
- Chillotti Caterina
- Chipi Elena
- Chung Sun Ju
- Ciccone Simona
- Ciullo Valentina
- Claassen Jurgen A.H.R.
- Clarimon Jordi
- Clarimon Jordi
- Clarimon Jordi
- Clarimón J.
- Clark Christopher
- Clarke Robert
- Collinge John
- Collinge John
- Conti Elisa
- Corbatón-Anchuelo A.
- Cores Valeria
- Corma-Gómez Anaïs
- Costa Marcos R
- Costantini Emanuele
- Craig David
- Craig David
- Cruz-Gamero J.M.
- Cuesta Carolina
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Damotte Vincent
- Damotte Vincent
- Daniele Antonio
- Daniele Antonio
- Dardiotis Efthimios
- Darling Daniel
- Dartigues Jean-Francois
- Dartigues Jean-François
- David Smith A.
- David Smith A.
- Davies Chloe
- de Deyn Peter Paul
- de Mendonça Alexandre
- de Mendonça Alexandre
- de Munain Adolfo Lopez
- de Pancorbo M.M.
- De Roeck Ellen
- de Rojas I.
- de Rojas I.
- de Rojas Itziar
- de Rojas Itziar
- Debette Stéphanie
- Debette Stéphanie
- Deckert Jürgen
- del Ser T.
- del Ser Teodoro
- Del Zompo Maria
- Deleuze Jean-François
- Deleuze Jean-François
- Deloukas Panagiotis
- Deloukas Pangiotis
- den Bussche Hendrik
- Denning Nicola
- Denning Nicola
- Deramecourt Vincent
- Dermecourt Vincent
- Dichgans Martin
- Dichgans Martin
- Dichgans Martin
- Diego S.
- Diego Susana
- Diehl-Schmid Janine
- Diez-Fairen M.
- Diez-Fairen Mónica
- Dionigi Rossi Paolo
- Djurovic Srdjan
- Djurovic Srdjan
- Dolores Alonso María
- Dowzell Kimberley
- Drichel Dmitriy
- Dubois Bruno
- Dufouil Carole
- Dufouil Carole
- Dufouil Carole
- During Emmanuel
- Duron Emmanuelle
- Düzel Emrah
- Düzel Emrah
- Engelborghs Sebastiaan
- Epelbaum Jacques
- Escott-Price Valentina
- Escott-Price Valentina
- Escuela R.
- Escuela R.
- Espinosa A.
- Espinosa Ana
- Etchepareborda Ignacio
- Eugenia Sáez María
- Ewers Michael
- Fabrizio Tagliavini
- Fallgaard Nielsen Sune
- Farotti Lucia
- Fenoglio Chiara
- Fernández-Fuertes Marta
- Ferrarese Carlo
- Ferreira Catarina B
- Ferri Evelyn
- Feulner Thomas
- Fievet Nathalie
- Fievet Nathalie
- Fin Bertrand
- Fischer Peter
- Fisher Elizabeth
- Fladby Tormod
- Fladby Tormod
- Fließbach Klaus
- Foo Jia Nee
- Foo Jia Nee
- Forsell Charlotte
- Fortea J.
- Fortea Juan
- Fostinelli Silvia
- Fox Nick
- Fox Nick C.
- Fox Nick C.
- Franco E.
- Franco-Macías Emlio
- Frank-García A.
- Frank-García Ana
- Frikke-Schmidt Ruth
- Frikke-Schmidt Ruth
- Froelich Lutz
- Frölich Lutz
- Gailhajenet A.
- Gailhajenet Anna
- Galeano Pablo
- Galimberti Daniela
- Galimberti Daniela
- Gan-Or Ziv
- Garcia Madrona S.
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas G.
- Garcia-Ribas Guillermo
- Garcia-Ribas Guillermo
- García-Alberca J.M.
- García-Alberca José María
- García-González P.
- García-González Pablo
- García-González Pablo
- Garrote-Espina L.
- Garrote-Espina L.
- Germani Sandra
- Gerrish Amy
- Gerrish Amy
- Ghanbari Mohsen
- Ghidoni Roberta
- Giedraitis Vilmantas
- Giedraitis Vilmantas
- Giegling Ina
- Giegling Ina
- Gill Michael
- Gill Michael
- Gill Michael
- Gim Jungsoo
- Giorgio Giaccone
- Goldhardt Oliver
- Goldhardt Oliver
- González-Péerez A.
- González-Pérez Antonio
- Graff Caroline
- Graff Caroline
- Grande Giulia
- Green Emma
- Greicius Michael D.
- Grenier-Boley Benjamin
- Grenier-Boley Benjamin
- Grenier-Boley Benjamin
- Grimmer Timo
- Grünblatt Edna
- Grünblatt Edna
- Gu Wei
- Guerreiro Rita
- Guetta-Baranes Tamar
- Guitart M.
- Guitart Marina
- Gurling Hugh
- Gwilliam Rhian
- Gwilliam Rhian
- Gómez-Garre P.
- Gómez-Garre P.
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Hampel Harald
- Hampel Harald
- Hannequin Didier
- Hanon Olivier
- Hanon Olivier
- Hanon Olivier
- Hardy John
- Hardy John
- Hardy John
- Harold Denise
- Harold Denise
- Hartmann Annette M.
- Hartmann Annette M.
- Harwood Janet
- Hausner Lucrezia
- Hausner Lucrezia
- He Zihuai
- Heilmann-Heimbach Stefanie
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T.
- Hernández Isabel
- Herold Christine
- Herrmann Martin J.
- Heun Reinhard
- Heuser Isabella
- Hevilla S.
- Hiltunen Mikko
- Hiltunen Mikko
- Hodges Angela
- Hoffmann Per
- Hoffmann Per
- Hollingworth Paul
- Hollingworth Paul
- Holmans Peter
- Holmans Peter A.
- Holmes Clive
- Holmes Clive
- Holstege Henne
- Holstege Henne
- Hooper Nigel M.
- Hort Jakub
- Hort Jakub
- Huerto Vilas Raquel
- Hulsman Marc
- Hüll Michael
- Ibarria M.
- Ibarria Marta
- Ignacio Bacha Juan
- Ignacio Brusco Luis
- Ikeuchi Takeshi
- Ingelsson Martin
- Ingelsson Martin
- Ingino Carlos
- Jan Biessels Geert
- Janowitz Daniel
- Jansen Iris
- Jansen Iris
- Jeon Beom S.
- Jessen Frank
- Jessen Frank
- Jessen Frank
- Jesús S.
- Jesús S.
- Jiang Lulu
- Johansson Charlotte
- Johnston Janet A.
- Johnston Jarret A.
- Jones Lesley
- Jones Lesley
- Jung Yoo Jin
- Jöckel Karl-Heinz
- Jürgen Deckert
- Kauwe John
- Kehoe Patrick
- Kehoe Patrick G.
- Kehoe Patrick G.
- Kern Silke
- Khor Chiea Chuen
- Kilander Lena
- Kinhult Ståhlbom Anne
- Kivipelto Miia
- Kleineidam Luca
- Klopp Norman
- Kochen Silvia
- Koh Woon-Puay
- Kohler Eduardo
- Kohler Matias
- Koivisto Anne
- Kornhuber Johannes
- Kornhuber Johannes
- Kosmidis Mary H.
- Kuulasmaa Teemu
- Kuulasmaa Teemu
- Kölsch Heike
- Küçükali Fahri
- Küçükali Fahri
- Laatikainen Tiina
- Labrador Espinosa M.A.
- Labrador Ma
- Lacidogna Giordano
- Lacour ndré
- Laczo Jan
- Lafuente A.
- Lafuente Asunción
- Lage C.
- Lage Carmen
- Lage Carmen
- Lambert Jean-Charles
- Lambert Jean-Charles
- Lambert Jean-Charles
- Laske Christoph
- Laukka Erika J
- Lauria Alessandra
- Lawlor Brian
- Lawlor Brian
- Le Guen Yann
- Lee Kun Ho
- Legaz A.
- Lehtisalo Jenni
- Lerch Ondrej
- Lian Michelle M.
- Lian Michelle Mulan
- Lim Jia Lun
- Lim Shen-Yang
- Lin Juei-Jueng
- Lin Ling
- Lindström Jaana
- Lis Palacio Dana
- Lisso Julieta
- Liu Chunfeng
- Liu Jianjun
- Livingston Gill
- Livingston Gill
- Lleó Alberto
- Lleóo A.
- Lord Jenny
- Love Seth
- Love Seth
- Lovestone Simon
- Lovestone Simon
- Luckcuck Lauren
- Luckcuck Lauren
- Luis Royo Jose
- Luo Guo
- Lupton Michelle
- Lupton Michelle
- Luís Royo Jose
- Lynch Aoibhinn
- Lynch Aoibhinn
- Lóopez de Munáin A.
- López-García S.
- López-García Sara
- Löwemark Malin
- Macias J.
- Macias-García D.
- Macias-García D.
- MacLeod Catherine A.
- Macías Juan
- Magda Tsolaki
- Maier Wolfgang
- Maier Wolfgang
- Malik Rainer
- Mangialasche Francesca
- Mangone Carlos
- Mann David
- Mann David
- Manzanares S.
- Mao Chengjie
- Marco Spallazzi
- Maria García-Alberca Jose
- Maroñas O.
- Marquié M.
- Marquié M.
- Marquié Marta
- Marshall Rachel
- Marshall Rachel
- Martín Montes A.
- Martín Montes Angel
- Martín E.
- Martín Elvira
- Martínez Rodríguez Carmen
- Martínez B.
- Martínez C.
- Martínez M.T.
- Martínez V.
- Martínez-Lage Álvarez A.
- Marín M.
- Marín M.
- Marín T.
- Marín-Muñoz J.
- Masullo Carlo
- Masullo Carlo
- Mata Ignacio
- Mather Karen
- Matoska Vaclav
- Mauleón Ana
- Mayhaus Manuel
- Mayo Kevin
- McGuinness Bernadette
- McGuinness Bernadette
- McQuillin Andrew
- McQuillin Andrew
- Mead Simon
- Mead Simon
- Meah Wee-Yang
- Mecocci Patrizia
- Mecocci Patrizia
- Medel Nancy
- Medina M.
- Medina Miguel
- Meggy Alun
- Meggy Alun
- Mehrabian Shima
- Mehrabian Shima
- Mendioroz Iriarte M.
- Mendoza Silvia
- Menéndez-González M.
- Menéndez-González Manuel
- Mignot Emmanuel
- Mir P.
- Mir Pablo
- Mir Pablo
- Miyashita Akinori
- Moebus Susanne
- Moebus Susanne
- Moebus Susanne
- Mok Shi Qi
- Mok Vincent
- Mol Merel
- Molina-Porcel Laura
- Montrreal L.
- Montrreal L.
- Montrreal Laura
- Morelli Laura
- Moreno Fermin
- Moreno Fermin
- Moreno M.
- Moreno Mariona
- Moreno-Grau S.
- Moreno-Grau Sonia
- Morgan Kevin
- Morgan Kevin
- Morizono Takashi
- Morris John
- Muchnik Carolina
- Mummery Catherine
- Möthen Markus M
- Nacmias Benedetta
- Nacmias Benedetta
- Naito Tatsuhiko
- Nash William
- Natunen Teemu
- Ng Ebonne Y.
- Ngandu Tiia
- Nicolas Aude
- Nicolas Gael
- Nicolas Gael
- Niida Shumpei
- Nordestgaard Børge G.
- Nordestgaard Børge G.
- Novack Gisela
- Nuñez-Llaves R.
- Nöthen Markus M.
- O'Donovan Michael
- O'Donovan Michael C.
- Okada Yukinori
- Olaso Robert
- Olivar Natividad
- Olivé C.
- Orellana A.
- Orellana A.
- Orellana Adelina
- Orsini Michela
- Ortega G.
- Ortega Gemma
- Ortiz Cecilia
- Owen Michael
- Owen Michael J.
- Ozaki Kouichi
- Pablo Tartan Juan
- Padovani Alessandro
- Pancho A.
- Pancho Ana
- Paola Zoia Chiara
- Paolo Caffarra
- Papenberg Goran
- Papenberg Goran
- Papma Janne
- Park Hyeonseul
- Parnetti Lucilla
- Parnetti Lucilla
- Parveen Kayenat
- Parveen Kayenat
- Pasquier Florence
- Pasquier Florence
- Pasquier Florence
- Passmore Peter
- Passmore Peter
- Pastor P.
- Pastor Pau
- Pastor Pau
- Patel Yogen
- Pei Zhong
- Peixoto Leal Thiago
- Pelejà E.
- Pelejà Esther
- Peltonen Markku
- Peng Rong
- Pericard Pierre
- Periñán Mt
- Periñán-Tocino T.
- Perneczky Robert
- Peters Oliver
- Peters Oliver
- Pickering-Brown Stuart
- Pijnenburg Yolande A. L.
- Pijnenburg Yolande A.L.
- Pinchler Sabrina
- Pineda J.A.
- Pineda Juan A.
- Pineda-Sánchez R.
- Pineda-Sánchez R.
- Piras Fabrizio
- Piras Federica
- Pisanu Claudia
- Piñol Ripoll G.
- Piñol-Ripoll Gerard
- Piñol-Ripoll Gerard
- Polak Thomas
- Politis Daniel G.
- Popp Julius
- Popp Julius
- Porcel Laura Molina
- Posthuma Danielle
- Powell John
- Powell John F.
- Prakash Kumar-M.
- Preckler S.
- Preckler Silvia
- Priller Josef
- Proitsi Petra
- Proitsi Petra
- Prokic Ivana
- Puerta R.
- Puerta Raquel
- Puerta Raquel
- Péerez Tur J.
- Pérez-Cordon A.
- Pérez-Cordón Alba
- Pérez-Tur Jordi
- Pérez-Tur Jordi
- Quenez Olivier
- Quintela I.
- Quintela Inés
- Qvist Thomassen Jesper
- Rainero Innocenzo
- Rainero Innocenzo
- Ramakers Inez
- Ramakers Inez
- Ramirez Alfredo
- Ramirez Alfredo
- Ramirez Alfredo
- Real de Asúa D.
- Real L.M.
- Real Luis M.
- Real Luis M.
- Reinders Marcel J.T.
- Reyes Toso Carlos
- Riedel-Heller Steffi
- Riedel-Heller Steffi
- Riedel-Heller Steffi
- Riederer Peter
- Riemenschneider Matthias
- Rios Mario
- Ritchie Karen
- Roberto Natalia
- Rodrigo S.
- Rodrigo-Herrero Silvia
- Rodriguez-Rodriguez Eloy
- Rodriguez-Rodriguez Eloy
- Rodríguez-Rodríguez E.
- Rojo Matias
- Rong Zhang Bao
- Rongve Arvid
- Rongve Arvid
- Rosas Allende Irene
- Rosende-Roca M.
- Rosende-Roca Maitée
- Ross Owen A.
- Rossi Giacomina
- Rossi Giacomina
- Rossor Martin
- Rossor Martin
- Roveta Fausto
- Royo J.L.
- Rubino Elisa
- Rubinsztein David C.
- Rubinsztein David C.
- Ruiz A.
- Ruiz A.
- Ruiz Agustín
- Ruiz Agustín
- Rujescu Dan
- Rujescu Dan
- Rujescu Dan
- Ryan Natalie S.
- Ryan Nathalie
- Ráabano A.
- Rábano Alberto
- Sachdev Perminder
- Saenz Aldo
- Sakka Paraskevi
- Sala Gessica
- Saltvedt Ingvild
- Saltvedt Ingvild
- Salvadori Nicola
- Sanabria A.
- Sanabria Ángela
- Sanchez Abalos Mariana
- Sanchez del Valle Díaz R.
- Sanchez-Garcia Florentino
- Sando Sigrid B.
- Sando Sigrid B.
- Sastre Merlín Isabel
- Sastre I.
- Satake Wataru
- Scamosci Michela
- Scarmeas Nikolaos
- Scarmeas Nikolaos
- Scarpini Elio
- Scheltens Philip
- Scheltens Philip
- Scherbaum Norbert
- Scherbaum Norbert
- Scherer Martin
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Schneider Anja
- Schott Jonathan M.
- Schott Jonathan M.
- Schürmann Britta
- Selbæk Geir
- Selbæk Geir
- Selnes Per
- Sempere Vicente
- Seripa Davide
- Seripa Davide
- Serpente Maria
- Serrano-Rios M.
- Sevillano Zulma
- Shadrin Alexey A.
- Shadrin Alexey A.
- Shang Hui-Fang
- Shaw Christopher E.
- Shaw Christopher E.
- Shi Chang-He
- Shofany Jacob
- Sims Rebecca
- Sims Rebecca
- Sims Rebecca
- Singleton Andrew B.
- Skoog Ingmar
- Skrobot Olivia
- Sleegers Kristel
- Sleegers Kristel
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solfrizzi Vincenzo
- Solis Patricia
- Solomon Alina
- Song Kyuyoung
- Sorbi Sandro
- Sotolongo-Grau O.
- Sotolongo-Grau O.
- Sotolongo-Grau Oscar
- Spalletta Gianfranco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Squassina Alessio
- Stordal Eystein
- Stordal Eystein
- Strandberg Timo
- Sussams Rebecca
- Sáez M.E.
- Sánchez Juan Pascual
- Sánchez-Arjona María Bernal
- Sánchez-Juan P.
- Sánchez-Juan Pascual
- Sánchez-Valle Raquel
- Sánchez-Valle Raquel
- Takalo Mari
- Talyansky Seth D.
- Tan Ai Huey
- Tan Eng-King
- Tan Eng-King
- Tan Louis C.S.
- Tandiono Moses
- Tegos Thomas
- Teipel Stefan
- Teresa Martínez-Larrad María
- Tesí Niccolo
- Teunissen Charlotte
- Thalamuthu Anbupalam
- Thomas Charlene
- Thomas Tegos
- Thomassen Jesper Qvist
- Thonberg Håkan
- Toda Tatsushi
- Todd Stephen
- Todd Stephen
- Traykov Latchezar
- Tremolizzo Lucio
- Tremolizzo Lucio
- Tsolaki Magda
- Tsolaki Magda
- Tuomilehto Jaakko
- Turton James
- Tybjærg-Hansen Anne
- Tzourio Christophe
- Táarraga L.
- Tárraga Lluís
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Ulstein Ingun
- Uphill James
- Vacca Alessandro
- Valero S.
- Valero S.
- Valero Sergi
- Van Broeckhoven Christine
- van der Flier Wiesje
- van der Flier Wiesje M.
- van der Lee Sven J.
- van der Lugt Aad
- Van Dongen Jasper
- van Duijn Cornelia M.
- Van Duin Cornelia
- van Rooij Jeroen
- van Swieten John
- van Swieten John
- Vandenberghe Rik
- Vardy Emma
- Vargas L.
- Vargas Liliana
- Verhey Frans
- Verhey Frans
- Vicente M.P.
- Vidal Jean-Sébastien
- Vigo-Ortega R.
- Vigo-Ortega R.
- Vivancos L.
- Vogelgsang Jonathan
- Vyhnalek Martin
- Vyhnalek Martin
- Waern Margda
- Wagner Michael
- Wallon David
- Wallon David
- Warden Donald
- Warner Nick
- Warren Jason D.
- Weber Heike
- Weinhold Leonie
- Wichmann H-Erich
- Wilcock Gordon
- Williams Amy
- Williams Julie
- Williams Julie
- Williams Julie
- Wiltfang Jens
- Wiltfang Jens
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Wu Yih-Ru
- Xu Renshi
- Xu Yu-ming
- Yan Yaping
- Yang Jing
- Yannakoulia Mary
- Yaqub Amber
- Yogeshwar Selina Maria
- Yonkova Mihova Kalina
- Yu Eric
- Zetterberg Henrik
- Zettergren Anna
- Zhang Jing
- Zulaica Miren
- Álvarez I.
- Álvarez V.
- Álvarez Victoria
- Publication venue
- National Academy of Sciences
- Publication date
- 29/08/2023
- Field of study
Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues
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