Pengaruh Struktur Modal, Profitabilitas, dan Ukuran Perusahaan terhadap Nilai Perusahaan LQ-45 Yang Terdaftar Di Bursa Efek Indonesia Periode 2014-2018

This study aims to analyze the influence of capital structure, profitability, and firm size on firm value of LQ-45. The population in this research is all companies LQ�45 which are listed in Indonesia stock Exchange period 2014-2018. The Data used is secondary data in the form of financial statements of the company obtained from the annual financial reports that have been published through the official website of the Indonesia stock Exchange. The sampling technique is done by purposive sampling method obtained 24 of the company as a sample, the amount of data used during the study a total of 110 with the period of the study for 5 years. Methods of data analysis using the analysis of multiple linear. Based on the results if the data with the help of SPSS version 25 for partial known that the variable of capital structure has no significant effect on firm value. Variable profitability has positive and significant effect on firm value. The variable size of the company does not have a significant effect on firm value. Variable the value of the company can be explain by the variable capital structure, profitability, and firm size by 18.4%, while the rest of 81.6% is explained by other variables.Keywords: Firm Value, Capital Structure, Profitability, Size of the Company

Covalent Inhibitors of Human Monoacylglycerol Lipase: Ligand-Assisted Characterization of the Catalytic Site by Mass Spectrometry and Mutational Analysis

SummaryThe active site of recombinant hexa-histidine-tagged human monoacylglycerol lipase (hMGL) is characterized by mass spectrometry using the inhibitors 5-((biphenyl-4-yl)methyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide (AM6701), and N-arachidonylmaleimide (NAM) as probes. Carbamylation of Ser129 by AM6701 in the putative hMGL catalytic triad demonstrates this residue's essential role in catalysis. Partial NAM alkylation of hMGL cysteine residues 215 and/or 249 was sufficient to achieve ∼80% enzyme inhibition. Although Cys215 and/or Cys249 mutations to alanine(s) did not affect hMGL hydrolytic activity as compared with nonmutated hMGL, the C215A displayed heightened NAM sensitivity, whereas the C249A evidenced reduced NAM sensitivity. These data conclusively demonstrate a sulfhydryl-based mechanism for NAM inhibition of hMGL in which Cys249 is of paramount importance. Identification of amino acids critical to the catalytic activity and pharmacological modulation of hMGL informs the design of selective MGL inhibitors as potential drugs

Necesidades educativas e inclusión escolar: el peso de las actitudes

The results obtained after evaluating attitudes towards the inclusion of students with special educational needs in ordinary classrooms are presented. In this preliminary study the sample is composed of 91 participants, all of them students of the Master's degree. , of which 22% are men and 78% are women, aged between 22 and 45 years (M = 28.13, Dt = 6.4). The Opinion Questionnaire was applied to Integration, which consists of 30 items with a Likert type response format of 5 points and higher scores denoting more favorable attitudes. The results indicated that women and those who have contact with the attitudinal reference consider that the teaching staff is better prepared to face the challenges of inclusion. However, there does not seem to be a linear relationship between contact frequency and attitudes toward integration, so it is necessary to deepen the type of contact and the types of educational needs with which you are familiar, in order to determine the weight of these factors in the formation of more or less favorable attitudes. The present findings as well as the continuation of this study will allow us to establish guidelines for intervention with teachers in training, who will be key elements in the promotion of inclusion in the classrooms of the future.Se presentan los resultados obtenidos tras evaluar las actitudes hacia la inclusión de alumnos con necesidades educativas especiales en aulas ordinarias. En este estudio preliminar la muestra está compuesta por 91 participantes, todos ellos estudiantes del grado de Maestro. , de los cuales un 22% son hombres y un 78% son mujeres, de edades comprendidas entre los 22 y los 45 años (M=28,13; Dt=6,4). Se aplicó el Cuestionario de Opiniones hacia la Integración, que está formado por 30 items con un formato de respuesta tipo Likert de 5 puntos y puntuaciones más altas denotan actitudes más favorables. Los resultados indicaron que las mujeres y quienes tienen contacto con el referente actitudinal consideran que el profesorado está mejor preparado para hacer frente a los retos de la inclusión. Sin embargo, no parece existir una relación lineal entre frecuencia de contacto y actitudes hacia la integración, por lo que es necesario profundizar en el tipo de contacto y en los tipos de necesidades educativas con los que se está familiarizado, para poder determinar el peso de estos factores en la conformación de unas actitudes más o menos favorables. Los presentes hallazgos así como la continuación del presente estudio nos permitirán establecer pautas para la intervención con maestros en formación, quienes serán elementos clave de la promoción de la inclusión en las aulas del futuro

Actitudes, barreras y oportunidades para el empleo de personas con discapacidad intelectual

In our society, employment represents one of the most important aspects that condition our life and relationships and even our health. Work is one of the fundamental activities of life. However, access to it is conditioned by a series of personal and contextual variables that, in interaction, become barriers to participation in society. A traditionally excluded group is composed of people with disabilities. The objective of this work was to: 1) Evaluate the perceptions of workers with intellectual disabilities about their quality of work life; 2) Know the main attitudes, barriers and opportunities that favor and / or hinder employment in these workers; and 3) Identify areas of intervention to improve the quality of work life in workers and organizations. To this end, the opinions expressed by 12 workers with intellectual disabilities who currently worked in Supported Employment (ECA) using qualitative methodologies through the focus group procedure and through the analysis of textual fragments were analyzed. The results obtained showed that the quality of working life is a multidimensional construct formed by objective and subjective indicators, and that the attitudes, barriers and opportunities perceived by the workers impact on their well-being. Finally, strategies are proposed to improve the services oriented towards the standardized employment of people with intellectual disabilities.En nuestra sociedad el empleo representa uno de los aspectos más importantes que condicionan nuestra vida y relaciones e incluso nuestra salud. El trabajo constituye una de las actividades fundamentales de la vida. Sin embargo, el acceso al mismo se encuentra condicionado por una serie de variables personales y contextuales que, en interacción, se convierten en barreras para la participación en la sociedad. Un grupo tradicionalmente excluido es el compuesto por personas con discapacidad. El objetivo de este trabajo consistió en: 1) Evaluar las percepciones de los trabajadores con discapacidad intelectual sobre su calidad de vida laboral; 2) Conocer las principales actitudes, barreras y oportunidades que favorecen y/o dificultan el empleo en estos trabajadores; y 3) Identificar áreas de intervención para mejorar la calidad de vida laboral en los trabajadores y organizaciones. Para ello se analizaron las opiniones expresadas por 12 trabajadores con discapacidad intelectual que actualmente trabajaban en Empleo con Apoyo (ECA) utilizando metodologías cualitativas a través del procedimiento de grupos focales y mediante el análisis de fragmentos textuales. Los resultados obtenidos pusieron de manifiesto que la calidad de vida laboral es un constructo multidimensional formado por indicadores objetivos y subjetivos, y que las actitudes, barreras y oportunidades percibidas por los trabajadores impactan en su bienestar. Finalmente se proponen estrategias para mejorar los servicios orientados hacia el empleo normalizado de personas con discapacidad intelectual

The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD+(H)

This study compared serum pyridine levels (NAD+ /NADH) in trained (n = 6) and untrained (n = 7) subjects after continuous progressive exercise at 50%, 70% then 95% of physical work capacity until fatigue (TTF) after consuming a placebo or antioxidant (AO) cocktail (Lactaway©). An increase of 17% in TTF was observed in AO as compared to placebo (p = 0.032). This was accompanied by a significant increase in serum NAD+ levels (p = 0.037) in the AO supplemented group post exercise. The increases in NAD+ and improved endurance reflect lower oxidative stress-induced suppression of aerobic respiration

Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s)

ACKNOWLEDGMENTS The work was supported by National Institutes of Health grants DA027113 and EY024717 to G.A.T. and DA09158 to A.M. A portion of this work was submitted in 2011 by A. Kulkarni in partial fulfillment of M.S. degree requirements from Northeastern University, Boston, MA.Peer reviewedPublisher PD

Supplementation with cactus pear (Opuntia ficus-indica) fruit decreases oxidative stress in healthy humans: A comparative study with vitamin C

Background: Cactus pear (Opuntia ficus-indica) fruit contains vitamin C and characteristic betalain pigments, the radical-scavenging properties and antioxidant activities of which have been shown in vitro. Objective: We investigated the effects of short-term supplementation with cactus pear fruit compared with vitamin C alone on total-body oxidative status in healthy humans. Design: In a randomized, crossover, double-treatment study, 18 healthy volunteers received either 250 g fresh fruit pulp or 75 mg vitamin C twice daily for 2 wk, with a 6-wk washout period between the treatments. Before (baseline) and after each treatment, 8-epiprostaglandin F2α (8-epi-PGF2α) and malondialdehyde in plasma, the ratio of reduced to oxidized glutathione (GSH:GSSG) in erythrocytes, and lipid hydroperoxides in LDL were measured as biomarkers of oxidative stress; plasma Trolox-equivalent antioxidant activity (TEAC) and vitamins A, E, and C were evaluated as indexes of antioxidant status. Results: Both treatments caused comparable increases compared with baseline in plasma concentrations of vitamin E and vitamin C (P < 0.05); vitamin A and TEAC did not change significantly. After supplementation with cactus pear fruit, 8-epi-PGF2α and malondialdehyde decreased by ≈30% and 75%, respectively; GSH:GSSG shifted toward a higher value (P < 0.05); and LDL hydroperoxides were reduced by almost one-half. Supplementation with vitamin C did not significantly affect any marker of oxidative stress. Conclusions: Consumption of cactus pear fruit positively affects the body's redox balance, decreases oxidative damage to lipids, and improves antioxidant status in healthy humans. Supplementation with vitamin C at a comparable dosage enhances overall antioxidant defense but does not significantly affect body oxidative stress. Components of cactus pear fruit other than antioxidant vitamins may play a role in the observed effects. © 2004 American Society for Clinical Nutrition

Lutein decreases oxidative stress and inflammation in liver and eyes of guinea pigs fed a hypercholesterolemic diet

Guinea pigs were fed a hypercholesterolemic diet (0.25 g/100 g cholesterol) and randomly allocated either to a Control group (n = 9) or to a Lutein (0.1 g/100 g) group (n = 10) for 12 weeks to evaluate oxidative stress and inflammation in both liver and eyes. Malondialdehyde (MDA) concentrations and inflammatory cytokines were measured as well as hepatic nuclear factor-kappaB (NF-κB) binding. Lutein concentrations were greater in eyes (P < 0.01) and liver (P < 0.001) in the Lutein group. All guinea pigs had high concentrations of hepatic cholesterol as well as high plasma ALT and AST levels indicative of liver injury. However, the Lutein group had 43% lower hepatic free cholesterol than the Controls (P < 0.05). Hepatic MDA and MDA in the eye were lower in the Lutein compared to the Control group (P < 0.05). Hepatic tumor necrosis factor-α was 32% lower in the Lutein group (P < 0.05). Lastly, the Lutein group presented lower NF-κB DNA binding activity than the Control group (P < 0.001). These results suggest that in the presence of high cholesterol, lutein exerts both antioxidant and anti-inflammatory effects, which can be explained by attenuated NF-κB DNA binding activity. Furthermore, results also suggest that lutein accumulates in the eyes of guinea pigs to protect against oxidative stress